Status Report

NASA Spaceline Current Awareness List #634 – 6 February 2015

By SpaceRef Editor

February 6, 2015

Filed under ISS, Spaceline, Spaceline Current Awareness, US

Papers deriving from NASA support:

Moore DJ, Barlow MA, Gonzales JU, McGowan CL, Pawelczyk JA, Proctor DN.

Evidence for the emergence of leg sympathetic vasoconstrictor tone with age in healthy women.

Physiol Rep. 2015 Jan;3(1).

http://www.ncbi.nlm.nih.gov/pubmed/25626874

PI: J.A. Pawelczyk

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal.

Funding: “This study was funded by National Institutes of Health R01 AG018246 (to D.N. Proctor) and M01 RR10732 (to General Clinical Research Center), and National Aeronautics and Space Administration NNJ04HF45G (to J.A. Pawelczyk).”

Prisby RD, Behnke BJ, Allen MR, Delp MD.

Effects of skeletal unloading on the vasomotor properties of the rat femur principal nutrient artery.

J Appl Physiol (1985). 2015 Jan 29:jap.00576.2014. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25635000

PIs: M.D. Delp, R.K. Globus

Note: Hindlimb unloading study.

Journal Impact Factor: 3.434

Funding: “This study was supported by grants from the National Aeronautics and Space Administration (NNX12AL41G) [Editor’s Note: and NNX14AQ57G], National Space and Biomedical Research Institute (MA02501), and National Institutes of Health (AG-31317).”

Chang J, Feng W, Wang Y, Luo Y, Allen AR, Koturbash I, Turner J, Stewart B, Raber J, Hauer-Jensen M, Zhou D, Shao L.

Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice.

Radiat Res. 2015 Jan 30. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25635345

PIs: J. Raber; M. Boerma/NSBRI Center for Space Radiation Research

Journal Impact Factor: 2.445

Funding: “This study was supported in part by NASA grant NNJ12ZSA001N (JR), the National Space Biomedical Research Institute (NSBRI) Center for Space Radiation Research (RE03701) through NASA NCC 9–58 (LS, MH-J and DZ), Arkansas Research Alliance Scholarship and Rockefeller Leukemia and Lymphoma Research Endowment (DZ), UAMS Clinical and Translational Science Award UL1TR000039 and KL2TR000063 (IK), and the Arkansas Biosciences Institute, the major research component of the Arkansas Tobacco Settlement Proceeds Act of 2000 (IK).”

Wang X, Farris AB 3^rd, Wang P, Zhang X, Wang H, Wang Y.

Relative effectiveness at 1 Gy after acute and fractionated exposures of heavy ions with different linear energy transfer for lung tumorigenesis.

Radiat Res. 2015 Jan 30. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25635344

PIs: Y. Wang/H. Wang/NSCOR

Journal Impact Factor: 2.445

Funding: “This work is supported by grants from the National Aeronautics and Space Administration [NNX11AC30G (YW) and P30CA138292 to the Institute].”

Healy AF, Tack LA, Schneider VI, Barshi I.

Training specificity and transfer in time and distance estimation.

Mem Cognit. 2015 Jan 24. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25616777

Journal Impact Factor: 2.021

Funding: “This research was supported in part by National Aeronautics and Space Administration Grant Numbers NNX10AC87A and NNX14AB75A to the University of Colorado.” I. Barshi is at NASA Ames Research Center.

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Other papers of interest:

Huang B, Liu N, Rong X, Ruan J, Huang Y.

Effects of simulated microgravity and spaceflight on morphological differentiation and secondary metabolism of Streptomyces coelicolor A3(2).

Appl Microbiol Biotechnol. 2015 Jan 30. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25634016

Note: Shenzhou-8 results. A rotating clinostat was used to simulate microgravity.

Rejc E, di Prampero PE, Lazzer S, Grassi B, Simunic B, Pisot R, Antonutto G, Narici M.

A 35-day bed rest does not alter the bilateral deficit of the lower limbs during explosive efforts.

Eur J Appl Physiol. 2015 Jan 23. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25613402

Note: Bed rest study.

Yang Y, Pu F, Lv X, Li S, Li J, Li D, Li M, Fan Y.

Comparison of postural responses to galvanic vestibular stimulation between pilots and the general populace.

