NASA Spaceline Current Awareness 23 September 2011 (Recent Space Life Science Research Results)

Beginning October 1, 2011, there will be significant changes to the SPACELINE Current Awareness lists, web pages, and the planned database.

Due to a challenging budget environment for SPACELINE, the SPACELINE website and the planned production of a comprehensive database of the list content will cease. Those wishing to look at previous lists on the website should do so before October 3.

List content for the most relevant material will continue. The NASA-supported part of the Current Awareness lists will continue unchanged. The “Other” part of the list will continue to cover all life sciences space flight research and relevant ground research, including microgravity analogs (bed rest, hindlimb suspension, other disuse models), gravitational physiology and biology, and the most relevant research in fields like radiation, neuroscience, cardiovascular, etc. Less directly related material, such as basic bone and muscle physiology, exercise, aging, mechanobiology, etc. will be covered to a much reduced extent.

The Current Awareness lists will continue to be produced every other week for the time being in order to complete some related tasks. The lists will eventually resume on a weekly basis.

Papers deriving from NASA support:

1
Crucian B, Stowe R, Quiriarte H, Pierson D, Sams C.
Monocyte phenotype and cytokine production profiles are dysregulated by short-duration spaceflight.
Aviat Space Environ Med. 2011 Sep;82(9):857-62.
http://www.ncbi.nlm.nih.gov/pubmed/21888268
(PI: R. Stowe)
NOTE: STS (STS-124, STS-125, STS-126) results.

2
Minard CG, de Carvalho MF, Iyengar MS.
Optimizing medical resources for spaceflight using the integrated medical model.
Aviat Space Environ Med. 2011 Sep;82(9):890-4.
http://www.ncbi.nlm.nih.gov/pubmed/21888273

3
Zhang Q, Yan X, Strangman GE.
Development of motion resistant instrumentation for ambulatory near-infrared spectroscopy.
J Biomed Opt. 2011 Aug;16(8):087008.
http://www.ncbi.nlm.nih.gov/pubmed/21895335
(PI: G.E. Strangman)
NOTE: Parabolic flight results.

4
Rassweiler JJ, Knoll T, Koehrmann KU, McAteer JA, Lingeman JE, Cleveland RO, Bailey MR, Chaussy C.
Shock wave technology and application: An update.
Eur Urol. 2011 May;59(5):784-96. Epub 2011 Feb 23.
http://www.ncbi.nlm.nih.gov/pubmed/21354696
(PI: L. Crum)

5
Kennedy AR, Wan XS.
Countermeasures for space radiation induced adverse biologic effects.
Adv Space Res. 2011 Nov 1;48(9):1460-79.
http://dx.doi.org/10.1016/j.asr.2011.07.007
(PI: A.R. Kennedy)

6
Shay JW, Cucinotta FA, Sulzman FM, Coleman CN, Minna JD.
From Mice and Men to Earth and Space: Joint NASA-NCI Workshop on Lung Cancer Risk Resulting from Space and Terrestrial Radiation.
Cancer Res. 2011 Sep 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21900398
NOTE: Abstract: “On June 27-28, 2011 scientists from the National Cancer Institute (NCI), NASA, and academia met in Bethesda to discuss major lung cancer issues confronting each organization. For NASA – available data suggest lung cancer is the largest potential cancer risk from space travel for both men and women and quantitative risk assessment information for mission planning is needed. In space the radiation risk is from high energy and charge (HZE) nuclei (such as Fe) and high energy protons from solar flares and not from gamma radiation. By contrast the NCI is endeavoring to estimate the increased lung cancer risk from the potential wide-spread implementation of computed tomography (CT) screening in individuals at high risk for developing lung cancer based on the National Lung Cancer Screening Trial (NLST). For the latter, exposure will be x-rays from CT scans from the screening (which uses “low dose” CT scans) and also from follow-up scans used to evaluate abnormalities found during initial screening. Topics discussed included the risk of lung cancer arising after HZE particle, proton, and low dose Earth radiation exposure. The workshop examined preclinical models, epidemiology, molecular markers, “omics” technology, radiobiology issues, and lung stem cells (LSC) that relate to the development of lung cancer.”

