Status Report

NASA Spaceline Current Awareness 22 February 2013 (Recent Space Life Science Research Results)

By SpaceRef Editor
February 22, 2013
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NASA Spaceline Current Awareness 22 February 2013 (Recent Space Life Science Research Results)

Next list: March 8, 2013
Papers deriving from NASA support:

Arzeno NM, Stenger MB, Lee SM, Ploutz-Snyder R, Platts SH.
Gender differences in blood pressure control during 6-degree head-down tilt bed rest.
Am J Physiol Heart Circ Physiol. 2013 Feb 8. [Epub ahead of print]
(PI: S.H. Platts)
NOTE: Bed rest study.

Taibbi G, Cromwell RL, Kapoor KG, Godley BF, Vizzeri G.
The effect of microgravity on ocular structures and visual function: A review.
Surv Ophthalmol. 2013 Mar-Apr;58(2):155-63. Epub 2013 Jan 29.
(PI: R.L. Cromwell)

Kramer LA, Sargsyan AE, Hasan KM, Polk JD, Hamilton DR.
Emissary veins and neuroanatomic changes in space.
Radiology. 2013 Jan;266(1):363.
NOTE: This letter is a response to a letter by D.H. Kim and C.F. Parsa (PMID 23264529; excerpt at: ) concerning a 2012 paper by Kramer et al.: “Orbital and intracranial effects of microgravity: Findings at 3-T MR imaging” (PMID 22416248).

Migeotte PF, De Ridder S, Tank J, Pattyn N, Funtova I, Baevsky R, Neyt X, Prisk GK.
Three dimensional ballisto- and seismo-cardiography: HIJ wave amplitudes are poorly correlated to maximal systolic force vector.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:5046-9.
(PI: G.K. Prisk)
NOTE: STS-55 (Spacelab D-2) and parabolic flight results.

Judex S, Zhang W, Donahue LR, Ozcivici E.
Genetic loci that control the loss and regain of trabecular bone during unloading and reambulation.
J Bone Miner Res. 2013 Feb 7. [Epub ahead of print]
(PI: S. Judex)

Shi W, Guo L, Kasdan H, Tai YC.
Four-part leukocyte differential count based on sheathless microflow cytometer and fluorescent dye assay.
Lab Chip. 2013 Feb 7. [Epub ahead of print]
(PI: Y.C. Tai)

Yu H, Mohan S, Natarajan M.
Radiation-triggered NF-B activation is responsible for the angiogenic signaling pathway and neovascularization for breast cancer cell proliferation and growth.
Breast Cancer (Auckl). 2012;6:125-35. Epub 2012 Jul 23.
NOTE: This article may be obtained online without charge.
(PI: M. Natarajan)

Zhang S, Chen BP.
Disablement of DNA-PKcs phosphorylation induces hematopoietic failure in mice through the p53 signaling pathway.
Treatment Strategies – Hematology. 2012 Feb;2(1):36-40.
(PI: B.P. Chen)
NOTE: This article may be obtained online without charge, though the site may not be working.

Tian J, Tian S, Gridley DS.
Comparison of acute proton, photon, and low-dose priming effects on genes associated with extracellular matrix and adhesion molecules in the lungs.
Fibrogenesis Tissue Repair. 2013 Feb 4;6:4.
(PI: D.S. Gridley)
NOTE: This article may be obtained online without charge.

Cho Y, Turner ND, Davidson LA, Chapkin RS, Carroll RJ, Lupton JR.
A chemoprotective fish oil/pectin diet enhances apoptosis via Bcl-2 promoter methylation in rat azoxymethane-induced carcinomas.
Exp Biol Med (Maywood). 2012 Dec 1;237(12):1387-93.
(PI: J.R. Lupton)

Tang H, Xiao G, Behrens C, Schiller J, Allen J, Chow CW, Suraokar M, Corvalan A, Mao JH, White M, Wistuba II, Minna JD, Xie Y.
A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small-cell lung cancer patients.
Clin Cancer Res. 2013 Jan 28. [Epub ahead of print]
(PIs: J.D. Minna/Y. Xie/NSCOR)

Olsen RH, Johnson LA, Zuloaga DG, Limoli C, Raber J.
Enhanced hippocampus-dependent memory and reduced anxiety in mice over-expressing human catalase in mitochondria.
J Neurochem. 2013 Feb 5. [Epub ahead of print]
(PIs: G. Nelson/C. Limoli/J. Raber/NSCOR)

Kukreja SL, Stone LS, Boyle RD.
A sparse matrix approach for simultaneous quantification of nystagmus and saccade.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:5478-81.

