Status Report

NASA Spaceline Current Awareness 22 March 2013 (Recent Space Life Science Research Results)

By SpaceRef Editor
March 22, 2013
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NASA Spaceline Current Awareness 22 March 2013 (Recent Space Life Science Research Results)

Next list: April 5, 2013 Papers deriving from NASA support:

Sayson JV, Lotz J, Parazynski S, Hargens AR.
Back pain in space and post-flight spine injury: Mechanisms and countermeasure development.
Acta Astronaut. 2013 May-Jun;86:24-38.
(PI: A.R. Hargens)
NOTE: This article, a comprehensive review of this subject, includes descriptions of the biophysics and physiology of the spine, possible mechanisms causing the problems, and potential countermeasures.

Swift JM, Hogan HA, Bloomfield SA.
-1 Adrenergic agonist mitigates unloading-induced bone loss by maintaining formation.
Med Sci Sports Exerc. 2013 Mar 6. [Epub ahead of print]
(PIs: S.A. Bloomfield; J.M. Swift, NSBRI Graduate Fellowship)

Zia Uddin SM, Hadjiargyrou M, Cheng J, Zhang S, Hu M, Qin YX.
Reversal of the detrimental effects of simulated microgravity on human osteoblasts by modified low intensity pulsed ultrasound.
Ultrasound Med Biol. 2013 Feb 27. [Epub ahead of print]
(PI: Y.X. Qin)

Raber J, Allen AR, Rosi S, Sharma S, Dayger C, Davis MJ, Fike JR.
Effects of whole body (56)Fe radiation on contextual freezing and Arc-positive cells in the dentate gyrus.
Behav Brain Res. 2013 Feb 28. [Epub ahead of print]
(PIs: J.R. Fike; G. Nelson/J. Raber/J.R. Fike/NSCOR)

Aravindan S, Natarajan M, Herman TS, Awasthi V, Aravindan N.
Molecular basis of ‘hypoxic’ breast cancer cell radio-sensitization: Phytochemicals converge on radiation induced Rel signaling.
Radiat Oncol. 2013 Mar 4;8:46.
(PI: M. Natarajan)
NOTE: This article may be obtained online without charge.

Mishra NN, Cameron E, Nelson R, Whitaker S, Maki W, Maki G.
Radiation tolerant nano-FED biosensing for space application.
J Exp Nanoscience 2013 Feb 1;8(2):240-7.

Scheer FA, Morris CJ, Shea SA.
The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors.
Obesity (Silver Spring). 2013 Mar 1. [Epub ahead of print]
(PI: C.J. Morris, NSBRI Postdoctoral Fellowship Program)

Hursh SR, Roma PG.
Behavioral economics and empirical public policy.
J Exp Analysis Behav. 2013 Jan;99(1):98-124.
(PIs: J.V. Brady, P.G. Roma)
NOTE: This article may be obtained online without charge.

Abboud T, Bamsey M, Paul AL, Graham T, Braham S, Noumeir R, Berinstain A, Ferl R.
Deployment of a fully-automated green fluorescent protein imaging system in a High Arctic autonomous greenhouse.
Sensors (Basel). 2013 Mar 13;13(3):3530-48.
(PIs: R. Ferl, A-L. Paul)
NOTE: This article may be obtained online without charge:

Other papers of interest:

Kriuchkov BI, Kuritsyn AA, Usov VM, Popova EV, Polyakov AV.
[Research activities of cosmonauts in long-duration orbital missions]
Aviakosm Ekolog Med. 2012 Jul-Aug;46(4):22-6. Russian.

Patushkova LKh, Pakharukova NA, Novoselova NM, Dobrokhotov IV, Valeeva OA, Custaud MA, Larina IM.
[Direct proteomic profiling of human urine and blood serum in an experiment with 5-day dry immersion]
Aviakosm Ekolog Med. 2012 Jul-Aug;46(4):31-7. Russian.

