NASA Spaceline Current Awareness List #1,003 10 June 2022 (Space Life Science Research Results)

 

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

 

Papers deriving from NASA support:

 

1

Goukassian D, Arakelyan A, Brojakowska A, Bisserier M, Hakobyan S, Hadri L, Rai AK, Evans A, Sebastian A, Truongcao M, Gonzalez C, Bajpai A, Cheng Z, Dubey PK, Addya S, Mills P, Walsh K, Kishore R, Coleman M, Garikipati VNS.

Clin Transl Med. 2022 Jun;12(6):e845.

PIs: D. Goukassian, K. Walsh

Note: From the article: “We performed sRNAseq [small RNA sequencing] using sEVs [small extracellular vesicles] isolated from deidentified plasma collected 10 days before launch, the day of landing, and 3 days post-landing from 14 astronauts who flew various space Shuttle missions between 1998–2001.” This article may be obtained online without charge.

Journal Impact Factor: 11.492

Funding: “We would like to thank Stepan Nersisyan Faculty of Biology and Biotechnology, HSE University, Moscow, Russia for his assistance with miRNA sequencing analysis. This work was supported by the Translational Research Institute for Space Health FIP0005 and National Aeronautics and Space Administration grant 80NSSC19K1079 to D.A.G. and by National Aeronautics and Space Administration grant 80NSSC21K0549 to D.A.G. and K.W. …”

 

2

Huff JL, Plante I, Blattnig SR, Norman RB, Little MP, Khera A, Simonsen LC, Patel ZS.

Front Cardiovasc Med. 2022 May 19;9:873597. Review.

Note: This article is part of Research Topic “Aerospace Health and Safety: Today and the Future” (https://www.frontiersin.org/research-topics/10667/aerospace-health-and-safety-today-and-the-future#articles). The Research Topic also includes articles from previous Current Awareness Lists #873 https://doi.org/10.3389/fphys.2019.01366, #893 https://doi.org/10.3389/fphys.2020.00299, #897 https://doi.org/10.3389/fpubh.2020.00119, #907 https://doi.org/10.3389/fphys.2020.00837, #910 https://doi.org/10.3389/fphys.2020.00781, #911 https://doi.org/10.3389/fphys.2020.00960, #918 https://doi.org/10.3389/fpubh.2020.00327, #936 https://doi.org/10.3389/fphys.2020.577325, #940 https://doi.org/10.3389/fphys.2021.643943, and #942 https://doi.org/10.3389/fphys.2021.651977, and #969 https://doi.org/10.3389/fphys.2021.712628. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

Journal Impact Factor: 6.050

Funding: “This work was supported by the Human Research Program of the Human Exploration and Operations Mission Directorate of the National Aeronautics and Space Administration [JH, SB, RN, and LS] and by the Human Health and Performance contract NNJ15HK11B [IP and ZP]; by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics [ML]; NASA 80NSSC19M0207 [AK].”

 

3

Braveboy-Wagner J, Lelkes PI.

npj Microgravity. 2022 Jun 7;8:20.

PI: P.I. Lelkes

Note: A random positioning machine was used in this study. This article may be obtained online without charge.

Journal Impact Factor: 4.415

Funding: “This study was supported in part by NASA grant 80NSSC18K1480 (P.I.L.) and a Temple University Dissertation completion grant (J.B.W.).”

 

4

Stutte GW, Yorio NC, Edney SL, Richards JT, Hummerick MP, Stasiak M, Dixon M, Wheeler RM.

Life Sci Space Res. 2022 Aug;34:37-44.

PI: R.M. Wheeler

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.082

Funding: “…Funding for this research was provided through the NASA Innovative Partnership Program. The authors also want to thank Dr. Thomas Graham and Ping Zhang of the University of Guelph for performing the statistical analysis of the data.”

 

5

Lan M, Buckey JC Jr, Anderson A, Van Akin M.

Acta Astronaut. 2022 Jun 3. Online ahead of print.

