Status Report

NASA Spaceline Current Awareness 5 April 2013 (Recent Space Life Science Research Results)

By SpaceRef Editor
April 5, 2013
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NASA Spaceline Current Awareness 5 April 2013 (Recent Space Life Science Research Results)

Next list: April 19, 2013

Papers deriving from NASA support:

Morris CJ, Hastings JA, Boyd K, Krainski F, Perhonen MA, Scheer FA, Levine BD.
Day/night variability in blood pressure: Influence of posture and physical activity.
Am J Hypertens. 2013 Mar 27. [Epub ahead of print]
(PIs: B.D. Levine; C.J. Morris, NSBRI Postdoctoral Fellowship Program)
NOTE: Bed rest study.

Grenon SM, Jeanne M, Aguado-Zuniga J, Conte MS, Hughes-Fulford M.
Effects of gravitational mechanical unloading in endothelial cells: Association between caveolins, inflammation and adhesion molecules.
Sci Rep. 2013 Mar 20;3:1494.
(PI: M. Hughes-Fulford)
NOTE: Used Random Positioning Machine, centrifuge, and hindlimb suspension. This article may be obtained online without charge.

Darquenne C, Prisk GK.
Particulate deposition in the human lung under lunar habitat conditions.
Aviat Space Environ Med. 2013 Mar;84(3):190-5.
(PI: G.K. Prisk)
NOTE: Parabolic flight results.

Foster PP, Pollock NW, Conkin J, Dervay JP, Caillot N, Chhikara RS, Vann RD, Butler BD, Gernhardt ML.
Protective mechanisms in hypobaric decompression.
Aviat Space Environ Med. 2013 Mar;84(3):212-25.

Komorowski M, Watkins SD, Lebuffe G, Clark JB.
Potential anesthesia protocols for space exploration missions.
Aviat Space Environ Med. 2013 Mar;84(3):226-33.

Blue RS, Law J, Norton SC, Garbino A, Pattarini JM, Turney MW, Clark JB.
Overview of medical operations for a manned stratospheric balloon flight.
Aviat Space Environ Med. 2013 Mar;84(3):237-41.

Doarn CR.
An historical summary of advisory boards for aerospace medicine at NASA.
Aviat Space Environ Med. 2013 Mar;84(3):252-9.

Orwoll ES, Adler RA, Amin S, Binkley N, Lewiecki EM, Petak SM, Shapses SA, Sinaki M, Watts NB, Sibonga JD.
Skeletal health in long-duration astronauts: Nature, assessment and management recommendations from the NASA Bone Summit.
J Bone Miner Res. 2013 Apr 2. [Epub ahead of print]
NOTE: This is a report of a panel meeting that reviewed mineral and bone data for astronauts that flew on Mir and/or ISS.

Holguin N, Martin JT, Elliott DM, Judex S.
Low-intensity vibrations partially maintain intervertebral disc mechanics and spinal muscle area during deconditioning.
Spine J. 2013 Mar 15. [Epub ahead of print]
(PIs: S. Judex; N. Holguin, NASA Harriet G. Jenkins Predoctoral Fellowship)

Govey PM, Loiselle AE, Donahue HJ.
Biophysical regulation of stem cell differentiation.
Curr Osteoporos Rep. 2013 Mar 27. [Epub ahead of print]
(PI: H.J. Donahue)

Raber J, Allen AR, Rosi S, Sharma S, Dayger C, Davis MJ, Fike JR.
Effects of (56)Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2).
Behav Brain Res. 2013 Mar 13;246C:69-75. [Epub ahead of print]
(PIs: J.R. Fike; G. Nelson/J. Raber/J.R. Fike/NSCOR)

Girdhani S, Sachs R, Hlatky L.
Biological effects of proton radiation: What we know and don’t know.
Radiat Res. 2013 Mar;179(3):257-72. Epub 2013 Feb 1.
(PIs: L. Hlatky/R. Sachs/NSCOR)
NOTE: This article is featured on the cover of the journal:

Sarkar S, Kantara C, Ortiz I, Swiercz R, Kuo J, Davey R, Escobar K, Ullrich R, Singh P.
Progastrin overexpression imparts tumorigenic/metastatic potential to embryonic epithelial cells: Phenotypic differences between transformed and nontransformed stem cells.
Int J Cancer. 2012 Oct 1;131(7):E1088-99. Epub 2012 May 17.
(PIs: R. Ullrich, S. Bailey)

Basner M, Rao H, Goel N, Dinges DF.
Sleep deprivation and neurobehavioral dynamics.
Curr Opin Neurobiol. 2013 Mar 20. [Epub ahead of print]
(PI: M. Basner)
NOTE: This article, and article #41 in the Other section, are in an upcoming themed issue on the topic “Circadian Rhythm and Sleep.”

Withers TR, Damron FH, Yin Y, Yu HD.
Truncation of type IV pilin induces mucoidy in Pseudomonas aeruginosa strain PAO579.
MicrobiologyOpen. 2013 Mar 27. [Epub ahead of print]
(PI: F.H. Damron, NASA Graduate Student Researcher Program)
NOTE: This article may be obtained online without charge.

Other papers of interest:

Sharp MK, Batzel JJ, Montani JP.
Space physiology IV: Mathematical modeling of the cardiovascular system in space exploration.
Eur J Appl Physiol. 2013 Mar 29. [Epub ahead of print]
NOTE: This is another in a series of six papers on Space Physiology that will appear in a future print issue of this journal.

Zhang LF.
Region-specific vascular remodeling and its prevention by artificial gravity in weightless environment.
Eur J Appl Physiol. 2013 Mar 24. [Epub ahead of print]
NOTE: Some space flight results are summarized in this article.

Villar R, Hughson RL.
Lower limb vascular conductance and resting popliteal blood flow during head-up and head-down postural challenges.
Clin Physiol Funct Imaging. 2013 May;33(3):186-91. Epub 2012 Nov 8.

Kuznetsov VI, Ryzhakov NI, Tarakanov SA, Nikitenko AN, Rassadina AA, Kozlenok AV, Moroshkin VS.
[Distance methods of cardiologic monitoring in diagnostics of high loading effects on organism of sportsman and cosmonaut]
Aviakosm Ekolog Med. 2012 Nov-Dec;46(6):9-13. Russian.

Ivanova SM, Morukov BV, Yarlykova YuV, Labetskaya OI.
[Studies of red blood cells biochemistry and erythropoiesis intensity in humans during the 520-day isolation study]
Aviakosm Ekolog Med. 2012 Nov-Dec;46(6):19-23. Russian.

Campos LA, Cipolla-Neto J, Michelini LC.
Melatonin modulates baroreflex control via area postrema.
Brain Behav. 2013 Mar;3(2):171-7. Epub 2013 Feb 17.
NOTE: This article may be obtained online without charge.

Thomas BP, Yezhuvath US, Tseng BY, Liu P, Levine BD, Zhang R, Lu H.
Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO(2).
J Magn Reson Imaging. 2013 Mar 22. [Epub ahead of print]

Ushakov IB.
[Intergeneration continuity and adherence to the traditions of fundamental physiological science-the basis for present and guarantee of future advancements in space physiology and medicine]
Aviakosm Ekolog Med. 2012 Nov-Dec;46(6):3-8. Russian.

Orlov OI, Bogomolov VV, Perevedentsev OV, Polyakov AV, Berkovich YuA.
[Telemedicine technologies at the spacecrew landing site]
Aviakosm Ekolog Med. 2012 Sep-Oct;46(5):67-72. Russian.

Grigorenko DE, Sapin MR.
[Splenic lymphoid structures reorganization in gerbils after space flight]
Morfologiia. 2012;142(4):67-71. Russian.
NOTE: Foton M3 results.

Atiakshin DA, Bykov EG.
[Morphological changes in gastric wall of Mongolian gerbils following the 12-day orbital flight aboard Foton-M3]
Aviakosm Ekolog Med. 2012 Sep-Oct;46(5):26-33. Russian.
NOTE: Foton M3 results.

