Status Report

NASA Spaceline Current Awareness List #645 – 24 April 2015

By SpaceRef Editor
April 24, 2015
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Papers deriving from NASA support:



Morris CJ, Yang JN, Garcia JI, Myers S, Bozzi I, Wang W, Buxton OM, Shea SA, Scheer FA.

Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans.

Proc Natl Acad Sci U S A. 2015 Apr 13. [Epub ahead of print]

PI: C.J. Morris, NSBRI Postdoctoral Fellowship Program

Journal Impact Factor: 9.809

Funding: “This study was supported by National Heart, Lung, and Blood Institute (NHLBI) Grant R01 HL094806 (to F.A.J.L.S.). C.J.M. was partly supported by the National Space Biomedical Research Institute through National Aeronautics and Space Administration Grant NCC 9-58. O.M.B. was partly supported by National Institute on Aging Grant P01 AG009975. I.B. was supported by the Brazilian National Council for Scientific and Technological Development. F.A.J.L.S. was supported in part by NHLBI Grant R01 HL094806, the Fund to Sustain Research Excellence by the Brigham and Women’s Hospital Biomedical Research Institute, National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK099512, and NHLBI Grant R01 HL118601. S.A.S. was supported in part by NHLBI Grant K24 HL076446. This project was supported by Clinical Translational Science Award UL1RR025758 to Harvard University and Brigham and Women’s Hospital from the National Center for Research Resources.”



Pathak R, Shao L, Ghosh SP, Zhou D, Boerma M, Weiler H, Hauer-Jensen M.

Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice.

PLoS One. 2015 Apr 10;10(4):e0122511.

PI: M. Boerma/NSBRI Center for Space Radiation Research

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.534

Funding: “This study was supported by National Institutes of Health (NIH) grants R37 CA71382 and U19 AI67798 (MH-J), the US Veterans Administration (MH-J), Arkansas Space Grant Consortium through National Aeronautics and Space Administration grant NNX13AB29A (RP), National Space Biomedical Research Institute (RE03701) through National Aeronautics and Space Administration NCC 9–58 (MB), NIH grant R01 CA148679 (MB), NIH grant R01 CA122023 (DZ), and the Edward P. Evans.”



Liu X, He Y, Li F, Huang Q, Kato TA, Hall RP, Li CY.

Caspase-3 promotes genetic instability and carcinogenesis.

Mol Cell. 2015 Apr 16;58(2):284-96. Epub 2015 Apr 9.

PI: C.-Y. Li

Journal Impact Factor: 14.464

Funding: “This study was supported in part by grants CA131408, CA136748, CA155270, and ES024015 from the NIH (to C.-Y.L.) and grant NNX12AB88G (to C.-Y.L.) from the NASA Space Radiation Biology Research Program, the Duke Skin Disease Research Core Center grant (AR066527) from the NIH to R.P.H., and grants 30428015 and 30325043 from the National Science Foundation of China and grant 2004CB518804 from the Ministry of Science of China “973 project” to Q.H.”



Plante I, Cucinotta FA.

Binary-Encounter-Bethe ionisation cross sections for simulation of DNA damage by the direct effect of ionising radiation.

Radiat Prot Dosimetry. 2015 Apr 13. [Epub ahead of print]

PI: S. Blattnig

Journal Impact Factor: 0.861

Funding: “Funding for this project was provided through the National Aeronautics and Space Administration (NASA contract number NAS9-02078).” I. Plante is funded through the NASA Space Radiation Risk Assessment Project.



Cucinotta FA, Alp M, Rowedder B, Kim M-HY.

Safe days in space with acceptable uncertainty from space radiation exposure.

Life Sci Space Res. 2015 Apr;5:31-8.

PI: S. Blattnig

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.183

Funding: “This study was supported by the University of Nevada, Las Vegas.” M-H. Y. Kim is funded through the NASA Space Radiation Risk Assessment Project.



Belavy DL, Adams M, Brisby H, Cagnie B, Danneels L, Fairbank J, Hargens AR, Judex S, Scheuring RA, Sovelius R, Urban J, van Dieën JH, Wilke HJ.

Disc herniations in astronauts: What causes them, and what does it tell us about herniation on earth?

