Status Report

NASA Spaceline Current Awareness List #1,007. 8 July 2022 (Space Life Science Research Results)

By SpaceRef Editor
July 8, 2022
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
In case you missed it: Furthering NASA’s efforts to advance diversity, equity, inclusion, and accessibility (DEIA), the National Academies of Sciences, Engineering, and Medicine has undertaken a study to evaluate ways NASA can address the lack of diversity in space mission leadership in their newly published book titled, Advancing Diversity, Equity, Inclusion, and Accessibility in the Leadership of Competed Space Missions. The full book description and free book download are available at
Papers deriving from NASA support:
Gabel L, Liphardt AM, Hulme PA, Heer M, Zwart SR, Sibonga JD, Smith SM, Boyd SK.
Incomplete recovery of bone strength and trabecular microarchitecture at the distal tibia 1 year after return from long duration spaceflight.
Sci Rep. 2022 Jun 30;12:9446.
PIs: J.D. Sibonga, S.M. Smith, S.R. Zwart
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 4.380
Funding: “This study was supported by the Canadian Space Agency (Contract #9F053-120605—Concept Definition and #9F008-140715—Operational Support) and German Aerospace Centre (DLR, Contract #50WB1217, #50WB1520, #50WB1937, #50WB2021). LG was supported by an Alberta Innovates Health Solutions Postgraduate Fellowship. The biomarker data were shared from the Biochemistry Profile project, which was funded by the NASA Human Research Program’s Human Health Countermeasures Element.”
Kumar RK, Singh NK, Balakrishnan S, Parker CW, Raman K, Venkateswaran K.
Metabolic modeling of the International Space Station microbiome reveals key microbial interactions.
Microbiome. 2022 Jul 6;10:102.
PI: K. Venkateswaran
Note: ISS results. GeneLab is available at This article may be obtained online without charge.
Journal Impact Factor: 14.652
Funding: “This research was funded by a 2012 Space Biology NNH12ZTT001N grant nos. 19-12829-26 under Task Order NNN13D111T award to KV, which also funded post-doctoral fellowship for NKS and CWP. KR acknowledges support from the Science and Engineering Board (SERB) MATRICS Grant MTR/2020/000490, IIT Madras, Centre for Integrative Biology and Systems mEdicine (IBSE) and Robert Bosch Center for Data Science and Artifcial Intelligence (RBCDSAI).”
Tu D, Basner M, Smith MG, Williams ES, Ryder VE, Romoser AA, Ecker A, Aeschbach D, Stahn AC, Jones CW, Howard K, Kaizi-Lutu M, Dinges DF, Shou H.
Dynamic ensemble prediction of cognitive performance in spaceflight.
Sci Rep. 2022 Jun 30;12:11032.
PIs: M. Basner, D.F. Dinges
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 4.380
Funding: “This work is supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (PI: M.B.). The original RST study was supported by the National Aeronautics and Space Administration through NASA NNX08AY09G (PI: DFD). CWJ was supported by a National Institutes of Health NRSA [5T32HL007713]. We thank Betty Lynn Ulrich and the Acoustics Office and Space Radiation Analysis Group at Johnson Space Center for their help with environmental data acquisition.”
Charvat JM, Leonard D, Barlow CE, DeFina LF, Willis BL, Lee SMC, Stenger MB, Mercaldo SF, Van Baalen M.
Long-term cardiovascular risk in astronauts: Comparing NASA mission astronauts with a healthy cohort from the Cooper Center Longitudinal Study.
Mayo Clin Proc. 2022 Jul 1;97(7):1237-46.
Note: The editorial for this article (Josephson et al.) is below in the “Other” section. From the article: “This study used a matched historical cohort design. CCLS [Cooper Center Longitudinal Study] participants who met the qualifying standards of the NASA Astronaut Corps were retrospectively matched in a ratio of 5:1 on sex, date of birth, and age at entrance into the Astronaut Corps or CCLS. The CVD [cardiovascular disease] outcomes were ascertained from records maintained by each respective group.
Journal Impact Factor: 11.104
Funding: “This study was supported in part by the National Space Biomedical Research Institute through NASA NCC 9-58. This funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. NASA authors were supported by The Human Research Program of the National Aeronautics and Space Administration. KBR authors were supported by the NASA Human Health and Performance contract NNJ15HK11B.”
Bisserier M, Brojakowska A, Saffran N, Rai AK, Lee B, Coleman M, Sebastian A, Evans A, Mills PJ, Addya S, Arakelyan A, Garikipati VNS, Hadri L, Goukassian DA.
Astronauts plasma-derived exosomes induced aberrant EZH2-mediated H3K27me3 epigenetic regulation of the vitamin D receptor.
Front Cardiovasc Med. 2022 Jun 16;9:855181.
