NASA Spaceline Current Awareness 3 June 2011 (Recent Space Life Science Research Results)

Papers deriving from NASA support:

1
Blaber AP, Goswami N, Bondar RL, Kassam MS.
Impairment of cerebral blood flow regulation in astronauts with orthostatic intolerance after flight.
Stroke. 2011 May 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21617145
(PI: J. Meck)
NOTE: STS results. From Conclusions: “Cerebrovascular regulation was found to be different between astronauts who were able to remain standing (finishers) or not (nonfinishers) without assistance for 10 minutes on landing day and across gender. On landing day, nonfinishers had a decrease in conductance with standing, whereas the finishers did not.”

2
Streeper T, Cavanagh PR, Hanson AM, Carpenter RD, Saeed I, Kornak J, Frassetto L, Grodsinsky C, Funk J, Lee SM, Spiering BA, Bloomberg J, Mulavara A, Sibonga J, Lang T.
Development of an integrated countermeasure device for use in long-duration spaceflight.
Acta Astronaut. 2011 Jun-Jul;68(11-12):2029-37.
http://dx.doi.org/10.1016/j.actaastro.2010.11.002
(PI: T. Lang)

3
Lloyd SA, Simske SJ, Bogren LK, Olesiak SE, Bateman TA, Ferguson VL.
Effects of combined insulin-like growth factor 1 and macrophage colony-stimulating factor on the skeletal properties of mice.
In Vivo. 2011 May-Jun;25(3):297-305.
http://www.ncbi.nlm.nih.gov/pubmed/21576402
(PI: T.A. Bateman)

4
Hu S, Cucinotta FA.
Characterization of the radiation-damaged precursor cells in bone marrow based on modeling of the peripheral blood granulocytes response.
Health Phys. 2011 Jul;101(1):67-78.
http://www.ncbi.nlm.nih.gov/pubmed/21617393
(PI: F.A. Cucinotta)

5
Walker SA, Slaba TC, Clowdsley MS, Blattnig SR.
Investigating material approximations in spacecraft radiation analysis.
Acta Astronaut. 2011 Jul-Aug;69(1-2):6-17.
http://dx.doi.org/10.1016/j.actaastro.2011.02.013
(PI: C. Sandridge)

6
Bates SC, Marquit J.
Space psychology: Natural elements in habitation design.
Personal Ubiq. Comput. 2011 June;15(5):519-23.
http://dx.doi.org/10.1007/s00779-010-0316-6
(PI: G. Bingham)
NOTE: See citation #30 in Other section for information about this issue.

Other papers of interest:

1
Etheridge T, Nemoto K, Hashizume T, Mori C, Sugimoto T, Suzuki H, Fukui K, Yamazaki T, Higashibata A, Szewczyk NJ, Higashitani A.
The effectiveness of RNAi in Caenorhabditis elegans is maintained during spaceflight.
PLoS ONE 2011;6(6):e20459. Epub 2011 June 1.
http://dx.doi.org/10.1371/journal.pone.0020459
NOTE: ISS results. This article may be obtained online without charge.

2
Pietsch J, Bauer J, Egli M, Infanger M, Wise P, Ulbrich C, Grimm D.
The effects of weightlessness on the human organism and mammalian cells.
Curr Mol Med. 2011 Jul;11(5):350-64.
http://www.ncbi.nlm.nih.gov/pubmed/21568935

3
Studer M, Bradacs G, Hilliger A, Huerlimann E, Engeli S, Thiel CS, Zeitner P, Denier B, Binggeli M, Syburra T, Egli M, Engelmann F, Ullrich O.
Parabolic maneuvers of the Swiss Air Force fighter jet F-5E as a research platform for cell culture experiments in microgravity.
Acta Astronaut. 2011 Jun-Jul;68(11-12):1729-41.
http://dx.doi.org/10.1016/j.actaastro.2010.11.005
NOTE: Parabolic flight results.

4
Kiviniemi AM, Frances MF, Tiinanen S, Craen R, Rachinsky M, Petrella RJ, Seppaenen T, Huikuri HV, Tulppo MP, Shoemaker JK.
Alpha-adrenergic effects on low frequency oscillations in blood pressure and R-R intervals during sympathetic activation.
Exp Physiol. 2011 May 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21602293

5
Bowles DK, Laughlin MH.
Mechanisms of beneficial effects of physical activity on atherosclerosis and coronary heart disease.
J Appl Physiol. 2011 May 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21617083
NOTE: This editorial introduces a “Highlighted Topics series of mini-reviews” on this topic to appear in this journal.

6
Xue JH, Chen LH, Zhao HZ, Pu YD, Feng HZ, Ma YG, Ma J, Chang YM, Zhang ZM, Xie MJ.
Differential regulation and recovery of intracellular Ca2+ in cerebral and small mesenteric arterial smooth muscle cells of simulated microgravity rat.
PLoS One. 2011;6(5):e19775. Epub 2011 May 18.
http://www.ncbi.nlm.nih.gov/pubmed/21611118
NOTE: This article may be obtained online without charge.