Breslow ER, Phillips AJ, Huang JM, St. Hilaire MA, Klerman EB.
A mathematical model of the circadian phase-shifting effects of exogenous melatonin.
J Biol Rhythms. 2013 Feb;28(1):79-89.
(PIs: E.B. Klerman; A.J. Phillips, NSBRI Postdoctoral Fellowship Program)

Moore ST, Yungher DA, Morris TR, Dilda V, MacDougall HG, Shine JM, Naismith SL, Lewis SJ.
Autonomous identification of freezing of gait in Parkinson’s disease from lower-body segmental accelerometry.
J Neuroeng Rehabil. 2013 Feb 13;10:19. [Epub ahead of print]
(PI: S.T. Moore)
NOTE: This article may be obtained online without charge.

Rabbi AF, Zony AN, de Leon P, Fazel-Rezai R.
Preliminary results of mental workload and task engagement assessment using electroencephalogram in a space suit.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:3549-52.

Other papers of interest:

Bolea J, Caiani EG, Pueyo E, Laguna P, Almeida R.
Microgravity effects on ventricular response to heart rate changes.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:3424-7.
NOTE: Bed rest study.

Weber T, Beijer A, Rosenberger A, Mulder E, Yang P, Schoenau E, Bloch W, Rittweger J.
Vascular adaptations induced by 6 weeks WBV resistance exercise training.
Clin Physiol Funct Imaging. 2013 Mar;33(2):92-100. Epub 2012 Sep 20.
NOTE: From conclusion in abstract: “Our findings seem to be at variance with the findings observed in a bed rest setting.”

Pollonini L, Re R, Simpson RJ, Dacso CC.
Integrated device for the measurement of systemic and local oxygen transport during physical exercise.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:3760-3.

Smith C, Goswami N, Robinson R, von der Wiesche M, Schneider S.
The relationship between brain cortical activity and brain oxygenation in the prefrontal cortex during hypergravity exposure.
J Appl Physiol. 2013 Jan 31. [Epub ahead of print]

Zuj KA, Arbeille P, Shoemaker JK, Hughson RL.
Cerebral critical closing pressure and CO2 responses during the progression towards syncope.
J Appl Physiol. 2013 Jan 31. [Epub ahead of print]
NOTE: Bed rest study.

Brown SJ, Raman A, Barnes MJ, Muendel T.
Autonomic cardiovascular response to acute hypoxia and passive head-up tilting in humans.
Eur J Appl Physiol. 2013 Feb 12. [Epub ahead of print]

Villar R, Hughson RL.
Repeatability of popliteal blood flow and lower limb vascular conductance at rest and exercise during body tilt using Doppler ultrasound.
Physiol Meas. 2013 Feb 12;34(3):291-306. [Epub ahead of print]

Lipponen JA, Tarvainen MP, Laitinen T, Karjalainen PA, Vanninen J, Koponen T, Lyyra-Laitinen T.
Estimation of arterial baroreflex sensitivity in relation to carotid artery stiffness.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:3408-11.

Garg A, Blaber AP.
Wavelet transform coherence based investigation of existence of relationship between the cardiovascular and postural control systems during orthostatic challenge.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:3588-91.

Li MH, Chen PH, Ho ST, Tung CS, Lin TC, Tseng CJ, Huang WS, Lu CC.
Lower body negative pressure-induced vagal reaction: Role for the osmopressor response?
Am J Hypertens. 2013 Jan;26(1):5-12.
NOTE: This article may be obtained online without charge.

Lackner HK, Weiss EM, Schulter G, Hinghofer-Szalkay H, Samson AC, Papousek I.
I got it! Transient cardiovascular response to the perception of humor.
Biol Psychol. 2013 Feb 1. [Epub ahead of print]

Wang C, Li W, Wu L, Lin P, Li F, Luo H, Xu Y, Xie Z.
[Clinical characteristics and treatment of 89 patients with head-up tilt table test induced syncope with convulsion]
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Jan;38(1):70-3. Chinese.
NOTE: From abstract: “No one died.” Translated title of journal: Journal of Central South University. Medical Sciences. This article may be obtained online without charge.

