Status Report

NASA Spaceline Current Awareness 20 July 2012 (Recent Space Life Science Research Results)

By SpaceRef Editor
July 24, 2012
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NASA Spaceline Current Awareness 20 July 2012 (Recent Space Life Science Research Results)

Papers deriving from NASA support:

1 Spatz JM, Fields EE, Yu EW, Pajevic PD, Bouxsein ML, Sibonga JD, Zwart SR, Smith SM.
Serum sclerostin increases in healthy adult men during bed rest.
J Clin Endocrinol Metab. 2012 Jul 5. [Epub ahead of print]
(PIs: M.L. Bouxsein, S.M. Smith, Flight Analogs Project)
NOTE: Bed rest study.

2 Poritz JM, Seaton KA, Zanello SB, Cromwell RL.
Outcome measure to assess head-down bed rest subject performance.
Aviat Space Environ Med. 2012 Jul;83(7):691-5.
(PI: R.L. Cromwell/Flight Analogs Project; NSBRI summer internship program)
NOTE: Analysis of bed rest studies.

3 Harper JD, Shah AR, Mitchell SB, Wang YN, Starr FL, Bailey MR, Crum LA.
Novel high-intensity focused ultrasound clamp – Potential adjunct for laparoscopic partial nephrectomy.
J Endourol. 2012 Jul 12. [Epub ahead of print]
(PI: L.A. Crum)

4 Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk NJ, Ishioka N, Honda S.
Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.
Sci Rep. 2012;2:487. Epub 2012 Jul 5.
NOTE: ISS results. ESA press release:
This article may be obtained online without charge via PubMed Central or at the publisher’s site:

5 Lloyd SA, Bandstra ER, Willey JS, Riffle SE, Tirado-Lee L, Nelson GA, Pecaut MJ, Bateman TA.
Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: A model of long-duration spaceflight.
Bone. 2012 Jul 9. [Epub ahead of print]
(PI: T.A. Bateman)

6 Norman RB, Blattnig SR, De Angelis G, Badavi FF, Norbury JW.
Deterministic pion and muon transport in Earth’s atmosphere.
Adv Space Res. 2012 Jul 1;50(1):146-55.
(PI: J.W. Norbury)

7 Zhang L, Komurov K, Wright WE, Shay JW.
Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer.
Int J Cancer. 2012 Jun 30. [Epub ahead of print]
(PIs: J.W. Shay; A.J. Fornace/W.E. Wright/J.W. Shay/NSCOR; J.D. Minna/J.W. Shay/NSCOR)

8 Fukuda AM, Pop V, Spagnoli D, Ashwal S, Obenaus A, Badaut J.
Delayed increase of astrocytic aquaporin 4 after juvenile traumatic brain injury: Possible role in edema resolution?
Neuroscience. 2012 Jun 20. [Epub ahead of print]

9 MacNeilage PR, Zhang Z, DeAngelis GC, Angelaki DE.
Vestibular facilitation of optic flow parsing.
PLoS One. 2012;7(7):e40264. Epub 2012 Jul 2.
(PI: P.R. MacNeilage, NSBRI Postdoctoral Fellowship Program)
NOTE: This article may be obtained online without charge.

10 Jones SB, Or D, Heinse R, Tuller M.
Beyond Earth: Designing root zone environments for reduced gravity conditions.
Vadose Zone J. 2012 Feb;11(1).
(PIs: G. Bingham, S. Steinberg)

Other papers of interest:

1 Tsvirkun D, Bourreau J, Mieuset A, Garo F, Vinogradova O, Larina I, Navasiolava N, Gauquelin-Koch G, Gharib C, Custaud MA.
Contribution of social isolation, restraint, and hindlimb unloading to changes in hemodynamic parameters and motion activity in rats.
PLoS One. 2012;7(7):e39923. Epub 2012 Jul 2.
NOTE: This article may be obtained online without charge.

2 Sun J, Sang H, Yang C, Dong H, Lei C, Lu Y, Ma Y, Zhou X, Sun X, Xiong L.
Electroacupuncture improves orthostatic tolerance in healthy individuals via improving cardiac function and activating the sympathetic system.
Europace. 2012 Jul 11. [Epub ahead of print]

3 Kordi M, Kluge N, Kloeckner M, Russomano T.
Gender influence on the performance of chest compressions in simulated hypogravity and microgravity.
Aviat Space Environ Med. 2012 Jul;83(7):643-8.

4 Eiken O, Mekjavic IB, Koelegard R.
Local intravascular pressure habituation in relation to G-induced arm pain.
Aviat Space Environ Med. 2012 Jul;83(7):667-72.

