Status Report

NASA Spaceline Current Awareness List #639 – 13 March 2015

By SpaceRef Editor
March 13, 2015
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NASA Spaceline Current Awareness List #639 – 13 March 2015


Papers deriving from NASA support:



Alwood JS, Shahnazari M, Chicana B, Schreurs AS, Kumar A, Bartolini A, Shirazi-Fard Y, Globus RK.

Ionizing radiation stimulates expression of pro-osteoclastogenic genes in marrow and skeletal tissue.

J Interferon Cytokine Res. 2015 Mar 3. [Epub ahead of print]

PIs: R.K. Globus; J.S. Alwood, 2012 Presidential Early Career Award for Scientist and Engineers (PECASE) and NASA Postdoctoral Fellowship; A. Kumar, NASA Postdoctoral Fellowship

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.297

Funding: “This research was supported by the National Space Biomedical Research Institute grant No. MA02501 under NASA cooperative agreement NCC 9-58 (R.K.G., J.S.A.), a DOE-NASA Interagency Award No. DE-SC0001507, supported by the Office of Science (Biological and Environmental Research), U.S. Department of Energy (R.K.G.), and 2 NASA Postdoctoral Program fellowships from NASA’s Space Biology Program ( J.S.A., A.K).”



Lerner ZF, Gadomski BC, Ipson AK, Haussler KK, Puttlitz CM, Browning RC.

Modulating tibiofemoral contact force in the sheep hind limb via treadmill walking: Predictions from an OpenSim musculoskeletal model.

J Orthop Res. 2015 Feb 26. [Epub ahead of print]

PI: C.M. Puttlitz

Journal Impact Factor: 2.972

Funding: “This work was supported by the National Aeronautics and Space Administration (NNX11AQ81G).”



Beheshti A, Benzekry S, McDonald JT, Ma L, Peluso M, Hahnfeldt P, Hlatky L.

Host age is a systemic regulator of gene expression impacting cancer progression.

Cancer Res. 2015 Mar 2. [Epub ahead of print]

PIs: L. Hlatky; L. Hlatky/P. Hahnfeldt/NSCOR

Journal Impact Factor: 9.284

Funding: “This project was supported, in part, by the National Aeronautics and Space Administration under NSCOR grants NNJ06HA28G and NNX11AK26G and by Award Number U54CA149233 from the National Cancer Institute, both to L. Hlatky.”



Watson AB.

Computing human optical point spread functions.

J Vis. 2015 Feb;15(2).

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.727

Funding: “This work supported by the NASA Space Human Factors Research Project WBS 466199.” A.B. Watson is at NASA Ames Research Center.



Gerelchuluun A, Manabe E, Ishikawa T, Sun L, Itoh K, Sakae T, Suzuki K, Hirayama R, Asaithamby A, Chen DJ, Tsuboi K.

The major DNA repair pathway after both proton and carbon-ion radiation is NHEJ, but the HR pathway is more relevant in carbon ions.

Radiat Res. 2015 Mar 4. [Epub ahead of print]

PI: A. Asaithamby

Journal Impact Factor: 2.445

Funding: “This work was supported in part by a Grant-in-Aid (24390287) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by the National Aeronautics and Space Association (NNX13AD57G to AA and DJC). Portions of this work were approved and performed under the Research Project with Heavy Ions at NIRS-HIMAC.”



Bell ST, Brown SG, Outland NB, Abben DR.

Critical team composition issues for long-distance and long-duration space exploration: A literature review, an operational assessment, and recommendations for practice and research.

Houston, TX: NASA Johnson Space Center, 2015 Feb. 78 p. NASA/TM-2015-218568.

Journal Impact Factor: Not applicable to this publication

Funding: The researcher reports that this research was funded by NASA contract NNJ13HF07P.



Other papers of interest:



Ogneva IV, Maximova MV, Larina IM.

[Desmin content and transversal stiffness of the left ventricle mouse cardiomyocytes and skeletal muscle fibers after a 30-day space flight on board “BION-M1” biosatellite].

Note: Bion-M1 results.



Chen Y, Lu J, Li H, Sun Q, Zhao Y, Su L, Liu M.

Effects of spaceflight and simulated microgravity on cell sub-microstructure and antioxidant enzyme activity in tomato.

Sci China Ser E. 2015 Feb;58(2):338-45.

Note: Shenzhou 8 and 3-D clinostat results.



Clément G, Bareille MP, Goel R, Linnarsson D, Mulder E, Paloski WH, Rittweger J, Wuyts FL, Zange J.

Effects of five days of bed rest with intermittent centrifugation on neurovestibular function.

J Musculoskelet Neuronal Interact. 2015 Mar;15(1):60-8.

Note: Bed rest and centrifugation study. This article may be obtained online without charge.



Carriot J, Jamali M, Brooks JX, Cullen KE.

Integration of canal and otolith inputs by central vestibular neurons is subadditive for both active and passive self-motion: Implication for perception.

J Neurosci. 2015 Feb 25;35(8):3555-65.



Liu H, Wang ZC, Bai YG, Cai Y, Yu JW, Zhang HJ, Bao JX, Ren XL, Xie MJ, Ma J.

