Status Report

NASA Spaceline Current Awareness List #648 – 15 May 2015

By SpaceRef Editor
May 15, 2015
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In case you missed it: Here is a link to an interview with Kasthuri Venkateswaran discussing the Microbial Observatory onboard the ISS — From the website: “NASA commentator Amiko Kauderer talks with Dr. Kasthuri Venkateswaran, principal investigator for the Microbial Observatory experiment aboard the International Space Station that focuses on the millions of other living things on the station other than the crew: the microbes which share the environment with the human crew. Dr. Venkateswaran is with the California Institute of Technology and the Jet Propulsion Laboratory in Pasadena.”


Papers deriving from NASA support:



Faghih R, Dahleh M, Adler G, Klerman E, Brown E.

Quantifying pituitary-adrenal dynamics and deconvolution of concurrent cortisol and adrenocorticotropic hormone data by compressed sensing.

IEEE Trans Biomed Eng. 2015 Apr 29. [Epub ahead of print]

PI: E. Klerman

Journal Impact Factor: 2.233

Funding: “RTF’s work was supported in part by the NSF Graduate Research Fellowship. For this work, ENB is supported in part by NIH DP1 OD003646, and NSF 0836720, MAD is supported in part by EFRI-0735956, EBK is supported in part by NIH P01-AG09975, K24-HL105664, RC2-HL101340, R01-HL-11408, R01-64105018 and HFP01603 and HFP02802 from the National Space Biomedical Research Institute through NASA NCC 9-58 and GKA is supported in part by NIH K24 HL103845. Clinical studies were performed at the Brigham and Women’s Hospital General Clinical Research Center. Grants supporting the original data collection include NIH R01AR43130 (GKA), M01RR20635 (BWH GCRC), K01AG00661 (EBK), R01GM 53559 (ENB), and NASA NCC9-58 with the NSBRI.”



Parihar VK, Allen B, Tran KK, Macaraeg TG, Chu EM, Kwok SF, Chmielewski NN, Craver BM, Baulch JE, Acharya MM, Cucinotta FA, Limoli CL.

What happens to your brain on the way to Mars.

Sci Adv. 2015 May 1;1(4): e1400256.

PIs: J.E. Baulch; C.L. Limoli; G.A. Nelson/C.L. Limoli/NSCOR

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal.

Funding: “This work was supported by NASA grants NNX13AK70G (J.E.B.), NNX13AD59G (C.L.L.), NNX10AD59G (C.L.L.), and NNX15AI22G (C.L.L.).”



Howden EJ, Perhonen M, Peshock RM, Zhang R, Arbab-Zadeh A, Adams-Huet B, Levine BD.

Females have a blunted cardiovascular response to 1-year of intensive supervised endurance training.

J Appl Physiol (1985). 2015 Apr 30:jap.00092.2015. [Epub ahead of print]

PI: G. Blomqvist/B.D. Levine/NSCORT

Journal Impact Factor: 3.434

Funding: “This study was supported by the NASA Specialized Center for Research and Training Grant NGW3582, the S. Finley Ewing Chair for Wellness at Texas Health Presbyterian Hospital, and the Harry S. Moss Heart Chair for Cardiovascular Research.”



Bederman IR, Lai N, Shuster J, Henderson L, Ewart S, Cabrera ME.

Chronic hindlimb suspension unloading markedly decreases turnover rates of skeletal and cardiac muscle proteins and adipose tissue triglycerides.

J Appl Physiol (1985). 2015 Apr 30:jap.00004.2014. [Epub ahead of print]

PI: M.E. Cabrera

Note: Hindlimb unloading study.

Journal Impact Factor: 3.434

Funding: “This work was supported by grants sponsored by the National Aeronautics and Space Administration (NASA), “Digital Astronaut” NNJ06HD81G (IR Bederman and ME Cabrera).”



Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, Liu S, Barry KJ, Uda Y, Lai F, Dedic C, Balcells-Camps M, Kronenberg HM, Babij P, Divieti Pajevic P.

The Wnt-inhibitor sclerostin is up-regulated by mechanical unloading in osteocytes in-vitro.

