NASA Spaceline Current Awareness 17 August 2012 (Recent Space Life Science Research Results)

Next list: August 31, 2012

Papers deriving from NASA support:

1 James JT, Zalesak SM.
Prediction of crew health effects from air samples taken aboard the International Space Station.
Aviat Space Environ Med. 2012 Aug;83(8):795-9.
http://www.ncbi.nlm.nih.gov/pubmed/22872995
NOTE: ISS results.

2 Soller BR, Zou F, Ryan KL, Rickards CA, Ward K, Convertino VA.
Lightweight noninvasive trauma monitor for early indication of central hypovolemia and tissue acidosis: A review.
J Trauma Acute Care Surg. 2012 Aug;73(2 Suppl 1):S106-11.
http://www.ncbi.nlm.nih.gov/pubmed/22847078
(PI: B.R. Soller)

3 Somers JT, Granderson B, Melvin JW, Tabiei A, Lawrence C, Feiveson A, Gernhardt M, Ploutz-Snyder R, Patalak J.
Development of head injury assessment reference values based on NASA injury modeling.
Stapp Car Crash J. 2011 Nov;55:49-74.
http://www.ncbi.nlm.nih.gov/pubmed/22869304
(PI: M. Gernhardt)

4 Von Ohlen T, Luce-Fedrow A, Ortega MT, Ganta RR, Chapes SK.
Identification of critical host mitochondrial-associated genes during Ehrlichia chaffeensis infections.
Infect Immun. 2012 Jul 30. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22851751
(PI: S.K. Chapes)

5 Yokota H, Tovar A, Robling A.
Dynamic muscle loading and mechanotransduction.
Bone. 2012 Jul 28. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22864148
NOTE: This is a commentary on a paper by Hu, Cheng, and Qin (PI=Qin, http://www.ncbi.nlm.nih.gov/pubmed/22820398 ) that appeared in the previous Current Awareness list. The commentary states that the authors “present a novel, unconventional technique for applying mechanical loading to bone, with the goal of enhancing bone formation and/or preventing bone loss.”

6 Chylack LT Jr, Feiveson AH, Peterson LE, Tung WH, Wear ML, Marak LJ, Hardy DS, Chappell LJ, Cucinotta FA.
NASCA Report 2: Longitudinal study of relationship of exposure to space radiation and risk of lens opacity.
Radiat Res. 2012 Jul;178(1):25-32. Epub 2012 Jun 12.
http://www.ncbi.nlm.nih.gov/pubmed/22687051
(PI: L.T. Chylack Jr)

7 Girdhani S, Lamont C, Hahnfeldt P, Abdollahi A, Hlatky L.
Proton irradiation suppresses angiogenic genes and impairs cell invasion and tumor growth.
Radiat Res. 2012 Jul;178(1):33-45. Epub 2012 Jun 14.
http://www.ncbi.nlm.nih.gov/pubmed/22702646
(PI: L. Hlatky/P. Hahnfeldt/A. Abdollahi/NSCOR)

8 Gridley DS, Rizvi A, Makinde AY, Luo-Owen X, Mao XW, Tian J, Slater JM, Pecaut MJ.
Space-relevant radiation modifies cytokine profiles, signaling proteins and Foxp3(+) T cells.
Int J Radiat Biol. 2012 Aug 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22852758
(PI: D.S. Gridley)

9 Zhou Z, Ware JH, Kennedy AR.
Carbon and iron ion radiation-induced cytotoxicity and transformation in vitro.
Oncol Lett. 2011 Sep-Oct;2(5):915-8. Epub 2011 Jul 5.
http://www.ncbi.nlm.nih.gov/pubmed/22866150
(PI: A.R. Kennedy)
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site: http://www.spandidos-publications.com/ol/2/5/915

10 Morris CJ, Yang JN, Scheer FA.
The impact of the circadian timing system on cardiovascular and metabolic function.
Prog Brain Res. 2012;199:337-58.
http://www.ncbi.nlm.nih.gov/pubmed/22877674
(PI: C.J. Morris/ NSBRI Postdoctoral Fellowship Program)
NOTE: This article and the following article are in a volume titled: “The Neurobiology of Circadian Timing”: http://www.sciencedirect.com/science/bookseries/00796123

