Status Report

NASA Spaceline Current Awareness List #609 1 August 2014

By SpaceRef Editor
August 1, 2014
Filed under , , ,
Papers deriving from NASA Support:
Prisk GK.
Microgravity and the respiratory system.
Eur Respir J. 2014 May;43(5):1459-71. Epub 2014 Mar 6. Review.
(PI: G.K. Prisk)
Journal Impact Factor: 6.355
Funding: “G.K. Prisk is supported by US National Institutes of Health grant R01-HL104117 and by the National Space Biomedical Research Institute though National Aeronautics and Space Administration (NASA) co-operative agreement NCC 9-58. Many of the studies were performed under contracts and grants from NASA.”
Norsk P.
Blood pressure regulation IV: Adaptive responses to weightlessness.
Eur J Appl Physiol. 2014 Mar;114(3):481-97. Epub 2014 Jan 5.
Note: Ground-based simulations and spaceflight studies are reviewed.
English KL, Loehr JA, Lee SM, Smith SM.
Early-phase musculoskeletal adaptations to different levels of eccentric resistance after 8 weeks of lower body training.
Eur J Appl Physiol. 2014 Jul 22. [Epub ahead of print]
(PI: S.M. Smith)
Journal Impact Factor: 2.660
Funding: No funding cited.
Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ.
Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load.
J Bone Miner Res. 2014 Feb;29(2):275-86. Review.
(PI: H.J. Donahue)
Note: This article may be obtained online without charge at
Journal Impact Factor: 6.128
Funding: “This work supported by the National Space Biomedical Research Institute through NASA NCC 9-58 (MA02802), as well as R01 AG013087 from the National Institute on Aging.”
Snijders AM, Mannion BJ, Leung SG, Moon SC, Kronenberg A, Wiese C.
Micronucleus formation in human keratinocytes is dependent on radiation quality and tissue architecture.
Environ Mol Mutagen. 2014 Jul 10.21887. [Epub ahead of print]
(PI: C. Wiese)
Journal Impact Factor: 3.708
Funding: “Grant sponsor: NASA; Grant number: NNJ11HB91I.”
Basner M, Dinges DF, Mollicone DJ, Savelev I, Ecker AJ, Di Antonio A, Jones CW, Hyder EC, Kan K, Morukov BV, Sutton JP.
Psychological and behavioral changes during confinement in a 520-day simulated interplanetary mission to Mars.
PLoS One. 2014 Mar 27;9(3):e93298.
(PI: D.F. Dinges)
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.730
Funding: “The research was supported by the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58, and by the Institute for Experimental Psychiatry Research Foundation.”
Fulcher BD, Phillips AJ, Postnova S, Robinson PA.
A physiologically based model of orexinergic stabilization of sleep and wake.
PLoS One. 2014 Mar 20;9(3):e91982.
(PI: A.J. Phillips)
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.730
Funding: “This work was supported by the Australian Research Council, the National Health and Medical Research Council, Westmead Millennium Institute, and the National Space Biomedical Research Institute through NASA NCC 9–58.”
Stevens RG, Brainard GC, Blask DE, Lockley SW, Motta ME.
Breast cancer and circadian disruption from electric lighting in the modern world.
CA Cancer J Clin. 2014 May-Jun;64(3):207-18. Epub 2013 Dec 24.
(PIs: G.C. Brainard, S.W. Lockley)
Note: This article may be obtained online without charge at
Journal Impact Factor: 153.459 
Funding: “This work was supported in part by the Institute for Integrative Health to G.C.B. and in part by grant 1R21CA129875 from the National Cancer Institute to D.E.B. This work was also supported by the National Space Biomedical Research Institute through grant NASA NCC 9-58 to G.C.B. and S.W.L.”
Veley KM, Maksaev G, Frick EM, January E, Kloepper SC, Haswell ES.
Arabidopsis MSL10 has a regulated cell death signaling activity that is separable from its mechanosensitive ion channel activity.
Plant Cell. 2014 Jul 22. pii:tpc.114.128082. [Epub ahead of print]
(PI: E.S. Haswell)
Journal Impact Factor: 9.251
Funding: “This work was supported by the National Science Foundation (MCB1253103), the National Institutes of Health (GM084211) and NASA (NNX13AM55G) to E.S.H., and the Howard Hughes Medical Institute for a Summer Undergraduate Research Fellowship to S.C.K.”
Committee on Ethics Principles and Guidelines for Health Standards for Long Duration and Exploration Spaceflights, Board on Health Sciences Policy, Institute of Medicine; Kahn J, Liverman CT, McCoy MA, editors.
