Status Report

NASA Spaceline Current Awareness List #1,005 24 June 2022 (Space Life Science Research Results)

By SpaceRef Editor
June 24, 2022
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SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
Pardon LP, Macias BR, Ferguson CR, Greenwald SH, Ploutz-Snyder R, Alferova IV, Ebert D, Dulchavsky SA, Hargens AR, Stenger MB, Laurie SS.
Changes in optic nerve head and retinal morphology during spaceflight and acute fluid shift reversal.
JAMA Ophthalmol. 2022 Jun 16. Online ahead of print.
PIs: S.A. Dulchavsky, A.R. Hargens
Note: ISS results.
Journal Impact Factor: 7.4
Funding: “This study was supported by human research program grants NNJ11ZSA002NA (Dr Stenger), NNX13AK30G (Dr. Dulchavsky), and NNX13AJ12G (Dr. Hargens) from the National Aeronautics and Space Administration.”
Levine BD, Nicol ED, Davos CH.
Space: The final frontier?
Eur J Prev Cardiol. 2022 Jun 17;zwac125. Online ahead of print.
PI: B.D. Levine
Note: This article is a Comment on an article by Jirak et al. that appeared in Current Awareness List #987 This article may be obtained online without charge.
Journal Impact Factor: 7.804
Funding: “Dr. Levine was supported by NASA grant 80NSSC20K0987 during the preparation of this editorial.”
Salazar AP, McGregor HR, Hupfeld KE, Beltran NE, Kofman IS, De Dios YE, Riascos RF, Reuter-Lorenz PA, Bloomberg JJ, Mulavara AP, Wood SJ, Seidler R.
Changes in working memory brain activity and task-based connectivity after long-duration spaceflight.
Cereb Cortex. 2022 Jun 16;bhac232. Online ahead of print.
PI: R. Seidler
Note: The spaceflight information is not evident in the available abstract.
Journal Impact Factor: 5.357
Funding: “NNX11AR02G/NASA/NASA/United States; Natural Sciences and Engineering Research Council of Canada; DGE-1315138/National Science Foundation Graduate Research Fellowship; T32-NS082128/NS/NINDS NIH HHS/United States; 1F99AG068440/AG/NIA NIH HHS/United States.”
Piechowski S, Johannes B, Pustowalow W, Arz M, Mulder E, Jordan J, Wolf OT, Rittweger J.
Visual attention relates to operator performance in spacecraft docking training.
Aerosp Med Hum Perform. 2022 Jun 1;93(6):480-6.
Note: Head-down tilt bed rest study.
Journal Impact Factor: 1.904
Funding: “The AGBRESA study was funded by the German Aerospace Center, the European Space Agency (contract number 4000113871/15/ NL/PG), and the National Aeronautics and Space Administration (contract number 80JSC018P0078). This specific work was further supported by the German Aerospace Center (DLR), acting as space agency [DARA-Grants 50WB9128, 50WB93401, 50WB93401-ZA; DLR-Grants 50WB 96220, 50WP0306, 50WP0501, 50WP0602, 50WP0603, 50WP1104, 50WP1304, 50WP1609].”
Hann EC, Overa S, Harland-Dunaway M, Narvaez AF, Le DN, Orozco-Cárdenas ML, Jiao F, Jinkerson RE.
A hybrid inorganic–biological artificial photosynthesis system for energy-efficient food production.
Nature Food. 2022 Jun 23;3:461-71.
PI: R.E. Jinkerson
Note: To view a full press release of this article on the SpaceRef website go to This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “…The following funding supported this work: Translational Research Institute for Space Health (TRISH) through NASA grant no. NNX16AO69A (R.E.J., E.H., M.H.-D., M.L.O.-C. and A.N.), Foundation for Food & Agriculture Research grant no. FF-NIA20–000000009 (R.E.J.), National Science Foundation grant no. DBI-1922642 (M.H.-D.), a Link Foundation Energy Fellowship (E.H.), Department of Energy grant no. DE-FE0029868 (F.J. and S.O.) and National Science Foundation grant no. CBET 1803200 (F.J. and S.O.). The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of the Foundation for Food & Agriculture Research (FFAR).”
Buckey JC Jr, Lan M.
Why central venous pressure falls below supine levels in weightlessness.
J Appl Physiol (1985). 2022 Jun 16. Online ahead of print.
PI: J.C. Buckey Jr
Journal Impact Factor: 3.531
Funding: “NNX13AD35A/NASA EPSCoR; CA03401/National Space Biomedical Research Institute (NSBRI).”
