NASA Spaceline Current Awareness 19 April 2013 (Recent Space Life Science Research Results)

Next list: May 10, 2013

Papers deriving from NASA support:
1
Vignaux G, Besnard S, Ndong J, Philoxene B, Denise P, Elefteriou F.
Bone remodeling is regulated by inner ear vestibular signals.
J Bone Miner Res. 2013 Apr 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23553797
(PIs: F. Elefteriou; G. Vignaux, NSBRI Postdoctoral Fellowship Program)

2
Sibonga JD.
Spaceflight-induced bone loss: Is there an osteoporosis risk?
Curr Osteoporos Rep. 2013 Apr 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23564190
(PI: J.D. Sibonga)
NOTE: As with most Springer journals, the first two pages of the article may be obtained online without charge.

3
Lee PH, Vandenburgh H.
Skeletal muscle atrophy in bioengineered skeletal muscle: A new model system.
Tissue Eng Part A. 2013 Apr 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23574457
(PI: H. Vandenburgh)

4
Lu W, Sapozhnikov OA, Bailey MR, Kaczkowski PJ, Crum LA.
Evidence for trapped surface bubbles as the cause for the twinkling artifact in ultrasound imaging.
Ultrasound Med Biol. 2013 Apr 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23562014
(PI: L.A. Crum)

5
Hunt CR, Ramnarain D, Horikoshi N, Iyengar P, Pandita RK, Shay JW, Pandita TK.
Histone modifications and DNA double-strand break repair after exposure to ionizing radiations.
Radiat Res. 2013 Apr;179(4):383-92. Epub 2013 Feb 1.
http://www.ncbi.nlm.nih.gov/pubmed/23373901
(PIs: J.W. Shay; J.D. Minna/J.W. Shay/NSCOR; A.J. Fornace/J.W. Shay/NSCOR)
NOTE: This article is featured on the cover of the journal: http://www.bioone.org/toc/rare/179/4

6
Loucas BD, Cornforth MN.
The LET dependence of unrepaired chromosome damage in human cells: A Break Too Far?
Radiat Res. 2013 Apr;179(4):393-405.
http://www.ncbi.nlm.nih.gov/pubmed/23578187
(PIs: M.N. Cornforth; S.M. Bailey)

7
Gonon G, Groetz JE, de Toledo SM, Howell RW, Fromm M, Azzam EI.
Nontargeted stressful effects in normal human fibroblast cultures exposed to low fluences of high charge, high energy (HZE) particles: Kinetics of biologic responses and significance of secondary radiations.
Radiat Res. 2013 Apr;179(4):444-57. Epub 2013 Mar 6.
http://www.ncbi.nlm.nih.gov/pubmed/23465079
(PI: E.I. Azzam)

8
Villasana L, Dayger C, Raber J.
Dose- and apoE isoform-dependent cognitive injury after cranial (56)Fe irradiation in female mice.
Radiat Res. 2013 Apr;179(4):493-500. Epub 2013 Mar 15.
http://www.ncbi.nlm.nih.gov/pubmed/23496055
(PIs: J. Raber; G.A. Nelson/J. Raber/NSCOR)

9
Datta K, Suman S, Kallakury BV, Fornace AJ Jr.
Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater -catenin activation than radiation in APC(Min/+) mice.
PLoS One. 2013;8(3):e59295. Epub 2013 Mar 21.
http://www.ncbi.nlm.nih.gov/pubmed/23555653
(PIs: A.J. Fornace; A.J. Fornace/K. Datta/NSCOR)
NOTE: This article may be obtained online without charge.

10
Rithidech KN, Udomtanakunchai C, Honikel L, Whorton E.
Lack of genomic instability in bone marrow cells of SCID mice exposed whole-body to low-dose radiation.
Int J Environ Res Public Health. 2013 Apr 2;10(4):1356-77.
http://www.ncbi.nlm.nih.gov/pubmed/23549227
(PI: K.N. Rithidech)
NOTE: This article may be obtained online without charge.

11
Ray FA, Zimmerman E, Robinson B, Cornforth MN, Bedford JS, Goodwin EH, Bailey SM.
Directional genomic hybridization for chromosomal inversion discovery and detection.
Chromosome Res. 2013 Apr;21(2):165-74. Epub 2013 Apr 10.
http://www.ncbi.nlm.nih.gov/pubmed/23572395
(PI: E.H. Goodwin)
NOTE: This article may be obtained online without charge.