J Biol Chem. 2015 May 7. [Epub ahead of print]

Note: A Rotating Wall Vessel system was used. This article may be obtained online without charge.

Journal Impact Factor: 4.6

Funding: “This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Disease (NIAMS), part of the National Institutes of Health, grant AR059655 to PDP. JMS was supported by a Northrop Grumman Aerospace Systems Ph.D. Training Fellowship, MIT Hugh Hampton Young Fellowship, the National Space Biomedical Research Institute through NASA NCC 9-58, and the U.S. Army Institute for Environmental Medicine Qak Ridge Science Institute for Science and Education fellowship program. HMK was supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK011794. MNW was supported by NIDDK DK100215. MBC was supported by Spain’s Ministerio de Economia e Innovacion (BFU 2009-09804), Posimat and Fundacio Empreses IQS.” J.M. Spatz is part of NSBRI’s Mentored Research Program.



Rabin BM, Heroux NA, Shukitt-Hale B, Carrihill-Knoll KL, Beck Z, Baxter C.

Lack of reliability in the disruption of cognitive performance following exposure to protons.

Radiat Environ Biophys. 2015 May 3. [Epub ahead of print]

PI: B.M. Rabin

Journal Impact Factor: 1.582

Funding: “The research reported here was carried out under National Aeronautics and Space Administration Grants NNJ06HD93G, NNX08AM66G and NNX13AB73G.”



Committee to Review NASA’s Evidence Reports on Human Health Risks, Board on Health Sciences Policy, Institute of Medicine.

Review of NASA’s evidence reports on human health risks: 2014 letter report.

Washington (DC): National Academies Press (US). 2015; 92 p.

Note: From the abstract: “This report builds on the 2008 IOM report Review of NASA’s Human Research Program Evidence Books: A Letter Report, which provided an initial and brief review of the evidence reports. This letter report reviews seven evidence reports and examines the quality of the evidence, analysis, and overall construction of each report; identifies existing gaps in report content; and provides suggestions for additional sources of expert input.” This monograph may be obtained online without charge.

Funding: “This project was supported by Contract NNH13CK19B, Task Order NNH13CK20D, between the National Academy of Sciences and the National Aeronautics and Space Administration.”



Other papers of interest:



Riwaldt S, Pietsch J, Sickmann A, Bauer J, Braun M, Segerer J, Schwarzwälder A, Aleshcheva G, Corydon TJ, Infanger M, Grimm D.

Identification of proteins involved in inhibition of spheroid formation under microgravity.

Note: ISS results.



Tsybko AS, Ilchibaeva TV, Kulikov AV, Kulikova EA, Krasnov IB, Sychev VN, Shenkman BS, Popova NK, Naumenko VS.

Effect of microgravity on glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor gene expression in the mouse brain.

J Neurosci Res. 2015 May 6. [Epub ahead of print]

Note: Bion-M1 results.



O’Brien KA, Griffin JL, Murray AJ, Edwards LM.

Mitochondrial responses to extreme environments: Insights from metabolomics.

Extrem Physiol Med. 2015 May 4;4:7. Review.

Note: This article may be obtained online without charge.



Pavei G, Biancardi CM, Minetti AE.

Skipping vs. running as the bipedal gait of choice in hypogravity.

J Appl Physiol (1985). 2015 Apr 30:jap.01021.2014. [Epub ahead of print]

Note: A suspension device was used to simulate weightlessness.



Zhang D, Xu H, Shull PB, Liu J, Zhu X.

Somatotopical feedback versus non-somatotopical feedback for phantom digit sensation on amputees using electrotactile stimulation.

J Neuroeng Rehabil. 2015 May 2;12(1):44.

Note: The NASA TLX was used to determine differences in mental workload between test groups. This article may be obtained online without charge.



Marusic U, Kavcic V, Giordani B, Gerževič M, Meeusen R, Pišot R.

Computerized spatial navigation training during 14 days of bed rest in healthy older adult men: Effect on gait performance.

Psychol Aging. 2015 May 4. [Epub ahead of print]

Note: Bed rest study.



