Status Report

NASA Spaceline Current Awareness 26 July 2013 (Recent Space Life Science Research Results)

By SpaceRef Editor
July 26, 2013
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NASA Spaceline Current Awareness 26 July 2013 (Recent Space Life Science Research Results)

Next list: August 9, 2013

Papers deriving from NASA support:

Mader TH, Gibson CR, Pass AF, Lee AG, Killer HE, Hansen HC, Dervay JP, Barratt MR, Tarver WJ, Sargsyan AE, Kramer LA, Riascos R, Bedi DG, Pettit DR.
Optic disc edema in an astronaut after repeat long-duration space flight.
J Neuroophthalmol. 2013 Jul 17. [Epub ahead of print]
NOTE: ISS results.

Hackney KJ, Everett M, Scott JM, Ploutz-Snyder L.
Blood flow-restricted exercise in space.
Extrem Physiol Med. 2012 Dec 1;1:12.
NOTE: This article may be obtained online without charge.

Ellerby GE, Smith CP, Zou F, Scott P, Soller BR.
Validation of a spectroscopic sensor for the continuous, noninvasive measurement of muscle oxygen saturation and pH.
Physiol Meas. 2013 Jul 17;34(8):859-71. [Epub ahead of print]
(PI: B.R. Soller)
NOTE: This article may be obtained online without charge.

Conkin J, Gernhardt ML, Abercromby AF, Feiveson AH.
Probability of hypobaric decompression sickness including extreme exposures.
Aviat Space Environ Med. 2013 Jul;84(7):661-8.

Suer MK, Crane JD, Trappe TA, Jemiolo B, Trappe SW, Harber MP.
Amino acid infusion alters the expression of growth-related genes in multiple skeletal muscles.
Aviat Space Environ Med. 2013 Jul;84(7):669-74.
(PI: S.W. Trappe)

Shirazi-Fard Y, Anthony RA, Kwaczala AT, Judex S, Bloomfield SA, Hogan HA.
Previous exposure to simulated microgravity does not exacerbate bone loss during subsequent exposure in the proximal tibia of adult rats.
Bone. 2013 Jul 17. [Epub ahead of print]
(PI: H.A. Hogan)

Parihar VK, Limoli CL.
Cranial irradiation compromises neuronal architecture in the hippocampus.
Proc Natl Acad Sci U S A. 2013 Jul 15. [Epub ahead of print]
(PIs: C.L. Limoli; G. Nelson/C.L. Limoli/NSCOR)

Almog N, Briggs C, Beheshti A, Ma L, Wilkie KP, Rietman E, Hlatky L.
Transcriptional changes induced by the tumor dormancy-associated microRNA-190.
Transcription. 2013 Jul 1;4(4). [Epub ahead of print]
(PI: L. Hlatky)
NOTE: This article may be obtained online without charge.

Liao AC, Craver BM, Tseng BP, Tran KK, Parihar VK, Acharya MM, Limoli CL.
Mitochondrial-targeted human catalase affords neuroprotection from proton irradiation.
Radiat Res. 2013 Jul;180(1):1-6. Epub 2013 May 14.
(PIs: C.L. Limoli; G. Nelson/C.L. Limoli/NSCOR)
NOTE: This article is featured on the cover of the journal.

Sanzari JK, Wan XS, Wroe AJ, Rightnar S, Cengel KA, Diffenderfer ES, Krigsfeld GS, Gridley DS, Kennedy AR.
Acute hematological effects of solar particle event proton radiation in the porcine model.
Radiat Res. 2013 Jul;180(1):7-16. Epub 2013 May 14.
(PIs: A.R. Kennedy/X.S. Wan/K.A. Cengel/Center of Acute Radiation Research)

Li Z, Hudson FZ, Wang H, Wang Y, Bian Z, Murnane JP, Dynan WS.
Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells.
Radiat Res. 2013 Jul;180(1):17-24. Epub 2013 May 21.
(PIs: Y. Wang/H. Wang/W.S. Dynan/NSCOR)

George KA, Hada M, Chappell L, Cucinotta FA.
Biological effectiveness of accelerated particles for the induction of chromosome damage: Track structure effects.
Radiat Res. 2013 Jul;180(1):25-33. Epub 2013 May 21.
(PI: F.A. Cucinotta)