PI: D.A. Goukassian
Note: From the abstract: “There are unique stressors in the spaceflight environment. Exposure to such stressors may be associated with adverse effects on astronauts’ health, including increased cancer and cardiovascular disease risks. Small extracellular vesicles (sEVs, i.e., exosomes) play a vital role in intercellular communication and regulate various biological processes contributing to their role in disease pathogenesis. To assess whether spaceflight alters sEVs transcriptome profile, sEVs were isolated from the blood plasma of 3 astronauts at two different time points: 10 days before launch (L-10) and 3 days after return (R+3) from the Shuttle mission.” This article may be obtained online without charge.
Journal Impact Factor: 5.846
Funding: “This work was supported by the Translational Research Institute for Space Health Funds FIP0005 (to DG), National Aeronautics and Space Administration Grant 80NSSC19K1079 (to DG), American Heart Association Career Development Award 18CDA34110277, and startup funds from the Ohio State University Medical Center (to VG), American Heart Association-Post Doctoral Fellowship Grant 915681 (AR), National Institutes of Health Grant R01 HL133554 and American Heart Association 18IPA34170321 (to LH), NIH 5T32HL007824-22, and the Cardiovascular Medical Research and Education Fund (CMREF) (to LH and MB).”
Ding LH, Fallgren CM, Yu Y, McCarthy M, Edmondson EF, Ullrich RL, Weil MM, Story MD.
Orthologs of human circulating miRNAs associated with hepatocellular carcinoma are elevated in mouse plasma months before tumour detection.
Sci Rep. 2022 Jun 28;12:10927.
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.380
Funding: “We thank NSRL in Brookhaven National Lab for supporting radiation experiments. This study was funded by the NASA Specialized Center of Research on Radiation Carcinogenesis (NSCOR) programs (NNJ08ZSA003N and NNX15AK13G). Dr. Ullrich is supported in part by the Radiation Efects Research Foundation, Hiroshima and Nagasaki, Japan which is a public interest foundation funded by the Japanese Ministry of Health, Labor, and Welfare (MHLW) and the US Department of Energy (DOE).”
Meyers A, Wyatt SE.
Plant space biology in the genomics age.
Annu plant rev online. 2022 May 4;5(2):p. 123-50.
PI: S.E. Wyatt
Note: From the abstract: “Advances in molecular technologies have ushered in a new age of understanding across all disciplines of biology. Research in plant biology has capitalized on these novel capabilities, unlocking new understanding of how plants respond to a myriad of conditions. Plant growth in spaceflight environments represents a decades-long endeavor, but the past 20 years have produced a wealth of data aimed toward understanding gravitational biology and informing the optimization of plant growth for long-duration spaceflight missions.”
Journal Impact Factor: Not Available for this journal
Funding: “Partial support for this manuscript was provided by NASA Biological and Physical Sciences grant #80NSSC19K1481.”
Other papers of interest:
Josephson RA, Gillombardo CB.
The right stuff.
Mayo Clin Proc. 2022 July 1;97(7):1222-3.
Note: This is an editorial to an article above (Charvat et al.) in the “NASA” section. This editorial may be obtained online without charge.
Ekman R, Green DA, Scott JPR, Huerta Lluch R, Weber T, Herssens N.
Introducing the concept of exercise holidays for human spaceflight – What can we learn from the recovery of bed rest passive control groups.
Front Physiol. 2022 Jul 4;13:898430. Review.
Note: This article is part of Research Topic “Space Countermeasures and Medicine – Implementation into Earth medicine and Rehabilitation” (–-implementation-into-earth-medicine-and-rehabilitation#articles). The Research Topic also includes articles from previous Current Awareness Lists #997 and #1,004 Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Seoane-Viaño I, Ong JJ, Basit AW, Goyanes A.
To infinity and beyond: Strategies for fabricating medicines in outer space.
Int J Pharm X. 2022 Dec;4:100121.
Note: This article may be obtained online without charge.
Acharya A, Nemade H, Papadopoulos S, Hescheler J, Neumaier F, Schneider T, Rajendra Prasad K, Khan K, Hemmersbach R, Gusmao EG, Mizi A, Papantonis A, Sachinidis A.
Microgravity-induced stress mechanisms in human stem cell-derived cardiomyocytes.
iScience. 2022 Jul 15;25(7):104577.
Note: A 2D clinostat was used in this study. This article may be obtained online without charge.
Arshad I, Ferrè ER.
Express: Cognition in zero gravity: Effects of non-terrestrial gravity on human behaviour.
Q J Exp Psychol (Hove). 2022 Jul 4:17470218221113935. Online ahead of print.