Krasnov IB, Frolov VN.
[Electron-microscopy analysis of the myocardium of rats developed in hypergravity]
Aviakosm Ekolog Med. 2012 Jul-Aug;46(4):38-40. Russian.

Baranov MV, Perfilov DV, Kovalev AS, Repenkova LG, Chernogorov RV.
[Changes in rats’ pain sensitivity reaction after 21-day suspension]
Aviakosm Ekolog Med. 2012 Jul-Aug;46(4):53-5. Russian.

Shibao C, Lipsitz LA, Biaggioni I.
ASH Position Paper: Evaluation and Treatment of Orthostatic Hypotension.
J Clin Hypertens (Greenwich). 2013 Mar;15(3):147-53. Epub 2013 Jan 14.
NOTE: This article may be obtained online without charge.

Blanc JJ.
Clinical laboratory testing: What is the role of tilt-table testing, active standing test, carotid massage, electrophysiological testing and ATP test in the syncope evaluation?
Prog Cardiovasc Dis. 2013 Jan-Feb;55(4):418-24.
NOTE: This article appears in an issue dedicated to the topic of syncope. The entire issue may be obtained online without charge:

Shortreed SM, Peeters A, Forbes AB.
Estimating the effect of long-term physical activity on cardiovascular disease and mortality: Evidence from the Framingham Heart Study.
Heart. 2013 Mar 8. [Epub ahead of print]

Thom SR, Milovanova TN, Bogush M, Yang M, Bhopale VM, Pollock NW, Ljubkovic M, Denoble PJ, Madden D, Lozo M, Dujic Z.
Bubbles, microparticles and neutrophil activation: Changes with exercise level and breathing gas during open-water SCUBA diving.
J Appl Physiol. 2013 Mar 14. [Epub ahead of print]

Ni XX, Ni M, Fan DF, Sun Q, Kang ZM, Cai ZY, Liu Y, Liu K, Li RP, Xu WG.
Heat-shock protein 70 is involved in hyperbaric oxygen preconditioning on decompression sickness in rats.
Exp Biol Med (Maywood). 2013 Jan 1;238(1):12-22.

Kurhaluk N, Tkachenko H, Nosar V.
The effects of intermittent hypoxia training on mitochondrial oxygen consumption in rats exposed to skeletal unloading.
Ann Clin Lab Sci. 2013 Winter;43(1):54-63.
NOTE: Hindlimb suspension was the technique used. [Additional note from RD: I usually add a note about the technique used for unloading or simulating microgravity if the technique is not specified in the abstract; if it is mentioned in the abstract, I do not give it. There are a number of instances of this in this list. I’m happy to receive comments regarding the extra information in the NOTES, too much, too little, etc.]

Muir J, Kiel DP, Rubin CT.
Safety and severity of accelerations delivered from whole body vibration exercise devices to standing adults.
J Sci Med Sport. 2013 Mar 1. [Epub ahead of print]

Wang Y, Pessin JE.
Mechanisms for fiber-type specificity of skeletal muscle atrophy.
Curr Opin Clin Nutr Metab Care. 2013 Mar 13. [Epub ahead of print]

Iqbal S, Ostojic O, Singh K, Joseph AM, Hood DA.
Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuse.
Muscle Nerve. 2013 Mar 14. [Epub ahead of print]
NOTE: Chronic use (chronic contractile activity) was produced by electrical stimulation.

Talbert EE, Smuder AJ, Min K, Kwon OS, Powers SK.
Calpain and capase-3 play required roles in immobilization-induced limb muscle atrophy.
J Appl Physiol. 2013 Mar 7. [Epub ahead of print]

Tyapkina OV, Malomouzh AI, Nurullin LF, Nikolsky EE.
Quantal and non-quantal acetylcholine release at neuromuscular junctions of muscles of different types in a model of hypogravity.
Dokl Biol Sci. 2013 Jan;448(1):4-6. Epub 2013 Mar 12.
NOTE: Hindlimb suspension was used. This paper is a translation in English of the Russian original published in Doklady Akademii Nauk 2013;448(1):105-8. The first two pages of this 3-page article are available online without charge.