Simulated microgravity promotes monocyte adhesion to rat aortic endothelium via NF-kappaB activation.

Clin Exp Pharmacol Physiol. 2015 Mar 4. [Epub ahead of print]

Note: Hindlimb unloading study.



Goswami N, Bruner M, Xu D, Bareille MP, Beck A, Hinghofer-Szalkay H, Blaber AP.

Short-arm human centrifugation with 0.4g at eye and 0.75g at heart level provides similar cerebrovascular and cardiovascular responses to standing.

Eur J Appl Physiol. 2015 Mar 4. [Epub ahead of print]

Note: Centrifugation was used.



Zhao XH, Zhang WJ, Zhou X, Gao Y, Fan XL, Liu GB.

[Changes in muscle spindle afferent discharge activities in rat soleus following hindlimb immobilization].

Nan Fang Yi Ke Da Xue Xue Bao. 2015 Feb;35(2):252-5. Chinese.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Kuznetsov MV, Baltin ME, Fedyanin AO, Eremeyev AA, Baltina TV.

[Effect of vibrostimulation of foot and supporting afferentation on functional state of shin muscles in rats during hindlimb unloading].

Note: Hindlimb unloading study.



Ham DJ, Kennedy TL, Caldow MK, Chee A, Lynch GS, Koopman R.

Citrulline does not prevent skeletal muscle wasting or weakness in limb-casted mice.

J Nutr. 2015 Mar 4. [Epub ahead of print]

Note: Hindlimb unloading study.



Martin KS, Blemker SS, Peirce-Cottler SM.

Agent-based computational model of skeletal muscle investigates muscle-specific responses to disuse-induced muscle atrophy.

J Appl Physiol (1985). 2015 Feb 26:jap.01150.2014. [Epub ahead of print]



Mabilleau G, Mieczkowska A, Libouban H, Simon Y, Audran M, Chappard D.

Comparison between quantitative X-ray imaging, dual energy X-ray absorptiometry and microCT in the assessment of bone mineral density in disuse-induced bone loss.

J Musculoskelet Neuronal Interact. 2015 Mar;15(1):42-52.

Note: Botulinum toxin was used to immobilize the hindlimbs. This article may be obtained online without charge.



Shtemberg AS, Lebedeva-Georgievskaya KB, Matveeva MI, Kudrin VA, Narkevich VB, Klodt PM, Bazyan AS.

[Effect of space flight factors simulated in ground-based experiments on the behavior, discriminant learning, and exchange of monoamines in different brain structures of rats].

Izv Akad Nauk Ser Biol. 2014 Apr;41(2):168-75. Russian.

Note: Space flight was simulated using “long-term fractionated gamma irradiation, antiorthostatic hypdynamia, and the combination of these factors” (from the abstract).



Turner HC, Shuryak I, Taveras M, Bertucci A, Perrier JR, Chen C, Elliston CD, Johnson GW, Smilenov LB, Amundson SA, Brenner DJ.

Effect of dose rate on residual gamma-H2AX levels and frequency of micronuclei in X-irradiated mouse lymphocytes.

Radiat Res. 2015 Mar 4. [Epub ahead of print]



Lucarotti C, Totaro M, Sadeghi A, Mazzolai B, Beccai L.

Revealing bending and force in a soft body through a plant root inspired approach.

Sci Rep. 2015 Mar 5;5:8788.

Note: This article may be obtained online without charge.



Solopova IA, Selionov VA, Sylos-Labini F, Gurfinkel VS, Lacquaniti F, Ivanenko YP.

Tapping into rhythm generation circuitry in humans during simulated weightlessness conditions.

Front Syst Neurosci. 2015 Feb;9:14. Review.

Note: Lower body suspension systems were used to simulate weightlessness. This article may be obtained online without charge.



Sato A, Sasaki S, Matsuzaki J, Yamamoto KT.

Negative phototropism is seen in Arabidopsis inflorescences when auxin signaling is reduced to a minimal level by an Aux/IAA dominant mutation, axr2.

Plant Signal Behav. 2015 Mar 4. [Epub ahead of print]



Kang J, Puskar KM, Ehrlicher AJ, LeDuc PR, Schwartz RS.

Structurally governed cell mechanotransduction through multiscale modeling.

Sci Rep. 2015 Feb 27;5:8622.

Note: This article may be obtained online without charge.



Étienne J, Fouchard J, Mitrossilis D, Bufi N, Durand-Smet P, Asnacios A.

Cells as liquid motors: Mechanosensitivity emerges from collective dynamics of actomyosin cortex.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2740-5. Epub 2015 Feb 17.



Guilluy C, Burridge K.

Nuclear mechanotransduction: Forcing the nucleus to respond.

Note: This article may be obtained online without charge.



Hickey EJ, Nosikova Y, Pham-Hung E, Gritti M, Schwartz S, Caldarone CA, Redington A, Van Arsdell GS.

National Aeronautics and Space Administration “threat and error” model applied to pediatric cardiac surgery: Error cycles precede approximately 85% of patient deaths.

J Thorac Cardiovasc Surg. 2015 Feb;149(2):496-507.e4. Epub 2014 Oct 15.


SpaceRef staff editor.