NASA Spaceline Current Awareness 22 April 2011 (Recent Space Life Science Research Results)

Papers deriving from NASA support:

1
Zhang S, Yajima H, Huynh H, Zheng J, Callen E, Chen HT, Wong N, Bunting S, Lin YF, Li M, Lee KJ, Story M, Gapud E, Sleckman BP, Nussenzweig A, Zhang CC, Chen DJ, Chen BP.
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.
J Cell Biol. 2011 Apr 18;193(2):295-305. Epub 2011 Apr 11.
http://www.ncbi.nlm.nih.gov/pubmed/21482716
(PI: B.P. Chen)
NOTE: There is a comment on this article in this issue; it is available online without charge: http://jcb.rupress.org/content/193/2/253.full
The first paragraph of the comment summarizes the research: “If you can’t help out during an emergency, it’s better to get out of the way and let someone else take over. The same principle could apply to DNA repair; as Zhang et al. reveal, mutating DNA-dependent protein kinase (DNA-PK) blocks several repair pathways, resulting in the loss of hematopoietic stem cells (1).”

2
Sachs RK, Johnsson K, Hahnfeldt P, Luo J, Chen A, Hlatky L.
A multicellular basis for the origination of blast crisis in chronic myeloid leukemia.
Cancer Res. 2011 Apr 15;71(8):2838-47. Epub 2011 Apr 12.
http://www.ncbi.nlm.nih.gov/pubmed/21487044
(PI: L. Hlatky/R.K. Sachs/P. Hahnfeldt/NSCOR)
NOTE: This article may be obtained online without charge.

3
Ly P, Eskiocak U, Kim SB, Roig AI, Hight SK, Lulla DR, Zou YS, Batten K, Wright WE, Shay JW.
Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cells.
Neoplasia. 2011 Apr;13(4):348-57.
http://www.ncbi.nlm.nih.gov/pubmed/21472139
(PIs: J.W. Shay; A. Fornace/A.I. Roig/K. Batten/W.E. Wright/J.W. Shay/NSCOR)
NOTE: This article may be obtained online without charge via PubMed Central.

4
Li L, Stone LS, Chen J.
Influence of optic-flow information beyond the velocity field on the active control of heading.
J Vis. 2011 Apr 14;11(4). pii: 9.
http://www.ncbi.nlm.nih.gov/pubmed/21493706
NOTE: This article may be obtained online without charge.

5
Balaban PM, Malyshev AY, Ierusalimsky VN, Aseyev N, Korshunova TA, Bravarenko NI, Lemak MS, Roshchin M, Zakharov IS, Popova Y, Boyle R.
Functional changes in the snail statocyst system elicited by microgravity.
PLoS One. 2011 Mar 29;6(3):e17710.
http://www.ncbi.nlm.nih.gov/pubmed/21479267
(PI: R. Boyle)
NOTE: Foton-M2 and Foton-M3 results. This article may be obtained online without charge.

6
Nayar M, Fox GE.
Defining 5S rRNA structure space: Point mutation data can be used to predict the phenotype of multi-change variants.
Mol Biol Evol. 2011 Apr 5. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21470967

Other papers of interest:

1
Liu J, Verheyden B, Beckers F, Aubert AE.
Haemodynamic adaptation during sudden gravity transitions.
Eur J Appl Physiol. 2011 Apr 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21479958
NOTE: Parabolic flight results.

2
Barodka VM, Joshi BL, Berkowitz DE, Hogue CW Jr, Nyhan D.
Implications of vascular aging.
Anesth Analg. 2011 May;112(5):1048-60. Epub 2011 Apr 7.
http://www.ncbi.nlm.nih.gov/pubmed/21474663
NOTE: This is a useful and clear review of this topic.