Krasnov IB, Diachkova LN, Burtseva TD, Krasnikova IV.
[Ultrastructure of dendritic spines in the somatosensory cortex of rat’s brain following 5- and 33-day hypergravity]
Aviakosm Ekolog Med. 2012 Sep-Oct;46(5):46-51. Russian.

Eiken O, Groenkvist M.
Signs and symptoms during supra-tolerance +G(z) exposures, with reference to G-garment failure.
Aviat Space Environ Med. 2013 Mar;84(3):196-205.
NOTE: Used a human-use centrifuge.

Papadopoulou V, Eckersley RJ, Balestra C, Karapantsios TD, Tang MX.
A critical review of physiological bubble formation in hyperbaric decompression.
Adv Colloid Interface Sci. 2013 May;191-192:22-30. Epub 2013 Mar 13.

James RS, Staples JF, Brown JC, Tessier SN, Storey KB.
The effects of hibernation on the contractile and biochemical properties of skeletal muscles in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus.
J Exp Biol. 2013 Mar 26. [Epub ahead of print]

Schwartz C, Hampton M, Andrews MT.
Seasonal and regional differences in gene expression in the brain of a hibernating mammal.
PLoS One. 2013;8(3):e58427. Epub 2013 Mar 20.
NOTE: This article may be obtained online without charge.

Rittweger J, Mueller K, Bareille MP, Felsenberg D, Zange J.
Muscle X-ray attenuation is not decreased during experimental bed rest.
Muscle Nerve. 2013 Mar 20. [Epub ahead of print]
NOTE: “Long Term Bed Rest” study (Toulouse, 2001 and 2002).

Deutz NE, Pereira SL, Hays NP, Oliver JS, Edens NK, Evans CM, Wolfe RR.
Effect of -hydroxy–methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults.
Clin Nutr. 2013 Mar 4. [Epub ahead of print]
NOTE: Bed rest study. This article may be obtained online without charge:

Killian ML, Lim CT, Thomopoulos S, Charlton N, Kim HM, Galatz LM.
The effect of unloading on gene expression of healthy and injured rotator cuffs.
J Orthop Res. 2013 Mar 18. [Epub ahead of print]

Eliasson P, Andersson T, Hammerman M, Aspenberg P.
Primary gene response to mechanical loading in healing rat Achilles tendons.
J Appl Physiol. 2013 Mar 21. [Epub ahead of print]

Wan Q, Cho E, Yokota H, Na S.
RhoA GTPase interacts with beta-catenin signaling in clinorotated osteoblasts.
J Bone Miner Metab. 2013 Mar 26. [Epub ahead of print]

Jin L, Feng G, Reames DL, Shimer AL, Shen FH, Li X.
The effects of simulated microgravity on intervertebral disc degeneration.
Spine J. 2013 Mar;13(3):235-42.

Ju YI, Sone T, Ohnaru K, Choi HJ, Choi KA, Fukunaga M.
Jump exercise during hindlimb unloading protect against the deterioration of trabecular bone microarchitecture in growing young rats.
Springerplus. 2013 Jan;2(1):35. Epub 2013 Jan 31.
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site:

Birmingham E, Grogan JA, Niebur GL, McNamara LM, McHugh PE.
Computational modelling of the mechanics of trabecular bone and marrow using fluid structure interaction techniques.
Ann Biomed Eng. 2013 Apr;41(4):814-26. Epub 2012 Dec 4.

Ivanov DG, Podkovkin VG.
[Effects of distorted geomagnetic field on the functioning of systems supporting rat’s bone matrix adaptation and metabolism in open field]
Aviakosm Ekolog Med. 2012 Nov-Dec;46(6):23-9. Russian.

Komissarova DV, Gurieva TS, Dadasheva OA, Sychev VN.
[Early bone and cartilage histogenesis in embryonic Japanese quails in the conditions of microgravity]
Aviakosm Ekolog Med. 2012 Sep-Oct;46(5):64-7. Russian.
NOTE: Mir results.

Repina LA, Vorozhtsova SV, Abrosimova AN, Novitskaya NN, Snigireva GP, Ivanov AA.
[Dynamics of chromosomal aberrations in primates subject to continuous and fractionated gamma-irradiation by equally effective residual doses]
Aviakosm Ekolog Med. 2012 Nov-Dec;46(6):30-5. Russian.

