NASA Spaceline Current Awareness List #1,004 17 June 2022 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm . Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Jones CW, Basner M, Mollicone DJ, Mott CM, Dinges DF.
Sleep deficiency in spaceflight is associated with degraded neurobehavioral functions and elevated stress in astronauts on six-month missions aboard the International Space Station.
Sleep. 2022 Mar 14;45(3):zsac006.
PI: D.F. Dinges
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 5.849
Funding: “Supported by the National Aeronautics and Space Administration NNX08AY09G (PI: DFD). CWJ was supported by a National Institutes of Health (5T32HL007713).”
2
Nestorova GG, Crews N, Schramm AK, Aquilina RA, Parra M, Chin M, Chinn T, Hee L.
Spaceflight validation of one-step gene sampling tool for genetic analysis on the International Space Station.
Acta Astronaut. 2022 Jun 14. Onlie ahead of print.
Note: ISS and ground control test results.
Journal Impact Factor: 2.413
Funding: “Funding for this study was provided by NASA EPSCoR grant 80NSSC19M0078.”
3
Ju Z, Thomas TN, Chiu YJ, Yamanouchi S, Yoshida Y, Abe JI, Takahashi A, Wang J, Fujiwara K, Hada M.
Adaptation and changes in actin dynamics and cell motility as early responses of cultured mammalian cells to altered gravitational vector.
Int J Mol Sci. 2022 May 30;23(11):6127.
PI: M. Hada
Note: A 3D clinostat was used in this study. This article is part of Special Issue “Molecular Mechanobiology in Space and on Earth 2.0” (https://www.mdpi.com/journal/ijms/special_issues/Mechanobiology_2 ). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 5.924
Funding: “This work was supported by the NASA Space Biology Program (80NSSC19K0133 to M.H., K.F. and A.T.), MEXT Grant-in-Aid for Scientific Research on Innovative Areas ‘Living in Space’ (JP15H05945 to A.T), and Gunma University’s Promotion of Scientific Research (A.T.). The work was also supported by P30CA016672 Cancer Center Support (CORE) Grant FP2373. The RPPA Core is supported by NCI Grant # CA16672 and Dr. Yiling Lu’s NIH R50 Grant # R50CA221675: Functional Proteomics by Reverse Phase Protein Array in Cancer.”
4
DiCarlo AL, Scott-Carnell LA, Rios CI, Prasanna PG.
Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments.
Life Sci Space Res. 2022 Jun 14. Online ahead of print.
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.082
Funding: “Author salaries were supported by NASA’s Biological and Physical Sciences Division, NIAID’s RNCP, and NCI’s RRP. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.”
5
Sishc BJ, Zawaski J, Saha J, Carnell LS, Fabre KM, Elgart SR.
The need for biological countermeasures to mitigate the risk of space radiation-induced carcinogenesis, cardiovascular disease, and central nervous system deficiencies.
Life Sci Space Res. 2022 Jun 14. Review. Online ahead of print.
Journal Impact Factor: 2.082
Funding: J. Zawaski is affiliated with NASA Johnson Space Center. L.S. Carnell is affiliated with NASA Physical and Biological Sciences Division, NASA Headquarters.
6
Ton ST, Laghi JR, Tsai SY, Blackwell AA, Adamczyk NS, Oltmanns JRO, Britten RA, Wallace DG, Kartje GL.
Exposure to 5 cGy 28Si particles induces long-term microglial activation in the striatum and subventricular zone and concomitant neurogenic suppression.
Radiat Res. 2022 Apr 4.
PI: R.A. Britten
Journal Impact Factor: 2.841
Funding: “We thank the Office of Academic Affiliations, VA Advanced Fellowship in Polytrauma/Traumatic Brain Injury Rehabilitation; Department of Veterans Affairs and funding from NASA grant award NNX14AE73G.”