7
Inan OT, Marcu O, Sanchez ME, Bhattacharya S, Kovacs GT.
A portable system for monitoring the behavioral activity of Drosophila.
J Neurosci Methods. 2011 Sep 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21907735
(PI: S. Bhattacharya)
NOTE: Hypergravity experiments were part of the testing of this system.

8
Denison FC, Paul AL, Zupanska AK, Ferl RJ.
14-3-3 proteins in plant physiology.
Semin Cell Dev Biol. 2011 Aug 31. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21907297
(PI: A.L. Paul)

9
Chen Y, Brandizzi F.
AtIRE1A/AtIRE1B and AGB1 independently control two essential unfolded protein response pathways in Arabidopsis.
Plant J. 2011 Sep 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21914012
(PI: F. Brandizzi)

Other papers of interest:

1
Coupe M, Yuan M, Demiot C, Bai Y, Jiang S, Li Y, Arbeille P, Gauquelin-Koch G, Levrard T, Custaud MA, Li Y.
Low-magnitude whole body vibration with resistive exercise as a countermeasure against cardiovascular deconditioning after 60 days of head-down bed rest.
Am J Physiol Regul Integr Comp Physiol. 2011 Sep 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21900640
NOTE: This bed rest study was performed in China.

2
Abe C, Kawada T, Sugimachi M, Morita H.
Interaction between vestibulo-cardiovascular reflex and arterial baroreflex during postural change in rats.
J Appl Physiol. 2011 Sep 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21921247

3
Akimoto T, Sugawara J, Ichikawa D, Terada N, Fadel PJ, Ogoh S.
Enhanced open-loop but not closed-loop cardiac baroreflex sensitivity during orthostatic stress in humans.
Am J Physiol Regul Integr Comp Physiol. 2011 Sep 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21900646

4
Zahner MR, Kulikowicz E, Schramm LP.
Recovery of baroreflex control of renal sympathetic nerve activity after spinal lesions in the rat.
Am J Physiol Regul Integr Comp Physiol. 2011 Sep 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21900643

5
Lanier JB, Mote MB, Clay EC.
Evaluation and management of orthostatic hypotension.
Am Fam Physician. 2011 Sep 1;84(5):527-36.
http://www.ncbi.nlm.nih.gov/pubmed/21888303

6
Reyes Del Paso GA, Mata JL, Martin-Vazquez M.
Relationships between baroreceptor cardiac reflex sensitivity and cognitive performance: Modulations by gender and blood pressure.
Psychophysiology. 2011 Sep 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21895685

7
Poda R, Guaraldi P, Solieri L, Calandra-Buonaura G, Marano G, Gallassi R, Cortelli P.
Standing worsens cognitive functions in patients with neurogenic orthostatic hypotension.
Neurol Sci. 2011 Sep 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21894556

8
Porta A, Bari V, Badilini F, Tobaldini E, Gnecchi-Ruscone T, Montano N.
Frequency domain assessment of the coupling strength between ventricular repolarization duration and heart period during graded head-up tilt.
J Electrocardiol. 2011 Sep 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21908003
NOTE: This article may be obtained online without charge.

9
Sugita Y.
Has the disease identity of restless legs syndrome developed or been distorted? Astronauts in zero gravity may know the answer.
Intern Med J. 2011 Sep;41(9):706-7.
http://www.ncbi.nlm.nih.gov/pubmed/21899687
NOTE: Last paragraph of this Letter to the Editor: “Although the RLS hypothesis [a peripheral blood circulation problem] is difficult to confirm, the effect of zero gravity might provide a clue. So far, more than 500 astronauts have already travelled into space. The prevalence of RLS, affecting 5-10% of the general population, is so high that an appreciable proportion of astronauts with RLS might have already been in space. Therefore, it might be worth asking astronauts about the sensations they experience in their legs while lying down in zero gravity. Because changes in body position would not influence blood flow dynamics in zero gravity, it might be expected that any unpleasant sensations might disappear during the time spent in space, and then become exacerbated after returning to earth.”