5 Richard NA, Koehle MS.
Differences in cardio-ventilatory responses to hypobaric and normobaric hypoxia: A review.
Aviat Space Environ Med. 2012 Jul;83(7):677-84.

6 Abnous K, Dieni CA, Storey KB.
Suppression of MAPKAPK2 during mammalian hibernation.
Cryobiology. 2012 Jul 5. [Epub ahead of print]

7 Hall KL, Phillips CA, Reynolds DB, Mohler SR, Neidhard-Doll AT.
Pneumatic muscle actuator (PMA) task-specific resistance for potential use in microgravity exercise.
Aviat Space Environ Med. 2012 Jul;83(7):696-701.

8 Mirzoev TM, Shenkman BS, Ushakov IB, Ogneva IV.
Desmin and -actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading.
Dokl Biochem Biophys. 2012 May;444(1):144-6. Epub 2012 Jul 8.
NOTE: This paper is a translation in English of the Russian original published in Doklady Akademii Nauk 2012;444(2):216-8.

9 Seene T, Kaasik P.
Role of exercise therapy in prevention of decline in aging muscle function: Glucocorticoid myopathy and unloading.
J Aging Res. 2012;2012:172492. Epub 2012 Jun 17.
NOTE: This article may be obtained online without charge.

10 Ho TC, Horn NA, Huynh T, Kelava L, Lansman JB.
Evidence TRPV4 contributes to mechanosensitive ion channels in mouse skeletal muscle fibers.
Channels (Austin). 2012 Jul/Aug;6(4). [Epub ahead of print]

11 Tirrell TF, Cook MS, Carr JA, Lin E, Ward SR, Lieber RL.
Human skeletal muscle biochemical diversity.
J Exp Biol. 2012 Aug 1;215(Pt 15):2551-9.
NOTE: Interesting journal cover:

12 Couppe C, Suetta C, Kongsgaard M, Justesen L, Hvid LG, Aagaard P, Kjaer M, Magnusson SP.
The effects of immobilization on the mechanical properties of the patellar tendon in younger and older men.
Clin Biomech (Bristol, Avon). 2012 Jul 9. [Epub ahead of print]

13 Shuang F, Sun Y, Yang HH, Shao YC, Li H, Hu W, Zhong J, Zou HX.
Destrin deletion enhances the bone loss in hindlimb suspended mice.
Eur J Appl Physiol. 2012 Jul 6. [Epub ahead of print]
NOTE: Used both the hindlimb suspension and rotary wall vessel bioreactor techniques.

14 Vandamme K, Holy X, Bensidhoum M, Deschepper M, Logeart-Avramoglou D, Naert I, Duyck J, Petite H.
Impaired osteoblastogenesis potential of progenitor cells in skeletal unloading is associated with alterations in angiogenic and energy metabolism profile.
Biomed Mater Eng. 2012 Jan 1;22(4):219-26.

15 Baud’huin M, Solban N, Cornwall-Brady M, Sako D, Kawamoto Y, Liharska K, Lath D, Bouxsein ML, Underwood KW, Ucran J, Kumar R, Pobre E, Grinberg A, Seehra J, Canalis E, Pearsall RS, Croucher PI.
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength.
Proc Natl Acad Sci U S A. 2012 Jul 3. [Epub ahead of print]

16 Moriishi T, Fukuyama R, Ito M, Miyazaki T, Maeno T, Kawai Y, Komori H, Komori T.
Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading.
PLoS One. 2012;7(6):e40143. Epub 2012 Jun 29.
NOTE: This article may be obtained online without charge.

17 Coughlin TR, Niebur GL.
Fluid shear stress in trabecular bone marrow due to low-magnitude high-frequency vibration.
J Biomech. 2012 Jul 9. [Epub ahead of print]

18 Cui L, Li XT, Zhang D.
Effect of fluid flow-induced shear stress on osteoclast formation induced by osteocyte.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Jun;34(3):207-11. Chinese.
NOTE: This article, which is in Chinese, may be obtained online without charge.
Translated title of journal is Acta Academiae Medicinae Sinicae.

19 Leucht P, Monica SD, Temiyasathit S, Lenton K, Manu A, Longaker MT, Jacobs CR, Spilker RL, Guo H, Brunski JB, Helms JA.
Primary cilia act as mechanosensors during bone healing around an implant.
Med Eng Phys. 2012 Jul 12. [Epub ahead of print]

20 Kumar A, Jalota S, Gupta R.
Simulation of depth-dose distributions for various ions in polyethylene medium.
Adv Space Res. 2012 Jun 15;49(12):1691-7.

