Status Report

NASA Spaceline Current Awareness List #631 – 16 January 2015

By SpaceRef Editor
January 16, 2015
Filed under , , ,

Papers deriving from NASA support:



Lejeune L, Caiani EG, Prisk GK, Migeotte PF.

Evaluation of ensemble averaging methods in 3D ballistocardiography.

Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:5176-9.

PI: G.K. Prisk

Journal Impact Factor: Not available for this journal.

Funding: “Research supported by the Belgian Federal Science Policy Office (BELSPO) via the European Space Agency PRODEX program and by the Italian Space Agency (contract 2013-064-R.0, recipient E.G. Caiani). G. K. Prisk is supported by the National Space Biomedical Research Institute through NASA NCC 9-58.”



Gladding PA, Cave A, Zareian M, Smith K, Hussan J, Hunter P, Erogbogbo F, Aguilar Z, Martin DS, Chan E, Homer ML, Shevade AV, Kassemi M, Thomas JD, Schlegel TT.

Open access integrated therapeutic and diagnostic platforms for personalized cardiovascular medicine.

J Pers Med. 2013 Aug 21;3(3):203-37.

PI: J.D. Thomas

Note: This article is included because it was recently added to PubMed; it may be obtained without charge.

Journal Impact Factor: Not available for this journal.

Funding: “Funded in part by the NSBRI Foundation, NASA Grant NCC 9-58.”



Ball RL, Feiveson AH, Schlegel TT, Starc V, Dabney AR.

Predicting “heart age” using electrocardiography.

J Pers Med. 2014 Mar 7;4(1):65-78.

Note: This article is included because it was recently added to PubMed; it may be obtained without charge.

Journal Impact Factor: Not available for this journal.

Funding: “This work was funded, in part, by the NASA Graduate Student Researchers Program (GSRP) Fellowship, number NNX11AN08H.” A.H. Feiveson and T.T. Schlegel are at NASA Johnson Space Center.



Martinez EM, Yoshida MC, Candelario TT, Hughes-Fulford M.

Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation.

Am J Physiol Regul Integr Comp Physiol. 2015 Jan 7:ajpregu.00449.2014. [Epub ahead of print].

PI: M. Hughes-Fulford

Journal Impact Factor: 3.529

Funding: “This work was supported by NASA grant NNX09AH21G and NIH (NIA) grant 4UH3AG037628.”



Jangiam W, Tungjai M, Rithidech KN.

Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice.

Int J Radiat Biol. 2015 Jan 7:1-28. [Epub ahead of print].

PI: K.N. Rithidech

Journal Impact Factor: 1.837

Funding: “This research was supported by the National Aeronautics and Space Administration (NASA) Grant # NNX11AK91G.”



Sridharan DM, Asaithamby A, Bailey SM, Costes SV, Doetsch PW, Dynan WS, Kronenberg A, Rithidech KN, Saha J, Snijders AM, Werner E, Wiese C, Cucinotta FA, Pluth JM.

Understanding cancer development processes after HZE-particle exposure: Roles of ROS, DNA damage repair and inflammation.

Radiat Res. 2015 Jan 1;183(1):1-26. Epub 2015 Jan 7. Review.

PIs: A. Asaithamby; S.M. Bailey; A. Kronenberg; J.M. Pluth; K.N. Rithidech; C. Weise; J.D. Minna/A. Asaithamby/NSCOR; M.H. Barcellas-Hoff/S.V. Costes/NSCOR; Y. Wang/W.S. Dynan/D.W. Deutsch/E. Werner/NSCOR

Journal Impact Factor: 2.445

Funding: “This work was supported by: NASA NNX13AD57G and NSCOR NNX11AC54G (A. Asaithamby); NASA NNX08AB65G (S. Bailey); NIH/NIAID R01080486-02 (S. Bailey); NASA NNJ09HC64I and the Low Dose Scientific Focus Area, U.S. Department of Energy DE-AC02-05CH11231 (S. V. Costes); NASA NNX11AC30G (W. Dynan, P. Doetsch and E. Werner); NASA NNJ12HB88I (A. Kronenberg); NASA NNJ06HA33I and NNJ13HA96I (J. Pluth, D. Sridharan); NASA NNX11AK91G (K. Rithidech); Low Dose Scientific Focus Area, U.S. Department of Energy DE-AI02-10ER64969 (J. Saha); Low Dose Scientific Focus Area, U.S. Department of Energy DE-AC02-05CH11231 (A. Snijders); NASA NNJ11HB91I (C. Weise).”