Yamamoto ML, Maier I, Dang AT, Berry D, Liu J, Ruegger PM, Yang JI, Soto PA, Presley LL, Reliene R, Westbrook AM, Wei B, Loy A, Chang C, Braun J, Borneman J, Schiestl RH.
Intestinal bacteria modify lymphoma incidence and latency by affecting systemic inflammatory state, oxidative stress, and leukocyte genotoxicity.
Cancer Res. 2013 Jul 15;73(14):4222-32.
(PI: R.H. Schiestl)
NOTE: Precis from Table of Contents: “This potentially seminal study reveals the powerful effects that intestinal microbiota can exert on lymphoma penetrance in genetically susceptible mice, with possible implications for preventing this cancer in individuals who are at risk of disease.” This article was listed on the cover of the journal.

Casner SM, Geven RW, Williams KT.
The effectiveness of airline pilot training for abnormal events.
Hum Factors. 2013 Jun;55(3):477-85.
NOTE: This article may be obtained online without charge:

Choi S, Chang MS, Stuecker T, Chung C, Newcombe DA, Venkateswaran K.
Retraction: A fosmid cloning strategy for detecting the widest possible spectrum of microbes from the International Space Station drinking water system.
Genomics Inform. 2013 Jun;11(2):97.
NOTE: This article, which appeared in the 2/1/13 Current Awareness list, has been retracted due to material copied from other publications. Information about the retraction may be obtained online without charge.

Other papers of interest:

Markin AA, Zhuravleva OA, Morukov BV, Kuzichkin DS, Zabolotskaya IV, Vostrikova LV.
Reference values of blood biochemical indices in Russian cosmonauts.
Hum Physiol. 2013 Mar;39(2):178-83.
NOTE: This article reports results of blood samples taken from ISS main and backup crews 45-30 days prior to launch. This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2013 Mar-Apr;39(2):79-84:

Grigoriev AI, Noskov VB.
Functional load tests in the assessment of the state of the kidneys and water-electrolyte metabolism.
Hum Physiol. 2013 Mar;39(2):119-25.
NOTE: This review article contains some space flight results. This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2013 Mar-Apr;39(2):10-8:

Hinkelbein J, Spelten O.
Going beyond anesthesia in space exploration missions: Emergency medicine and emergency medical care.
Aviat Space Environ Med. 2013 Jul;84(7):747.
NOTE: This letter and the response to it may be obtained online without charge:

Russomano T, Baers JH, Velho R, Cardoso RB, Ashcroft A, Rehnberg L, Gehrke RD, Dias MK, Baptista RR.
A comparison between the 2010 and 2005 basic life support guidelines during simulated hypogravity and microgravity.
Extrem Physiol Med. 2013 Apr 1;2:11.
NOTE: This article may be obtained online without charge.

Scott JP, Jungius J, Connolly D, Stevenson AT.
Subjective and objective measures of relaxed +Gz tolerance following repeated +Gz exposure.
Aviat Space Environ Med. 2013 Jul;84(7):684-91.

Carrillo AE, Cheung SS, Flouris AD.
Autonomic nervous system modulation during accidental syncope induced by heat and orthostatic stress.
Aviat Space Environ Med. 2013 Jul;84(7):722-5.

Kim JB, Suh SI, Seo WK, Koh SB, Kim JH.
Right insular atrophy in neurocardiogenic syncope: A volumetric MRI study.
AJNR Am J Neuroradiol. 2013 Jul 4. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Khadilkar SV, Yadav RS, Jagiasi KA.
Are syncopes in sitting and supine positions different? Body positions and syncope: A study of 111 patients.
Neurol India. 2013 May-Jun;61(3):239-43.
NOTE: The html version of this article may be able to be obtained online without charge if accessed via the Table of Contents:

Nilsson LM, Lindenberger DM, Hahn RG.
The effect of positive end-expiratory pressure and tripled tidal volume on pleth variability index during hypovolaemia in conscious subjects: A volunteer study.
Eur J Anaesthesiol. 2013 Jul 9. [Epub ahead of print]

Waldreus N, Hahn RG, Engvall J, Skoog J, Ewerman L, Lindenberger M.
Thirst response to acute hypovolaemia in healthy women and women prone to vasovagal syncope.
Physiol Behav. 2013 Jul 5;120C:34-9. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Whinnery T, Forster EM.
The +Gz-induced loss of consciousness curve.
Extrem Physiol Med. 2013 Jun 6;2:19.
NOTE: This article may be obtained online without charge (click on the pdf link at the PubMed Central abstract: fun drawing).