7
Ogneva IV, Veselova OM, Larina IM.
Changes in cell respiration of postural muscle fibers under long-term gravitational unloading after aqddition of succinate into diet.
Biophys 2011 Feb;56(1):103-7.
http://dx.doi.org/10.1134/S0006350911010167
NOTE: This article, which may temporarily be obtained online without charge, is a translation in English of the Russian original published in Biofizika. 2011 Jan-Feb;56(1):122-8: http://www.ncbi.nlm.nih.gov/pubmed/21442893

8
Kazi AA, Hong-Brown L, Lang SM, Lang CH.
Deptor knockdown enhances mTOR activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy.
Mol Med. 2011 May 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21607293
NOTE: This article may be obtained online without charge.

9
Hody S, Leprince P, Sergeant K, Renaut J, Croisier JL, Wang F, Rogister B.
Human muscle proteome modifications following acute or repeated eccentric exercises.
Med Sci Sports Exerc. 2011 May 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21606878

10
Kashyap L, Perera S, Fisher AL.
Identification of novel genes involved in sarcopenia through RNAi screening in Caenorhabditis elegans.
J Gerontol A Biol Sci Med Sci. 2011 May 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21593014

11
Sukumar D, Ambia-Sobhan H, Zurfluh R, Schlussel Y, Stahl TJ, Gordon CL, Shapses SA.
Areal and volumetric bone mineral density and geometry at two levels of protein intake during caloric restriction: A randomized, controlled trial.
J Bone Miner Res. 2011 Jun;26(6):1339-48.
http://www.ncbi.nlm.nih.gov/pubmed/21611972

12
Schett G.
Effects of inflammatory and anti-inflammatory cytokines on the bone.
Eur J Clin Invest. 2011 May 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21615394

13
Pan J, Zhang T, Mi L, Zhang B, Wang B, Yang L, Deng L, Wang L.
Stepwise increasing and decreasing fluid shear stresses differentially regulate the functions of osteoblasts.
Cell Mol Bioeng. 2010 Dec;3(4):376-86.
http://www.ncbi.nlm.nih.gov/pubmed/21603107
NOTE: This article may be obtained online without charge via PubMed Central.

14
Griffith DM, Walsh TS.
Bone loss during critical illness: A skeleton in the closet for the intensive care unit survivor?
Crit Care Med. 2011 Jun;39(6):1554-6.
http://www.ncbi.nlm.nih.gov/pubmed/21610619
NOTE: This is a comment on a paper by Orford et al.: http://www.ncbi.nlm.nih.gov/pubmed/21336120

15
Moustafa A, Sugiyama T, Prasad J, Zaman G, Gross TS, Lanyon LE, Price JS.
Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered.
Osteoporos Int. 2011 May 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21573880
NOTE: This article may be obtained online without charge.

16
Ni C, Wang C, Li Y, Li Y, Dai Z, Zhao D, Sun H, Wu B.
Detection of the quantity of kinesin and microgravity-sensitive kinesin genes in rat bone marrow stromal cells grown in a simulated microgravity environment.
Acta Astronaut. 2011 Jun-Jul;68(11-12):1722-8.
http://dx.doi.org/10.1016/j.actaastro.2010.12.009

17
Bouma HR, Verhaag EM, Otis JP, Heldmaier G, Swoap SJ, Strijkstra AM, Henning RH, Carey HV.
Induction of torpor: Mimicking natural metabolic suppression for biomedical applications.
J Cell Physiol. 2011 May 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21618525
NOTE: The mechanisms underlying torpor are still largely unknown, according to the authors.

18
Webb JT, Pilmanis AA.
Fifty years of decompression sickness research at Brooks AFB, TX: 1960-2010.
Aviat Space Environ Med. 2011 May;82(5 Suppl):A1-25.
http://www.ncbi.nlm.nih.gov/pubmed/21614886
NOTE: This article may be obtained online without charge: http://www.ingentaconnect.com/content/asma/asem/2011/00000082/A00105s1/a…
Also see: http://www.ncbi.nlm.nih.gov/pubmed/21614874

19
Hugon J, Rostain JC, Gardette B.
A new biophysical decompression model for estimating the risk of articular bends during and after decompression.
J Theor Biol. 2011 May 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21609722

20
Chinnadurai M, Chidambaram S, Ganesan V, Baraneedharan U, Sundaram L, Paul SF, Venkatachalam P.
Bleomycin, neocarzinostatin and ionising radiation-induced bystander effects in normal diploid human lung fibroblasts, bone marrow mesenchymal stem cells, lung adenocarcinoma cells and peripheral blood lymphocytes.
Int J Radiat Biol. 2011 May 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21599612

21
Ghosh S, Narang H, Sarma A, Kaur H, Krishna M.
Activation of DNA damage response signaling in lung adenocarcinoma A549 cells following oxygen beam irradiation.
Mutat Res. 2011 May 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21609781