Biomed Res Int. 2015;2015:567690. Epub 2015 Jan 6.

http://www.ncbi.nlm.nih.gov/pubmed/25632395

Note: This article may be obtained online without charge.

Hromatka BS, Tung JY, Kiefer AK, Do CB, Hinds DA, Eriksson N.

Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes, and glucose homeostasis.

Hum Mol Genet. 2015 Jan 26. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25628336

Note: This article may be obtained online without charge.

Yan L, Kudej RK, Vatner DE, Vatner SF.

Myocardial ischemic protection in natural mammalian hibernation.

Basic Res Cardiol. 2015 Mar;110(2):462. Epub 2015 Jan 2.

http://www.ncbi.nlm.nih.gov/pubmed/25613166

Tank J, Jordan J.

Mighty hearts in space.

J Physiol. 2015 Feb 1;593(3):485-6.

http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2015.270000/abstract

Note: This article is a commentary on: Norsk P, Asmar A, Damgaard M, Christensen NJ. Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight. J Physiol. 2015 Feb 1;593(3):573-84. A reference for the preprint appeared in SPACELINE Current Awareness List #632 on January 23rd. This article may be obtained online without charge at:http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2014.284869/abstract.

Ghosh P, Mora Solis FR, Dominguez JM 2nd, Spier SA, Donato AJ, Delp MD, Muller-Delp JM.

Exercise training reverses aging-induced impairment of myogenic constriction in skeletal muscle arterioles.

J Appl Physiol (1985). 2015 Jan 29:jap.00277.2014. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25634999

Sun Z, Cao X, Zhang Z, Hu Z, Zhang L, Wang H, Zhou H, Li D, Zhang S, Xie M.

Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1 osteoblasts.

Sci Rep. 2015 Jan 28;5:8077.

http://www.ncbi.nlm.nih.gov/pubmed/25627864

Note: A clinostat was used. This article may be obtained online without charge.

Judex S, Koh TJ, Xie L.

Modulation of bone’s sensitivity to low-intensity vibrations by acceleration magnitude, vibration duration, and number of bouts.

Osteoporos Int. 2015 Jan 23. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/25614140

Plotkin LI, Speacht TL, Donahue HJ.

Cx43 and mechanotransduction in bone.

Curr Osteoporos Rep. 2015 Jan 24. [Epub ahead of print] Review.

http://www.ncbi.nlm.nih.gov/pubmed/25616771

Poje M, Vuković B, Radolić V, Miklavčić I, Planinić J.

Neutron radiation measurements on several international flights.

Health Phys. 2015 Mar;108(3):344-50.

http://www.ncbi.nlm.nih.gov/pubmed/25627946

Ribeiro CA, Pupo AS.

Involvement of alpha-adrenoceptors in the anti-immobility effect of imipramine in the tail suspension test.

Eur J Pharmacol. 2015 Mar 5;750:39-42. Epub 2015 Jan 21.

http://www.ncbi.nlm.nih.gov/pubmed/25617795

Note: Hindlimb unloading was used.

Suedfeld P, Brcic J, Johnson PJ, Gushin V.

Coping strategies during and after spaceflight: Data from retired cosmonauts.

Acta Astronaut. 2015 May-Jun;110:43-9.

http://www.sciencedirect.com/science/article/pii/S0094576514005177

Note: The participants were 20 retired Russian cosmonauts of whom ten had flown on Mir, four on ISS, and six on both.

Fuchs PA.

How many proteins does it take to gate hair cell mechanotransduction?

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1254-5. Epub 2015 Jan 23.

http://www.ncbi.nlm.nih.gov/pubmed/25617369

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Also of interest:

This week FASEB Journal issued a press release for an article about how spaceflight ages the immune system prematurely. The article appeared in Current Awareness List # 624 (11/21/2014) when it appeared online ahead of print. A link to the press release can be found at FASEB’s Latest News website: http://www.fasebj.org/site/Press_Room/Latest_News.xhtml.

Here is the updated citation to the published article:

Lescale C, Schenten V, Djeghloul D, Bennabi M, Gaignier F, Vandamme K, Strazielle C, Kuzniak I, Petite H, Dosquet C, Frippiat JP, Goodhardt M.

Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging.

FASEB J. 2015 Feb;29(2):455-63. Epub 2014 Nov 5.

http://www.ncbi.nlm.nih.gov/pubmed/25376832