11 Spaeth AM, Goel N, Dinges DF.
Managing neurobehavioral capability when social expediency trumps biological imperatives.
Prog Brain Res. 2012;199:377-98.
http://www.ncbi.nlm.nih.gov/pubmed/22877676
(PI: D.F. Dinges)

12 Anderson C, Sullivan JP, Flynn-Evans EE, Cade BE, Czeisler CA, Lockley SW.
Deterioration of neurobehavioral performance in resident physicians during repeated exposure to extended duration work shifts.
Sleep. 2012 Aug 1;35(8):1137-46.
http://www.ncbi.nlm.nih.gov/pubmed/22851809
(PIs: C.A. Czeisler, S.W. Lockley)

13 Tannenbaum SI, Cerasoli CP.
Do team and individual debriefs enhance performance? A meta-analysis.
Hum Factors. 2012 Jun 4. [Epub ahead of print]
http://dx.doi.org/10.1177/0018720812448394
(PI: S.I. Tannenbaum)

14 Iscla I, Blount P.
Sensing and responding to membrane tension: The bacterial MscL channel as a model system.
Biophys J. 2012 Jul 18;103(2):169-74. Epub 2012 Jul 17.
http://www.ncbi.nlm.nih.gov/pubmed/22853893
(PI: P. Blount)

Other papers of interest:

1 Bai Y, Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, Jin M, Cai W, Jin HL, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato M, Iwatsubo K, Ishikawa Y, Okumura S.
Pharmacological stimulation of type 5 adenylyl cyclase stabilizes heart rate under both microgravity and hypergravity induced by parabolic flight.
J Pharmacol Sci. 2012 Jul 31. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22850613
NOTE: Parabolic flight results. This article may be obtained online without charge: https://www.jstage.jst.go.jp/article/jphs/advpub/0/advpub_12102FP/_article

2 Geinas JC, Marsden KR, Tzeng YC, Smirl JD, Smith KJ, Willie CK, Lewis NC, Binsted G, Bailey DM, Bakker A, Day TA, Ainslie PN.
Influence of posture on the regulation of cerebral perfusion.
Aviat Space Environ Med. 2012 Aug;83(8):751-7.
http://www.ncbi.nlm.nih.gov/pubmed/22872988

3 Wu B, Xue Y, Wu P, Gu Z, Wang Y, Jing X.
Physiological responses of astronaut candidates to simulated +Gx orbital emergency re-entry.
Aviat Space Environ Med. 2012 Aug;83(8):758-63.
http://www.ncbi.nlm.nih.gov/pubmed/22872989

4 Matsuo T, Ohkawara K, Seino S, Shimojo N, Yamada S, Ohshima H, Tanaka K, Mukai C.
An exercise protocol designed to control energy expenditure for long-term space missions.
Aviat Space Environ Med. 2012 Aug;83(8):783-9.
http://www.ncbi.nlm.nih.gov/pubmed/22872993

5 Kobayashi A, Kikukawa A, Kimura M, Inui T, Miyamoto Y.
Cerebral near-infrared spectroscopy to evaluate anti-G straining maneuvers in centrifuge training.
Aviat Space Environ Med. 2012 Aug;83(8):790-4.
http://www.ncbi.nlm.nih.gov/pubmed/22872994

6 Shoemaker JK, Wong SW, Cechetto DF.
Cortical circuitry associated with reflex cardiovascular control in humans: Does the cortical autonomic network “speak” or “listen” during cardiovascular arousal.
Anat Rec (Hoboken). 2012 Sep;295(9):1375-84. Epub 2012 Jul 31.
http://www.ncbi.nlm.nih.gov/pubmed/22848047

7 Tuboly G, Rudas L, Csillik A, Nagy A, Benedek K, Benedek G, Braunitzer G.
Haemodynamic parameters and cognitive function during modeled acute volume loss.
Acta Physiol Hung. 2012 Jun;99(2):118-25.
http://www.ncbi.nlm.nih.gov/pubmed/22849835

