Status Report

NASA Spaceline Current Awareness 4 January 2013 (Recent Space Life Science Research Results)

By SpaceRef Editor
January 4, 2013
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NASA Spaceline Current Awareness 4 January 2013 (Recent Space Life Science Research Results)

Next list: January 18, 2013
Papers deriving from NASA support:

Smith SM, McCoy T, Gazda D, Morgan JL, Heer M, Zwart SR.
Space flight calcium: Implications for astronaut health, spacecraft operations, and Earth.
Nutrients. 2012 Dec 18;4(12):2047-68.
NOTE: This article may be obtained online without charge:
(PI: S.M. Smith)

Iwaniec UT, Turner RT.
Failure to generate bone marrow adipocytes does not protect mice from ovariectomy-induced osteopenia.
Bone. 2012 Dec 12;53(1):145-53. [Epub ahead of print]
(PI: R.T. Turner)

Rose RD, Buckey JC Jr, Zbozinek TD, Motivala SJ, Glenn DE, Cartreine JA, Craske MG.
A randomized controlled trial of a self-guided, multimedia, stress management and resilience training program.
Behav Res Ther. 2012 Nov 21;51(2):106-12. [Epub ahead of print]
(PI: R.D. Rose)

Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O’Banion MK.
Galactic cosmic radiation leads to cognitive impairment and increased A plaque accumulation in a mouse model of Alzheimer’s disease.
PLoS One. 2012;7(12):e53275. Epub 2012 Dec 31.
(PI: M.K. O’Banion)
NOTE: This article, which generated numerous press announcements, may be obtained online without charge.

Wang M, Saha J, Hada M, Anderson JA, Pluth JM, O’Neill P, Cucinotta FA.
Novel Smad proteins localize to IR-induced double-strand breaks: Interplay between TGF and ATM pathways.
Nucleic Acids Res. 2012 Dec 5. [Epub ahead of print]
(PIs: J.M. Pluth, F.A. Cucinotta)
NOTE: This article may be obtained online without charge.

Datta K, Hyduke DR, Suman S, Moon BH, Johnson MD, Fornace AJ Jr.
Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland.
Radiat Oncol. 2012 Dec 5;7:205. [Epub ahead of print]
(PI: A.J. Fornace Jr.)
NOTE: This article may be obtained online without charge.

Sharma P, Templin T, Grabham P.
Short term effects of gamma radiation on endothelial barrier function: Uncoupling of PECAM-1.
Microvasc Res. 2012 Dec 5. [Epub ahead of print]
(PI: P. Grabham)

Mehrotra S, Pecaut MJ, Gridley DS.
Effects of minocycline on hematopoietic recovery after whole-body irradiation.
In Vivo. 2013 Jan-Feb;27(1):11-28.

Phillips AJ, Robinson PA, Klerman EB.
Arousal state feedback as a potential physiological generator of the ultradian REM/NREM sleep cycle.
J Theor Biol. 2012 Dec 5;319C:75-87. [Epub ahead of print]
(PIs: A.J. Phillips, NSBRI Postdoctoral Fellowship Program; E.B. Klerman)

Shine JM, Matar E, Bolitho SJ, Dilda V, Morris TR, Naismith SL, Moore ST, Lewis SJ.
Modeling freezing of gait in Parkinson’s disease with a virtual reality paradigm.
Gait Posture. 2012 Dec 4. [Epub ahead of print]
(PI: S.T. Moore)

Paul AL, Amalfitano CE, Ferl RJ.
Plant growth strategies are remodeled by spaceflight.
BMC Plant Biol. 2012 Dec 7;12:232. [Epub ahead of print]
(PIs: R.J. Ferl, A-L. Paul)
NOTE: ISS results. This article may be obtained online without charge. S.J. Roux wrote a commentary on this article, entitled “Root waving and skewing – unexpectedly in micro-g,” emphasizing the novel finding of this article. The comment, also available online without charge, is available at:

Wyatt SE, Kiss JZ.
Plant tropisms: From Darwin to the International Space Station.
Am J Bot. 2013 Jan;100(1):1-3. Epub 2013 Jan 1.
(PIs: S.E. Wyatt, J.Z. Kiss)
NOTE: This article, which is available online without charge, introduces an issue on the topic “Advances in Plant Tropisms,” with a primary focus on tropistic responses to water, light, and gravity. Some of the articles appeared in previous Current Awareness lists as epubs before print, and some appear below and in the Other section of this list. The Table of Contents (and cover, a composite of various images) can be viewed at:

Toyota M, Gilroy S.
Gravitropism and mechanical signaling in plants.
Am J Bot. 2013 Jan;100(1):111-25. Epub 2013 Jan 1.
(PI: S. Gilroy)

Smith CM, Desai M, Land ES, Perera IY.
A role for lipid-mediated signaling in plant gravitropism.
Am J Bot. 2013 Jan;100(1):153-60. Epub 2012 Dec 20.
(PI: I.Y. Perera)

Withers JC, Shipp MJ, Rupasinghe SG, Sukumar P, Schuler MA, Muday GK, Wyatt SE.
GRAVITY PERSISTENT SIGNAL 1 (GPS1) reveals novel cytochrome P450s involved in gravitropism.
Am J Bot. 2013 Jan;100(1):183-93.
(PIs: S.E. Wyatt, G.K. Muday)

Paul AL, Wheeler RM, Levine HG, Ferl RJ.
Fundamental plant biology enabled by the Space Shuttle.
Am J Bot. 2013 Jan;100(1):226-34. Epub 2013 Jan 1.
(PIs: R.J. Ferl, A-L. Paul)
NOTE: Review of Shuttle experiments with plants.

Zupanska AK, Denison FC, Ferl RJ, Paul AL.
Spaceflight engages heat shock protein and other molecular chaperone genes in tissue culture cells of Arabidopsis thaliana.
Am J Bot. 2013 Jan;100(1):235-48. Epub 2012 Dec 20.
(PIs: R.J. Ferl, A-L. Paul)
NOTE: STS-131, hypergravity, clinorotation, and parabolic flight results.

Other papers of interest:

Grenon SM, Saary J, Gray G, Vanderploeg JM, Hughes-Fulford M.
Can I take a space flight? Considerations for doctors.
BMJ. 2012 Dec 13;345:e8124.

Bergouignan A, Antoun E, Momken I, Schoeller DA, Gauquelin-Koch G, Simon C, Blanc S.
Effect of contrasted levels of habitual physical activity on metabolic flexibility.
J Appl Physiol. 2012 Dec 13. [Epub ahead of print]
NOTE: Includes WISE-2005 bed rest study results.

Guo Y, Guo N, Liu C, Wang D, Wang J, Sun X, Fan S, Wang C, Yang C, Zhang Y, Lu D, Yao Y.
Effect of artificial gravity with exercise training on lung function during head-down bed rest in humans.
Clin Physiol Funct Imaging. 2013 Jan;33(1):24-9. Epub 2012 Aug 2.
NOTE: Bed rest study. This article may be obtained online without charge.

Weber T, Ducos M, Mulder E, Herrera F, Bruggemann GP, Bloch W, Rittweger J.
The specific role of gravitational accelerations for arterial adaptations.
J Appl Physiol. 2012 Dec 6. [Epub ahead of print]
NOTE: The HEPHAISTOS orthosis used in this research can be viewed at:

Bergstrom HC, Housh TJ, Zuniga JM, Traylor DA, Lewis RW Jr, Camic CL, Schmidt RJ, Johnson GO.
Mechanomyographic and metabolic responses during continuous cycle ergometry at critical power from the 3-min all-out test.
J Electromyogr Kinesiol. 2012 Dec 14. [Epub ahead of print]

Park J, Quyyumi AA, Middlekauff HR.
Exercise pressor response and arterial baroreflex unloading during exercise in chronic kidney disease.
J Appl Physiol. 2012 Dec 13. [Epub ahead of print]

Maniere D.
[Complications of immobility and bed rest. Prevention and management]
Rev Prat. 2012 Sep;62(7):1013-23. French.