Musson DM, Doyle TE, Saary J.
Systems modeling of space medical support architecture: Topological mapping of high level characteristics and constraints.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:6090-4.

Musson DM, Doyle TE.
A social cybernetic analysis of simulation-based, remotely delivered medical skills training in an austere environment: Developing a test bed for spaceflight medicine.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:6086-9.

Oakes JM, Scadeng M, Breen EC, Prisk GK, Darquenne C.
Regional distribution of aerosol deposition in rat lungs using magnetic resonance imaging.
Ann Biomed Eng. 2013 Jan 25. [Epub ahead of print]

Si S, Song S, Shi L, Liu J, Xu B, Yi Y, Tan X, Zhang J.
[Simulated weightlessness inhibits antitumor immunity of T lymphocytes in melanoma-bearing mice]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Feb;29(2):127-31. Chinese.
NOTE: Translated title of journal: Chinese Journal of Cellular and Molecular Immunology.

Schiwon K, Arends K, Rogowski KM, Fuerch S, Prescha K, Sakinc T, Van Houdt R, Werner G, Grohmann E.
Comparison of antibiotic resistance, biofilm formation and conjugative transfer of Staphylococcus and Enterococcus isolates from International Space Station and Antarctic Research Station Concordia.
Microb Ecol. 2013 Feb 15. [Epub ahead of print]
NOTE: ISS results.

Kutschke M, Grimpo K, Kastl A, Schneider S, Heldmaier G, Exner C, Jastroch M.
Depression of mitochondrial respiration during daily torpor of the Djungarian hamster, Phodopus sungorus, is specific for liver and correlates with body temperature.
Comp Biochem Physiol A Mol Integr Physiol. 2013 Feb 1;164(4):584-9. [Epub ahead of print]

Tahimic CG, Wang Y, Bikle DD.
Anabolic effects of IGF-1 signaling on the skeleton.
Front Endocrinol (Lausanne). 2013;4:6. Epub 2013 Feb 4.
NOTE: This article may be obtained online without charge.

Chan ME, Uzer G, Rubin CT.
The potential benefits and inherent risks of vibration as a non-drug therapy for the prevention and treatment of osteoporosis.
Curr Osteoporos Rep. 2013 Jan 31. [Epub ahead of print]

Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato T, Kawano H, Aihara KI, Nakamichi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y.
Vitamin D receptor in osteoblasts is a negative regulator of bone mass control.
Endocrinology. 2013 Mar 1;154(3):1008-20. Epub 2013 Feb 6.

Liu M, Wu X, Tong M.
Effects of ultra-early stage hyperbaric oxygenation on the hind limb bone mineral density in rats after complete spinal cord transection.
Undersea Hyperb Med. 2013 Jan-Feb;40(1):15-22.

Gortazar AR, Martin-Millan M, Bravo B, Plotkin LI, Bellido T.
Crosstalk between caveolin-1/ERKs and -catenin survival pathways in osteocyte mechanotransduction.
J Biol Chem. 2013 Feb 11. [Epub ahead of print]
NOTE: This article may temporarily be obtained online without charge.

Stern AR, Nicolella DP.
Measurement and estimation of osteocyte mechanical strain.
Bone. 2013 Jan 28. [Epub ahead of print]

Zhao L, Shim JW, Dodge TR, Robling AG, Yokota H.
Inactivation of Lrp5 in osteocytes reduces Young’s modulus and responsiveness to the mechanical loading.
Bone. 2013 Jan 26;54(1):35-43. [Epub ahead of print]

Zhu J.
Influences of traditional Chinese medicine intervention on the bone growth and metabolism of rats with simulated weightlessness.
Asian Pac J Trop Med. 2013 Mar;6(3):224-7.

