Status Report

NASA Spaceline Current Awareness 29 April 2011 (Recent Space Life Science Research Results)

By SpaceRef Editor
April 29, 2011
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NASA Spaceline Current Awareness 29 April 2011 (Recent Space Life Science Research Results)

Papers deriving from NASA support:

Aerospace Medical Association Commercial Spaceflight Working Group.
Suborbital commercial spaceflight crewmember medical issues.
Aviat Space Environ Med. 2011 Apr;82(4):475-84.
NOTE: The table of contents of this issue, which has many relevant articles, may be viewed at ingentaconnect:

Sakowski C, Starc V, Smith SM, Schlegel TT.
Sedentary long-duration head-down bed rest and ECG repolarization heterogeneity.
Aviat Space Environ Med. 2011 Apr;82(4):416-23.
NOTE: Support includes the JSC Flight Analogs Project and the Human Test Subject Facility. Bed rest study.

Jarvis SS, VanGundy TB, Galbreath MM, Shibata S, Okazaki K, Reelick MF, Levine BD, Fu Q.
Sex differences in the modulation of vasomotor sympathetic outflow during static handgrip exercise in healthy young humans.
Am J Physiol Regul Integr Comp Physiol. 2011 Apr 20. [Epub ahead of print]
(PI: B.D. Levine)

Swift JM, Swift SN, Nilsson MI, Hogan HA, Bouse SD, Bloomfield SA.
Cancellous bone formation response to simulated resistance training during disuse is blunted by concurrent alendronate treatment.
J Bone Miner Res. 2011 Apr 20. [Epub ahead of print]
(PIs: S.A. Bloomfield; J.M. Swift, NSBRI Graduate Training Fellowship)

Sulkowski CM, Gilkey KM, Lewandowski BE, Samorezov S, Myers JG Jr.
An extravehicular suit impact load attenuation study to improve astronaut bone fracture prediction.
Aviat Space Environ Med. 2011 Apr;82(4):455-62.
(PI: J.G. Myers Jr.)

Stowe RP, Kozlova EV, Sams CF, Pierson DL, Walling DM.
Latent and lytic Epstein-Barr virus gene expression in the peripheral blood of astronauts.
J Med Virol. 2011 Jun;83(6):1071-7.
(PI: R.P. Stowe)
NOTE: Shuttle and ISS results.

Chuong MC, Prasad D, LeDuc B, Du B, Putcha L.
Stability of vitamin B complex in multivitamin and multimineral supplement tablets after space flight.
J Pharm Biomed Anal. 2011 Mar 29. [Epub ahead of print]
(PI: L. Putcha)
NOTE: Shuttle and ISS results.

Cho Y, Kim H, Turner ND, Mann JC, Wei J, Taddeo SS, Davidson LA, Wang N, Vannucci M, Carroll RJ, Chapkin RS, Lupton JR.
A chemoprotective fish oil- and pectin-containing diet temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis.
J Nutr. 2011 Apr 20. [Epub ahead of print]
(PI: J.R. Lupton)

Badaut J, Ashwal S, Obenaus A.
Aquaporins in cerebrovascular disease: A target for treatment of brain edema?
Cerebrovasc Dis. 2011 Apr 12;31(6):521-31. [Epub ahead of print]

Peters BT, Miller CA, Brady RA, Richards JT, Mulavara AP, Bloomberg JJ.
Dynamic visual acuity during walking after long-duration spaceflight.
Aviat Space Environ Med. 2011 Apr;82(4):463-6.
(PIs: A.P. Mulavara, J.J. Bloomberg)
NOTE: ISS results.

Griofa MO, Blue RS, Cohen KD, O’Keeffe DT.
Sleep stability and cognitive function in an Arctic Martian analogue.
Aviat Space Environ Med. 2011 Apr;82(4):434-41.

Other papers of interest:

Campbell MR, Garbino A.
History of suborbital spaceflight: Medical and performance issues.
Aviat Space Environ Med. 2011 Apr;82(4):469-74.

Limper U, Gauger P, Beck LE.
Upright cardiac output measurements in the transition to weightlessness during parabolic flights.
Aviat Space Environ Med. 2011 Apr;82(4):448-54.
NOTE: Parabolic flight results.

Takahata T, Shouji I, Maruyama S, Sato Y, Nishida Y, Ueno T.
Teeth clenching and positive acceleration-induced cerebral arterial hypotension in rats.
Aviat Space Environ Med. 2011 Apr;82(4):442-7.

Wong BJ, Sheriff DD.
Role of splanchnic constriction in governing the hemodynamic responses to gravitational stress in conscious dogs.
J Appl Physiol. 2011 Apr 21. [Epub ahead of print]

McCain ML, Parker KK.
Mechanotransduction: The role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function.
Pflugers Arch. 2011 Apr 19. [Epub ahead of print]

Ma XW, Li Q, Xu PT, Zhang L, Li H, Yu ZB.
Tetanic contractions impair sarcomeric Z-disk of atrophic soleus muscle via calpain pathway.
Mol Cell Biochem. 2011 Apr 16. [Epub ahead of print]
NOTE: Unloading accomplished by tail suspension.