Arieli R, Marmur A.
Dynamics of gas micronuclei formed on a flat hydrophobic surface, the predecessors of decompression bubbles.
Respir Physiol Neurobiol. 2012 Dec 14. [Epub ahead of print]

Ostojic O, O’Leary MF, Singh K, Menzies KJ, Vainshtein A, Hood DA.
The effects of chronic muscle use and disuse on cardiolipin metabolism.
J Appl Physiol. 2012 Dec 6. [Epub ahead of print]

Hvid LG, Suetta C, Aagaard P, Kjaer M, Frandsen U, Ortenblad N.
Four days of muscle disuse impairs single fiber contractile function in young and old healthy men.
Exp Gerontol. 2012 Dec 3. [Epub ahead of print]

O’Leary MF, Vainshtein A, Iqbal S, Ostojic O, Hood DA.
Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle.
Am J Physiol Cell Physiol. 2012 Dec 5. [Epub ahead of print]

Renaud G, Llano-Diez M, Ravar B, Gorza L, Feng HZ, Jin JP, Cacciani N, Gustafson AM, Ochala J, Corpeno R, Li M, Hedstroem Y, Ford GC, Nair KS, Larsson L.
Sparing of muscle mass and function by passive loading in an experimental intensive care unit model.
J Physiol. 2012 Dec 24. [Epub ahead of print]

Jackman RW, Wu CL, Kandarian SC.
The ChIP-seq-defined networks of Bcl-3 gene binding support its required role in skeletal muscle atrophy.
PLoS One. 2012;7(12):e51478. Epub 2012 Dec 10.
NOTE: Used hindlimb unloading. This article may be obtained online without charge.

Tanaka M, Hirayama Y, Fujita N, Fujino H.
Comparison of premodulated interferential and pulsed current electrical stimulation in prevention of deep muscle atrophy in rats.
J Mol Histol. 2012 Dec 21. [Epub ahead of print]

Wu X, Gao YF, Zhao XH, Cui JH.
[Effects of tetramethylpyrazine on nitric oxide synthase activity and calcium ion concentration of skeletal muscle in hindlimb unloading rats]
Zhonghua Yi Xue Za Zhi. 2012 Aug 7;92(29):2075-7. Chinese.
NOTE: Translated title of journal is Chinese Medical Journal.

Mirzoev TM, Biryukov NS, Veselova OM, Larina IM, Shenkman BS, Ogneva IV.
Parameters of fiber cell respiration and desmin content in rat soleus muscle at early stages of gravitational unloading.
Biophysics. 2012 May;57(3):377-81.
NOTE: This paper is a translation in English of the Russian original published in Biofizika. 2012 May-Jun;57(3):509-14:

Manini TM, Hong SL, Clark BC.
Aging and muscle: A neuron’s perspective.
Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):21-6.

Kachaeva EV, Ushakov IB, Shenkman BS.
[Activity of the skeletal muscle proteolytic systems during functional unloading]
Usp Fiziol Nauk. 2012 Jul-Sep;43(3):3-20. Russian.

Trappe TA, Standley RA, Jemiolo B, Carroll CC, Trappe SW.
Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults.
Am J Physiol Regul Integr Comp Physiol. 2012 Dec 5. [Epub ahead of print]

Tankisheva E, Jonkers I, Boonen S, Delecluse C, Harry van Lenthe G, Druyts H, Spaepen P, Verschueren SM.
Transmission of whole body vibration and its effect on muscle activation.
J Strength Cond Res. 2012 Dec 4. [Epub ahead of print]

Deutz NE, Wolfe RR.
Is there a maximal anabolic response to protein intake with a meal?
Clin Nutr. 2012 Dec 1. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Patil S, Steklov N, Bugbee WD, Goldberg T, Colwell CW Jr, D’Lima DD.
Anti-gravity treadmills are effective in reducing knee forces.
J Orthop Res. 2012 Dec 13. [Epub ahead of print]

Sonenblum SE, Sprigle SH, Cathcart JM, Winder RJ.
3-dimensional buttocks response to sitting: A case report.
J Tissue Viability. 2012 Dec 22. [Epub ahead of print]

Albi E, Curcio F, Spelat R, Lazzarini A, Lazzarini R, Cataldi S, Loreti E, Ferri I, Ambesi-Impiombato FS.
Loss of parafollicular cells during gravitational changes (microgravity, hypergravity) and the secret effect of pleiotrophin.
PLoS One. 2012;7(12):e48518. Epub 2012 Dec 19.
NOTE: ISS results. This article may be obtained online without charge.