Hill EC, Rivera PM, Proppe CE, Gonzalez Rojas DH, Wizenberg AM, Keller JL.
Greater neuromuscular fatigue following low load blood flow restriction than non blood flow restriction resistance exercise among recreationally active men.
J Neurophysiol. 2022 Jun 15. Online ahead of print.
Note: From the abstract: “The purpose of this study was to examine the acute effects of low-load blood flow restriction (LLBFR) and low-load non-BFR (LL) on neuromuscular function following a bout of standardized, fatiguing leg extension muscle actions.”
Journal Impact Factor: 2.714
Funding: “E.C.H. is supported by a research grant from the NASA Planetary Science Division, under the Solar System Exploration Research Virtual Institute Cooperative Agreement (NNH16ZDA001N) program titled ‘Radiation Effects on Volatiles and Exploration of Asteroids and Lunar Surfaces (REVEALS)’ related to crew safety and human space exploration.”
Grant LK, St Hilaire MA, Brainard GC, Czeisler CA, Lockley SW, Rahman SA.
Endogenous circadian regulation and phase resetting of clinical metabolic biomarkers.
J Pineal Res. 2021 Sep;71(2):e12752.
PIs: M.A. St Hilaire, S.W. Lockley
Journal Impact Factor: 13.007
Funding: “This work was supported by the National Space Biomedical Research Institute (Lockley: HPF02801) through NSBRI under NASA Cooperative Agreement NCC 9-58. MSH was supported by the National Aeronautics and Space Administration (NASA 80NSSC20K0576) and the National Institute of Nursing Research (NINR R21- NR018974). The project described was supported by Grant Number 8 UL1 TR000170 and 1UL1TR001102, Harvard Clinical and Translational Science Center, from the National Center for Advancing Translational Science; GrantNumber 1 UL1 RR025758, Harvard Clinical and Translational Science Center, from the National Center for Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources, the National Center for Advancing Translational Science or the National Institutes of Health.”
Roma PG, Blackwell Landon L, Spencer CA, Whitmire AM, Williams TJ.
The Subjective Habitability & Acceptability Questionnaire (SHAQ): Development and validation.
Hum Factors. 2022 Jan 29;187208211053462.
PI: P.G. Roma
Journal Impact Factor: 2.888
Funding: “We thank NASA’s Research Operations and Integration team for their contributions to HERA facility management, study logistics, and implementation. We also thank Lindsey Sirianni for contributions to data collection and processing, and Diana Arias for superb project management support. With sincere gratitude, we thank all HERA Campaign 5 crewmembers for their contributions, sacrifice, and dedication in service to science and human space exploration. PGR, LBL, and CAS are supported by KBR’s Human Health and Performance Contract NNJ15HK11B through the National Aeronautics and Space Administration. AMW and TJW are supported by the NASA Human Research Program. This project was supported in part by NASA Human Research Program Directed Projects Spaceflight Habitability & Acceptability Questionnaire (SHAQ): Development and Validation (PIs: TJ Williams, AM Whitmire, PG Roma), Identification and Validation of HFBP Exploration Measures in HERA for Transport (PI: PG Roma), and HFBP Exploration Measures in HERA for Mars (PI: PG Roma), and intramural funds from the NASA ECLSS-Crew Health and Performance Systems Capability Leadership Team.”
Ayora-Talavera G, Kirstein OD, Puerta-Guardo H, Barrera-Fuentes GA, Ortegòn-Abud D, Che-Mendoza A, Parra M, Peña-Miranda F, Culquichicon C, Pavia-Ruz N, Beheshti A, Trovão NS, Granja-Pérez P, Manrique-Saide P, Vazquez-Prokopec GM, Earnest JT.
SARS-CoV-2 antibody prevalence in a pediatric cohort of unvaccinated children in Mérida, Yucatán, México.
PLOS Glob Public Health. 2022 Jun 15;2(6):e0000354.
PI: A. Beheshti
Journal Impact Factor: Not available for this journal
Funding: “This work was conducted using ‘future use’ blood specimens collected by the TIRS-project located in Mérida (NIH: U01AI148069) and receiving support from the Universidad Autónoma de Yucatán to G.V.P. A.B. was supported by supplemental funds for COVID-19 research from Translational Research Institute of Space Health through NASA Cooperative Agreement NNX16AO69A (T-0404), and further funding from KBR, Inc. G.A.T. received funds from CONACYT grant 314296.”
Other papers of interest:
Sabatino R, Sbaffi T, Corno G, de Carvalho DS, Uetanabaro APT, Góes-Neto A, Podolich O, Kozyrovska N, de Vera JP, Azevedo V, Barh D, Di Cesare A.