Kartashov DA, Shurshakov VA.
[A new approach to shielding function calculation: Radiation dose estimation for a phantom inside space station compartment]
Aviakosm Ekolog Med. 2012 Nov-Dec;46(6):55-61. Russian.
NOTE: Describes calculations and possibly results of radiation dose in the MATROSHKA-R phantom on ISS.

Burkovskaya TE, Shafirkin AV, Petrov VM, Shtemberg AS, Chelnaya NA, Ivanova SM.
[Radiation lesion formation and character of repair processes in the hematopoietic system of primates exposed to continuous and fractionated gamma-irradiation by equally effective doses]
Aviakosm Ekolog Med. 2012 Sep-Oct;46(5):33-41. Russian.

Voskanian KSh, Voroshtsova SV, Abrosimova AN, Mitsyn GV, Gaevsky VN.
[Modification of radiation damage to biological objects by lasers]
Aviakosm Ekolog Med. 2012 Sep-Oct;46(5):42-6. Russian.

Fujii Y, Genet MD, Roybal EJ, Kubota N, Okayasu R, Miyagawa K, Fujimori A, Kato TA.
Comparison of the bromodeoxyuridine-mediated sensitization effects between low-LET and high-LET ionizing radiation on DNA double-strand breaks.
Oncol Rep. 2013 Mar 20. [Epub ahead of print]

Kang AD, Cosenza SC, Bonagura M, Manair M, Reddy MV, Reddy EP.
ON01210.Na (Ex-RAD((R))) mitigates radiation damage through activation of the AKT pathway.
PLoS One. 2013;8(3):e58355. Epub 2013 Mar 7.
NOTE: This article may be obtained online without charge.

Lychakov DV.
Motion sickness in lower vertebrates: Studies in weightlessness and under normal conditions.
J Evol Biochem Physiol. 2012 Sep;48(5-6):574-95.
NOTE: This paper is a translation in English of the Russian original published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii. 2012 Nov-Dec;48(6):613-31:

Webb CM, Estrada A, Athy JR.
Motion sickness prevention by an 8-Hz stroboscopic environment during air transport.
Aviat Space Environ Med. 2013 Mar;84(3):177-83.

McKinley RA, Tripp LD Jr, Fullerton KL, Goodyear C.
Sustained acceleration on perception of relative position and motion.
Aviat Space Environ Med. 2013 Mar;84(3):184-9.

Gorgiladze GI, Shipov AA, Horn E.
[Biological experiments in microgravity: Equilibrium function]
Aviakosm Ekolog Med. 2012 Sep-Oct;46(5):3-18. Russian.
NOTE: This article is a review of various flight experiments (including ISS) with different organisms in different developmental stages of the balance systems. Tables of the experiments are included.

Deans MR.
A balance of form and function: Planar polarity and development of the vestibular maculae.
Semin Cell Dev Biol. 2013 Mar 15. [Epub ahead of print]

Georgi JA, Sipla JS, Forster CA.
Turning semicircular canal function on its head: Dinosaurs and a novel vestibular analysis.
PLoS One. 2013;8(3):e58517. Epub 2013 Mar 13.
NOTE: This article may be obtained online without charge.

Cohen B, Martinelli GP, Raphan T, Schaffner A, Xiang Y, Holstein GR, Yakushin SB.
The vasovagal response of the rat: Its relation to the vestibulosympathetic reflex and to Mayer waves.
FASEB J. 2013 Mar 15. [Epub ahead of print]

Tarnutzer AA, Bockisch CJ, Straumann D.
Visually guided adjustments of body posture in the roll plane.
Exp Brain Res. 2013 Mar 28. [Epub ahead of print]

Menaker M, Murphy ZC, Sellix MT.
Central control of peripheral circadian oscillators.
Curr Opin Neurobiol. 2013 Mar 26. [Epub ahead of print]

Stepanova SI, Galichiy VA, Nesterov VF, Saraev IF.
[Topics of cosmonauts’ work and rest management on board the International Space Station]
Aviakosm Ekolog Med. 2012 Nov-Dec;46(6):14-8. Russian.
NOTE: ISS results.