Randsoe T, Hyldegaard O.
Threshold altitude for bubble decay and stabilization in rat adipose tissue at hypobaric exposures.
Aviat Space Environ Med. 2013 Jul;84(7):675-83.

Debevec T, Pialoux V, Mekjavic IB, Eiken O, Mury P, Millet GP.
Moderate exercise blunts oxidative stress induced by normobaric hypoxic confinement.
Med Sci Sports Exerc. 2013 Jul 10. [Epub ahead of print]

Morukov BV, Rykova MP, Antropova EN, Berendeeva TA, Morukov IB, Ponomarev SA.
Immunological aspects of a space flight to Mars.
Hum Physiol. 2013 Mar;39(2):126-35.
NOTE: 520-day isolation study, part of the Mars-500 project. This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2013 Mar-Apr;39(2):19-30:

McCarville JL, Clarke ST, Shastri P, Liu Y, Kalmokoff M, Brooks SP, Green-Johnson JM.
Spaceflight influences both mucosal and peripheral cytokine production in PTN-Tg and wild type mice.
PLoS One. 2013 Jul 10;8(7):e68961.
NOTE: ISS results. This article may be obtained online without charge.

Pietsch J, Ma X, Wehland M, Aleshcheva G, Schwarzwaelder A, Segerer J, Birlem M, Horn A, Bauer J, Infanger M, Grimm D.
Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 Space mission.
Biomaterials. 2013 Oct;34(31):7694-705. Epub 2013 Jul 15.
NOTE: Shenzhou 8 results.

Ma X, Wehland M, Aleshcheva G, Hauslage J, Wasser K, Hemmersbach R, Infanger M, Bauer J, Grimm D.
Interleukin-6 expression under gravitational stress due to vibration and hypergravity in follicular thyroid cancer cells.
PLoS One. 2013 Jul 2;8(7):e68140.
NOTE: These vibration and hypergravity tests were done to better characterize the complex mechanical effects affecting cells during parabolic flight. This article may be obtained online without charge.

Li H, Liu T, Chen W, Jain MR, Vatner DE, Vatner SF, Kudej RK, Yan L.
Proteomic mechanisms of cardioprotection during mammalian hibernation in woodchucks, Marmota monax.
J Proteome Res. 2013 Jul 12. [Epub ahead of print]

Alway SE, Pereira SL, Edens NK, Hao Y, Bennett BT.
-Hydroxy–methylbutyrate (HMB) enhances the proliferation of satellite cells in fast muscles of aged rats during recovery from disuse atrophy.
Exp Gerontol. 2013 Jul 4. [Epub ahead of print]

Zhang BT, Yeung SS, Cheung KK, Chai ZY, Yeung EW.
The adaptive responses of TRPC1 and TRPC3 during skeletal muscle atrophy and regrowth.
Muscle Nerve. 2013 Jul 15. [Epub ahead of print]

Naritomi H, Moriwaki H.
Prevention of post-stroke disuse muscle atrophy with a free radical scavenger.
Front Neurol Neurosci. 2013;32:139-47. Epub 2013 Jul 8.

Pratesi A, Tarantini F, Di Bari M.
Skeletal muscle: An endocrine organ.
Clin Cases Miner Bone Metab. 2013 Jan-Apr;10(1):11-4.
NOTE: At the end of the abstract, note this phrase: “the diseasome of physical inactivity.” This article may be obtained online without charge.

Nardo L, Sandman DN, Virayavanich W, Zhang L, Souza RB, Steinbach L, Guindani M, Link TM.
Bone marrow changes related to disuse.
Eur Radiol. 2013 Jul 7. [Epub ahead of print]

Matsumoto T, Goto D, Sato S.
Subtraction micro-computed tomography of angiogenesis and osteogenesis during bone repair using synchrotron radiation with a novel contrast agent.
Lab Invest. 2013 Jul 8. [Epub ahead of print]

Knapik DM, Perera P, Nam J, Blazek AD, Rath B, Leblebicioglu B, Das H, Wu LC, Hewett TE, Agarwal Jr SK, Robling AG, Flanigan DC, Lee BS, Agarwal S.
Mechanosignaling in bone health, trauma and inflammation.
Antioxid Redox Signal. 2013 Jul 1. [Epub ahead of print]