European Spine Journal. 2015 Apr 18. [Epub ahead of print]

PI: A.R. Hargens

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.473

Funding: “The “European Space Agency Topical Team: Intervertebral Disc Herniations in Astronauts” was supported by contract number 4000110441/14/NL/PG from the European Space Agency. ARH was supported by NASA grant NNX13AM89G.”



Salas E, Grossman R, Hughes AM, Coultas CW.

Measuring team cohesion: Observations from the science.

Hum Factors. 2015 May;57(3):365-74.

PI: E. Salas

Journal Impact Factor: 1.290

Funding: “This work was supported by NASA Grant NNX09AK48G awarded to the University of Central Florida.”



Massa GD, Chase E, Santini JB, Mitchell CA.

Temperature affects long-term productivity and quality attributes of day-neutral strawberry for a space life-support system.

Life Sci Space Res. 2015 Apr;5:39-46.

PI: C.A. Mitchell/NSCORT

Journal Impact Factor: 1.183

Funding: “This project was supported, in part, by NASA Grant NAG 5 1286.”



Other papers of interest:



Widjaja D, Vandeput S, Van Huffel S, Aubert AE.

Cardiovascular autonomic adaptation in lunar and martian gravity during parabolic flight.

Eur J Appl Physiol. 2015 Feb 10. [Epub ahead of print]

Note: Parabolic flight results.



Ferré ER, Walther LE, Haggard P.

Multisensory interactions between vestibular, visual and somatosensory signals.

PLoS One. 2015 Apr 13;10(4):e0124573.

Note: This article may be obtained online without charge.



Rancz EA, Moya J, Drawitsch F, Brichta AM, Canals S, Margrie TW.

Widespread vestibular activation of the rodent cortex.

J Neurosci. 2015 Apr 15;35(15):5926-34.



Zuma EMFC, Mangabeira Albernaz PL, Cal R, Brusco TR, da Costa SS.

Assessment of the vestibuloocular reflex in fighter pilots with the video head impulse test.

Acta Otolaryngol. 2015 Apr 14:1-4. [Epub ahead of print]



Kean DJ, Peacock CA, Sanders GJ, McDaniel J, Colvin LA, Glickman EL.

The effects of cold and lower body negative pressure on cardiovascular homeostasis.

Biomed Res Int. 2015;2015:728145. Epub 2015 Mar 19.

Note: This article may be obtained online without charge.



Li P, Shi J, Zhang P, Wang K, Li J, Liu H, Zhou Y, Xu X, Hao J, Sun X, Pang X, Li Y, Wu H, Chen X, Ge Q.

Simulated microgravity disrupts intestinal homeostasis and increases colitis susceptibility.

FASEB J. 2015 Apr 15. [Epub ahead of print]

Note: Hindlimb unloading study.



Milan G, Romanello V, Pescatore F, Armani A, Paik JH, Frasson L, Seydel A, Zhao J, Abraham R, Goldberg AL, Blaauw B, DePinho RA, Sandri M.

Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy.

Nat Commun. 2015 Apr 10;6:6670.

Note: This article may be obtained online without charge.



Zhang R, Gong H, Zhu D, Ma R, Fang J, Fan Y.

Multi-level femoral morphology and mechanical properties of rats of different ages.



Wang X, Thomas CD, Clement JG, Das R, Davies H, Fernandez JW.

A mechanostatistical approach to cortical bone remodelling: An equine model.

Biomech Model Mechanobiol. 2015 Apr 11. [Epub ahead of print]



Sun Z, Cao X, Hu Z, Zhang L, Wang H, Zhou H, Li D, Zhang S, Xie M.

MiR-103 inhibits osteoblast proliferation mainly through suppressing Cav1.2 expression in simulated microgravity.

Note: A clinostat was used.



Verbruggen SW, Mc Garrigle MJ, Haugh MG, Voisin MC, McNamara LM.

Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis.

Biophys J. 2015 Apr 7;108(7):1587-98.



Repp F, Vetter A, Duda GN, Weinkamer R.

The connection between cellular mechanoregulation and tissue patterns during bone healing.

Med Biol Eng Comput. 2015 Apr 11. [Epub ahead of print]



Ballarini F, Altieri S, Bortolussi S, Carante M, Giroletti E, Protti N.

The role of DNA cluster damage and chromosome aberrations in radiation-induced cell killing: A theoretical approach.