Warden SJ, Galley MR, Richard JS, George LA, Dirks RC, Guildenbecher EA, Judd AM, Robling AG, Fuchs RK.
Reduced gravitational loading does not account for the skeletal effect of botulinum toxin-induced muscle inhibition suggesting a direct effect of muscle on bone.
Bone. 2013 Feb 4. [Epub ahead of print]

Al-Nassan S, Fujita N, Kondo H, Murakami S, Fujino H.
Chronic exercise training down-regulates TNF- and atrogin-1/MAFbx in mouse gastrocnemius muscle atrophy induced by hindlimb unloading.
Acta Histochem Cytochem. 2012 Dec 26;45(6):343-9. Epub 2012 Oct 27.
NOTE: This article may be obtained online without charge.

Benavides Damm T, Richard S, Tanner S, Wyss F, Egli M, Franco-Obregon A.
Calcium-dependent deceleration of the cell cycle in muscle cells by simulated microgravity.
FASEB J. 2013 Jan 30. [Epub ahead of print]
NOTE: Used Random Positioning Machine to simulate microgravity.

Zhu S, Nagashima M, Khan MA, Yasuhara S, Kaneki M, Martyn JA.
Lack of caspase-3 attenuates immobilization-induced muscle atrophy and loss of tension generation along with mitigation of apoptosis and inflammation.
Muscle Nerve. 2013 Feb 9. [Epub ahead of print]

Manning CD, McDonald PL, Murnaghan CD, Bawa P.
Reciprocal inhibition versus unloading response during stretch reflex in humans.
Exp Brain Res. 2013 Jan 25. [Epub ahead of print]

Surdutovich E, Yakubovich AV, Solov’yov AV.
Biodamage via shock waves initiated by irradiation with ions.
Sci Rep. 2013 Feb 15;3:1289.
NOTE: This article may be obtained online without charge.

Fujii Y, Yurkon CR, Maeda J, Genet SC, Okayasu R, Kitamura H, Fujimori A, Kato TA.
Influence of track directions on the biological consequences in cells irradiated with high LET heavy ions.
Int J Radiat Biol. 2013 Jan 30. [Epub ahead of print]

Holloway RP, Dale RG.
Theoretical implications of incorporating relative biological effectiveness into radiobiological equivalence relationships.
Br J Radiol. 2013 Feb 1;86(1022):20120417.

Wu Z, Wang X, Yang R, Liu Y, Zhao W, Si J, Ma X, Sun C, Liu Y, Tan Y, Liu W, Zhang X, Di C, Wang Z, Zhang H, Zhang Z.
Effects of carbon ion beam irradiation on lung injury and pulmonary fibrosis in mice.
Exp Ther Med. 2013 Mar;5(3):771-6. Epub 2013 Jan 4.
NOTE: This article may be obtained online without charge:

Stahler C, Roth J, Cordes N, Taucher-Scholz G, Mueller-Klieser W.
Impact of carbon ion irradiation on epidermal growth factor receptor signaling and glioma cell migration in comparison to conventional photon irradiation.
Int J Radiat Biol. 2013 Jan 30. [Epub ahead of print]

Bojados M, Herbin M, Jamon M.
Kinematics of treadmill locomotion in mice raised in hypergravity.
Behav Brain Res. 2013 Jan 23. [Epub ahead of print]

Wall C, Wrisley D, Oddsson L.
Vibrotactile feedback of mediolateral trunk tilt or foot pressure increases locomotor performance in healthy older adults – a pilot study.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:6145-8.

Napadow V, Sheehan J, Kim J, Dassatti A, Thurler AH, Surjanhata B, Vangel M, Makris N, Schaechter JD, Kuo B.
Brain white matter microstructure is associated with susceptibility to motion-induced nausea.
Neurogastroenterol Motil. 2013 Jan 29. [Epub ahead of print]

De Saedeleer C, Vidal M, Lipshits M, Bengoetxea A, Cebolla AM, Berthoz A, Cheron G, McIntyre J.
Weightlessness alters up/down asymmetries in the perception of self-motion.
Exp Brain Res. 2013 Feb 9. [Epub ahead of print]
NOTE: ISS results.

Stolzenberg N, Belav DL, Rawer R, Felsenberg D.
Whole-body vibration versus proprioceptive training on postural control in post-menopausal osteopenic women.
Gait Posture. 2013 Jan 31. [Epub ahead of print]

Ersal T, Sienko KH.
A mathematical model for incorporating biofeedback into human postural control.
J Neuroeng Rehabil. 2013 Feb 2;10:14.
NOTE: This article may be obtained online without charge.