21 Dachev TP, Tomov BT, Matviichuk YN, Dimitrov PG, Bankov NG, Reitz G, Horneck G, Haeder DP, Lebert M, Schuster M.
Relativistic electron fluxes and dose rate variations during April-May 2010 geomagnetic disturbances in the R3DR data on ISS.
Adv Space Res. 2012 Jul 15;50(2):282-92.
NOTE: ISS results.

22 Di Fino L, Zaconte V, Ciccotelli A, Larosa M, Narici L.
Fast Probabilistic Particle Identification algorithm using silicon strip detectors.
Adv Space Res. 2012 Aug 1;50(3):408-14.
NOTE: About experiment on ISS.

23 Puchalska M, Sihver L, Sato T, Berger T, Reitz G.
Simulations of MATROSHKA experiment outside the ISS using PHITS.
Adv Space Res. 2012 Aug 15;50(4):489-95.
NOTE: Compares radiation estimations with ISS data.

24 Snigiryova GP, Novitskaya NN, Fedorenko BS.
Cytogenetic examination of cosmonauts for space radiation exposure estimation.
Adv Space Res. 2012 Aug 15;50(4):502-7.
NOTE: Mir and ISS results.

25 Kalanxhi E, Dahle J.
Transcriptional responses in irradiated and bystander fibroblasts after low dose -particle radiation.
Int J Radiat Biol. 2012 Jul 18. [Epub ahead of print]

26 Sabatino L, Picano E, Andreassi MG.
Telomere shortening and ionizing radiation: A possible role in vascular dysfunction?
Int J Radiat Biol. 2012 Jul 4. [Epub ahead of print]

27 Tamura H, Ohgami N, Yajima I, Iida M, Ohgami K, Fujii N, Itabe H, Kusudo T, Yamashita H, Kato M.
Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice.
PLoS One. 2012;7(6):e39807. Epub 2012 Jun 29.
NOTE: This article may be obtained online without charge.

28 Pu F, Yang Y, Li D, Li S, Li Y, Fan Y.
Galvanic vestibular stimulation and the ability to maintain arm-hand posture.
Aviat Space Environ Med. 2012 Jul;83(7):654-9.

29 Shaikh AG, Palla A, Marti S, Olasagasti I, Optican LM, Zee DS, Straumann D.
Role of cerebellum in motion perception and vestibulo-ocular reflex — Similarities and disparities.
Cerebellum. 2012 Jul 10. [Epub ahead of print]

30 Baber C, Butler M.
Expertise in crime scene examination: Comparing search strategies of expert and novice crime scene examiners in simulated crime scenes.
Hum Factors. 2012 Jun;54(3):413-24.
NOTE: For CSI fans.

31 Sheehy SP, Grosberg A, Parker KK.
The contribution of cellular mechanotransduction to cardiomyocyte form and function.
Biomech Model Mechanobiol. 2012 Jul 7. [Epub ahead of print]

32 Balleza D.
Mechanical properties of lipid bilayers and regulation of mechanosensitive function: From biological to biomimetic channels.
Channels (Austin). 2012 Jul/Aug;6(4). [Epub ahead of print]

33 West-Foyle H, Robinson DN.
Cytokinesis mechanics and mechanosensing.
Cytoskeleton (Hoboken). 2012 Jul 3. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

34 Guo HJ, Zhao HB, Zhao LS, Gu JY, Zhao SR, Li JH, Liu QC, Liu LX.
Characterization of a novel chlorophyll-deficient mutant Mt6172 in wheat.
J Integr Agri. 2012 Jun;11(6):888-97.
NOTE: Results from plants grown from seeds flown on a Chinese satellite (Shijian 8).

35 Soh H, Choi Y, Lee TK, Yeo UD, Han K, Auh C, Lee S.
Identification of unique cis-element pattern on simulated microgravity treated Arabidopsis by in silico and gene expression.
Adv Space Res. 2012 Aug 1;50(3):397-407.
NOTE: Used 3-D clinostat.

36 Stasiak M, Gidzinski D, Jordan M, Dixon M.
Crop selection for advanced life support systems in the ESA MELiSSA program: Durum wheat (Triticum turgidum var durum).
Adv Space Res. 2012 Jun 15;49(12):1684-90.

37 Molders K, Quinet M, Decat J, Secco B, Duliere E, Pieters S, van der Kooij T, Lutts S, Van Der Straeten D.
Selection and hydroponic growth of potato cultivars for bioregenerative life support systems.
Adv Space Res. 2012 Jul 1;50(1):156-65.

38 Dong X, Li W.
Biological features of an early-maturity mutant of sweet sorghum induced by carbon ions irradiation and its genetic polymorphism.
Adv Space Res. 2012 Aug 15;50(4):496-501.

SpaceRef staff editor.