NASA Spaceline Current Awareness 2 March 2012 (Recent Space Life Science Research Results)

Papers deriving from NASA support:

1
Hastings JL, Krainski F, Snell PG, Pacini E, Jain M, Bhella PS, Shibata S, Fu Q, Palmer MD, Levine BD.
The effect of rowing ergometry and oral volume loading on cardiovascular structure and function during bed rest.
J Appl Physiol. 2012 Feb 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22345434
(PI: B.D. Levine)
NOTE: Bed rest study.

2
Jarvis SS, Florian JP, Curren MJ, Pawelczyk JA.
A somatostatin analog improves tilt table tolerance by decreasing splanchnic vascular conductance.
J Appl Physiol. 2012 Feb 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22345429
(PIs: J.A. Pawelczyk; S.S. Jarvis, NASA Harriet G. Jenkins Predoctoral Fellowship)

3
Drummond MJ, Dickinson JM, Fry CS, Walker DK, Gundermann DM, Reidy PT, Timmerman KL, Markofski MM, Paddon-Jones D, Rasmussen BB, Volpi E.
Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults.
Am J Physiol Endocrinol Metab. 2012 Feb 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22338078
(PI: D. Paddon-Jones)
NOTE: Bed rest study.

4
Casperson SL, Sheffield-Moore M, Hewlings SJ, Paddon-Jones D.
Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein.
Clin Nutr. 2012 Feb 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22357161
(PI: D. Paddon-Jones)

5
Mukherjee B, Tomimatsu N, Amancherla K, Camacho CV, Pichamoorthy N, Burma S.
The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses.
Neoplasia. 2012 Jan;14(1):34-43.
http://www.ncbi.nlm.nih.gov/pubmed/22355272
(PI: S. Burma)
NOTE: This article may be obtained online without charge at the publisher’s site or via PubMed Central.

6
Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, Khanna KK, Burma S.
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.
DNA Repair (Amst). 2012 Feb 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22326273
(PI: S. Burma)

7
von Neubeck C, Shankaran H, Karin NJ, Kauer PM, Chrisler WB, Wang X, Robinson RJ, Waters KM, Tilton SC, Sowa MB.
Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: Implications for medical exposures.
Environ Mol Mutagen. 2012 Feb 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22351304
(PI: M.B. Sowa)

8
Dicello JF, Pisacane VL, Dolecek QE, Rosenfeld AB, Rusek A, Sivertz M, Malak H.
Feasibility study of solid-state microdosimetry for energetic protons and heavy ions with coincident particle identification.
Radiat Meas. 2011 Dec;46(12):1539-42.
http://dx.doi.org/10.1016/j.radmeas.2011.05.036
(PI: V.L. Pisacane/J. Ziegler)

9
Keeton KE, Schmidt LL, Slack KJ, Malka AA.
The rocket science of teams.
Ind Organ Psychol. 2012 Mar;5(1):32-5.
http://dx.doi.org/10.1111/j.1754-9434.2011.01399.x
(PI: K.E. Keeton)
NOTE: This article may be obtained online without charge.

10
Srivastava R, Chen Y, Deng Y, Brandizzi F, Howell SH.
Elements proximal to and within the transmembrane domain mediate the organelle-to-organelle movement of bZIP28 under ER stress conditions.
Plant J. 2012 Feb 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22335396
(PI: F. Brandizzi)

Other papers of interest:

1
Arvedsen SK, Damgaard M, Norsk P.
Body height and blood pressure regulation in humans during anti-orthostatic tilting.
Am J Physiol Regul Integr Comp Physiol. 2012 Feb 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22338081

2
Fu Q, Verheyden B, Wieling W, Levine BD.
Cardiac output and sympathetic vasoconstrictor responses during upright tilt to presyncope in healthy humans.
J Physiol. 2012 Feb 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22331415

3
Holmegard HN, Benn M, Kaijer M, Haunso S, Mehlsen J.
Differences in autonomic balance in patients with cardioinhibitory and vasodepressor type of reflex syncope during head-up tilt test and active standing.
Scand J Clin Lab Invest. 2012 Feb 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22332835

4
Rowland T, Unnithan V, Barker P, Guerra M, Roche D, Lindley M.
Orthostatic effects on echocardiographic measures of ventricular function.
Echocardiography. 2012 Feb 13. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/22329868

5
Eiken O, Mekjavic I, Sundblad P, Koelegard R.
G tolerance vis-a-vis pressure-distension and pressure-flow relationships of leg arteries.
Eur J Appl Physiol. 2012 Feb 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22350358