Farin AM, Manzo ND, Kirsch DG, Stripp BR.

Low- and high-LET radiation drives clonal expansion of lung progenitor cells in vivo.

Radiat Res. 2015 Jan 1;183(1):124-32. Epub 2015 Jan 7.

PIs: D.G. Kirsch/P.R. Stripp/NSCOR

Journal Impact Factor: 2.445

Funding: “This work was supported by NASA NSCOR grant NNX11AC60G (BRS and DGK) and CIRM grant LA1_C12-06915 (BRS).”



Xie M, Park D, You S, Li R, Owonikoko TK, Wang Y, Doetsch PW, Deng X.

Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation.

Nucleic Acids Res. 2015 Jan 7:pi: gku1358. [Epub ahead of print].

PI: X. Deng

Note: This article may be obtained online without charge.

Journal Impact Factor: 8.808

Funding: “NASA [NNX12AC30G to X.D.]. Funding for open access charge: NASA [NNX12AC30G].”



Schneider R, Liao K, Walker MF, Bronstein A, Leigh RJ.

Behavior of the human translational vestibulo-ocular reflex during simultaneous head translation and rotation.

J Vestib Res. 2014;24(5-6):329-33. Epub 2015 Jan 8.

Journal Impact Factor: 1.456

Funding: “Supported by NIH grant EY06717, the Office of Research and Development, Medical Research Service, Department of Veterans Affairs, NASA/NSBRI NA00208, and the Evenor Armington Fund.”



Kunz H, Bishop NC, Spielmann G, Pistillo M, Reed J, Ograjsek T, Park Y, Mehta SK, Pierson DL, Simpson RJ.

Fitness level impacts salivary antimicrobial protein responses to a single bout of cycling exercise.

Eur J Appl Physiol. 2015 Jan 4. [Epub ahead of print].

PI: R.J. Simpson

Journal Impact Factor: 2.298

Funding: “This work was supported by NASA Grant NNX12AB48G to R.J. Simpson.”




Other papers of interest:



Liu Z, Wan Y, Zhang L, Tian Y, Lv K, Li Y, Wang C, Chen X, Chen S, Guo J.

Alterations in heart rate and activity rhythms of three orbital astronauts on a space mission.

Life Sci Space Res. 2015 Jan 9. [Article in Press].

Note: Chinese 15-day-mission space flight results. This article may be obtained online without charge.



Pugliese M, Loffredo F, Quarto M, Roca V, Vivaldo G, Zanini A.

The assessment of space radiation exposure of biology experiments during two short-term missions.

Am J Environ Prot. 2014 Dec 31;3(6):323-6.

Note: FOTON M3 and STS-34 results. This article may be obtained online without charge.



Lackner JR.

An earthbound perspective on orientation illusions experienced in aerospace flight.

In: Vidulich MA, Tsang PS, Flach JM, editors. Advances in Aviation Psychology: Volume 1. Ashgate Studies in Human Factors for Flight Operations. Burlington, VT: Ashgate Publishing Co.; 2014. p. 29-48.

Note: Skylab and parabolic flight results. Other chapters include: Aviation psychology: Optimizing human and system performance; Applying systems thinking to aviation psychology; NASA NextGen flight deck research: A database of research areas and results; Flight deck models of workload and multitasking: An overview of validation; Clarifying cognitive complexity and controller strategies in disturbed inbound peak air traffic control operations; Ecological flight deck design-the world behind the glass; Risk perception in ecological information systems; Implications of text chat for air crew communication and coordination; Human-centered automation as effective work design; Enhancing military helicopter pilot assistant systems through resource adaptive dialogue management; Individual pilot factors predict runway incursion outcomes; Synthetic task environments and the three-body problem; Enhancing management of complex and unforeseen situations among pilots: New trends in cognitive-adaptation training; and Distribution of attention as a function of time: A different approach to measure a specific aspect of situation awareness.