Brueel A, Vegger JB, Raffalt AC, Andersen JE, Thomsen JS.
PTH (1-34), but not strontium ranelate counteract loss of trabecular thickness and bone strength in disuse osteopenic rats.
Bone. 2012 Dec 11;53(1):51-8. [Epub ahead of print]

Bakker AD, Zandieh-Doulabi B, Klein-Nulend J.
Strontium Ranelate affects signaling from mechanically-stimulated osteocytes towards osteoclasts and osteoblasts.
Bone. 2012 Dec 9;53(1):112-9. [Epub ahead of print]

Tsuchie H, Miyakoshi N, Kasukawa Y, Aonuma H, Shimada Y.
Intermittent administration of human parathyroid hormone before osteosynthesis stimulates cancellous bone union in ovariectomized rats.
Tohoku J Exp Med. 2012;229(1):19-28.
NOTE: This article may be obtained online without charge.

Sapir-Koren R, Livshits G.
Is interaction between age-dependent decline in mechanical stimulation and osteocyte-estrogen receptor levels the culprit for postmenopausal-impaired bone formation?
Osteoporos Int. 2012 Nov 15. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Wang X, Guo B, Li Q, Peng J, Yang Z, Wang A, Li D, Hou Z, Lv K, Kan G, Cao H, Wu H, Song J, Pan X, Sun Q, Ling S, Li Y, Zhu M, Zhang P, Peng S, Xie X, Tang T, Hong A, Bian Z, Bai Y, Lu A, Li Y, He F, Zhang G, Li Y.
miR-214 targets ATF4 to inhibit bone formation.
Nat Med. 2012 Dec 9. [Epub ahead of print]

Ishihara Y, Sugawara Y, Kamioka H, Kawanabe N, Hayano S, Balam TA, Naruse K, Yamashiro T.
Ex vivo real-time observation of Ca(2+) signaling in living bone in response to shear stress applied on the bone surface.
Bone. 2012 Dec 13. [Epub ahead of print]

Jilka RL, Noble B, Weinstein RS.
Osteocyte apoptosis.
Bone. 2012 Dec 10. [Epub ahead of print]

Hirobe T, Eguchi-Kasai K, Sugaya K, Murakami M.
Effects of low-dose heavy ions on embryonic development in mice and on melanocyte differentiation in the epidermis and hair bulb.
J Radiat Res. 2012 Dec 9. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Pilling S, Mendes LA, Bordalo V, Guaman CF, Ponciano CR, da Silveira EF.
The influence of crystallinity degree on the glycine decomposition induced by 1 MeV proton bombardment in space analog conditions.
Astrobiology. 2012 Dec 18. [Epub ahead of print]

Zou Y, Corniola R, Leu D, Khan A, Sahbaie P, Chakraborti A, Clark DJ, Fike JR, Huang TT.
Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation.
Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21522-7. Epub 2012 Dec 10.

Sparvoli R, For the PAMELA Collaboration.
Main results from the PAMELA space experiment after five years in flight.
Nucl Instrum Methods Phys Res A. 2012 Nov 11;692:29-33.

Govorun MI, Usachev VI, Golovanov AE, Kuznetsov MS.
[The stabilometric evaluation of resistance to motion sickness in man]
Vestn Otorinolaringol. 2012;(4):40-1. Russian.

Thibault G, Pasqualotto A, Vidal M, Droulez J, Berthoz A.
How does horizontal and vertical navigation influence spatial memory of multifloored environments?
Atten Percept Psychophys. 2013 Jan;75(1):10-5.

Demichelis A, Olivier G, Berthoz A.
Motor transfer from map ocular exploration to locomotion during spatial navigation from memory.
Exp Brain Res. 2012 Dec 7. [Epub ahead of print]
NOTE: This article may temporarily be obtained online without charge.

Crane BT.
Direction specific biases in human visual and vestibular heading perception.
PLoS One. 2012;7(12):e51383. Epub 2012 Dec 7.
NOTE: This article may be obtained online without charge.

Chen G, King JA, Burgess N, O’Keefe J.
How vision and movement combine in the hippocampal place code.
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):378-83. Epub 2012 Dec 19.

Chaudhuri SE, Merfeld DM.
Signal detection theory and vestibular perception: III. Estimating unbiased fit parameters for psychometric functions.
Exp Brain Res. 2012 Dec 19. [Epub ahead of print]
NOTE: This article may temporarily be obtained online without charge.