Health standards for long duration and exploration spaceflight: Ethics principles, responsibilities, and decision framework.
Washington (DC): National Academies Press (US); 2014 Jun 23: 187 p.
Note: This article may be obtained online without charge.
Funding: “This project was supported by Contract NNH13CK14D between the National
Academy of Sciences and the National Aeronautics and Space Administration.”
Other papers of interest:
Monsieurs P, Mijnendonckx K, Provoost A, Venkateswaran K, Ott CM, Leys N, Van  Houdt R.
Genome sequences of Cupriavidus metallidurans strains NA1, NA4, and NE12, isolated from space equipment.
Genome Announc. 2014 Jul 24;2(4). pii: e00719-14.
Note: This article may be obtained online without charge.
Ruggiu A, Cancedda R.
Bone mechanobiology, gravity and tissue engineering: Effects and insights.
J Tissue Eng Regen Med. 2014 Jul 23. [Epub ahead of print] Review.
Note: Spaceflight, bed rest, and hindlimb unloading studies are reviewed.
Jing D, Cai J, Wu Y, Shen G, Zhai M, Tong S, Xu Q, Xie K, Wu X, Tang C, Xu X, Liu J, Guo W, Jiang M, Luo E.
Moderate-intensity rotating magnetic fields do not affect bone quality and bone remodeling in hindlimb suspended rats.
PLoS One. 2014 Jul 21;9(7):e102956.
Note: Hindlimb unloading study.
Cao Q, Zhang J, Liu H, Wu Q, Chen J, Chen GQ.
The mechanism of anti-osteoporosis effects of 3-hydroxybutyrate and derivatives under simulated microgravity.
Note: Hindlimb unloading study.
Goudarzi M, Mak TD, Chen C, Smilenov LB, Brenner DJ, Fornace AJ.
The effect of low dose rate on metabolomic response to radiation in mice.
Radiat Environ Biophys. 2014 Jul 22. [Epub ahead of print]
Maruši? U, Meeusen R, Pišot R, Kavcic V.
The brain in micro- and hypergravity: The effects of changing gravity on the brain electrocortical activity.
Eur J Sport Sci. 2014 Apr 15:1-10. [Epub ahead of print] Review.
Note: ISS, parabolic flight, and bed rest studies.
Pujol R, Pickett SB, Nguyen TB, Stone JS.
Large basolateral processes on type II hair cells are novel processing units in mammalian vestibular organs.
J Comp Neurol. 2014 Dec 1;522(14):Spc1.
Lacquaniti F, Bosco G, Gravano S, Indovina I, La Scaleia B, Maffei V, Zago M.
Multisensory integration and internal models for sensing gravity effects in primates.
Biomed Res Int. 2014;2014:615854. Epub 2014 Jul 1. Review.
Note: This article may be obtained online without charge.
Grimm D, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Ulbrich C, Magnusson NE, Infanger M, Bauer J.
Growing tissues in real and simulated microgravity: New methods for tissue engineering.
Tissue Eng Part B Rev. 2014 Apr 4. [Epub ahead of print] Review.
Ulbrich C, Wehland M, Peitsch J, Aleshcheva G, Wise, P, van Loon J, Magnusson N, Infanger M, Grosse J, Eilles C, Sunaresan A, Grimm D.
The impact of simulated and real microgravity on bone cells and mesenchymal stem cells.
BioMed Res Int. 2014. Article ID 928507. Review.
Note: Reviews studies that used the random positioning machine, 2D-clinostat, and rotating wall vessel bioreactor. This article may be obtained online without charge.
Zhang S, Zhang B, Chen X, Chen L, Wang Z, Wang Y.
Three-dimensional culture in a microgravity bioreactor improves the engraftment efficiency of hepatic tissue constructs in mice.
J Mater Sci Mater Med. 2014 Jul 24. [Epub ahead of print]
Inglis PW, Ciampi AY, Salomão AN, Costa Tda S, Azevedo VC.
Expression of stress-related genes in zebrawood (Astronium fraxinifolium, Anacardiaceae) seedlings following germination in microgravity.
Genet Mol Biol. 2014 Mar;37(1):81-92. Epub 2013 Feb 28.
Note: ISS results. This article may be obtained online without charge.
Hoson T.
Plant growth and morphogenesis under different gravity conditions: Relevance to plant life in space.
  1. 2014, 4(2):205-16. Review.
Note: A 3D clinostat with two rotation axes was used. This article may be obtained online without charge.
Malsch P, Andratsch M, Vogl C, Link AS, Alzheimer C, Brierley SM, Hughes PA, Kress M.
Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression.
J Neurosci. 2014 Jul 23;34(30):9845-56.

SpaceRef staff editor.