Standley RA, Liu SZ, Jemiolo B, Trappe SW, Trappe TA.
Prostaglandin E(2) induces transcription of skeletal muscle mass regulators interleukin-6 and muscle RING finger-1 in humans.
Prostaglandins Leukot Essent Fatty Acids. 2013 Mar 13. [Epub ahead of print]

Penailillo L, Blazevich A, Numazawa H, Nosaka K.
Metabolic and muscle damage profiles of concentric versus repeated eccentric cycling.
Med Sci Sports Exerc. 2013 Mar 7. [Epub ahead of print]

Friesenbichler B, Nigg BM, Dunn JF.
Local metabolic rate during whole-body vibration.
J Appl Physiol. 2013 Mar 14. [Epub ahead of print]

Scheiner S, Pivonka P, Hellmich C.
Coupling systems biology with multiscale mechanics, for computer simulations of bone remodeling.
Comput Methods Appl Mech Engin. 2013 Feb;254:181-96.
NOTE: This article has a section about applying this modeling approach in microgravity-induced disuse.

Kabitskaya OE, Skripkin AM, Oganov VS, Khatiushin AI, Lobkaeva EP, Grigoriev VV.
[Compositon of distribution of mineral elements in rats’ bone samples after 14-day suspension and ensuing exposure in a low-frequency pulsed magnetic field]
Aviakosm Ekolog Med. 2012 Jul-Aug;46(4):56-7. Russian.

Wu AC, Morrison NA, Kelly WL, Forwood MR.
MCP-1 expression is specifically regulated during activation of skeletal repair and remodeling.
Calcif Tissue Int. 2013 Mar 5. [Epub ahead of print]

Yano S, Kitamura K, Satoh Y, Nakano M, Hattori A, Sekiguchi T, Ikegame M, Nakashima H, Omori K, Hayakawa K, Chiba A, Sasayama Y, Ejiri S, Mikuni-Takagaki Y, Mishima H, Funahashi H, Sakamoto T, Suzuki N.
Static and dynamic hypergravity responses of osteoblasts and osteoclasts in medaka scales.
Zoolog Sci. 2013 Mar;30(3):217-23.

Guo F, Dai Z, Wu F, Liu Z, Tan Y, Wan Y, Shang P, Li Y.
Gravity affects the responsiveness of Runx2 to 1, 25-dihydroxyvitamin D3 (VD3).
Acta Astronaut. 2013 Mar-Apr;84:189-96.

Yang X, Sun LW, Wu XT, Wang XN, Fan YB.
Effect of simulated microgravity on osteocytes responding to fluid shear stress.
Acta Astronaut. 2013 Mar-Apr;84:237-43.
NOTE: Microgravity was simulated by placing cells in flasks on a cell roller.

Bivi N, Pacheco-Costa R, Brun LR, Murphy TR, Farlow NR, Robling AG, Bellido T, Plotkin LI.
Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice.
J Orthop Res. 2013 Mar 11. [Epub ahead of print]

Rolfe R, Roddy K, Murphy P.
Mechanical regulation of skeletal development.
Curr Osteoporos Rep. 2013 Mar 7. [Epub ahead of print]

Shafirkin AV, Petrov VM.
[Structural and functional shifts in the central nervous system due to ionizing radiation; Human efficiency]
Aviakosm Ekolog Med. 2012 Jul-Aug;46(4):3-16. Russian.

Vorozhtsova SV, Ivanov AA.
[Effects of damage and post-radiation reparation of cornea epithelium cells chromosomal apparatus in mice following irradiation by protons with the energy of 25 MeV]
Aviakosm Ekolog Med. 2012 Jul-Aug;46(4):27-31. Russian.