10
Prabhakaran P, Tripathi KK.
Autonomic modulations during 5 hours at 4574 m (15,000 ft) breathing 40% oxygen.
Aviat Space Environ Med. 2011 Sep;82(9):863-70.
http://www.ncbi.nlm.nih.gov/pubmed/21888269

11
Tanaka K, Ikeda M, Mochizuki Y, Katafuchi T.
Mobility of an elastic glove for extravehicular activity without prebreathing.
Aviat Space Environ Med. 2011 Sep;82(9):909-12.
http://www.ncbi.nlm.nih.gov/pubmed/21888277

12
Seger RL, Cross RA, Rosen CJ, Causey RC, Gundberg CM, Carpenter TO, Chen TC, Halteman WA, Holick MF, Jakubas WJ, Keisler DH, Seger RM, Servello FA.
Investigating the mechanism for maintaining eucalcemia despite immobility and anuria in the hibernating American black bear (Ursus americanus).
Bone. 2011 Aug 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21893223
NOTE: Last sentence of abstract: “We hypothesize that ursine hibernation may represent a natural model in which suppression of the sympathetic nervous system prevents unloading-induced bone loss by influencing leptin’s skeletal effects and preventing transmission of loading information.”

13
Salanova M, Bortoloso E, Schiffl G, Gutsmann M, Belav DL, Felsenberg D, Furlan S, Volpe P, Blottner D.
Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise.
FASEB J. 2011 Sep 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21885651
NOTE: Second Berlin Bed Rest Study.

14
Salvadego D, Lazzer S, Marzorati M, Porcelli S, Rejc E, imuni B, Piot R, di Prampero PE, Grassi B.
Functional impairment of skeletal muscle oxidative metabolism during knee-extension exercise after bed rest.
J Appl Physiol. 2011 Sep 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21921243
NOTE: 2008 Italy/Slovenia bed rest study.

15
Okamoto T, Torii S, Machida S.
Differential gene expression of muscle-specific ubiquitin ligase MAFbx/Atrogin-1 and MuRF1 in response to immobilization-induced atrophy of slow-twitch and fast-twitch muscles.
J Physiol Sci. 2011 Sep 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21901639

16
Belav DL, Beller G, Ritter Z, Felsenberg D.
Bone structure and density via HR-pQCT in 60d bed-rest, 2-years recovery with and without countermeasures.
J Musculoskelet Neuronal Interact. 2011 Sep;11(3):215-26.
http://www.ncbi.nlm.nih.gov/pubmed/21885896
NOTE: Second Berlin Bed Rest Study. This article may be obtained online without charge.

17
Baecker N, Frings-Meuthen P, Heer M, Mester J, Liphardt AM.
Effects of vibration training on bone metabolism: Results from a short-term bed rest study.
Eur J Appl Physiol. 2011 Sep 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21894450
NOTE: Bed rest study.

18
Zhang Y, Paul EM, Sathyendra V, Davison A, Sharkey N, Bronson S, Srinivasan S, Gross TS, Donahue HJ.
Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone.
PLoS One. 2011;6(8):e23516. Epub 2011 Aug 29.
http://www.ncbi.nlm.nih.gov/pubmed/21897843
NOTE: This article may be obtained online without charge.

19
Xiong J, Onal M, Jilka RL, Weinstein RS, Manolagas SC, O’Brien CA.
Matrix-embedded cells control osteoclast formation.
Nat Med. 2011 Sep 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21909103

20
Yamaguchi M, Arbiser JL, Neale Weitzmann M.
Honokiol stimulates osteoblastogenesis by suppressing NF-B activation.
Int J Mol Med. 2011 Dec;28(6):1049-53. Epub 2011 Aug 31.
http://www.ncbi.nlm.nih.gov/pubmed/21887456

21
Al Nazer R, Lanovaz J, Kawalilak C, Johnston JD, Kontulainen S.
Direct in vivo strain measurements in human bone-A systematic literature review.
J Biomech. 2011 Sep 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21889149

22
Rantalainen T, Nikander R, Heinonen A, Daly RM, Sievaenen H.
An open source approach for regional cortical bone mineral density analysis.
J Musculoskelet Neuronal Interact. 2011 Sep;11(3):243-8.
http://www.ncbi.nlm.nih.gov/pubmed/21885899
NOTE: This article may be obtained online without charge.