12
Mender I, Senturk S, Ozgunes N, Akcali KC, Kletsas D, Gryaznov S, Can A, Shay JW, Dikmen ZG.
Imetelstat (a telomerase antagonist) exerts off target effects on the cytoskeleton.
Int J Oncol. 2013 May;42(5):1709-15. Epub 2013 Mar 27.
http://www.ncbi.nlm.nih.gov/pubmed/23545855
(PIs: J.W. Shay; J.D. Minna/J.W. Shay/NSCOR; A.J. Fornace/J.W. Shay/NSCOR)

13
DeCarolis NA, Mechanic M, Petrik D, Carlton A, Ables JL, Malhotra S, Bachoo R, Goetz M, Lagace DC, Eisch AJ.
In vivo contribution of nestin- and GLAST-lineage cells to adult hippocampal neurogenesis.
Hippocampus. 2013 Apr 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23554226
(PIs: A.J. Eisch; B.P. Chen)

14
Rabin BM, Carrihill-Knoll KL, Long LV, Pitts SC, Shukitt-Hale B.
Effects of 17-estradiol on cognitive performance of ovariectomized female rats exposed to space radiation.
J Behav Brain Sci. 2013 Feb;3(1):67-73.
http://www.scirp.org/journal/jbbs/
(PI: B.M. Rabin)
NOTE: This article may be obtained online without charge: http://dx.doi.org/10.4236/jbbs.2013.31007

15
Buytaert KI, MacDougall HG, Moore ST, Clement G, Pattyn N, Migeotte PF, Wuyts FL.
Validation of centrifugation as a countermeasure for otolith deconditioning during spaceflight: Preliminary data of the ESA SPIN study.
J Vestib Res. 2013 Jan 1;23(1):23-31.
http://www.ncbi.nlm.nih.gov/pubmed/23549052
(PI: S.T. Moore)
NOTE: ISS cosmonauts were tested before and after their stay on ISS.

16
Clement G, Wood SJ.
Eye movements and motion perception during off-vertical axis rotation after spaceflight.
J Vestib Res. 2013 Jan 1;23(1):13-22.
http://www.ncbi.nlm.nih.gov/pubmed/23549051
(PI: S.J. Wood)
NOTE: Astronauts were tested before and after Shuttle flights.

17
Mulavara AP, Cohen HS, Peters BT, Sangi-Haghpeykar H, Bloomberg JJ.
New analyses of the sensory organization test compared to the clinical test of sensory integration and balance in patients with benign paroxysmal positional vertigo.
Laryngoscope. 2013 Apr 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23553110
(PI: A.P. Mulavara)

Other papers of interest:

1
Becker JL, Souza GR.
Using space-based investigations to inform cancer research on Earth.
Nat Rev Cancer. 2013 Apr 12. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23584334
NOTE: This review, which will be featured on the cover of an upcoming issue, is receiving some press coverage, e.g.,: http://www.medicaldaily.com/articles/14637/20130412/cancer-research-spac…
The figures are available online:
http://www.nature.com/nrc/journal/vaop/ncurrent/fig_tab/nrc3507_ft.html
http://www.nature.com/nrc/journal/vaop/ncurrent/box/nrc3507_BX1.html
http://www.nature.com/nrc/journal/vaop/ncurrent/box/nrc3507_BX2.html

2
Wehland M, Ma X, Braun M, Hauslage J, Hemmersbach R, Bauer J, Grosse J, Infanger M, Grimm D.
The impact of altered gravity and vibration on endothelial cells during a parabolic flight.
Cell Physiol Biochem. 2013;31(2-3):432-51. Epub 2013 Mar 15.
http://www.ncbi.nlm.nih.gov/pubmed/23548630
NOTE: Parabolic flight results; centrifugation and vibration also. This article may be obtained online without charge.

3
Tanaka K, Nishimura N, Sato M, Kanikowska D, Shimizu Y, Inukai Y, Abe C, Iwata C, Morita H, Iwase S, Sugenoya J.
Arterial pressure oscillation and muscle sympathetic nerve activity after 20 days of head-down bed rest.
Auton Neurosci. 2013 Mar 29. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23541435
NOTE: Bed rest study.