Lazar AS, Santhi N, Hasan S, Lo JC, Johnston JD, Von Schantz M, Archer SN, Dijk DJ.
Circadian period and the timing of melatonin onset in men and women: Predictors of sleep during the weekend and in the laboratory.
J Sleep Res. 2012 Dec 6. [Epub ahead of print]
NOTE: This article may be obtained online without charge:

Herranz R, Anken R, Boonstra J, Braun M, Christianen PC, de Geest M, Hauslage J, Hilbig R, Hill RJ, Lebert M, Medina FJ, Vagt N, Ullrich O, van Loon JJ, Hemmersbach R.
Ground-based facilities for simulation of microgravity: Organism-specific recommendations for their use, and recommended terminology.
Astrobiology. 2012 Dec 19. [Epub ahead of print]

Zhang X, Nan Y, Wang H, Chen J, Wang N, Xie J, Ma J, Wang Z.
Model microgravity enhances endothelium differentiation of mesenchymal stem cells.
Naturwissenschaften. 2012 Dec 11. [Epub ahead of print]
NOTE: Used clinostat to model microgravity. This article may temporarily be obtained online without charge

Di S, Meng R, Qian A, Tian Z, Li J, Zhang R, Shang P.
Impact of osteoclast precursors subjected to Random Positioning Machine on osteoblasts.
J Mech Med Biol. 2012 Sep;12(4):1250074.

Polykandriotis E, Schmidt VJ, Kneser U, Jianming S, Boccaccini AR, Horch RE.
[Bioreactors in regenerative medicine-from a technical device to a reconstructive alternative?]
Handchir Mikrochir Plast Chir. 2012 Aug;44(4):198-203. Epub 2012 Aug 29. German.

Wang H, Lacoche S, Huang L, Xue B, Muthuswamy SK.
Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly.
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):163-8. Epub 2012 Dec 17.
NOTE: This article may be obtained online without charge.

Mel’kumiants AM.
[Role of endothelial glycocalyx in mechanogenic control of arterial hydraulic resistance]
Usp Fiziol Nauk. 2012 Oct-Dec;43(4):45-58. Russian.

Hala E, Bro TH, Bilenberg B, Kocer A.
Well-defined microapertures for ion channel biosensors.
Anal Chem. 2012 Dec 26. [Epub ahead of print]

Booth-Gauthier EA, Alcoser TA, Yang G, Dahl KN.
Force-induced changes in subnuclear movement and rheology.
Biophys J. 2012 Dec 19;103(12):2423-31. Epub 2012 Dec 18.
NOTE: This article may be obtained online without charge.

Schenck CA, Nadella V, Clay SL, Lindner J, Abrams Z, Wyatt SE.
A proteomics approach identifies novel proteins involved in gravitropic signal transduction.
Am J Bot. 2013 Jan;100(1):194-202. Epub 2013 Jan 1.

Spalding EP.
Diverting the downhill flow of auxin to steer growth during tropisms.
Am J Bot. 2013 Jan;100(1):203-14.

Strohm AK, Baldwin KL, Masson PH.
Multiple roles for membrane-associated protein trafficking and signaling in gravitropism.
Front Plant Sci. 2012;3:274. Epub 2012 Dec 11.
NOTE: This article may be obtained online without charge.

Rigas S, Ditengou FA, Ljung K, Daras G, Tietz O, Palme K, Hatzopoulos P.
Root gravitropism and root hair development constitute coupled developmental responses regulated by auxin homeostasis in the Arabidopsis root apex.
New Phytol. 2012 Dec 18. [Epub ahead of print]

Bastien R, Bohr T, Moulia B, Douady S.
Unifying model of shoot gravitropism reveals proprioception as a central feature of posture control in plants.
Proc Natl Acad Sci U S A. 2012 Dec 11. [Epub ahead of print]

Behrens TE, Fox P, Laird A, Smith SM.
What is the most interesting part of the brain?
Trends Cogn Sci. 2013 Jan;17(1):2-4. Epub 2012 Dec 5.
NOTE: This partly tongue-in-cheek article suggests that doing research on a “popular” area of the brain makes it easier for scientists to publish in higher impact journals. This article may be obtained online without charge.

SpaceRef staff editor.