23
Baliram R, Latif R, Berkowitz J, Frid S, Colaianni G, Sun L, Zaidi M, Davies TF.
Thyroid-stimulating hormone induces a Wnt-dependent, feed-forward loop for osteoblastogenesis in embryonic stem cell cultures.
Proc Natl Acad Sci U S A. 2011 Sep 12. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21911383

24
Zhang J, Lazarenko OP, Blackburn ML, Shankar K, Badger TM, Ronis MJ, Chen JR.
Feeding blueberry diets in early life prevent senescence of osteoblasts and bone loss in ovariectomized adult female rats.
PLoS One. 2011;6(9):e24486. Epub 2011 Sep 2.
http://www.ncbi.nlm.nih.gov/pubmed/21912699
NOTE: This article may be obtained online without charge.

25
Larosa M, Agostini F, Casolino M, De Santis C, Di Fino L, La Tessa C, Narici L, Picozza P, Rinaldi A, Zaconte V.
Ion rates in the International Space Station during the December 2006 Solar Particle Event.
J Phys G Nucl Part Phys 2011 Sep;38(9):095102.
http://dx.doi.org/10.1088/0954-3899/38/9/095102
NOTE: ISS results.

26
Lewis BJ, Smith MB, Ing H, Andrews HR, Machrafi R, Tomi L, Matthews TJ, Veloce L, Shurshakov V, Tchernykh I, Khoshooniy N.
Review of bubble detector response characteristics and results from space.
Radiat Prot Dosimetry. 2011 Sep 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21890528
NOTE: Bion, STS, Mir, ISS results.

27
Boehlen TT, Dosanjh M, Ferrari A, Gudowska I.
Simulations of microdosimetric quantities with the Monte Carlo code FLUKA for carbon ions at therapeutic energies.
Int J Radiat Biol. 2011 Sep 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21913815

28
Fike JR.
Physiopathology of radiation-induced neurotoxicity.
Rev Neurol (Paris). 2011 Oct;167(10):746-50. Epub 2011 Sep 1.
http://www.ncbi.nlm.nih.gov/pubmed/21889778

29
Mo FF, Qin HH, Wang XL, Shen ZL, Xu Z, Wang KH, Cai YL, Li M.
Acute hyperglycemia is related to gastrointestinal symptoms in motion sickness: An experimental study.
Physiol Behav. 2011 Sep 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21907224

30
Keshavarz B, Hecht H.
Validating an efficient method to quantify motion sickness.
Hum Factors. 2011 Aug;53(4):415-26.
http://www.ncbi.nlm.nih.gov/pubmed/21901938

31
Nobel G, Tribukait A, Mekjavic IB, Eiken O.
Effects of motion sickness on thermoregulatory responses in a thermoneutral air environment.
Eur J Appl Physiol. 2011 Sep 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21892631

32
Butler JS, Campos JL, Buelthoff HH, Smith ST.
The role of stereo vision in visual-vestibular integration.
Seeing Perceiving. 2011 24(5):453-70. Epub 2011 Sep 1.
http://www.ncbi.nlm.nih.gov/pubmed/21888763

33
Apker GA, Karimi CP, Buneo CA.
Contributions of vision and proprioception to arm movement planning in the vertical plane.
Neurosci Lett. 2011 Aug 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21889576

34
Bremner JG, Hatton F, Foster KA, Mason U.
The contribution of visual and vestibular information to spatial orientation by 6- to 14-month-old infants and adults.
Dev Sci. 2011 Sep;14(5):1033-45. Epub 2011 Jun 4.
http://www.ncbi.nlm.nih.gov/pubmed/21884319