7
Zea L, Piper SS, Gaikani H, Khoshnoodi M, Niederwieser T, Hoehn A, Grusin M, Wright J, Flores P, Wilson K, Lutsic A, Stodieck L, Carr CE, Moeller R, Nislow C.
Experiment verification test of the Artemis I ‘Deep Space Radiation Genomics’ experiment.
Acta Astronaut. 2022 Jun 16. Online ahead of print.
PI: L. Zea
Journal Impact Factor: 2.413
Funding: “This material is based upon work supported by the National Aeronautics and Space Administration under Grant No. 80NSSC19K0708. The authors acknowledge NASA’s Dr. Howard Levine, Denise Freeland, David Flowers, Dinah Dimapilis, Monica Soler, and Janet Powers, TOSC’s Kevin Tyre and Kamber Scott, the University of Colorado Boulder’s Stefanie Countryman, Melissa Dunivant, Maggie Kolicko, Gary Stanish, Prof. Delores Knipp, Kaiya Wahl, and Valerie Bernstein, and Universidad del Valle de Guatemala (UVG) Prof. Rodrigo Aragón, Prof. Andres Viau, Esteban Herbruger, Iñaki Alvarado, Diego Aguirre, Eileen Meda, and Diego Hernández.”
8
De Martino E, Hides J, Elliott JM, Hoggarth MA, Zange J, Lindsay K, Debuse D, Winnard A, Beard D, Cook JA, Salomoni SE, Weber T, Scott J, Hodges PW, Caplan N.
The effects of reconditioning exercises following prolonged bed rest on lumbopelvic muscle volume and accumulation of paraspinal muscle fat.
Front Physiol. 2022 Jun 14;13:862793.
Note: This article is part of Research Topic “Rising Stars in Environmental, Aviation and Space Physiology: 2022” (https://www.frontiersin.org/research-topics/29535/rising-stars-in-environmental-aviation-and-space-physiology-2022#articles ). The Research Topic also includes an article from previous Current Awareness List #993 https://doi.org/10.3389/fphys.2022.846229 . Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: 4.566
Funding: “The Funding for this selected project (ESA-HSO-U-LE-0629) was received from the STFC/UK Space Agency (ST/R005753/1).The AGBRESA study was funded by the German Aerospace Center, the European Space Agency (contract number: 4000113871/15/NL/PG), and the National Aeronautics and Space Administration (contract number: 80JSC018P0078). The study was performed at the: ENVIHAB research facility of the DLR Institute of Aerospace Medicine. Funding for this selected project (ESA-HSO-U-LE-0629) was received from the STFC/UK Space Agency (ST/R005753/1).”
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Other papers of interest:
1
Sherman KM, Williams DK, Welsh CA, Cooper AM, Falck A, Huggins S, Bokhari RS, Gaddy D, McKelvey KD, Dawson LA, Suva LJ.
Low bone mass and impaired fracture healing in mouse models of Trisomy21 (Down syndrome).
Bone. 2022 Jun 15;116471.
Note: From the abstract: “Individuals with Down syndrome (DS), the result of trisomy of human chromosome Hsa21 (Ts21), present with an array of skeletal abnormalities typified by altered craniofacial features, short stature and low bone mineral density (BMD). While bone deficits progress with age in both sexes, low bone mass is more pronounced in DS men than women and osteopenia appears earlier. In the current study, the reproductive hormone status (FSH, LH, testosterone) of 17 DS patients (males, ages range 19–52 years) was measured.”
2
Bloomfield SA, Dunbar BJ, Schmit CD, Sawyer AJ, Charles JB.
Developing an international database on long-term health effects of spaceflight.
Acta Astronaut. 2022 Jun 10. Online ahead of print.
Note: From the abstract: “NASA’s Lifetime Surveillance for Astronaut Health (LSAH) program collects health/medical data on active and retired U.S. and Canadian crew; to our knowledge, there are no parallel efforts collecting life-long data on the many international retired astronauts and cosmonauts. The long-term goal of this investigative team is to establish a secure data repository for biomedical data from international retired crew.”