Radiat Prot Dosimetry. 2015 Apr 15. [Epub ahead of print]



Matsuyoshi D, Morita T, Kochiyama T, Tanabe HC, Sadato N, Kakigi R.

Dissociable cortical pathways for qualitative and quantitative mechanisms in the face inversion effect.

J Neurosci. 2015 Mar 11;35(10):4268-79.



Durso FT, Stearman EJ, Morrow DG, Mosier KL, Fischer U, Pop VL, Feigh KM.

Exploring relationships of human-automation interaction consequences on pilots: Uncovering subsystems.

Hum Factors. 2015 May;57(3):397-406. Epub 2014 Sep 26.



Barber DJ, Reinerman-Jones LE, Matthews G.

Toward a tactile language for human-robot interaction: Two studies of tacton learning and performance.

Hum Factors. 2015 May;57(3):471-90. Epub 2014 Aug 28



Wang M, Xie B, Fu Y, Dong C, Hui L, Guanghui L, Liu H.

Effects of different elevated CO concentrations on chlorophyll contents, gas exchange, water use efficiency, and PSII activity on C3 and C4 cereal crops in a closed artificial ecosystem.

Photosynth Res. 2015 Apr 14. [Epub ahead of print]



Morozov Y, Kudenko Y, Trifonov S, Tikhomirov A.

The effects of the frequency and waveform of the activating current on physicochemical oxidation of organic wastes.

Life Sci Space Res. 2015 Apr 17. [Article in Press]



Kamal KY, Hemmersbach R, Javier Medina F, Herranz R.

Proper selection of 1g controls in simulated microgravity research as shown for clinorotated plant cell suspension cultures.

Life Sci Space Res. 2015 Apr 18. [Article in Press]

Note: 2D-clinorotaton was used.



Haga K, Tsuchida-Mayama T, Yamada M, Sakai T.

Arabidopsis ROOT PHOTOTROPISM2 contributes to the adaptation to high-intensity light in phototropic responses.

Plant Cell. 2015 Apr 14. [Epub ahead of print]



Haswell ES, Verslues PE.

The ongoing search for the molecular basis of plant osmosensing.

J Gen Physiol. 2015 Apr 13. [Epub ahead of print]



Popov C, Burggraf M, Kreja L, Ignatius A, Schieker M, Docheva D.

Mechanical stimulation of human tendon stem/progenitor cells results in upregulation of matrix proteins, integrins and MMPs, and activation of p38 and ERK1/2 kinases.

BMC Mol Biol. 2015 Mar 13;16(1):6.

Note: This article may be obtained online without charge.



Hao J, Zhang Y, Jing D, Shen Y, Tang G, Huang S, Zhao Z.

Mechanobiology of mesenchymal stem cells: A new perspective into the mechanically induced MSC fate.

Acta Biomater. 2015 Apr 11. [Epub ahead of print]



Duffy MP, Jacobs CR.

Seeing the unseen: Cell strain and mechanosensing.

Biophys J. 2015 Apr 7;108(7):1583-4.



Chatterjee S, Fujiwara K, Perez NG, Ushio-Fukai M, Fisher AB.

Mechanosignaling in the vasculature: Emerging concepts in sensing, transduction and physiological responses.

Am J Physiol Heart Circ Physiol. 2015 Apr 10:ajpheart.00105.2015. [Epub ahead of print]



Adapala RK, Thoppil RJ, Ghosh K, Cappelli HC, Dudley AC, Paruchuri S, Keshamouni V, Klagsbrun M, Meszaros JG, Chilian WM, Ingber DE, Thodeti CK.

Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.



Andreasson JO, Shastry S, Hancock WO, Block SM.

The mechanochemical cycle of mammalian kinesin-2 KIF3A/B under load.

Curr Biol. 2015 Apr 8. [Epub ahead of print]



Yuan J, Zhu Z, Ming Z, Luo Q.

An innovative method for simulating microgravity effects through combining electromagnetic force and buoyancy.

Adv Space Res. 2015 Apr 15. [Article in Press]

Note: From the abstract: “The new approach combines the neutral buoyancy and the electromagnetic force on the tested-body to balance the gravity and simulate the microgravity effects.” This article may be obtained online without charge.


SpaceRef staff editor.