3
Shi ZD, Tarbell JM.
Fluid flow mechanotransduction in vascular smooth muscle cells and fibroblasts.
Ann Biomed Eng. 2011 Apr 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21479754

4
Donina ZhA, Aleksandrova NP.
[Ventilatory response to hypercapnia during head-down tilt]
Ross Fiziol Zh Im I M Sechenova. 2010 Nov;96(11):1129-36. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/21427974

5
Bacabac RG, Van Loon JJ.
Stress response by bone cells and implications on microgravity environment.
Clin Rev Bone Miner Metab. 2010 Dec;8(4):179-88.
http://dx.doi.org/10.1007/s12018-011-9082-x
NOTE: This article and the following article are part of an issue on the topic “Mechanosensing in Bone.” The introduction to the issue is available online without charge and may be accessed via the Table of Contents: http://www.springerlink.com/content/1534-8644/8/4/

6
Bidwell JP, Pavalko FM.
The load-bearing mechanosome revisited.
Clin Rev Bone Miner Metab. 2010 Dec;8(4):213-23.
http://www.ncbi.nlm.nih.gov/pubmed/21479153

7
Kelly GM, Kilpatrick JI, van Es MH, Weafer PP, Prendergast PJ, Jarvis SP.
Bone cell elasticity and morphology changes during the cell cycle.
J Biomech. 2011 Apr 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21481877

8
Fernando HN, Czamanski J, Yuan TY, Gu W, Salahadin A, Huang CY.
Mechanical loading affects the energy metabolism of intervertebral disc cells.
J Orthop Res. 2011 Apr 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21484859

9
Kasturi GC, Adler RA.
Osteoporosis: Nonpharmacologic management.
PM R. 2011 Apr 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21478069

10
Ezenwa B, Yeoh HT.
Multiple vibration displacements at multiple vibration frequencies stress impact on human femur computational analysis.
J Rehabil Res Dev. 2011;48(2):179-90.
http://www.ncbi.nlm.nih.gov/pubmed/21480091
NOTE: This article may be obtained online without charge.

11
Kasturi G, Adler RA.
Mechanical means to improve bone strength: Ultrasound and vibration.
Curr Rheumatol Rep. 2011 Apr 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21484337

12
Altaeva EG, Ogneva IV, Shenkman BS.
Dynamics of calcium ions accumulation and changes of isoforms of sarcoplasmic reticulum Ca-ATPase (SERCA) in soleus muscle fibers of rats and Mongolian gerbils under gravitational unloading of various duration.
Cell Tissue Biol. 2010 Dec;4(6):594-9.
http://dx.doi.org/10.1134/S1990519X10060118
NOTE: Hindlimb suspension was used. This paper is a translation in English of the Russian original published in Tsitologiia. 2010;52(9):770-5: http://www.ncbi.nlm.nih.gov/pubmed/21105366

13
Jamart C, Raymackers JM, An GL, Deldicque L, Francaux M.
Prevention of muscle disuse atrophy by MG132 proteasome inhibitor.
Muscle Nerve. 2011 May;43(5):708-15. Epub 2011 Apr 1.
http://www.ncbi.nlm.nih.gov/pubmed/21462205

14
Schilder RJ, Kimball SR, Marden JH, Jefferson LS.
Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats.
J Exp Biol. 2011 May 1;214(Pt 9):1523-32.
http://www.ncbi.nlm.nih.gov/pubmed/21490260
NOTE: Nice cover on this issue: http://jeb.biologists.org/content/214/9.cover-expansion

15
Fujiwara SI, Endo H, Hutchinson JR.
Topsy-turvy locomotion: Biomechanical specializations of the elbow in suspended quadrupeds reflect inverted gravitational constraints.
J Anat. 2011 Apr 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21477151

16
von Haehling S, Morley JE, Anker SD.
An overview of sarcopenia: Facts and numbers on prevalence and clinical impact.
J Cachex Sarcopenia Muscle. 2010 Dec;1(2):129-133. Epub 2010 Dec 17.
http://www.ncbi.nlm.nih.gov/pubmed/21475695
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site: http://dx.doi.org/10.1007/s13539-010-0014-2

17
Rose JC, Epperson LE, Carey HV, Martin SL.
Seasonal liver protein differences in a hibernator revealed by quantitative proteomics using whole animal isotopic labeling.
Comp Biochem Physiol Part D Genomics Proteomics. 2011 Mar 5. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21481655

