Status Report

NASA Spaceline Current Awareness List #635 – 13 February 2015

By SpaceRef Editor
February 13, 2015
Filed under , , ,

Papers deriving from NASA support:



Casey T, Patel OV, Plaut K.

Transcriptomes reveal alterations in gravity impact circadian clocks and activate mechanotransduction pathways with adaptation through epigenetic change.

Physiol Genomics. 2015 Feb 3:physiolgenomics.00117.2014. [Epub ahead of print]

PI: K. Plaut

Note: STS-70 results.

Journal Impact Factor: 2.812

Funding: “Supported by NASA NCC2-1373 and NASA EPSCoR NCC5-581 grants.”



Natarajan M, Konopinski R, Krishnan M, Roman L, Bera A, Zheng H, Habib SL, Mohan S.

Inhibitor kappa B kinase attenuates Hsp90-dependent endothelial nitric oxide synthase function in vascular endothelial cells.

Am J Physiol Cell Physiol. 2015 Feb 4:ajpcell.00367.2014. [Epub ahead of print]

PI: M. Natarajan

Journal Impact Factor: 3.674

Funding: “This study was supported by the NIH/NIDDK grant 5 R01 DK096119 (SM), and the National Space Biomedical Research Institute (NSBRI) grant CA02802 through NASA NCC 9-58-298 (MN).”



Wright KP Jr, Drake AL, Frey DJ, Fleshner M, Desouza CA, Gronfier C, Czeisler CA.

Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance.

Brain Behav Immun. 2015 Jan 29. [Epub ahead of print]

PI: C.A. Czeisler

Journal Impact Factor: 6.128

Funding: “Supported by NASA Cooperative Agreement NCC9-58 with the National Space Biomedical Research Institute and NASA, by NIH R01 HL081761 and R21 DK092624. Data collection carried out in the Brigham and Women’s Hospital Center for Clinical Investigation (formally supported by NIH Grant M01 RR02635 currently part of Harvard Clinical and Translational Science Center supported by NIH UL1 RR025758).”



Nair BC, Krishnan SR, Sareddy GR, Mann M, Xu B, Natarajan M, Hasty P, Brann D, Tekmal RR, Vadlamudi RK.

Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response.

Cell Death Differ. 2014 Sep;21(9):1409-18. Epub 2014 May 2.

PI: M. Natarajan

Journal Impact Factor: 8.385

Funding: “This study was supported by the NIH/NCI grant CA095681 (RKV); NIH grants R01CA133093 and R01ES016354 (BX); NASA Grant NNX12-AC32G (MN); NIH/NINDS grant NS050730 (DB) and the Cancer Therapy and Research Center at the University of Texas Health Science Center at San Antonio through the NCI Cancer Center Support Grant P30CA054174-17.”



Swanson CM, Shea SA, Stone KL, Cauley JA, Rosen CJ, Redline S, Karsenty G, Orwoll ES.

Obstructive sleep apnea and metabolic bone disease: Insights into the relationship between bone and sleep.

J Bone Miner Res. 2015 Feb;30(2):199-211. Review.

PI: S.A. Shea

Note: This article may be obtained online without charge.

Journal Impact Factor: 6.589

Funding: “CMS is supported by NIH grant T32DK007674–20. SAS is supported by NASA grant NNX10AR10G and NIH grant K24-HL076446. GK is supported by NIH grant R01 AR045548. ESO and JAC, of The Osteoporotic Fractures in Men (MrOS) Study, are supported by National Institutes of Health funding via the following institutes: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research, under the following grant numbers: U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128. SR is supported by the NIH.”



Uddin SM, Qin YX.

Dynamic acoustic radiation force retains bone structural and mechanical integrity in a functional disuse osteopenia model.

PI: Y.X. Qin

Journal Impact Factor: 4.461

Funding: “This research is kindly supported by the National Institutes of Health (R01AR52379 and R01AR61821), the US Army Medical Research and Materiel Command, and the National Space Biomedical Research Institute through NASA Cooperative Agreement NCC 9–58.”