Note: From the abstract: “As humanity prepares for deep space exploration, understanding the impact of spaceflight on bodily physiology is critical. While the effects of non-terrestrial gravity on the body are well established, little is known about its impact on human behavior and cognition. Astronauts often describe dramatic alterations in sensorimotor functioning, including orientation, postural control and balance. Changes in cognitive functioning as well as in socio-affective processing have also been observed. Here, we have reviewed the key literature and explored the impact of non-terrestrial gravity across three key functional domains: sensorimotor, cognition, and socio-affective processing. We have proposed a neuroanatomical model to account for the effects of non-terrestrial gravity in these domains. Understanding the impact of non-terrestrial gravity on human behavior has never been more timely and it will help mitigate against risks in both commercial and non-commercial spaceflight.”
Huyan T, Li M, Chen W, Zhou X, Pei D, Shang P, Wu C.
Simulated microgravity promotes oxidative stress-induced apoptosis in ARPE-19 cells associated with Nrf2 signaling pathway.
Acta Astronaut. 2022 Sep;198:161-9.
Note: A random positioning machine was used in this study.
Timilsina S, Kirsch-Mangu T, Werth S, Shepard B, Ma T, Villa-Diaz LG.
Enhanced self-renewal of human pluripotent stem cells by simulated microgravity.
npj Microgravity. 2022 Jul 4;8(1):22.
Note: 2D clinostat was used in this study.
Koschate J, Möller F, Haeger M, Hoffmann U, Drescher U, Fomina E, Vogt T, Steinberg F.
Effects of aerobic exercise in confinement on cardiorespiratory kinetics and cognitive functions – Results from the 4-month SIRIUS-19 isolation project.
Acta Astronaut. 2022 Jul 5. Online ahead of print.
Note: From the abstract: “Six participants (34 ± 6 years, 3 females) spent 120 days in confinement, conducting eight weeks of either continuous (CON) or interval (INT) aerobic treadmill exercise in a crossover design. Heart rate (HR) and oxygen uptake (VO2) were assessed with an exercise test protocol, including pseudo-random work rate changes to determine the respective kinetics before the start of confinement (pre), five times during confinement (mission day (MD) 9(±1), 29(±1), 57(±1), 87(±1), and 117 (±1)), and after the termination of the mission phase (post). Additionally, constant work rate phases and incremental exercise were part of the protocol. During the constant phases of the exercise protocol, cognitive performance was assessed.”
Wen J, Xu Z, Ma X, Zhao Y.
Wound healing effects of Dracontomelon dao on bacterial infection wounds in rats and its potential mechanisms under simulated space environment.
Evid Based Complement Alternat Med. 2022 Jun 24;2022:4593201.
Note: Hindlimb unloading results. This article may be obtained online without charge.
Singh VK, Seed TM.
Medical countermeasures for extraterrestrial environments: Current status and future prospects with focus on acute injuries.
THREE. 2022 Jun 28.
Note: This article may be obtained online without charge.
Ding M, Fan Y, Lv Y, Liu J, Yu N, Kong D, Sun H, Li J.
A prodrug hydrogel with tumor microenvironment and near-infrared light dual-responsive action for synergistic cancer immunotherapy.
Acta Biomater. 2022 Jun 30;S1742-7061(22)00380-4. Online ahead of print.
Brito LC, Marin TC, Azevêdo L, Rosa-Silva JM, Shea SA, Thosar SS.
Chronobiology of exercise: Evaluating the best time to exercise for greater cardiovascular and metabolic benefits.
Compr Physiol. 2022 Jul;12(3):3621-39.
Fan J, Wang S, Lu X, Sun Z.
Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.
Metabolism. 2022 Sep 1;134:155249.
Jin X, Wang H, Liang X, Ru K, Deng X, Gao S, Qiu W, Huai Y, Zhang J, Lai L, Li F, Miao Z, Zhang W, Qian A.
Calycosin prevents bone loss induced by hindlimb unloading.
npj Microgravity. 2022 Jul 6;8:23.
Note: Hindlimb unloading study. This article may be obtained online without charge.
Zhang P, Zhou Y, Chen G, Li J, Wang B, Lu X.
Potential association of bone mineral density loss with cognitive impairment and central and peripheral amyloid-β changes: A cross-sectional study.
BMC Musculoskelet Disord. 2022 Jun 30;23:626.
Note: This article may be obtained online without charge.
Bazukyan IL, Rostomyan AV, Hovhannisyan AG, Aleksanyan TM, Hakobyan LL, Dallakyan AM, Haertlé T.
The effects of UV, gamma- and x-ray irradiation on the growth, antibacterial activity and radio-protective of Lactobacillus rhamnosus.
Lett Appl Microbiol. 2022 Jul 1. Online ahead of print.
Shuboni-Mulligan DD, Young DJ, De La Cruz Minyety J, Briceno N, Celiku O, King AL, Munasinghe J, Wang H, Adegbesan KA, Gilbert MR, Smart DK, Armstrong TS.
Histological analysis of sleep and circadian brain circuitry in cranial radiation-induced hypersomnolence (C-RIH) mouse model.
Sci Rep. 2022 Jul 1;12:11131.
Note: This article may be obtained online without charge.

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