18
Lee R, Nasonova E, Hartel C, Durante M, Ritter S.
Chromosome aberration measurements in mitotic and G(2)-PCC lymphocytes at the standard sampling time of 48 h underestimate the effectiveness of high-LET particles.
Radiat Environ Biophys. 2011 Apr 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21479955

19
Copeland K, Friedberg W, Sato T, Niita K.
Comparison of fluence-to-dose conversion coefficients for deuterons, tritons and helions.
Radiat Prot Dosimetry. 2011 Apr 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21474471

20
Blank M, Goodman R.
DNA is a fractal antenna in electromagnetic fields.
Int J Radiat Biol. 2011 Apr;87(4):409-15. Epub 2011 Feb 28.
http://www.ncbi.nlm.nih.gov/pubmed/21457072

21
Cullen KE, Yates BJ.
Vestibular neurophysiology: A collection of papers in honor of the career of Jay Goldberg.
Exp Brain Res. 2011 May;210(3-4):327-9.
http://www.ncbi.nlm.nih.gov/pubmed/21448574
NOTE: This article and the following article are from an issue honoring Jay Goldberg, as the title indicates. Many of the articles were in previous Current Awareness lists as epubs. This article may be obtained online without charge.

22
Goldberg JM, Cullen KE.
Vestibular control of the head: Possible functions of the vestibulocollic reflex.
Exp Brain Res. 2011 May;210(3-4):331-45. Epub 2011 Mar 26.
http://www.ncbi.nlm.nih.gov/pubmed/21442224

23
Moscatelli A, Lacquaniti F.
The weight of time: Gravitational force enhances discrimination of visual motion duration.
J Vis. 2011 Apr 8;11(4). pii: 5.
http://www.ncbi.nlm.nih.gov/pubmed/21478379
NOTE: Conclusion of paper: “The main timekeepers used by mankind for centuries–the water clock and the pendulum clock–relied on gravity. Here, we considered the hypothesis that the brain evolved neural mechanisms that exploit gravity effects to estimate time. Our experiments showed that the temporal resolution of visual processing is enhanced for stimuli compatible with expected gravity constraints, as compared with stimuli violating such constraints. This adds to previous evidence that information about physics (such as frictional interaction or momentum) is embedded within the neural mechanisms processing visual motion (Freyd & Finke, 1984; Gilroy & Blake, 2004).” This article may be obtained online without charge.

24
Meilinger T, Berthoz A, Wiener JM.
The integration of spatial information across different viewpoints.
Mem Cognit. 2011 Apr 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21472477

25
DeStefino VJ, Reighard DA, Sugiyama Y, Suzuki T, Cotter LA, Larson MG, Gandhi NJ, Barman SM, Yates BJ.
Responses of neurons in the rostral ventrolateral medulla (RVLM) to whole-body rotations: Comparisons in decerebrate and conscious cats.
J Appl Physiol. 2011 Apr 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21493724

26
Elkan-Miller T, Ulitsky I, Hertzano R, Rudnicki A, Dror AA, Lenz DR, Elkon R, Irmler M, Beckers J, Shamir R, Avraham KB.
Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear.
PLoS One. 2011 Apr 5;6(4):e18195.
http://www.ncbi.nlm.nih.gov/pubmed/21483685
NOTE: This article may be obtained online without charge.

27
Tafforin C.
The ethological approach as a new way of investigating behavioural health in the Arctic.
Int J Circumpolar Health. 2011 Apr 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21481302
NOTE: This article may be obtained online without charge.

28
Pathak A, Kumar S.
From molecular signal activation to locomotion: An integrated, multiscale analysis of cell motility on defined matrices.
PLoS One. 2011 Mar 31;6(3):e18423.
http://www.ncbi.nlm.nih.gov/pubmed/21483802
NOTE: This article may be obtained online without charge.

29
Desmaele D, Boukallel M, Regnier S.
Actuation means for the mechanical stimulation of living cells via microelectromechanical systems: A critical review.
J Biomech. 2011 Apr 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21489537