Status Report

NASA Spaceline Current Awareness List #651 – 5 June 2015

By SpaceRef Editor
June 5, 2015
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Papers deriving from NASA support:



Goodwin TJ, McCarthy M, Cohrs RJ, Kaufer BB.

3D tissue-like assemblies: A novel approach to investigate virus-cell interactions.

Journal Impact Factor: 3.221

Funding: “This work was supported in part by the NASA Human Research Program Grant/Rapid Operational Investigation (T.J.G.) and Public Health Service Grant AG032958 and NS082228 (R.J.C.) from the National Institutes of Health (NIH).” T.J. Goodwin is at NASA Johnson Space Center.



Vignaux G, Besnard S, Denise P, Elefteriou F.

The vestibular system: A newly identified regulator of bone homeostasis acting through the sympathetic nervous system.

Curr Osteoporos Rep. 2015 May 28. [Epub ahead of print]

PIs: F. Elefteriou; G. Vignaux, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: Not available for this journal.

Funding: “The authors would like to thank the National Aeronautics and Space Administration through grant NNX12AL35G (FE), the National Space Biomedical Research Institute (GV, NASA NCC 9–58), the European Union’s Seventh Framework Programme FP7/2007–2013/through REA grant #318980, and the Centre National d’Etudes Spatiales (CNES, Grant #715) for their support of this work.”



Conkin J, Abercromby AFJ, Dervay JP, Feiveson AH, Gernhardt ML, Norcross JR, Ploutz-Snyder R, Wessel JH.

Hypobaric decompression sickness treatment model.

Aerosp Med Hum Perform. 2015 Jun;86(6):508-17.

PI: J. Conkin

Journal Impact Factor: 0.782

Funding: “This work was made possible through a National Aeronautics and Space Administration Cooperative Agreement (NNJ11HE31A) with the Universities Space Research Association.”



Walb MC, Black PJ, Payne VS, Munley MT, Willey JS.

A reproducible radiation delivery method for unanesthetized rodents during periods of hind limb unloading.

Life Sci Space Res. 2015 May 27. [Article in Press]

PI: J.S. Willey, NSBRI Career Advancement Award

Note: Hindlimb unloading study.

Journal Impact Factor: 1.183

Funding: “This study was supported by National Space Biomedical Research Institute Career Advancement Award EO00008 through NASA NCC 9-58 [JSW]. Further support was provided by NIH grant T32 CA113267-9.”



Ding LH, Park S, Xie Y, Girard L, Minna JD, Story MD.

Elucidation of changes in molecular signalling leading to increased cellular transformation in oncogenically progressed human bronchial epithelial cells exposed to radiations of increasing LET.

PIs: J.D. Minna/Y. Xie/L. Girard/M.D. Story/NSCOR

Journal Impact Factor: 3.497

Funding: “This work was supported by NASA NSCOR (NNJ05HD36G, NNX11AC54G); and the NCI Cancer Center Support Grant (1P30 CA142543).”



Hu S, Blakely WF, Cucinotta FA.

HEMODOSE: A biodosimetry tool based on multi-type blood cell counts.

Health Phys. 2015 Jul;109(1):54-68.

PI: S. Blattnig

Journal Impact Factor: 0.774

Funding: “This work was supported by NASA Space Radiation Risk Assessment Project and the University of Nevada, Las Vegas.”



Badavi FF, Walker SA, Santos Koos LM.

Low Earth orbit assessment of proton anisotropy using AP8 and AP9 trapped proton models.

Life Sci Space Res. 2015 Apr;5:21-30.

Journal Impact Factor: 1.183

Funding: “This work was sponsored by the Human Research Program (HRP), under the Human Exploration and Operations Mission Directorate of NASA, and partially funded by the NASA Grants NNX12AN58A and NNX14AL778.”



Bell ST, Brown SG, Abben DR, Outland NB.

Team composition issues for future space exploration: A review and directions for future research.