Neis SM, Klaus DM.

Considerations toward defining medical “levels of care” for commercial spaceflight.

New Space. 2014 Dec;2(4):165-77. Epub 2014 Nov 11.

Note: The article is available free of charge on the New Space website until February 14, 2015.



Zhang S, Zhang Y, Jiang S, Liu Y, Huang L, Zhang T, Lu G, Gong K, Ji X, Shao G.

The effect of hypoxia preconditioning on DNA methyltransferase and PP1gamma in hippocampus of hypoxia preconditioned mice.

High Alt Med Biol. 2014 Dec;15(4):483-90.



Cunha MP, Pazini FL, Ludka FK, Rosa JM, Oliveira A, Budni J, Ramos-Hryb AB, Lieberknecht V, Bettio LE, Martin-de-Saavedra MD, Lopez MG, Tasca CI, Rodrigues AL.

The modulation of NMDA receptors and L-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test.

Amino Acids. 2015 Jan 3. [Epub ahead of print]

Note: Hindlimb unloading study.



Wibirama S, Hamamoto K.

Investigation of visually induced motion sickness in dynamic 3D contents based on subjective judgment, heart rate variability, and depth gaze behavior.

Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:4803-6.



Binder H, Wirth H, Arakelyan A, Lembcke K, Tiys ES, Ivanisenko VA, Kolchanov NA, Kononikhin A, Popov I, Nikolaev EN, Pastushkova L, Larina IM.

Time-course human urine proteomics in space-flight simulation experiments.

BMC Genomics. 2014 Dec 19;15 Suppl 12:S2. Epub 2014 Dec 19.

Note: Data are from the Mars 105 day isolation study. This article may be obtained online without charge at



Porta A, Marchi A, Bari V, Catai AM, Guzzetti S, Raimondi F, Colombo R.

Directionality in cardiovascular variability interactions during head-down tilt test.

Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:6008-11.

Note: Head-down tilt study.



He Y, Nathan K, Venkatakrishnan A, Rovekamp R, Beck C, Ozdemir R, Francisco GE, Contreras-Vidal JL.

An integrated neuro-robotic interface for stroke rehabilitation using the NASA X1 powered lower limb exoskeleton.

Conf Proc IEEE Eng Med Biol Soc. 2014 Aug;2014:3985-8.



Baldi M, Cerri G, Chiaraluce F, Eusebi L, Russo P.

Non-invasive UWB sensing of astronauts’ breathing activity.

Sensors (Basel). 2014 Dec 30;15(1):565-91.

Note: Ultra-wide bandwidth technology is used. This article may be obtained online without charge.



Hyunseok H, Sakurai T, Lim JY, Hatta H.

Changes in alphaB-crystallin, tubulin, and MHC isoforms by hindlimb unloading show different expression patterns in various hindlimb muscles.

J Exerc Nutrition Biochem. 2014 Jun;18(2):161-8. Epub 2014 May 12.

Note: Hindlimb unloading study. This article is included because it was recently added to PubMed; it may be obtained without charge.



Cannavino J, Brocca L, Sandri M, Grassi B, Bottinelli R, Pellegrino MA.

The role of alterations in mitochondrial dynamics and PGC-1alpha over-expression in fast muscle atrophy following hindlimb unloading.

J Physiol. 2015 Jan 7. [Epub ahead of print].

Note: Hindlimb unloading study.



Chaillou T, Jackson JR, England JH, Kirby TJ, Richards-White J, Esser KA, Dupont-Versteegden EE, McCarthy JJ.

Identification of a conserved set of upregulated genes in mouse skeletal muscle hypertrophy and regrowth.