Salnitsky VP, Dudukin AV, Savchenko EG, Stepanova SI, Nesterov VF, Saraev IF.
[Results of operator’s work during space flight (experiment “Pilot”) under different work-and-rest cycles].
Aviakosm Ekolog Med. 2012 Sep-Oct;46(5):19-25. Russian.
NOTE: ISS results.

Solonin YuG, Markov AL, Boiko ER.
[Multi-month dynamics of the functional condition of organism of normal male northeners of Russia]
Aviakosm Ekolog Med. 2012 Nov-Dec;46(6):36-40. Russian.
NOTE: Study was done in conjuction with the Mars-500 project.

Herranz R, Manzano AI, van Loon JJ, Christianen PC, Medina FJ.
Proteomic signature of Arabidopsis cell cultures exposed to magnetically induced hyper- and microgravity environments.
Astrobiology. 2013 Mar;13(3):217-24. Epub 2013 Mar 19.
NOTE: This article may be obtained online without charge.

Chebli Y, Pujol L, Shojaeifard A, Brouwer I, van Loon JJ, Geitmann A.
Cell wall assembly and intracellular trafficking in plant cells are directly affected by changes in the magnitude of gravitational acceleration.
PLoS One. 2013;8(3):e58246. Epub 2013 Mar 13.
NOTE: “Omnidirectional gravity” was produced by a Random Positioning Machine. This article may be obtained online without charge.

Berkovich YuA, Erokhin AN, Ziablova NV, Krivobok AS, Krivobok NM, Smolianina SO, Mukhamedieva LN, Pakhomova AA, Novikova ND, Poddubko SV, Korsak IV.
[Results of Salad machine experiment within the Mars-500 project]
Aviakosm Ekolog Med. 2012 Sep-Oct;46(5):59-64. Russian.

Azri W, Brunel N, Franchel J, Ben Rejeb I, Jacquot JP, Julien JL, Herbette S, Roeckel-Drevet P.
Putative involvement of Thioredoxin h in early response to gravitropic stimulation of poplar stems.
J Plant Physiol. 2013 May 1;170(7):707-11. Epub 2013 Mar 5.

Ogneva IV.
Cell mechanosensitivity: Mechanical properties and interaction with gravitational field.
Biomed Res Int. 2013;2013:598461. Epub 2012 Dec 26.
NOTE: This article may be obtained online without charge.

Huveneers S, de Rooij J.
Mechanosensitive systems at the cadherin-F-actin interface.
J Cell Sci. 2013 Jan 15;126(Pt 2):403-13. Epub 2013 Mar 22.

Dufrene YF, Pelling AE.
Force nanoscopy of cell mechanics and cell adhesion.
Nanoscale. 2013 Mar 28. [Epub ahead of print]

Liu Y, Yehl K, Narui Y, Salaita K.
Tension sensing nanoparticles for mechano-imaging at the living/nonliving interface.
J Am Chem Soc. 2013 Mar 26. [Epub ahead of print]

Steward RL Jr, Rosner SR, Zhou EH, Fredberg J.
Illuminating human health through cell mechanics.
Swiss Med Wkly. 2013 Mar 14;143:w13766.
NOTE: This article may be obtained online without charge.

The following articles are off topic but may be of interest:

Butler D.
Investigating journals: The dark side of publishing.
Nature. 2013 Mar 28;495(7442):433-5.
NOTE: This article discusses the proliferation of open-access publishers, some of whom may “exploit this model by charging the fee without providing all the expected publishing services.” The article is part of a special section in this issue of Nature discussing various aspects of the future of scientific publishing:
The articles, which have interesting images, may be obtained online without charge.

Lewandowsky S, Oberauer K, Gignac GE.
NASA faked the Moon landing–therefore, (climate) science is a hoax: An anatomy of the motivated rejection of science.
Psychol Sci. 2013 Mar 26. [Epub ahead of print]

SpaceRef staff editor.