Aerosp Med Hum Perform. 2015 Jun;86(6):548-56.

Note: From the Acknowledgements: “Similarities may be found between this journal article and our technical report submitted to the funding agency, NASA/TM-2015-218568.”

Journal Impact Factor: 0.782

Funding: “This work was supported by contract NNJ13HF07P awarded to the first author from the National Aeronautics and Space Administration (NASA).”



Other papers of interest:



Neutelings T, V. NB, Liu Y, Tavella S, Ruggiu A, Cancedda R, Gabriel M, Colige A, Lambert C.

Skin physiology in microgravity: A 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice.

npj Microgravity. 2015 May 27;1:15002.

Note: ISS results. This article may be obtained online without charge.



Pool-Goudzwaard AL, Belavý DL, Hides JA, Richardson CA, Snijders CJ.

Low back pain in microgravity and bed rest studies.

Aerosp Med Hum Perform. 2015 Jun;86(6):541-7.

Note: Soyuz, STS, ISS results and bed rest studies.



Pastushkova LH, Kononihin AS, Tijs ES, Obraztsova OA, Dobrokhotov IV, Ivanisenko VA, Nikolaev EN, Larina IM.

[Identification of biological processes on the composition of the urine proteome cosmonauts on the first day after long space flights].

Ross Fiziol Zh Im I M Sechenova. 2015 Feb;101(2):222-37. Russian.

Note: Spaceflight missions are not identified.



Du F, Ding Y, Zou J, Li Z, Tian J, She R, Wang D, Wang H, Lv D, Chang L.

Morphology and molecular mechanisms of hepatic injury in rats under simulated weightlessness and the protective effects of resistance training.

PLoS One. 2015 May 22;10(5):e0127047.

Note: Hindlimb unloading was used. This article may be obtained online without charge.



Goswami N, Evans J, Schneider S, von der Wiesche M, Mulder E, Rossler A, Hinghofer-Szalkay H, Blaber AP.

Effects of individualized centrifugation training on orthostatic tolerance in men and women.

PLoS One. 2015 May 28;10(5):e0125780.

Note: Centrifugation was used. This article may be obtained online without charge.



Michael AP, Marshall-Bowman K.

Spaceflight-induced intracranial hypertension.

Aerosp Med Hum Perform. 2015 Jun;86(6):557-62. Review.



Walmsley L, Hanna L, Mouland J, Martial F, West A, Smedley AR, Bechtold DA, Webb AR, Lucas RJ, Brown TM.

Colour as a signal for entraining the mammalian circadian clock.

PLoS Biol. 2015 Apr 15;13(4):e1002127.

Note: From the abstract: “. . . these data reveal a new sensory mechanism for telling time of day that would be available to any mammalian species capable of chromatic vision.” This article may be obtained online without charge.



van Diepen HC, Foster RG, Meijer JH.

A colourful clock.

PLoS Biol. 2015 May 21;13(5):e1002160.

Note: Comment on article by Walmsley, et al.: Colour as a signal for entraining the mammalian circadian clock. PLoS Biol. 2015 Apr 15:13(4):e1002127. This article may be obtained online without charge.



Heinis FI, Vermillion KL, Andrews MT, Metzger JM.

Myocardial performance and adaptive energy pathways in a torpid mammalian hibernator.

Am J Physiol Regul Integr Comp Physiol. 2015 May 27:ajpregu.00365.2014. [Epub ahead of print]



Miyazaki J, Yamamoto H, Ichimura Y, Yamashiro H, Murase T, Yamamoto T, Umeda M, Higuchi T.

Inter-hemispheric desynchronization of the human MT+ during visually induced motion sickness.

Exp Brain Res. 2015 May 28. [Epub ahead of print]



Ueda K, Ogawa Y, Yanagida R, Aoki K, Iwasaki K.

Dose-effect relationship between mild levels of hypergravity and autonomic circulatory regulation.

Aerosp Med Hum Perform. 2015 Jun;86(6):535-40.