35
Houpt TA, Cassell J, Carella L, Neth B, Smith JC.
Head tilt in rats during exposure to a high magnetic field.
Physiol Behav. 2011 Aug 31. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21903121

36
Pataky TC, Mu T, Bosch K, Rosenbaum D, Goulermas JY.
Gait recognition: Highly unique dynamic plantar pressure patterns among 104 individuals.
J R Soc Interface. 2011 Sep 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21900318
NOTE: Last sentence of abstract: “As dynamic pressure data are immediately usable, with little or no pre-processing required, and as they may be collected discreetly during uninterrupted gait using in-floor systems, foot pressure-based identification appears to have wide potential for both the security and health industries.”

37
Klingenberger JK.
You’re the flight surgeon. Labyrinthine dysfunction.
Aviat Space Environ Med. 2011 Sep;82(9):926-7.
http://www.ncbi.nlm.nih.gov/pubmed/21888282
NOTE: This article may be obtained online without charge: http://www.ingentaconnect.com/content/asma/asem/2011/00000082/00000009/a…

38
Hoey DA, Downs ME, Jacobs CR.
The mechanics of the primary cilium: An intricate structure with complex function.
J Biomech. 2011 Sep 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21899847

39
Sen B, Guilluy C, Xie Z, Case N, Styner M, Thomas J, Oguz I, Rubin C, Burridge K, Rubin J.
Mechanically induced focal adhesion assembly amplifies anti-adipogenic pathways in mesenchymal stem cells.
Stem Cells. 2011 Sep 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21898699

40
Leckband DE, le Duc Q, Wang N, de Rooij J.
Mechanotransduction at cadherin-mediated adhesions.
Curr Opin Cell Biol. 2011 Sep 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21890337

41
Mei Y, Jia WJ, Chu YJ, Xue HW.
Arabidopsis phosphatidylinositol monophosphate 5-kinase 2 is involved in root gravitropism through regulation of polar auxin transport by affecting the cycling of PIN proteins.
Cell Res. 2011 Sep 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21894193

42
Grigoriev AI, Potapov AN.
[From the flight of Yu.A. Gagarin to the contemporary piloted space flights and exploration missions]
Aviakosm Ekolog Med. 2011 Mar-Apr;45(2):3-15. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/21848209

43
Noskov VB.
[Orthostatic tolerance following space flight and modeling experiments: New approaches to evaluation and prophylaxis]
Aviakosm Ekolog Med. 2011 Mar-Apr;45(2):16-25. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/21848210

44
Atyakshin DA, Bykov EG, Ilyin EA, Pashkov AN.
[Tissue-specific reaction of the mucous coat of Mongolian gerbil small gut under the influence of spaceflight factors on board biosat “Foton M3”]
Aviakosm Ekolog Med. 2011 Mar-Apr;45(2):25-30. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/21848211
NOTE: Foton M3 results.

45
Dadasheva OA, Gurieva TS, Mednikova EI, Dadasheva MT, Sychev VN.
[Histogenesis of the liver of Japanese quail embryos developed in the conditions of microgravity]
Aviakosm Ekolog Med. 2011 Mar-Apr;45(2):30-4. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/21848212
NOTE: Mir? results.

46
Naidina VP, Pepelyaev YuV, Oganov VS, Morukov BV, Novikov VE.
[Interrelation of dynamics of blood lipids and bone mineral density in humans during 370-day bed rest]
Aviakosm Ekolog Med. 2011 Mar-Apr;45(2):34-8. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/21848213
NOTE: Bed rest study.

47
Nichiporuk IA, Vasilieva GYu, Noskov VB, Morukov BV.
[Dynamics of the body composition, neurohumoral and psychophysiological status of humans in the conditions of 105-day isolation and confinement]
Aviakosm Ekolog Med. 2011 Mar-Apr;45(2):39-44. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/21848214

48
Nikolaev VP.
[Theoretical analysis of causes for prolonged delay of decompression sickness onset in divers]
Aviakosm Ekolog Med. 2011 Mar-Apr;45(2):45-50. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/21848215