3
Marfia G, Navone SE, Guarnaccia L, Campanella R, Locatelli M, Miozzo M, Perelli P, Della Morte G, Catamo L, Tondo P, Campanella C, Lucertini M, Ciniglio Appiani G, Landolfi A, Garzia E.
Space flight and central nervous system: Friends or enemies? Challenges and opportunities for neuroscience and neuro-oncology.
J Neurosci Res. 2022 Jun 9. Review. Online ahead of print.
4
Kernagis DN, Balcer-Kubiczek E, Bazyar S, Orschell CM, Jackson IL.
Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space.
Life Sci Space Res. 2022 Jun 9. Review. Online ahead of print.
5
Gronwald B, Kijak K, Baszuk P, Lietz-Kijak D, Kosko K, Matuszczak M, Skomro P, Bielawska-Victorini H, Orzechowski L, Mintus A, Gronwald H.
Evaluation of physiotherapy impact on neuromuscular tension in analog astronauts at the LunAres Habitat.
Int J Environ Res Public Health. 2022 Jun 4;19(11):6888.
Note: This article is part of Special Issue “Advances in Physical Diagnosis, Physiotherapy and Rehabilitation in Medicine and Dentistry” (https://www.mdpi.com/journal/ijerph/special_issues/Diagnosis_Dentistry ). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
6
Motanova E, Bekreneva M, Rukavishnikov I, Shigueva TA, Saveko AA, Tomilovskaya ES.
Application of space technologies aimed at proprioceptive correction in terrestrial medicine in Russia.
Front Physiol. 2022 Jun 16;13:921862. Mini Review.
Note: This article is part of Research Topic “Space Countermeasures and Medicine – Implementation into Earth medicine and Rehabilitation” (https://www.frontiersin.org/research-topics/29370/space-countermeasures-and-medicine–-implementation-into-earth-medicine-and-rehabilitation#articles ). The Research Topic also includes an article from previous Current Awareness List #997 https://doi.org/10.3389/fphys.2022.897694 . Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
7
Inuzuka Y, Edo N, Araki Y, Hoshi T, Maruta M, Nakamoto N, Suzuki S.
Decompression illness treated with the Hart-Kindwall protocol in a monoplace chamber.
Am J Case Rep. 2022 Jun 12;23:e935534.
Note: This article may be obtained online without charge.
8
Plomariti CE, Frantzidis CA, Dimitriadou C, Velana M, Nday CM, Chriskos P, Chatziioannidis L, Ntakakis G, Nikolaidou A, Gkivogkli PT, Bamidis PD, Kourtidou-Papadeli C.
Microgravity induced resting state networks and metabolic alterations during sleep onset.
Acta Astronaut. 2022 Jun 9. Online ahead of print.
Note: Head-down tilt bed-rest sleep study.
9
Wang M, Li J, Zhang S, You Y, Zhu X, Xiang H, Yan L, Zhao F, Li Y.
Effects of titanium dioxide nanoparticles on cell growth and migration of A549 cells under simulated microgravity.
Nanomaterials (Basel). 2022 May 31;12(11):1879.
Note: This article is part of Special Issue “Advances in Nano-Bio Interactions: Nanosafety and Nanotoxicology” (https://www.mdpi.com/journal/nanomaterials/special_issues/nanosafety_nanotoxicology ). This article may be obtained online without charge.
10
Blain G, Vandenborre J, Villoing D, Fiegel V, Fois GR, Haddad F, Koumeir C, Maigne L, Métivier V, Poirier F, Potiron V, Supiot S, Servagent N, Delpon G, Chiavassa S.
Proton irradiations at ultra-high dose rate vs. conventional dose rate: Strong impact on hydrogen peroxide yield.
Radiat Res. 2022 Jun 8. Online ahead of print.