Endo I, Matsumoto T.
[Bone Structural Properties and Bone Strength. Bone architecture and strength on unloading].
Clin Calcium. 2013 Jul;23(7):1013-9. Japanese.
NOTE: This article and 13 other articles are part of an issue on the topic of bone structural properties and bone strength. The citations can be viewed by entering the journal title abbreviation clin calcium [ta] in PubMed. Journal site:

Hosseini SM, Wilson W, Ito K, van Donkelaar CC.
How preconditioning affects the measurement of poro-viscoelastic mechanical properties in biological tissues.
Biomech Model Mechanobiol. 2013 Jul 18. [Epub ahead of print]

Keenawinna L, Oest ME, Mann KA, Spadaro J, Damron TA.
Zoledronic acid prevents loss of trabecular bone after focal irradiation in mice.
Radiat Res. 2013 Jul;180(1):89-99. Epub 2013 Jun 17.

Georgakilas AG, O’Neill P, Stewart RD.
Induction and repair of clustered DNA lesions: What do we know so far?
Radiat Res. 2013 Jul;180(1):100-9. Epub 2013 May 17.

Allen AR, Eilertson K, Sharma S, Schneider D, Baure J, Allen B, Rosi S, Raber J, Fike JR.
Effects of radiation combined injury on hippocampal function are modulated in mice deficient in chemokine receptor 2 (CCR2).
Radiat Res. 2013 Jul;180(1):78-88. Epub 2013 Jun 17.

Alloni D, Campa A, Friedland W, Mariotti L, Ottolenghi A.
Integration of Monte Carlo simulations with PFGE experimental data yields constant RBE of 2.3 for DNA double-strand break induction by nitrogen ions between 125 and 225 keV/m LET.
Radiat Res. 2013 Jun;179(6):690-7. Epub 2013 May 6.

Matthiae D, Berger T, Reitz G.
Organ shielding and doses in Low-Earth orbit calculated for spherical and anthropomorphic phantoms.
Adv Space Res. 2013 Aug 1;52(3):528-35.
NOTE: Calculations based partly on estimated ISS shielding and ISS orbit; article includes some comparison of calculations with ISS results.

Vignard J, Mirey G, Salles B.
Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up.
Radiother Oncol. 2013 Jul 9. [Epub ahead of print]

Durante M, Reppingen N, Held KD.
Immunologically augmented cancer treatment using modern radiotherapy.
Trends Mol Med. 2013 Jul 4. [Epub ahead of print]
NOTE: The article is about the convergence of radiation and immune therapy; it has nice graphics illustrating molecular mechanisms underlying these therapies.

Thornton WE, Bonato F.
Space motion sickness and motion sickness: Symptoms and etiology.
Aviat Space Environ Med. 2013 Jul;84(7):716-21.

Diels C, Howarth PA.
Frequency characteristics of visually induced motion sickness.
Hum Factors. 2013 Jun;55(3):595-604.

Stoffregen TA, Chen FC, Varlet M, Alcantara C, Bardy BG.
Getting your sea legs.
PLoS One. 2013 Jun 19;8(6):e66949.
NOTE: This article may be obtained online without charge.

Chim D, Lasker DM, Migliaccio AA.
Visual contribution to the high-frequency human angular vestibulo-ocular reflex.
Exp Brain Res. 2013 Jul 14. [Epub ahead of print]

Kennedy MW, Crowell CR, Striegel AD, Villano M, Schmiedeler JP.
Relative efficacy of various strategies for visual feedback in standing balance activities.
Exp Brain Res. 2013 Jul 9. [Epub ahead of print]

Tribukait A, Eiken O, Lemming D, Levin B.
Use of an adjustable hand plate in studying the perceived horizontal plane during simulated flight.
Aviat Space Environ Med. 2013 Jul;84(7):739-45.

Verde P, Piccardi L, Bianchini F, Trivelloni P, Guariglia C, Tomao E.
Gender effects on mental rotation in pilots vs. nonpilots.
Aviat Space Environ Med. 2013 Jul;84(7):726-9.

Barra J, Perennou D.
[Is the sense of verticality vestibular?]
Neurophysiol Clin. 2013 Jun;43(3):197-204. Epub 2013 Mar 14. French.