22
Dong X, Yoshida K, Stoffregen TA.
Control of a virtual vehicle influences postural activity and motion sickness.
J Exp Psychol Appl. 2011 May 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21604911

23
Degardin A, Devos D, Cassim F, Bourriez JL, Defebvre L, Derambure P, Devanne H.
Deficit of sensorimotor integration in normal aging.
Neurosci Lett. 2011 May 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21600958

24
Suedfeld P, Brcic J.
Resolution of psychosocial crises associated with flying in space.
Acta Astronaut. 2011 Jul-Aug;69(1-2):24-9.
http://dx.doi.org/10.1016/j.actaastro.2011.02.011

25
Sandal GM, Bye HH, van de Vijver FJ.
Personal values and crew compatibility: Results from a 105 days simulated space mission.
Acta Astronaut. 2011 Aug-Sep;69(3-4):141-9.
http://dx.doi.org/10.1016/j.actaastro.2011.02.007

26
Howard J, Grill SW, Bois JS.
Turing’s next steps: The mechanochemical basis of morphogenesis.
Nat Rev Mol Cell Biol. 2011 Jun;12(6):392-8.
http://www.ncbi.nlm.nih.gov/pubmed/21602907

27
Du J, Chen X, Liang X, Zhang G, Xu J, He L, Zhan Q, Feng XQ, Chien S, Yang C.
Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity.
Proc Natl Acad Sci U S A. 2011 May 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21593411

28
Nakamura M, Toyota M, Tasaka M, Morita MT.
An Arabidopsis E3 ligase, SHOOT GRAVITROPISM9, modulates the interaction between statoliths and F-actin in gravity sensing.
Plant Cell. 2011 May 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21602290
NOTE: This article may be obtained online without charge.

29
Rakusova H, Gallego-Bartolome J, Vanstraelen M, Robert HS, Alabadi D, Blazquez MA, Benkova E, Friml J.
Polarization of PIN3-dependent auxin transport for hypocotyl gravitropic response in Arabidopsis thaliana.
Plant J. 2011 May 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21569134

30
McCandless J.
Introduction.
Personal Ubiq. Comput. 2011 June;15(5):443-4.
http://dx.doi.org/10.1007/s00779-010-0323-7
NOTE: The following 10 articles and one article in the NASA section constitute a theme issue on the topic: “Human Computer Interaction in Space.” There is also an editorial on page 441, which can be obtained online without charge: http://dx.doi.org/10.1007/s00779-011-0379-z

31
Neerincx MA.
Situated cognitive engineering for crew support in space.
Personal Ubiq. Comput. 2011 June;15(5):445-56.
http://dx.doi.org/10.1007/s00779-010-0319-3
NOTE: This article may be obtained online without charge.

32
Garcia JQ.
A study on PDAs for onboard applications and technologies and methodologies.
Personal Ubiq. Comput. 2011 June;15(5):457-78.
http://dx.doi.org/10.1007/s00779-010-0318-4

33
Kostakos V.
The challenges and opportunities of designing pervasive systems for deep-space colonies.
Personal Ubiq. Comput. 2011 June;15(5):479-86.
http://dx.doi.org/10.1007/s00779-010-0317-5

34
Schlacht IL.
Preface. Space extreme design: New ideas and approaches for space habitability.
Personal Ubiq. Comput. 2011 June;15(5):487-9.
http://dx.doi.org/10.1007/s00779-010-0320-x

35
Masali M, Ferrino M, Argenta M, Stricker FL.
Space anthropology: Physical and cultural adaptation in outer space.
Personal Ubiq. Comput. 2011 June;15(5):491-6.
http://dx.doi.org/10.1007/s00779-010-0324-6

36
Schlacht IL, Birke H.
Space design: Visual interface of space habitats.
Personal Ubiq. Comput. 2011 June;15(5):497-509.
http://dx.doi.org/10.1007/s00779-010-0326-4

37
Ono A, Schlacht IL.
Space art: Aesthetics design as psychological support.
Personal Ubiq. Comput. 2011 June;15(5):511-8.
http://dx.doi.org/10.1007/s00779-010-0325-5

38
Schlacht IL.
Conclusion. Space extreme design: Conclusion and acknowledgements.
Personal Ubiq. Comput. 2011 June;15(5):525-6.
http://dx.doi.org/10.1007/s00779-010-0321-9

39
de Negueruela C, Broschart M, Menon C, del R Millan J.
Brain-computer interfaces for space applications.
Personal Ubiq. Comput. 2011 June;15(5):527-37.
http://dx.doi.org/10.1007/s00779-010-0322-8

40
Poldma T.
The interior spatial environment: Dynamic 0g environments and human places.
Personal Ubiq. Comput. 2011 June;15(5):539-50.
http://dx.doi.org/10.1007/s00779-010-0348-y