4
Schwartz CE, Medow MS, Messer ZR, Stewart JM.
Spontaneous fluctuation indices of the cardiovagal baroreflex accurately measure the baroreflex sensitivity at the operating point during upright tilt.
Am J Physiol Regul Integr Comp Physiol. 2013 Apr 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23576616

5
Protheroe CL, Ravensbergen HR, Inskip JA, Claydon VE.
Tilt testing with combined lower body negative pressure: A “gold standard” for measuring orthostatic tolerance.
J Vis Exp. 2013 Mar 21;(73):e4315.
http://www.ncbi.nlm.nih.gov/pubmed/23542558

6
Faes L, Porta A, Rossato G, Adami A, Tonon D, Corica A, Nollo G.
Investigating the mechanisms of cardiovascular and cerebrovascular regulation in orthostatic syncope through an information decomposition strategy.
Auton Neurosci. 2013 Mar 27. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23541295

7
Faes L, Nollo G, Porta A.
Mechanisms of causal interaction between short-term RR interval and systolic arterial pressure oscillations during orthostatic challenge.
J Appl Physiol. 2013 Apr 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23580598

8
Ocon AJ.
Caught in the thickness of brain fog: Exploring the cognitive symptoms of Chronic Fatigue Syndrome.
Front Physiol. 2013;4:63. Epub 2013 Apr 5.
http://www.ncbi.nlm.nih.gov/pubmed/23576989
NOTE: This article may be obtained online without charge.

9
Lavery WJ, Kiel JW.
Effects of head down tilt on episcleral venous pressure in a rabbit model.
Exp Eye Res. 2013 Apr 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23567205

10
Feuerecker M, Mayer W, Kaufmann I, Gruber M, Muckenthaler F, Yi B, Salam AP, Briegel J, Schelling G, Thiel M, Chouker A.
A corticoid-sensitive cytokine release assay for monitoring stress-mediated immune modulation.
Clin Exp Immunol. 2013 May;172(2):290-9.
http://www.ncbi.nlm.nih.gov/pubmed/23574325
NOTE: Includes parabolic flight results.

11
Chouker A, Feuerecker B, Matzel S, Kaufmann I, Strewe C, Hoerl M, Schelling G, Feuerecker M.
Psychoneuroendocrine alterations during 5 days of head-down tilt bed rest and artificial gravity interventions.
Eur J Appl Physiol. 2013 Apr 12. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23579361
NOTE: Bed rest study; also centrifugation with short-arm centrifuge.

12
Fuld MK, Halaweish AF, Newell JD Jr, Krauss B, Hoffman EA.
Optimization of dual-energy xenon-computed tomography for quantitative assessment of regional pulmonary ventilation.
Invest Radiol. 2013 Apr 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23571834

13
Blatteau JE, Brubakk AO, Gempp E, Castagna O, Risso JJ, Vallee N.
Sidenafil pre-treatment promotes decompression sickness in rats.
PLoS One. 2013 Apr 8;8(4):e60639.
http://www.ncbi.nlm.nih.gov/pubmed/23580342
NOTE: No Viagra before EVAs. This article may be obtained online without charge.

14
Chung DJ, Szyszka B, Brown JC, Huener NP, Staples JF.
Changes in the mitochondrial phosphoproteome during mammalian hibernation.
Physiol Genomics. 2013 Apr 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23572536

15
Otto C, Shemenski R, Scott JM, Hartshorn J, Bishop S, Viegas S.
Evaluation of tele-ultrasound as a tool in remote diagnosis and clinical management at the Amundsen-Scott South Pole Station and the McMurdo Research Station.
Telemed J E Health. 2013 Mar;19(3):186-91.
http://www.ncbi.nlm.nih.gov/pubmed/23480714

16
Kramer A, Gollhofer A, Ritzmann R.
Acute exposure to microgravity does not influence the H-reflex with or without whole body vibration and does not cause vibration-specific changes in muscular activity.
J Electromyogr Kinesiol. 2013 Mar 27. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23541330
NOTE: Parabolic flight results.

17
Belav DL, Gast U, Daumer M, Fomina E, Rawer R, Schiessl H, Schneider S, Schubert H, Soaz C, Felsenberg D.
Progressive adaptation in physical activity and neuromuscular performance during 520d confinement.
PLoS One. 2013;8(3):e60090. Epub 2013 Mar 28.
http://www.ncbi.nlm.nih.gov/pubmed/23555896
NOTE: Mars500 study. This article may be obtained online without charge.