J Appl Physiol (1985). 2015 Jan 1;118(1):86-97. Epub 2014 Nov 13.

Note: Hindlimb unloading study.



Raue U, Jemiolo B, Yang Y, Trappe S.

TWEAK-Fn14 pathway activation after exercise in human skeletal muscle: Insights from two exercise modes and a time course investigation.

J Appl Physiol (1985). 2014 Dec 24:jap.00759.2014. [Epub ahead of print].



Shenkman BS, Lomonosova YN.

Expression of calsarcin isoforms and myosin phenotype stabilization in transitional unloaded muscle.

Dokl Biochem Biophys. 2014 Nov;459(1):214-6. Epub 2015 Jan 6.



Betts DC, Muller R.

Mechanical regulation of bone regeneration: Theories, models, and experiments.

Front Endocrinol (Lausanne). 2014 Dec;5:211. eCollection 2014. Review.

Note: This article may be obtained online without charge.



Zhang SB, Yang S, Vidyasagar S, Zhang M, Casey-Sawicki K, Liu C, Yin L, Zhang L, Cao Y, Tian Y, Swarts S, Fenton BM, Keng P, Zhang L, Okunieff P.

PicoGreen assay of circular DNA for radiation biodosimetry.

Radiat Res. 2015 Jan 9. [Epub ahead of print].  



Box MS, Huang BE, Domijan M, Jaeger KE, Khattak AK, Yoo SJ, Sedivy EL, Jones DM, Hearn TJ, Webb AA, Grant A, Locke JC, Wigge PA.

ELF3 controls thermoresponsive growth in Arabidopsis.

Curr Biol. 2014 Dec 30. [Epub ahead of print].


Note: The January issue of American Journal of Life Sciences is a Special Issue entitled “Space Flight Factors: From Cell to Body.” The articles may be downloaded without charge at



Alchinova I.

Changes in serum and cell homeostasis under irradiation: Factors of distant action.

Am J Life Sci. 2015 Jan;3(1-2):1-4.

Note: This article may be obtained online without charge.



Alchinova I, Arkhipova E, Medvedeva Y, Cherepov A, Antipov A, Lysenko N, Noskin L, Karganov M.

The complex of tests for the quantitative evaluation of the effects of radiation on laboratory animals.

Am J Life Sci. 2015 Jan;3(1-2):5-12.

Note: This article may be obtained online without charge.



Medvedeva Y, Arkhipova E, Alchinova I.

The effects of gamma-irradiation in sub-lethal doses in mice with different radiosensitivity.

Am J Life Sci. 2015 Jan;3(1-2):13-7.

Note: This article may be obtained online without charge.



Vyalkina M, Fedorov A, Eskina E, Medvedeva Y, Arkhipova E, Lebedeva M, Khlebnikova N, Baranov M, Karganov M.

Metabolic and morphological changes in rats’ eye after 7-days microgravity simulation.

Am J Life Sci. 2015 Jan;3(1-2):18-24.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Moisa SS, Zotin AA, Tsetlin VV.

The embryonic development of great ramshorn Planorbarius corneus under the hypomagnetic field.

Am J Life Sci. 2015 Jan;3(1-2):25-31.

Note: This article may be obtained online without charge.



Shafirkin A, Grigoriev Y.

Radiobiological foundation of crew radiation risk for Mars mission to the problem of the space flight safety.

Am J Life Sci. 2015 Jan;3(1-2):32-42.

Note: This article may be obtained online without charge.



Arkhipova E, Alchinova I, Karganov M.

Flight factors influence on human lymphocyte radioadaptive response and gamma-interferon production.

Am J Life Sci. 2015 Jan;3(1-2):43-7.

Note: This article may be obtained online without charge.



Cherepov A, Pozdeeva D, Arkhipova E.

The choice of informative parameters of the cardiovascular system for assessment of physiological effects of hypogravity.

Am J Life Sci. 2015 Jan;3(1-2):48-57.

Note: Bed rest study. This article may be obtained online without charge.


SpaceRef staff editor.