PIs: J.C. Buckey Jr, A.P. Anderson, NSBRI Postdoctoral Fellowship Program

Note: From the abstract: “An astronaut developed a left-sided internal jugular vein (IJV) thrombosis while in orbit, likely due to reduced IJV blood flow. We hypothesized that microgravity-induced flow reductions would be greatest on the non-dominant (usually left) side thereby increasing thrombosis risk. A Simulink®-based lumped parameter model (LPM) was used to explore causes of jugular flow reduction and asymmetric thrombosis risk. Vessel behavior is described by combinations of four discrete components: hydrostatic gradients, vessel compliance, flow resistance, and flow inertia. The cranial venous system features drainage pathways through the right IJV, the left IJV and the vertebral plexus. The right jugular vein was modeled as the dominant jugular pathway (60% of total undeformed jugular cross-sectional area). The left side accounted for the remaining 40% of jugular flow. Multiple variables were adjustable in the LPM: body position (supine, prone, head-down tilt), and gravity. A key feature of this LPM is the incorporation of extravascular pressure on the vessels by the weight of tissues.”

Journal Impact Factor: 2.413

Funding: “The development of the numerical models was supported by grant CA03401 from the National Space Biomedical Research Institute through NCC 9-58 and by NASA EPSCoR Cooperative Agreement NNX13AD35A.”

 

6

Schnellmann R, Ntekoumes D, Choudhury MI, Sun S, Wei Z, Gerecht S.

Adv Sci (Weinh). 2022 Jun 3;e2201483. Online ahead of print.

PI: S. Gerecht

Note: This article may be obtained online without charge.

Journal Impact Factor: 16.806

Funding: “…This work was supported by a fellowship from the Maryland Stem Cell Research Fund (MSCRFF-5159 to R.S.) and grants from the Air Force (FA9550-20-1-0356), the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A (RAD0102); and NCI (U54 CA210173-01) all to S.G.”

 

7

Enguita FJ, Leitão AL, McDonald JT, Zaksas V, Das S, Galeano D, Taylor D, Wurtele ES, Saravia-Butler A, Baylin SB, Meller R, Porterfield DM, Wallace DC, Schisler JC, Mason CE, Beheshti A.

Theranostics. 2022 May 9;12(8):3946-62.

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.262

Funding: A. Saravia-Butler and A. Beheshti are affiliated with Ames Research Center.

 

8

Yu Y, Li J, Solomon SA, Min J, Tu J, Guo W, Xu C, Song Y, Gao W.

Sci Robot. 2022 Jun 1;7(67):eabn0495.

Note: From the abstract: “Ultrasensitive multimodal physicochemical sensing for autonomous robotic decision-making has numerous applications in agriculture, security, environmental protection, and public health. Previously reported robotic sensing technologies have primarily focused on monitoring physical parameters such as pressure and temperature. Integrating chemical sensors for autonomous dry-phase analyte detection on a robotic platform is rather extremely challenging and substantially underdeveloped. Here, we introduce an artificial intelligence-powered multimodal robotic sensing system (M-Bot) with an all-printed mass-producible soft electronic skin-based human-machine interface.” This article may be obtained online without charge.

Journal Impact Factor: 23.748

Funding: “This work was supported by National Institutes of Health grant R01HL155815 (W.G.), Office of Naval Research grant N00014-21-1-2483 (W.G.), Translational Research Institute for Space Health grant NASA NNX16AO69A (W.G.), Tobacco-Related Disease Research Program grant R01RG3746 (W.G.), and Carver Mead New Adventures Fund at California Institute of Technology (W.G.).”

 

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Other papers of interest:

 

1

Henrich M, Ha P, Wang Y, Ting K, Stodieck L, Soo C, Adams JS, Chun R.

Skelet Muscle. 2022 May 31;12:11.

Note: ISS and ground control conditions results. This article may be obtained online without charge.

 

2

Strollo F, Gentile S, Pipicelli AMV, Mambro A, Monici M, Magni P.

Front Bioeng Biotechnol. 2022;10:868999. Review.

Note: This article is part of Research Topic “Wound Management and Healing in Space” (https://www.frontiersin.org/research-topics/14877/wound-management-and-healing-in-space#articles). The Research Topic also includes articles from previous Current Awareness Lists #958 https://doi.org/10.3389/fbioe.2021.679650, #972 https://doi.org/10.3389/fbioe.2021.720091, #973 https://doi.org/10.3389/fbioe.2021.720217 and https://doi.org/10.3389/fbioe.2021.716184, #995 https://doi.org/10.3389/fbioe.2022.666434, #998 https://doi.org/10.3389/fbioe.2022.873384, and #1,000 https://doi.org/10.3389/fbioe.2022.806362. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

3

Arora S, Puri S, Bhambri N.

FEMS Microbiol Lett. 2022 Jun 8;fnac049. Online ahead of print.