6
Gao F, Cheng JH, Xue JH, Bai YG, Chen MS, Huang WQ, Huang J, Wu SX, Han HC, Zhang LF.
[In-vivo and ex-vivo studies on region-specific remodeling of large elastic arteries due to simulated weightlessness and its prevention by gravity-based countermeasure]
Sheng Li Xue Bao. 2012 Feb 25;64(1):14-26. Chinese.
http://www.ncbi.nlm.nih.gov/pubmed/22348956
NOTE: This article may be obtained online without charge. The article is in Chinese but the front matter, figures, tables, and references are in English. The translated title of the journal is Acta Physiologica Sinica.

7
Mikus CR, Oberlin DJ, Libla JL, Taylor AM, Booth FW, Thyfault JP.
Lowering physical activity impairs glycemic control in healthy volunteers.
Med Sci Sports Exerc. 2012 Feb;44(2):225-31.
http://www.ncbi.nlm.nih.gov/pubmed/21716152

8
McBeth PB, Crawford I, Blaivas M, Hamilton T, Musselwhite K, Panebianco N, Melniker L, Ball CG, Gargani L, Gherdovich C, Kirkpatrick AW.
Simple, almost anywhere, with almost anyone: Remote low-cost telementored resuscitative lung ultrasound.
J Trauma. 2011 Dec;71(6):1528-35.
http://www.ncbi.nlm.nih.gov/pubmed/22182864
NOTE: From the introduction: “Thus, the practical question becomes how to use a potentially lifesaving technology, when there is no skilled ultrasound practitioner at the site of the emergency? Although there is no definitive answer to this question, potential solutions have involved using robotic ultrasound examiners, (refs) attempting 3-D ultrasound capture with a remote interpreter deciphering the data, (refs) and using technologies and techniques pioneered by the National Aeronautic and Space Administration (NASA) to allow remote experts to guide onsite novices to obtain clinically meaningful images. (refs)”

9
Swan AJ, Clark AR, Tawhai MH.
A computational model of the topographic distribution of ventilation in healthy human lungs.
J Theor Biol. 2012 Feb 4;300C:222-31. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22326472

10
Close DM, Xu T, Sayler GS, Ripp S.
In vivo bioluminescent imaging (BLI): Noninvasive visualization and interrogation of biological processes in living animals.
Sensors (Basel). 2011;11(1):180-206. Epub 2010 Dec 28.
http://www.ncbi.nlm.nih.gov/pubmed/22346573
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site.

11
Mantila Roosa SM, Turner CH, Liu Y.
Regulatory mechanisms in bone following mechanical loading.
Gene Regul Syst Bio. 2012;6:43-53. Epub 2012 Jan 17.
http://www.ncbi.nlm.nih.gov/pubmed/22346344
NOTE: This article may be obtained online without charge at the publisher’s site or via PubMed Central.

12
Thomsen JS, Christensen LL, Vegger JB, Nyengaard JR, Brueel A.
Loss of bone strength is dependent on skeletal site in disuse osteoporosis in rats.
Calcif Tissue Int. 2012 Feb 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22354132

13
Kennedy OD, Herman BC, Laudier DM, Majeska RJ, Sun HB, Schaffler MB.
Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations.
Bone. 2012 Feb 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22342796

14
Ma R, Zhu D, Gong H, Gu G, Huang X, Gao JZ, Zhang X.
High-frequency and low-magnitude whole body vibration with rest days is more effective in improving skeletal micro-morphology and biomechanical properties in ovariectomised rodents.
Hip Int. 2012 Feb 14:0. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22344486

15
Fedorov VB, Goropashnaya AV, Toien O, Stewart NC, Chang C, Wang H, Yan J, Showe LC, Showe MK, Donahue SW, Barnes BM.
Preservation of bone mass and structure in hibernating black bears (Ursus americanus) through elevated expression of anabolic genes.
Funct Integr Genomics. 2012 Feb 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22351243

16
Takahashi A, Suzuki H, Omori K, Seki M, Hashizume T, Shimazu T, Ishioka N, Ohnishi T.
Expression of p53-regulated proteins in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight.
J Radiat Res (Tokyo). 2012 Feb 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22374402
NOTE: ISS results. This article may be obtained online without charge.