Note: Centrifugation was used.



Provost RM, Zuj KA, Arbeille P.

5-Day bed rest: Portal and lower limb veins with and without artificial gravity countermeasures.

Aerosp Med Hum Perform. 2015 Jun;86(6):524-8. 

Note: Bed rest study; centrifugation also was used.



Indovina I, Mazzarella E, Maffei V, Cesqui B, Passamonti L, Lacquaniti F.

Sound-evoked vestibular stimulation affects the anticipation of gravity effects during visual self-motion.

Exp Brain Res. 2015 May 24. [Epub ahead of print]



Kumar SY, Unnithan AR, Sen D, Kim CS, Lee YS.

Microgravity biosynthesized penicillin loaded electrospun polyurethane–dextran nanofibrous mats for biomedical applications.

Colloids Surf A Physicochem Eng Asp. 2015 Jul 20;477:77-83.

Note: A High Aspect Ratio Vessel (HARV) was used.



Srinivasan PP, Parajuli A, Price C, Wang L, Duncan RL, Kirn-Safran CB.

Inhibition of T-type voltage sensitive calcium channel reduces load-induced OA in mice and suppresses the catabolic effect of bone mechanical stress on chondrocytes.

PLoS One. 2015 May 26;10(5):e0127290.

Note: This article may be obtained online without charge.



Spyropoulou A, Karamesinis K, Basdra EK.

Mechanotransduction pathways in bone pathobiology.

Biochim Biophys Acta. 2015 May 22. [Epub ahead of print]



Hamamura K, Chen A, Yokota H.

Enhancement of osteoblastogenesis and suppression of osteoclastogenesis by inhibition of de-phosphorylation of eukaryotic translation initiation factor 2 alpha.

Receptors Clin Investig. 2015;2(1).

Note: This article may be obtained online without charge.



Suman S, Khan Z, Zarin M, Chandna S, Seth RK.

Radioresistant Sf9 insect cells display efficient antioxidant defence against high dose gamma-radiation.

Int J Radiat Biol. 2015 May 22:1-40. [Epub ahead of print]



Pejchal J, Tichý A, Kmochová A, Ďuriŝová K, Kubelková K, Pohanka M, Bureš J, Tachecí I, Kuča K, Vávrová J, Šinkorová Z.

Attenuation of radiation-induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice.

Int J Radiat Biol. 2015 May 21:1-35. [Epub ahead of print]



Chen KB, Ponto K, Tredinnick RD, Radwin RG.

Virtual exertions: Evoking the sense of exerting forces in virtual reality using gestures and muscle activity.

Hum Factors. 2015 Jun;57(4):658-73. Epub 2014 Dec 5.

Note: The NASA Task Load Index was used.



Nérot A, Skalli W, Wang X.

An assessment of the realism of digital human manikins used for simulation in ergonomics.



Jansen KA, Donato DM, Balcioglu HE, Schmidt T, Danen EH, Koenderink GH.

A guide to mechanobiology: Where biology and physics meet.

Biochim Biophys Acta. 2015 May 18. [Epub ahead of print] Review.



Costa A, Sanchez-Guardado L, Juniat S, Gale JE, Daudet N, Henrique D.

Generation of sensory hair cells by genetic programming with a combination of transcription factors.



DiFrancesco JM, Olson JM.

The economics of microgravity research.

npj Microgravity. 2015;1:15001. Epub 2015 May 27.

Note: This article may be obtained online without charge.



Karahara I.

The history and current status of space life sciences in Asia – A report of the 10th Asian Microgravity Symposium 2014 Seoul.

Biol Sci Space. 2015;29:8-11.

Note: The biennial Asian Microgravity Symposium was held in Seoul, South Korea with 169 scientists from China, Japan, South Korea, Pakistan, Malaysia, and Saudi Arabia, as well as non-Asian countries (United States, Germany, and the Netherlands). This article may be obtained online without charge.

SpaceRef staff editor.