Ozdemir RA, Pourmoghaddam A, Paloski WH.
Sensorimotor posture control in the blind: Superior ankle proprioceptive acuity does not compensate for vision loss.
Gait Posture. 2013 Mar 8. [Epub ahead of print]

Taube JS, Valerio S, Yoder RM.
Is navigation in virtual reality with fMRI really navigation?
J Cogn Neurosci. 2013 Mar 14. [Epub ahead of print]

Luan H, Gdowski MJ, Newlands SD, Gdowski GT.
Convergence of vestibular and neck proprioceptive sensory signals in the cerebellar interpositus.
J Neurosci. 2013 Jan 16;33(3):1198-210.

Chen S, Zhou R, Xiu L, Chen S, Chen X, Tan C.
Effects of 45-day -6* head-down bed rest on the time-based prospective memory.
Acta Astronaut. 2013 Mar-Apr;84:81-7.
NOTE: Bed rest study.

Giddens CL, Barron KW, Byrd-Craven J, Clark KF, Winter AS.
Vocal indices of stress: A review.
J Voice. 2013 Feb 23. [Epub ahead of print]

Galichiy VA, Stepanova SI.
[Notion of A.L. Chizhevsky of rhythm and present-day foundations of space biorhythmology]
Aviakosm Ekolog Med. 2012 Jul-Aug;46(4):58-65. Russian.

Arunasri K, Adil M, Venu Charan K, Suvro C, Himabindu Reddy S, Shivaji S.
Effect of simulated microgravity on E. coli K12 MG1655 growth and gene expression.
PLoS One. 2013;8(3):e57860. Epub 2013 Mar 5.
NOTE: 3D clinostat was used. This article may be obtained online without charge.

Matsuo E, Kamikouchi A.
Neuronal encoding of sound, gravity, and wind in the fruit fly.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2013 Apr;199(4):253-62. Epub 2013 Mar 13.

Fuentes DE, Butler PJ.
Coordinated mechanosensitivity of membrane rafts and focal adhesions.
Cell Mol Bioeng. 2012 Jun;5(2):143-54.
NOTE: This article may be obtained online without charge via PubMed Central.

Anishkin A, Kung C.
Stiffened lipid platforms at molecular force foci.
Proc Natl Acad Sci U S A. 2013 Mar 8. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Xu D, Guo S, Liu M.
Identification of miRNAs involved in long-term simulated microgravity response in Solanum lycopersicum.
Plant Physiol Biochem. 2013 Feb 21;66C:10-9. [Epub ahead of print]
NOTE: A random positioning machine was used.

Jacques E, Buytaert J, Wells DM, Lewandowski M, Bennett MJ, Dirckx J, Verbelen JP, Vissenberg K.
Microfilament Analyzer, an image analysis tool for quantifying fibrillar orientation, reveals changes in microtubule organization during gravitropism.
Plant J. 2013 Mar 14. [Epub ahead of print]

Yan DW, Wang J, Yuan TT, Hong LW, Gao X, Lu YT.
Perturbation of auxin homeostasis by overexpression of wild-type IAA15 results in impaired stem cell differentiation and gravitropism in roots.
PLoS One. 2013;8(3):e58103. Epub 2013 Mar 5.
NOTE: This article may be obtained online without charge.

Krivobok AS, Berkovich YuA, Krivobok NM.
[Methods of bio-engineering destruction of root residues in application to a space vitamin greenhouse with ionite artificial soil]
Aviakosm Ekolog Med. 2012 Jul-Aug;46(4):48-52. Russian.

Hu D, Zhang H, Zhou R, Li M, Sun Y.
Controller development of photo bioreactor for closed-loop regulation of O2 production based on ANN model reference control and computer simulation.
Acta Astronaut. 2013 Feb-Mar;83:232-8.

Raftery M, Hoffman J.
International Space Station as a base camp for exploration beyond low Earth orbit.
Acta Astronaut. 2013 Apr-May;85: 25-32.

Siefert JL.
Man and his spaceships: Vehicles for extraterrestrial colonization?
Mob Genet Elements. 2012 Nov-Dec;2(6):272-8.
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site:

SpaceRef staff editor.