Metagenome analysis reveals a response of the antibiotic resistome to Mars-like extraterrestrial conditions.
Astrobiology. 2022 Jun 17. Online ahead of print.
Note: ISS results. From the abstract: “The spread of antibiotic resistance is becoming a serious global health concern. Numerous studies have been done to investigate the dynamics of antibiotic resistance genes (ARGs) in both indoor and outdoor environments. Nonetheless, few studies are available about the dynamics of the antibiotic resistome (total content of ARGs in the microbial cultures or communities) under stress in outer space environments. In this study, we aimed to experimentally investigate the dynamics of ARGs and metal resistance genes (MRGs) in Kombucha Mutualistic Community (KMC) samples exposed to Mars-like conditions simulated during the BIOMEX experiment outside the International Space Station with analysis of the metagenomics data previously produced.”
Félix H, Oliveira ES.
Non-invasive intracranial pressure monitoring and its applicability in spaceflight.
Aerosp Med Hum Perform. 2022 Jun 1;93(6):517-31. Review.
Note: From the abstract: “Neuro-ophthalmic findings collectively defined as Spaceflight-Associated Neuro-ocular Syndrome (SANS) are one of the leading health priorities in astronauts engaging in long duration spaceflight or prolonged microgravity exposure. Though multifactorial in etiology, similarities to terrestrial idiopathic intracranial hypertension (IIH) suggest these changes may result from an increase or impairing in intracranial pressure (ICP). Finding a portable, accessible, and reliable method of monitoring ICP is, therefore, crucial in long duration spaceflight. A review of recent literature was conducted on the biomedical literature search engine PubMed using the search term ‘non-invasive intracranial pressure’.”
Hou F, Zhou X, Zhou S, Liu H, Huang YE, Yuan M, Zhu J, Cao X, Jiang W.
DNA methylation dynamics associated with long-term isolation of simulated space travel.
iScience. 2022 Jun 17;25(6):104493.
Note: From the abstract: “Long-term isolation is one of the risk factors that astronauts will encounter in spaceflight. At present, few researches have explored DNA methylation dynamics during long-term isolation. In this study, using time series DNA methylation data from “Mars-500″ mission, we conducted a multi-step analysis to investigate the characteristics and dynamic patterns of DNA methylation as well as their functional insights during long-term isolation.” This article may be obtained online without charge.
Zeng D, Cui J, Yin Y, Dai C, Zhao H, Song C, Guan S, Cheng D, Sun Y, Lu W.
Combining proteomics and metabolomics to analyze the effects of spaceflight on rice progeny.
Front Plant Sci. 2022 Jun 21;13:900143.
Note: From the abstract: “Spaceflight is a special abiotic stress, the biological effect mechanism of which on contemporary rice has been clarified; however, its effect on offspring rice was still unclear. In order to understand the response mechanism of F2 generation plants to space flight, this study used SJ-10 recoverable satellite to carry DN423 rice seeds for 12.5 days in orbit flight. After returning to the ground, the plants were then planted to F2 generation to explore the biological effect mechanism. Our research showed that in the F2 generation of TLS, the rice plant height of the space flight group increased by 33.8%, the ear length and thousand-grain weight decreased by 9.7 and 4.6%, respectively, and the grain number per panicle increased by 6.5%.” This article may be obtained online without charge.
Huyan T, Li M, Chen W, Zhou X, Pei D, Shang P, Wu C.
Simulated microgravity promotes oxidative stress-induced apoptosis in ARPE-19 cells associated with Nrf2 signaling pathway.
Acta Astronaut. 2022 Sep;198:161-9.
Note: A random positioning machine was used in this study.
Ibrahim Z, Ramachandran G, El-Huneidi W, Elmoselhi A, Qaisar R.
Suppression of endoplasmic reticulum stress prevents disuse muscle atrophy in a mouse model of microgravity.
Life Sci Space Res. 2022 Aug;34:45-52.
Note: Hindlimb unloading results.
Wang Y, Shen W, Yin M, Huang W, Ye B, Li P, Shi S, Bai G, Guo X, Jin Y, Lin K, Zhang Y, Jiang Y, Wang J, Han Y, Zhao Z.
Changes in higher-order chromosomal structure of Klebsiella pneumoniae under simulated microgravity.
Front Microbiol. 2022 May 30;13:879321.
Note: A high aspect ratio vessel was used in this study. This article is part of Research Topic “Rising Stars in Evolutionary and Genomic Microbiology: 2022” ( Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Yura Y, Cochran JD, Walsh K.
Therapy-related clonal hematopoiesis: A new link between cancer and cardiovascular disease.