Hammam E, Kwok K, Macefield VG.
Modulation of muscle sympathetic nerve activity by low-frequency physiological activation of the vestibular utricle in awake humans.
Exp Brain Res. 2013 Jul 14. [Epub ahead of print]

Shpakov AV, Voronov AV, Fomina EV, Lysova NYu, Chernova MV, Kozlovskaya IB.
Comparative efficacy of different regimens of locomotor training in prolonged space flights as estimated from the data on biomechanical and electromyographic parameters of walking.
Hum Physiol. 2013 Mar;39(2):162-70.
NOTE: ISS results. This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2013 Mar-Apr;39(2):60-9:

Kazennikov OV, Levik YuS, Lipshits MI.
Dependence of the motor response time in discrimination task on the character of visual information available.
Hum Physiol. 2013 Mar;39(2):226-8.
NOTE: This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2013 Mar-Apr;39(2):134-6:

Du X, Li W, Gao X, West MB, Saltzman WM, Cheng CJ, Stewart C, Zheng J, Cheng W, Kopke RD.
Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA.
Hear Res. 2013 Jul 9. [Epub ahead of print]

Daanen HA, van Ling S, Tan TK.
Subjective ratings and performance in the heat and after sleep deprivation.
Aviat Space Environ Med. 2013 Jul;84(7):701-7.

Perry NC, Wiggins MW, Childs M, Fogarty G.
The application of reduced-processing decision support systems to facilitate the acquisition of decision-making skills.
Hum Factors. 2013 Jun;55(3):535-44.

Bachmat E, Khachaturov V, Kuperman R.
Optimal back-to-front airplane boarding.
Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Jun;87(6-1):062805. Epub 2013 Jun 12.
NOTE: No simple answer: in part it depends on how crowded the plane is.

Qiao L, Luo S, Liu Y, Li X, Wang G, Huang Z.
Reproductive and locomotory capacities of Caenorhabditis elegans were not affected by simulated variable gravities and spaceflight during the Shenzhou-8 mission.
Astrobiology. 2013 Jul;13(7):617-25. Epub 2013 Jul 9.
NOTE: Shenzhou-8, centrifuge, and clinostat results.

Kang H, Liu M, Fan Y, Deng X.
A potential gravity-sensing role of vascular smooth muscle cell glycocalyx in altered gravitational stimulation.
Astrobiology. 2013 Jul;13(7):626-36. Epub 2013 Jul 12.

Ricca BL, Venugopalan G, Fletcher DA.
To pull or be pulled: Parsing the multiple modes of mechanotransduction.
Curr Opin Cell Biol. 2013 Jul 2. [Epub ahead of print]

Martinac B, Nomura T, Chi G, Petrov E, Rohde PR, Battle AR, Foo A, Constantine M, Rothnagel R, Carne S, Deplazes E, Cornell B, Cranfield CG, Hankamer B, Landsberg MJ.
Bacterial mechanosensitive channels: Models for studying mechanosensory transduction.
Antioxid Redox Signal. 2013 Jul 8. [Epub ahead of print]

Beaulieu J, Giguere I, Deslauriers M, Boyle B, MacKay J.
Differential gene expression patterns in white spruce newly formed tissue on board the International Space Station.
Adv Space Res. 2013 Aug 15;52(4):760-72.
NOTE: ISS results.

Toyota M, Furuichi T, Sokabe M, Tatsumi H.
Analyses of a gravistimulation-specific Ca2+ signature in Arabidopsis using parabolic flights.
Plant Physiol. 2013 Jul 8. [Epub ahead of print]
NOTE: Parabolic flight results. This article may be obtained online without charge.

Zhang CB, Wu ZD, Xu DP, Liu HY, Rong TZ, Cao MJ.
[Combining ability analysis for SP4 lines of maize from space flight]
Yi Chuan. 2013 Jul;35(7):903-12. Chinese.
NOTE: Chinese satellite Shijian 8 results. Translated title of journal is Hereditas.

Ushakov IB, Orlov OI, Baevskii RM, Bersenev EYu, Chernikova AG.
Conception of health: Space-Earth.
Hum Physiol. 2013 Mar;39(2):115-8.
NOTE: This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2013 Mar-Apr;39(2):5-9:

Entradas M, Miller S, Peters HP.
Preaching to the converted? An analysis of the UK public for space exploration.
Public Underst Sci. 2013 Apr;22(3):269-86. Epub 2011 Jul 26.

SpaceRef staff editor.