18
Wall BT, van Loon LJ.
Nutritional strategies to attenuate muscle disuse atrophy.
Nutr Rev. 2013 Apr;71(4):195-208. Epub 2013 Feb 28.
http://www.ncbi.nlm.nih.gov/pubmed/23550781
NOTE: This article may be obtained online without charge.

19
Stolzenberg N, Belav DL, Rawer R, Felsenberg D.
Vibration or balance training on neuromuscular performance in osteopenic women.
Int J Sports Med. 2013 Apr 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23549694

20
Hirose T, Shiozaki T, Shimizu K, Mouri T, Noguchi K, Ohnishi M, Shimazu T.
The effect of electrical muscle stimulation on the prevention of disuse muscle atrophy in patients with consciousness disturbance in the intensive care unit.
J Crit Care. 2013 Apr 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23561945

21
Shenkman BS.
[Recovery of the atrophied muscle: From protein degradation to synthesis]
Ross Fiziol Zh Im I M Sechenova. 2012 Dec;98(12):1471-89. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/23461193

22
Reilly BD, Schlipalius D, Cramp RL, Ebert P, Franklin CE.
Frogs and aestivation: Transcriptional insights into metabolism and cell survival in a natural model of extended muscle disuse.
Physiol Genomics. 2013 Apr 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23548685

23
Pasqualini M, Lavet C, Elbadaoui M, Vanden Bossche A, Laroche N, Gnyubkin V, Vico L.
Skeletal site-specific effects of whole body vibration in mature rats: From deleterious to beneficial frequency-dependent effects.
Bone. 2013 Mar 29. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23545229

24
McBride SH, Silva MJ.
Adaptive and injury response of bone to mechanical loading.
Bonekey Osteovision. 2012 Oct 10;1:192.
http://www.ncbi.nlm.nih.gov/pubmed/23505338
NOTE: This article may be obtained online without charge via PubMed Central.

25
Oezcivici E.
Effects of spaceflight on cells of bone marrow origin.
Turk J Hematol. 2013 Mar;30(1):1-7.
http://www.tjh.com.tr/jvi.aspx
NOTE: Review of space flight results. This article may be obtained online without charge: http://dx.doi.org/10.4274/tjh.2012.0127

26
Zhao L, Dodge T, Nemani A, Yokota H.
Resonance in the mouse tibia as a predictor of frequencies and locations of loading-induced bone formation.
Biomech Model Mechanobiol. 2013 Apr 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23575747

27
Rendina E, Hembree KD, Davis MR, Marlow D, Clarke SL, Halloran BP, Lucas EA, Smith BJ.
Dried plum’s unique capacity to reverse bone loss and alter bone metabolism in postmenopausal osteoporosis model.
PLoS One. 2013;8(3):e60569. Epub 2013 Mar 29.
http://www.ncbi.nlm.nih.gov/pubmed/23555991
NOTE: This article may be obtained online without charge.

28
Mitsuhara T, Takeda M, Yamaguchi S, Manabe T, Matsumoto M, Kawahara Y, Yuge L, Kurisu K.
Simulated microgravity facilitates cell migration and neuroprotection after bone marrow stromal cell transplantation in spinal cord injury.
Stem Cell Res Ther. 2013 Apr 1;4:35. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23548163
NOTE: This article may be obtained online without charge.

29
Wang N, Wang H, Chen J, Zhang X, Xie J, Li Z, Ma J, Wang W, Wang Z.
The simulated microgravity enhances multipotential differentiation capacity of bone marrow mesenchymal stem cells.
Cytotechnology. 2013 Apr 12. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23579245
NOTE: Used rotating high aspect ratio vessels to simulate microgravity.

30
Chen J, Zhang C, Feng Y, Zong C, Chen J, Tang Z, Jia B, Tong X, Zheng Q, Wang J.
Studies on culture and osteogenic induction of human mesenchymal stem cells under CO(2)-independent conditions.
Astrobiology. 2013 Apr 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23577816

31
Qian AR, Gao X, Zhang W, Li JB, Wang Y, Di SM, Hu LF, Shang P.
Large gradient high magnetic fields affect osteoblast ultrastructure and function by disrupting collagen I or fibronectin/1 integrin.
PLoS One. 2013;8(1):e51036. Epub 2013 Jan 29.
http://www.ncbi.nlm.nih.gov/pubmed/23382804
NOTE: This article may be obtained online without charge.