 

4

Enfield RE, Pandya JK, Lu J, McClements DJ, Kinchla AJ.

Crit Rev Food Sci Nutr. 2022 Jun 1;1-14. Online ahead of print.

Note: From the abstract: “This review highlights the potential applications of 3D printing for creating custom-made foods in space and the challenges that need to be addressed.”

 

5

Silvani G, Bradbury P, Basirun C, Mehner C, Zalli D, Poole K, Chou J.

npj Microgravity. 2022 Jun 3;8:19.

Note: A random positioning machine and 3D clinostat were used in this study. This article may be obtained online without charge.

 

6

Yoshikawa M, Ishikawa C, Li H, Kudo T, Shiba D, Shirakawa M, Murtani M, Takahashi S, Aizawa S, Shiga T.

Comparing effects of microgravity and amyotrophic lateral sclerosis in the mouse ventral lumbar spinal cord.

Mol Cell Neurosci. 2022 Jun 2;103745. Online ahead of print.

Note: From the abstract: “Microgravity (MG) exposure and motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), lead to motor deficits, including muscle atrophy and loss of neuronal activity. Abnormalities in motor neurons and muscles caused by MG exposure can be recovered by subsequent ground exercise. In contrast, the degeneration that occurs in ALS is irreversible. A common phenotype between MG exposure and ALS pathology is motor system abnormality, but the causes may be different. In this study, to elucidate the motor system that is affected by each condition, we investigated the effects of MG and the human SOD1 ALS mutation on gene expression in various cell types of the mouse ventral lumbar spinal cord, which is rich in motor neurons innervating the lower limb.”

 

7

Rollock AE, Klaus DM.

Acta Astronaut. 2022 June 7. Online ahead of print.

Note: From the abstract: “This work presents an initial framework aimed at defining and characterizing a new paradigm for enabling increasingly sustainable, deep space habitat design and operation.”

 

8

Karimpour K, Brenner RJ, Dong GZ, Cleve J, Martina S, Harris C, Graf GJ, Kistler BJ, Hoang AH, Jackson O, Papadopoulou V, Tillmans F.

Front Physiol. 2022 Jun 9;13:907651.

Note: This article is part of Research Topic “Insights in Environmental, Aviation and Space Physiology: 2022” (https://www.frontiersin.org/research-topics/34248/insights-in-environmental-aviation-and-space-physiology-2022#articles). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

 

9

Sánchez-Villalobos JM, Fortuna-Alcaraz ML, Serrano-Velasco L, Pujante-Escudero Á, Garnés-Sánchez CM, Pérez-Garcilazo JE, Olea-González A, Pérez-Vicente JA.

Tomography. 2022 Apr 19;8(3):1172-83. Review.

Note: This article may be obtained online without charge.

 

10

Lima-Silveira L, Hasser EM, Kline DD.

Cardiovascular deconditioning increases GABA signaling in the nucleus tractus solitarii.

J Neurophysiol. 2022 Jun 1. Online ahead of print.

 

11

Tarannum M, Vivero-Escoto JL.

Adv Drug Deliv Rev. 2022 Aug;187:114357.

 

12

Bokov RO, Popov DV.

Hum Physiol. 2022 Jun 3;48:261-70.

 

13

Branecka N, Yildizdag ME, Ciallella A, Giorgio I.

Biomimetics (Basel). 2022 May 6;7(2):59.

Note: This article may be obtained online without charge.

 

14

Moukhamedieva L, Dolch M, Ozerov D, Fetter V, Lenic J, Kornienko A, Grosser J, Tsarkov D, Roth P, Nitzer R.

Acta Astronaut. 2022 Jun 3. Online ahead of print.

 

15

Chauntry AJ, Bishop NC, Hamer M, Paine NJ.

Biol Psychol. 2022 Jun 3;108374. Review. Online ahead of print.

 

16

Kanarskii MM, Nekrasova JY, Kurova NA, Redkin IV.

Hum Physiol. 2022 Jun 3;48:328-39.

 

17

Roenneberg T, Foster RG, Klerman EB.

J Sleep Res. 2022 Jun 7;e13621. Review. Online ahead of print.

Note: This article may be obtained online without charge.

 

18

Yusupova A, Shved D, Gushin V, Chekalina A, Supolkina N, Savinkina A.

Acta Astronaut. 2022 Jun 6. Online ahead of print.