Heart Fail Clin. 2022 Jul;18(3):349-59. Review.
Damato EG, Fillioe SJ, Vannix IS, Norton LK, Margevicius SP, Beebe JL, Decker MJ.
Characterizing the dose response of hyperoxia with brain perfusion.
Aerosp Med Hum Perform. 2022 Jun 1;93(6):493-8.
Robin A, Navasiolava N, Gauquelin-Koch G, Gharib C, Custaud MA, Treffel L.
Spinal changes after 5-day dry immersion as shown by magnetic resonance imaging (DI-5-CUFFS).
Am J Physiol Regul Integr Comp Physiol. 2022 Jun 14. Online ahead of print.
Note: Dry immersion results.
Chen J, Li Z, Zhang Y, Zhang X, Zhang S, Liu Z, Yuan H, Pang X, Liu Y, Tao W, Chen X, Zhang P, Chen GQ.
Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrate.
Cell Biosci. 2022 Jun 20;12(1):94.
Note: This article may be obtained online without charge.
Ahmed R, Uppuganti S, Derasari S, Meyer J, Pennings J, Elefteriou F, Nyman JS.
Identifying bone matrix impairments in a mouse model of NF1 by clinically translatable techniques.
J Bone Miner Res. 2022 Jun 12. Online ahead of print.
Fahl WE, Cadarso M, Goesch TR.
Significant reduction of total-body irradiation-induced death in mice treated with PrC-210 24 hours postirradiation.
Radiat Res. 2022. Jun 21. Online ahead of print.
Nakajima T, Ninomiya Y, Unno K, Morioka T, Nishimura M, Kakinuma S.
Impacts of psychological stress on high dose-rate radiation acute effects in a mouse experimental model.
J Radiat Res. 2022 Jun 20;rrac028. Online ahead of print.
Note: This article may be obtained online without charge.
Shaw DM, Henderson L, van den Berg M.
Cognitive, sleep, and autonomic responses to induction of a ketogenic diet in military personnel: A pilot study.
Aerosp Med Hum Perform. 2022 Jun 1;93(6):507-16.
Liu F, Zhang M, Chen T, Zhai L, Zhang Z, Xue J.
Equilibrium and vestibular safety of modafinil in healthy volunteers.
Aerosp Med Hum Perform. 2022 Jun 1;93(6):487-92.
Note: From the abstract: “Modafinil, as a wake-promoting agent, is commonly used to relieve fatigue during military operations. However, there is a lack of clarity regarding the effects of modafinil on the equilibrium and vestibular organs, especially when prescribing this drug to flight crewmembers. The objective of this study was to evaluate the equilibrium- and vestibular-related safety effects of modafinil.”
Furber MJW, Young GR, Holt GS, Pyle S, Davison G, Roberts MG, Roberts JD, Howatson G, Smith DL.
Gut microbial stability is associated with greater endurance performance in athletes undertaking dietary periodization.
mSystems. 2022 May 17;e0012922.
Note: From the abstract: “Dietary manipulation with high-protein or high-carbohydrate content are frequently employed during elite athletic training, aiming to enhance athletic performance. Such interventions are likely to have an impact upon gut microbial content. This study explored the impact of acute high-protein or high-carbohydrate diets on measured endurance performance and associated gut microbial community changes.” This article may be obtained online without charge.
Norasi H, Tetteh E, Law KE, Ponnala S, Hallbeck MS, Tollefson M.
Intraoperative workload during robotic radical prostatectomy: Comparison between multi-port da Vinci Xi and single port da Vinci SP robots.
Appl Ergon. 2022 Oct;104:103826.
Note: NASA Task Load Index was used in this study. From the abstract: “The goal of this study was to quantify and compare prospective self-reported intraoperative workload and teamwork during robot-assisted radical prostatectomy (RARP) for multi-port da Vinci Xi (MP) and single-port da Vinci SP (SP) robots. The self-reported workload (surgeon and surgical team) and teamwork (surgeon) measures were collected and compared between MP and SP RARPs, as well as the learning curve. Results from 25 MP and SP RARPs showed that overall, the NASA-TLX workload subscales were lower, and the teamwork modified NOTECHS subscales were higher for the MP RARPs compared to the SP RARPs.”
Jose M, Bronckaers A, Kumar RSN, Reenaers D, Vandenryt T, Thoelen R, Deferme W.
Stretchable printed device for the simultaneous sensing of temperature and strain validated in a mouse wound healing model.
Sci Rep. 2022 Jun 16;12:10138.
Note: This article may be obtained online without charge.

SpaceRef staff editor.