Arshad Q, Nigmatullina Y, Bronstein AM.
Handedness-related cortical modulation of the vestibular-ocular reflex.
J Neurosci. 2013 Feb 13;33(7):3221-7.

Barnett-Cowan M, Jenkin HL, Dyde RT, Jenkin MR, Harris LR.
Asymmetrical representation of body orientation.
J Vis. 2013 Feb 1;13(2):3.
NOTE: This article may be obtained online without charge.

Yang Y, Pu F, Li S, Li Y, Li D, Fan Y.
Training complexity is not decisive factor for improving adaptation to visual sensory conflict.
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:3584-7.

King WM.
Getting ahead of oneself: Anticipation and the vestibulo-ocular reflex.
Neuroscience. 2013 Jan 29. [Epub ahead of print]

Bockisch CJ, Khojasteh E, Straumann D, Hegemann SC.
Eye position dependency of nystagmus during constant vestibular stimulation.
Exp Brain Res. 2013 Feb 6. [Epub ahead of print]

van Elk M, Blanke O.
Imagined own-body transformations during passive self-motion.
Psychol Res. 2013 Feb 15. [Epub ahead of print]

Ushakov IB, Gushin VI, Larina IM, Shved DM, Patushkova IKh, Vinokhodova AG.
Content and structure of crew’s communicative behavior and gonadal hormone excretion during long-term chamber isolation of all-male international crew.
Hum Physiol. 2012 Nov;38(6):640-8.
NOTE: Mars-105 experiment. This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2012 Nov-Dec;38(6):95-104:

Pietsch J, Riwaldt S, Bauer J, Sickmann A, Weber G, Grosse J, Infanger M, Eilles C, Grimm D.
Interaction of proteins identified in human thyroid cells.
Int J Mol Sci. 2013 Jan 9;14(1):1164-78.
NOTE: Used Random Positioning Machine to simulate microgravity. This article may be obtained online without charge.

Chang D, Xu H, Guo Y, Jiang X, Liu Y, Li K, Pan C, Yuan M, Wang J, Li T, Liu C.
Simulated microgravity alters the metastatic potential of a human lung adenocarcinoma cell line.
In Vitro Cell Dev Biol Anim. 2013 Feb 13. [Epub ahead of print]

Kalpana D, Lee YS.
Synthesis and characterization of bactericidal silver nanoparticles using cultural filtrate of simulated microgravity grown Klebsiella pneumoniae.
Enzyme Microb Technol. 2013 Mar 5;52(3):151-6. Epub 2012 Dec 27.
NOTE: Used rotating bioreactor to simulate microgravity.

Baik AD, Qiu J, Hillman EM, Dong C, Guo XE.
Simultaneous tracking of 3D actin and microtubule strains in individual MLO-Y4 osteocytes under oscillatory flow.
Biochem Biophys Res Commun. 2013 Jan 23. [Epub ahead of print]

Fu BM, Tarbell JM.
Mechano-sensing and transduction by endothelial surface glycocalyx: Composition, structure, and function.
Wiley Interdiscip Rev Syst Biol Med. 2013 Feb 7. [Epub ahead of print]

Xu T, Yue W, Li CW, Yao X, Yang M.
Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells.
Lab Chip. 2013 Feb 19;13(6):1060-9.

Sun Y, Fu J.
Mechanobiology: A new frontier for human pluripotent stem cells.
Integr Biol (Camb). 2013 Jan 21. [Epub ahead of print]

Loefke C, Zwiewka M, Heilmann I, Van Montagu MC, Teichmann T, Friml J.
Asymmetric gibberellin signaling regulates vacuolar trafficking of PIN auxin transporters during root gravitropism.
Proc Natl Acad Sci U S A. 2013 Feb 7. [Epub ahead of print]

Kosuge K, Iida S, Katou K, Mimura T.
Circumnutation on the water surface: Female flowers of Vallisneria.
Sci Rep. 2013;3:1133. Epub 2013 Jan 25.
NOTE: This article may be obtained online without charge.

SpaceRef staff editor.