17
Dilmanian FA, Rusek A, Fois GR, Olschowka J, Desnoyers NR, Park JY, Dioszegi I, Dane B, Wang R, Tomasi D, Lee H, Hurley SD, Coyle PK, Meek AG, O’Banion MK.
Interleaved carbon minibeams: An experimental radiosurgery method with clinical potential.
Int J Radiat Oncol Biol Phys. 2012 Feb 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22342299
NOTE: Research was carried out at NASA’s Space Radiation Laboratory at Brookhaven National Laboratory.

18
Girardi C, De Pitta C, Casara S, Sales G, Lanfranchi G, Celotti L, Mognato M.
Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravity.
PLoS One. 2012;7(2):e31293. Epub 2012 Feb 9.
http://www.ncbi.nlm.nih.gov/pubmed/22347458
NOTE: This article may be obtained online without charge.

19
Naseri AR, Grant PR.
Human discrimination of translational accelerations.
Exp Brain Res. 2012 Feb 22. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22354103

20
Tagliabue M, McIntyre J.
Eye-hand coordination when the body moves: Dynamic egocentric and exocentric sensory encoding.
Neurosci Lett. 2012 Feb 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22343022

21
Lewis RF, Priesol AJ, Nicoucar K, Lim K, Merfeld DM.
Dynamic tilt thresholds are reduced in vestibular migraine.
J Vestib Res. 2011 Jan 1;21(6):323-30.
http://www.ncbi.nlm.nih.gov/pubmed/22348937

22
Zeng H, Zhao Y.
Sensing movement: Microsensors for body motion measurement.
Sensors (Basel). 2011;11(1):638-60. Epub 2011 Jan 10.
http://www.ncbi.nlm.nih.gov/pubmed/22346595
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site.

23
Kozlov AS, Andor-Ardo D, Hudspeth AJ.
Anomalous Brownian motion discloses viscoelasticity in the ear’s mechanoelectrical-transduction apparatus.
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2896-901. Epub 2012 Feb 10.
http://www.ncbi.nlm.nih.gov/pubmed/22328158
NOTE: This article may be obtained online without charge.

24
Lazar AS, Slak A, Lo JC, Santhi N, von Schantz M, Archer SN, Groeger JA, Dijk DJ.
Sleep, diurnal preference, health, and psychological well-being: A prospective single-allelic-variation study.
Chronobiol Int. 2012 Mar;29(2):131-46.
http://www.ncbi.nlm.nih.gov/pubmed/22324552

25
Qian AR, Li D, Han J, Gao X, Di SM, Zhang W, Hu LF, Shang P.
Fractal dimension as a measure of altered actin cytoskeleton in MC3T3-E1 cells under simulated microgravity using 3-D /2-D clinostats.
IEEE Trans Biomed Eng. 2012 Feb 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22345524

26
Van Dyke WS, Sun X, Richard AB, Nauman EA, Akkus O.
Novel mechanical bioreactor for concomitant fluid shear stress and substrate strain.
J Biomech. 2012 Feb 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22356846

27
Yan J, Shang P, Zheng D, Dong Y, Mao J, Wang S, Liu X, Yang S.
Effect of simulated space gravity environment on Gibberella moniliformis EZG0807.
Curr Microbiol. 2012 Feb 21. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22350001

28
MacKay JL, Keung AJ, Kumar S.
A genetic strategy for the dynamic and graded control of cell mechanics, motility, and matrix remodeling.
Biophys J. 2012 Feb 8;102(3):434-42. Epub 2012 Feb 7.
http://www.ncbi.nlm.nih.gov/pubmed/22325265
NOTE: This article may be obtained online without charge.

29
Judokusumo E, Tabdanov E, Kumari S, Dustin ML, Kam LC.
Mechanosensing in T lymphocyte activation.
Biophys J. 2012 Jan 18;102(2):L5-7.
http://www.ncbi.nlm.nih.gov/pubmed/22339876

30
Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX.
Mechanical stress-activated integrin 51 induces opening of connexin 43 hemichannels.
Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3359-64. Epub 2012 Feb 13.
http://www.ncbi.nlm.nih.gov/pubmed/22331870

31
Turlo KA, Noel OD, Vora R, LaRussa M, Hall-Glenn F, Iruela-Arispe ML.
An essential requirement for 1 integrin in the assembly of extracellular matrix proteins within the vascular wall.
Dev Biol. 2012 Feb 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22331032

32
Jiang J, Su M, Wang L, Jiao C, Sun Z, Cheng W, Li F, Wang C.
Exogenous hydrogen peroxide reversibly inhibits root gravitropism and induces horizontal curvature of primary root during grass pea germination.
Plant Physiol Biochem. 2012 Feb 1;53C:84-93. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22342943