Badrov MB, Usselman CW, Shoemaker JK.

Sympathetic neural recruitment strategies: Responses to severe chemoreflex and baroreflex stress.

Am J Physiol Regul Integr Comp Physiol. 2015 May 6:ajpregu.00077.2015. [Epub ahead of print]



Keshavarz B, Riecke BE, Hettinger LJ, Campos JL.

Vection and visually induced motion sickness: How are they related?

Front Psychol. 2015 Apr 20;6:472. Review.

Note: This article may be obtained online without charge.



Braunecker S, Douglas B, Hinkelbein J.

Comparison of different techniques for cardiopulmonary resuscitation in microgravity – A simple mathematic estimation of cardiopulmonary resuscitation quality for space environment.

Am J Emerg Med. 2015 Apr 15. [Epub ahead of print]

Note: After a literature review, five types of CPR were identified for use in weightlessness. The authors conclude that “Concerning CPR quality, the HS [handstand] seems to be most effective to treat a cardiac arrest. In some environmental conditions where this technique cannot be used, the ER [Evetts-Russomano] technique is a good alternative because CPR quality is only slightly lower.”



Lee YH, Seo DH, Park JH, Kabayama K, Opitz J, Lee KH, Kim HS, Kim TJ.

Effect of Oenothera odorata root extract on microgravity and disuse-induced muscle atrophy.

Evid Based Complement Alternat Med. 2015;2015:130513.

Note: A 3D-clinostat was used. This article may be obtained online without charge.



Nam J, Perera P, Gordon R, Jeong Y, Blazek AD, Kim DG, Tee BC, Sun Z, Eubank TD, Zhao Y, Lablebecioglu B, Liu S, Litsky A, Weisleder NL, Lee BS, Butterfield T, Schneyer AL, Agarwal S.

Follistatin-like 3 is a mediator of exercise-driven bone formation and strengthening.



Ehnes DD, Price FD, Shrive NG, Hart DA, Rancourt DE, Zur Nieden NI.

Embryonic stem cell-derived osteocytes are capable of responding to mechanical oscillatory hydrostatic pressure.

J Biomech. 2015 Apr 16. [Epub ahead of print]



El-Jaby S, Richardson RB.

Monte Carlo simulations of the secondary neutron ambient and effective dose equivalent rates from surface to suborbital altitudes.

Life Sci Space Res. 2015 May 7. [Article in Press]



Yu XJ, Dickman JD, DeAngelis GC, Angelaki DE.

Neuronal thresholds and choice-related activity of otolith afferent fibers during heading perception.

Proc Natl Acad Sci U S A. 2015 May 4. [Epub ahead of print]



Guo Y, Wang Y, Liu Y, Liu Y, Zeng Q, Zhao Y, Zhang X, Zhang X.

MicroRNA-218, microRNA-191*, microRNA-3070a and microRNA-33 are responsive to mechanical strain exerted on osteoblastic cells.

Mol Med Rep. 2015 Apr 30. [Epub ahead of print]



Mousavi SJ, Hamdy Doweidar M.

Role of mechanical cues in cell differentiation and proliferation: A 3D numerical model.

PLoS One. 2015 May 1;10(5):e0124529.

Note: This article may be obtained online without charge.



Draelants D, Avitabile D, Vanroose W.

Localized auxin peaks in concentration-based transport models of the shoot apical meristem.

J R Soc Interface. 2015 May 6;12(106).



König K, Weinigel M, Pietruszka A, Bückle R, Gerlach N, Heinrich U.

Multiphoton tomography of astronauts.

Proc SPIE, Multiphoton Microscopy in the Biomedical Sciences XV. 2015 Mar 5;9329:93290Q-Q-6.

Note:  From the abstract: “Within the Skin B project, skin physiological changes during long duration space flights are currently investigated on three European astronauts that work for nearly half a year at the ISS. Measurements on the hydration, the transepidermal water loss, the surface structure, elasticity and the tissue density by ultrasound are conducted. Furthermore, high-resolution in vivo histology is performed by multiphoton tomography with 300 nm spatial and 200 ps temporal resolution.”


SpaceRef staff editor.