11
Zhen X, Moya EA, Gautane M, Zhao H, Lawrence ES, Gu W, Barnes LA, Yuan JX, Jain PP, Xiong M, Catalan Serra P, Pham LV, Malhotra A, Simonson TS, Mesarwi OA.
Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype.
Sleep. 2022 Jun 13;45(6):zsab290.
Note: From the abstract: “Chronic obstructive pulmonary disease and obstructive sleep apnea overlap syndrome is associated with excess mortality, and outcomes are related to the degree of hypoxemia. People at high altitudes are susceptible to periodic breathing, and hypoxia at altitude is associated with cardio-metabolic dysfunction. Hypoxemia in these scenarios may be described as superimposed sustained hypoxia (SH) plus intermittent hypoxia (IH), or overlap hypoxia (OH), the effects of which have not been investigated. We aimed to characterize the cardio-metabolic consequences of OH in mice.” This article may be obtained online without charge.
12
Hashem S, Ali TA, Akhtar S, Nisar S, Sageena G, Ali S, Al-Mannai S, Therachiyil L, Mir R, Elfaki I, Mir MM, Jamal F, Masoodi T, Uddin S, Singh M, Haris M, Macha M, Bhat AA. Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents.
Biomed Pharmacother. 2022 Jun;150:113054. Review.
Note: This article may be obtained online without charge.
13
Ao Z, Cai H, Wu Z, Hu L, Li X, Kaurich C, Gu M, Cheng L, Lu X, Guo F.
Evaluation of cancer immunotherapy using mini-tumor chips.
Theranostics. 2022 May 1;12(8):3628-36.
Note: This article may be obtained online without charge.
14
Hormuth DA, Farhat M, Christenson C, Curl B, Chad Quarles C, Chung C, Yankeelov TE.
Opportunities for improving brain cancer treatment outcomes through imaging-based mathematical modeling of the delivery of radiotherapy and immunotherapy.
Adv Drug Deliv Rev. 2022 Aug;187:114367.
15
Ma S, Wang F, Wang N, Jin J, Ba Y, Ji H, Du J, Hu S.
Multiomics data analysis and identification of immune-related prognostic signatures with potential implications in prognosis and immune checkpoint blockade therapy of glioblastoma.
Front Neurol. 2022 May 20;13:886913.
Note: This article is part of Research Topic “Molecular Biology of Biomarkers in Diagnosis and Treatment of Glioblastoma Multiforme” (https://www.frontiersin.org/research-topics/23678/molecular-biology-of-biomarkers-in-diagnosis-and-treatment-of-glioblastoma-multiforme#articles ). This article may be obtained online without charge.
16
Chen F, Xie Y, Xu P, Zhao Z, Zhang D, Liao H.
Efficient lower-limb segmentation for large-scale volumetric CT by using projection view and voxel group attention.
Med Biol Eng Comput. 2022 Jun 6.
17
Paul GR, Vallaster P, Rüegg M, Scheuren AC, Tourolle DC, Kuhn GA, Wehrle E, Müller R.
Tissue-level regeneration and remodeling dynamics are driven by mechanical stimuli in the microenvironment in a post-bridging loaded femur defect healing model in mice.
Front Cell Dev Biol. 2022 May 24;10:856204.
Note: This article is part of Research Topic “Mechanobiology and the Microenvironment: Computational and Experimental Approaches” (https://www.frontiersin.org/research-topics/19758/mechanobiology-and-the-microenvironment-computational-and-experimental-approaches#articles ). This article may be obtained online without charge.
18
Zhang CY, Fu CP, Li XY, Lu XC, Hu LG, Kankala RK, Wang SB, Chen AZ.
Three-dimensional bioprinting of decellularized extracellular matrix-based bioinks for tissue engineering.
Molecules. 2022 May 26;27(11):3442. Review.
Note: This article may be obtained online without charge.
19
Selahi A, Chakraborty S, Muthuchamy M, Zawieja DC, Jain A.