Horstman AM, de Ruiter CJ, van Duijnhoven NT, Hopman MT, de Haan A.
Changes in muscle contractile characteristics and jump height following 24 days of unilateral lower limb suspension.
Eur J Appl Physiol. 2011 Apr 20. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Ge X, McFarlane C, Vajjala A, Lokireddy S, Ng ZH, Tan CK, Tan NS, Wahli W, Sharma M, Kambadur R.
Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts.
Cell Res. 2011 Apr 19. [Epub ahead of print]

Vazeille E, Slimani L, Claustre A, Magne H, Labas R, Bechet D, Taillandier D, Dardevet D, Astruc T, Attaix D, Combaret L.
Curcumin treatment prevents increased proteasome and apoptosome activities in rat skeletal muscle during reloading and improves subsequent recovery.
J Nutr Biochem. 2011 Apr 15. [Epub ahead of print]

Nowlan NC, Dumas G, Tajbakhsh S, Prendergast PJ, Murphy P.
Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis.
Biomech Model Mechanobiol. 2011 Apr 20. [Epub ahead of print]
NOTE: This article may be obtained online without charge:

Gesty-Palmer D, Luttrell LM.
‘Biasing’ the parathyroid hormone receptor: A novel anabolic approach to increasing bone mass?
Br J Pharmacol. 2011 Apr 21. [Epub ahead of print]

Dontas IA, Lelovas PP, Kourkoulis SK, Aligiannis N, Paliogianni A, Mitakou S, Galanos A, Kassi E, Mitousoudis A, Xanthos TT, Papaioannou N, Lyritis GP.
Protective effect of Sideritis euboea extract on bone mineral density and strength of ovariectomized rats.
Menopause. 2011 Apr 18. [Epub ahead of print]

Burra S, Nicolella DP, Jiang JX.
Dark horse in osteocyte biology: Glycocalyx around the dendrites is critical for osteocyte mechanosensing.
Commun Integr Biol. 2011 Jan-Feb;4(1):48-50.
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site.

Cheung B, Nakashima AM, Hofer KD.
Various anti-motion sickness drugs and core body temperature changes.
Aviat Space Environ Med. 2011 Apr;82(4):409-15.

LaCount LT, Barbieri R, Park K, Kim J, Brown EN, Kuo B, Napadow V.
Static and dynamic autonomic response with increasing nausea perception.
Aviat Space Environ Med. 2011 Apr;82(4):424-33.

Thornton WE.
A rationale for space motion sickness.
Aviat Space Environ Med. 2011 Apr;82(4):467-8.

McMahon T, Newman DG.
Caffeine chewing gum as an in-flight countermeasure to fatigue.
Aviat Space Environ Med. 2011 Apr;82(4):490-1.
NOTE: This article may be obtained online without charge:…

Rizzo-Sierra CV, Leon-Sarmiento FE.
Pathophysiology of movement disorders due to gravity transitions: The channelopathy linkage in human balance and locomotion.
Med Hypotheses. 2011 Apr 11. [Epub ahead of print]

Bascandziev I, Harris PL.
Gravity is not the only ruler for falling events: Young children stop making the gravity error after receiving additional perceptual information about the tubes mechanism.
J Exp Child Psychol. 2011 Apr 17. [Epub ahead of print]

DuFort CC, Paszek MJ, Weaver VM.
Balancing forces: Architectural control of mechanotransduction.
Nat Rev Mol Cell Biol. 2011 May;12(5):308-19.
NOTE: Nice review of this topic.

Farge E.
Mechanotransduction in development.
Curr Top Dev Biol. 2011;95:243-65.
NOTE: This article is in a volume titled: “Forces and Tension in Development.”

Luo W, Xiong W, Qiu M, Lv Y, Li Y, Li F.
Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype utilizing simulated microgravity in vitro.
J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31(2):199-203. Epub 2011 Apr 20.
NOTE: Microgravity simulated by rotary cell culture system.

Bai S, Li Y, Wang J, Zhai D, Kong Q, Liu Y, Liu X, Sun B, Xu J, Wang D, Wang G, Mu L, Xu X, Li H.
Modeled microgravity suppressed expansion of the MBP-specific T lymphocytes of rats with experimental autoimmune encephalomyelitis.
Immunol Invest. 2011 Apr 21. [Epub ahead of print]

Peer WA, Blakeslee JJ, Yang H, Murphy AS.
Seven things we think we know about auxin transport.
Mol Plant. 2011 Apr 19. [Epub ahead of print]

SpaceRef staff editor.