Wallace IJ, Gupta S, Sankaran J, Demes B, Judex S.

Bone shaft bending strength index is unaffected by exercise and unloading in mice.

J Anat. 2015 Feb 2. [Epub ahead of print]

PI: S. Judex

Note: Hindlimb unloading was used.

Journal Impact Factor: 2.227

Funding: “The funding for this research was provided by the National Aeronautics and Space Administration (grants NNX08BA35G and NNX12AL25G) and the L.S.B. Leakey Foundation (grant 49357).”



Gupta V, Holets-Bondar L, Roby KF, Enders G, Tash JS.

A tissue retrieval and postharvest processing regimen for rodent reproductive tissues compatible with long-term storage on the International Space Station and postflight biospecimen sharing program.

Biomed Res Int. 2015;2015:475935. Epub 2015 Jan 13.

PI: J.S. Tash

Journal Impact Factor: 2.706

Funding: “This study is supported by NASA Grant NNX09AP04G to Joseph S.Tash.”



Clark TK, Newman MC, Merfeld DM, Oman CM, Young LR.

Human manual control performance in hyper-gravity.

Exp Brain Res. 2015 Feb 5. [Epub ahead of print]

PIs: L.R. Young, C.M. Oman; T.K. Clark, NSBRI Postdoctoral Fellowship Program

Note: A long-radius centrifuge was used.

Journal Impact Factor: 2.168

Funding: “This work was supported by the National Space Biomedical Research Institute (NSBRI) through NASA NCC9-58 (TKC, CMO, LRY) and via National Institute on Deafness and Other Communication Disorders (NIDCD)/National Institutes of Health (NIH) R01 DC04158 (DMM).”




Other papers of interest:



Rizzo AM, Altiero T, Corsetto PA, Montorfano G, Guidetti R, Rebecchi L.

Space flight effects on antioxidant molecules in dry tardigrades: The TARDIKISS Experiment.

Biomed Res Int. 2015;2015:167642. Epub 2015 Jan 13.

Note: STS-134 results. The experiment was part of the Biokon in Space (BIOKIS) payload for the Italian Space Agency’s DAMA mission. This article may be obtained online without charge.



Chen W, Chao JG, Chen XW, Wang JK, Tan C.

Quantitative orientation preference and susceptibility to space motion sickness simulated in a virtual reality environment.

Brain Res Bull. 2015 Jan 31. [Epub ahead of print]

Note: The space simulation virtual reality was created with three high-definition TV screens in a darkened room. A computer-generated stimulus scene was of a spacecraft interior and included a virtual astronaut as a highly polarized visual cue.



Dauchy RT, Wren MA, Dauchy EM, Hoffman AE, Hanifin JP, Warfield B, Jablonski MR, Brainard GC, Hill SM, Mao L, Dobek GL, Dupepe LM, Blask DE.

The influence of red light exposure at night on circadian metabolism and physiology in Sprague-Dawley rats.

J Am Assoc Lab Anim Sci. 2015;54(1):40-50.



Ogoh S, Sato K, Okazaki K, Miyamoto T, Hirasawa A, Sadamoto T, Shibasaki M.

Internal carotid and vertebral arteries blood flow during graded lower body negative pressure in humans.

Exp Physiol. 2015 Jan 13. [Epub ahead of print]

Note: The Early View online article at the publisher’s website is entitled: “Blood flow in internal carotid and vertebral arteries during graded lower body negative pressure in humans.”



Lee J, Kim K, Park S.

Factors associated with residual symptoms after recompression in type I decompression sickness.

Am J Emerg Med. 2014 Dec 18. [Epub ahead of print]



Tøien Ø, Blake J, Barnes BM.

Thermoregulation and energetics in hibernating black bears: Metabolic rate and the mystery of multi-day body temperature cycles.