Intracellular calcium dynamics of lymphatic endothelial and muscle cells co-cultured in a Lymphangion-Chip under pulsatile flow.
Analyst. 2022 Jun 6. Online ahead of print.
20
Bowers SJ, Summa KC, Thompson RS, González A, Vargas F, Olker C, Jiang P, Lowry CA, Dorrestein PC, Knight R, Wright KP, Jr., Fleshner M, Turek FW, Vitaterna MH.
A prebiotic diet alters the fecal microbiome and improves sleep in response to sleep disruption in rats.
Front Neurosci. 2022 May 24;16:889211.
Note: This article is part of Research Topic “Systems Biology in Brain-Gut Axis Research” (https://www.frontiersin.org/research-topics/24574/systems-biology-in-brain-gut-axis-research#articles ). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
21
Edelson JL, Schneider LD, Amar D, Brink-Kjaer A, Cederberg KL, Kutalik Z, Hagen EW, Peppard PE, Tempaku PF, Tufik S, Evans DS, Stone K, Tranah G, Cade B, Redline S, Haba-Rubio J, Heinzer R, Marques-Vidal P, Vollenweider P, Winkelmann J, Zou J, Mignot E.
The genetic etiology of periodic leg movement in sleep.
Sleep. 2022 Jun 7. Online ahead of print.
22
Jiang CY, Wu J, Shu L, Sun XH, Pan H, Xu Q, Wu SC, Liu JR, Li Y, Chen W.
Clinical and cVEMP evaluation predict short-term residual dizziness after successful repositioning in benign paroxysmal positional vertigo.
Front Med (Lausanne). 2022 May 24;9:881307.
Note: From the abstract: “Residual dizziness (RD) is a frequent symptom with unknown pathogenesis, often complained about by the patients with benign paroxysmal positional vertigo (BPPV), even after a successful canalith repositioning procedure (CRP). This study aims to quantitatively evaluate the short-term RD severity and its risk factors in patients with BPPV after successful CRPs.” This article may be obtained online without charge.
23
Tomiyama Y, Mochizuki T, Tanifuji O, Nishino K, Tanaka M, Omori G, Yamamoto N, Koga H, Koga Y, Kawashima H.
Normal coronal kinematics of dynamic alignment and bony positions relative to the ground in three-dimensional motion analysis during gait: A preliminary study.
Biomed Mater Eng. 2022 Jun 6. Online ahead of print.
Note: From the abstract: “During gait, healthy knee coronal kinematics of each bony axis and lower extremity alignment are important because they could be useful as reference data for several surgeries and provide clarification of the etiology of diseases around the knee in healthy participants; however, it remains unknown.”
24
Patel Z, Gharat SA, Al-Tabakha MM, Ashames A, Boddu SHS, Momin MM.
Recent advancements in electrospun nanofibers for wound healing: Polymers, clinical and regulatory perspective.
Crit Rev Ther Drug Carrier Syst. 2022;39(4):83-118.
Note: From the abstract: “Wound management is an unmet therapeutic challenge and a global healthcare burden. Current treatment strategies provide limited efficiency in wound management, thus undergoing constant evolution in the treatment approaches. As wound healing is a complex physiological process involving precise synchronization of various phases like hemostasis, inflammation and remodeling, which necessitates innovative treatment strategies. Nanotechnology platforms like polymeric nanofibers (NFs) offer a promising solution for wound management. NFs contain a porous mesh-like structure that mimics the natural extracellular matrix and promote the cell adhesion and proliferation in the wound bed, thus displaying a great potential as a wound healing scaffold. Electrospinning is a simple, versatile, and scalable technique for producing highly porous and tuneable NFs with a high surface area. Electrospun NFs are presenting extensive application in wound management, especially for burns and diabetic foot ulcers. This review briefly discusses the wound physiology and conventional treatment strategies. It also provides an overview of the electrospinning process and its principle, highlighting the application of electrospun polymeric NFs in wound management.”