32
Louw TM, Budhiraja G, Viljoen HJ, Subramanian A.
Mechanotransduction of ultrasound is frequency dependent below the cavitation threshold.
Ultrasound Med Biol. 2013 Apr 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23562015

33
Badavi FF.
Exposure estimates for repair satellites at geosynchronous orbit.
Acta Astronaut. 2013 Feb-Mar;83:18-26.
http://dx.doi.org/10.1016/j.actaastro.2012.09.021
NOTE: Includes radiation exposure prediction for a large structure, represented by the ISS.

34
Monzen S, Yoshino H, Kasai-Eguchi K, Kashiwakura I.
Characteristics of myeloid differentiation and maturation pathway derived from human hematopoietic stem cells exposed to different linear energy transfer radiation types.
PLoS One. 2013;8(3):e59385. Epub 2013 Mar 12.
http://www.ncbi.nlm.nih.gov/pubmed/23555027
NOTE: This article may be obtained online without charge.

35
Lorimore SA, Rastogi S, Mukherjee D, Coates PJ, Wright EG.
The influence of p53 functions on radiation-induced inflammatory bystander-type signaling in murine bone marrow.
Radiat Res. 2013 Apr;179(4):406-15.
http://www.ncbi.nlm.nih.gov/pubmed/23578188

36
Singh SK, Bencsik-Theilen A, Mladenov E, Jakob B, Taucher-Scholz G, Iliakis G.
Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions.
Radiat Oncol. 2013 Apr 2;8:77.
http://www.ncbi.nlm.nih.gov/pubmed/23547740
NOTE: This article may be obtained online without charge.

37
Ma Y, Wang Z, Zhu M, Yu C, Cao Y, Zhang D, Zhou G.
Increased lipid productivity and TAG content in Nannochloropsis by heavy-ion irradiation mutagenesis.
Bioresour Technol. 2013 Mar 14;136C:360-7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23567703

38
Tomilovskaya ES, Berger M, Gerstenbrand F, Kozlovskaya IB.
Effects of long-duration space flights on characteristics of the vertical gaze fixation reaction.
J Vestib Res. 2013 Jan 1;23(1):3-12.
http://www.ncbi.nlm.nih.gov/pubmed/23549050
NOTE: Mir results.

39
Dakin CJ, Inglis JT, Chua R, Blouin JS.
Muscle-specific modulation of vestibular reflexes with increased locomotor velocity and cadence.
J Neurophysiol. 2013 Apr 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23576695

40
Zhang E, Luo J, Zhang J, Wang Y, Zhong J, Li Q.
Neural mechanisms of shifts of spatial attention induced by object words with spatial associations: An ERP study.
Exp Brain Res. 2013 Apr 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23575954

41
Pittman-Polletta BR, Scheer FA, Butler MP, Shea SA, Hu K.
The role of the circadian system in fractal neurophysiological control.
Biol Rev Camb Philos Soc. 2013 Apr 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23573942

42
Verbruggen SW, Vaughan TJ, McNamara LM.
Fluid flow in the osteocyte mechanical environment: A fluid-structure interaction approach.
Biomech Model Mechanobiol. 2013 Apr 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23567965

43
Kuo JC.
Mechanotransduction at focal adhesions: Integrating cytoskeletal mechanics in migrating cells.
J Cell Mol Med. 2013 Apr 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23551528
NOTE: This article may be obtained online without charge.

44
Twiss F, de Rooij J.
Cadherin mechanotransduction in tissue remodeling.
Cell Mol Life Sci. 2013 Apr 7. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23563964

45
Landrein B, Hamant O.
How mechanical stress controls microtubule behavior and morphogenesis in plants: History, experiments and revisited theories.
Plant J. 2013 Mar 28. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23551516

46
Liu Y, Lai N, Gao K, Chen F, Yuan L, Mi G.
Ammonium inhibits primary root growth by reducing the length of meristem and elongation zone and decreasing elemental expansion rate in the root apex in Arabidopsis thaliana.
PLoS One. 2013;8(4):e61031. Epub 2013 Apr 8.
http://www.ncbi.nlm.nih.gov/pubmed/23577185
NOTE: This article may be obtained online without charge.

47
Nag S, Katz JG, Saenz-Otero A.
Collaborative gaming and competition for CS-STEM education using SPHERES Zero Robotics.
Acta Astronaut. 2013 Feb-Mar;83:145-74.
http://dx.doi.org/10.1016/j.actaastro.2012.09.006
NOTE: Game used autonomous nanosatellites (SPHERES) that are on ISS.