J Comp Physiol B. 2015 Feb 4. [Epub ahead of print]



Palombo C, Morizzo C, Baluci M, Lucini D, Ricci S, Biolo G, Tortoli P, Kozakova M.

Large artery remodeling and dynamics following simulated microgravity by prolonged head-down tilt bed rest in humans.

Biomed Res Int. 2015;2015:342565. Epub 2015 Jan 13.

Note: Bed rest study. This article may be obtained online without charge.



Kravtsova VV, Matchkov VV, Bouzinova EV, Vasiliev AN, Razgovorova IA, Heiny JA, Krivoi, II.

Isoform-specific Na,K-ATPase alterations precede disuse-induced atrophy of rat soleus muscle.

Biomed Res Int. 2015;2015:720172. Epub 2015 Jan 13.

Note: This article may be obtained online without charge.



Ridha H, Almitani KH, Chamekh A, Toumi H, Tavares JM.

A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study.

Math Biosci. 2015 Jan 30. [Epub ahead of print]



Florio CS.

Development and implementation of a coupled computational muscle force optimization bone shape adaptation modeling method.

Int J Numer Method Biomed Eng. 2015 Jan 29. [Epub ahead of print]



Aguado E, Pascaretti-Grizon F, Goyenvalle E, Audran M, Chappard D.

Bone mass and bone quality are altered by hypoactivity in the chicken.

PLoS One. 2015 Jan 30;10(1):e0116763.

Note: From the Conclusion: “The confined chicken represents a new animal model of hypodynamia that can be used to study its effects on bone quality. The development of countermeasures, such as the return to free walking, may be beneficial in evaluating its effects on bone mass and bone quality.” This article may be obtained online without charge.



Dachev TP, Semkova JV, Tomov BT, Matviichuk YN, Dimitrov PG, Koleva RT, Malchev S, Bankov NG, Shurshakov VA, Benghin VV, Yarmanova EN, Ivanova OA, Häder DP, Lebert M, Schuster MT, Reitz G, Horneck G, Uchihori Y, Kitamura H, Ploc O, Cubancak J, Nikolaev I.

Overview of the Liulin type instruments for space radiation measurement and their scientific results.

Life Sci Space Res. 2015 Jan;4:92-114.



Shao Y, Xie C, Jiang L, Shi J, Zhu J, He Y.

Discrimination of tomatoes bred by spaceflight mutagenesis using visible/near infrared spectroscopy and chemometrics.

Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 17;140c:431-6. [Epub ahead of print]



Brungs S, Kolanus W, Hemmersbach R.

Syk phosphorylation – a gravisensitive step in macrophage signalling.

Cell Commun Signal. 2015 Feb 3;13(1):9. [Epub ahead of print]

Note: A 2D clinostat was used. This article may be obtained online without charge.



Chen X, Chalfie M.

Regulation of mechanosensation in C. elegans through ubiquitination of the MEC-4 mechanotransduction channel.

J Neurosci. 2015 Feb 4;35(5):2200-12.



Ellison C, Brun YV.

Mechanosensing: A regulation sensation.

Curr Biol. 2015 Feb 2;25(3):R113-5.



Osmanagic-Myers S, Dechat T, Foisner R.

Lamins at the crossroads of mechanosignaling.

Genes Dev. 2015 Feb 1;29(3):225-37. Review.

Note: This article may be obtained online without charge.



Kang KS, Robling AG.

New insights into Wnt-Lrp5/6-β-catenin signaling in mechanotransduction.

Front Endocrinol (Lausanne). 2015 Jan 20;5:246. Review.

Note: This article may be obtained online without charge.



Gupta M, Kocgozlu L, Sarangi BR, Margadant F, Ashraf M, Ladoux B.

Micropillar substrates: A tool for studying cell mechanobiology.

Methods Cell Biol. 2015;125:289-308. Epub 2015 Jan 8.


SpaceRef staff editor.