8 Hosokawa K, Ide T, Tobushi T, Sakamoto K, Onitsuka K, Sakamoto T, Fujino T, Saku K, Sunagawa K.
Bionic baroreceptor corrects postural hypotension in rats with impaired baroreceptor.
Circulation. 2012 Jul 31. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22851542

9 Willeford B.
Orthostatic hypotension in the anesthetized rabbit in the sitting position exceeds cerebral autoregulation.
J Basic Clin Physiol Pharmacol. 2012 Mar;23(1):11-5.
http://www.ncbi.nlm.nih.gov/pubmed/22865437

10 Cvirn G, Schlagenhauf A, Leschnik B, Koestenberger M, Roessler A, Jantscher A, Vrecko K, Juergens G, Hinghofer-Szalkay H, Goswami N.
Coagulation changes during presyncope and recovery.
PLoS One. 2012;7(8):e42221. Epub 2012 Aug 2.
http://www.ncbi.nlm.nih.gov/pubmed/22876309
NOTE: This article may be obtained online without charge.

11 Chinkin AS.
[Mechanisms of self-regulation of myocardial contractile function during hypokinesia and muscle training]
Usp Fiziol Nauk. 2012 Apr-Jun;43(2):72-82. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/22690592

12 Schnidrig S, Casaulta C, Schibler A, Riedel T.
Influence of end-expiratory level and tidal volume on gravitational ventilation distribution during tidal breathing in healthy adults.
Eur J Appl Physiol. 2012 Aug 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22872368

13 Brocca L, Cannavino J, Coletto L, Biolo G, Sandri M, Bottinelli R, Pellegrino MA.
The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms.
J Physiol. 2012 Aug 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22848045
NOTE: Two bed rest studies.

14 Jackman RW, Cornwell EW, Wu CL, Kandarian SC.
NF-kappaB signaling pathway and transcriptional regulation in skeletal muscle atrophy.
Exp Physiol. 2012 Jul 30. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22848079

15 Kaux JF, Drion P, Libertiaux V, Colige A, Hoffmann A, Nusgens B, Besancon B, Forthomme B, Le Goff C, Franzen R, Defraigne JO, Cescotto S, Rickert M, Crielaard JM, Croisier JL.
Eccentric training improves tendon biomechanical properties: A rat model.
J Orthop Res. 2012 Jul 30. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22847600

16 Elmer SJ, Danvind J, Holmberg HC.
Development of a novel eccentric arm cycle ergometer for training the upper body.
Med Sci Sports Exerc. 2012 Jul 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22843110

17 Elliott B, Renshaw D, Getting S, Mackenzie R.
The central role of myostatin in skeletal muscle and whole body homeostasis.
Acta Physiol (Oxf). 2012 Jul;205(3):324-40. Epub 2012 Feb 17.
http://www.ncbi.nlm.nih.gov/pubmed/22340904
NOTE: This article may be obtained online without charge.

18 Oganov VS, Grigor’ev AI.
[Mechanisms of human osteopenia and some peculiarities of bone metabolism in weightlessness conditions]
Ross Fiziol Zh Im I M Sechenova. 2012 Mar;98(3):395-409. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/22645949
NOTE: Mir, ISS results.

19 Prodanov L, van Loon J, te Riet J, Jansen J, Walboomers XF.
Substrate nano-texture and hypergravity through centrifugation enhance initial osteoblastogenesis.
Tissue Eng Part A. 2012 Aug 8. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22871341

20 Armas LA, Recker RR.
Pathophysiology of osteoporosis: New mechanistic insights.
Endocrinol Metab Clin North Am. 2012 Sep;41(3):475-86. Epub 2012 Jun 9.
http://www.ncbi.nlm.nih.gov/pubmed/22877425

21 Ahles CP, Singh H, Joo W, Lee Y, Lee LC, Colazas W, Pierce RA, Prakash A, Jaque SV, Sumida KD.
High volumes of resistance exercise are not required for greater BMD during growth.
Med Sci Sports Exerc. 2012 Jul 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22843104

22 Dodge T, Wanis M, Ayoub R, Zhao L, Watts NB, Bhattacharya A, Akkus O, Robling A, Yokota H.
Mechanical loading, damping, and load-driven bone formation in mouse tibiae.
Bone. 2012 Jul 30. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22878153

23 Goldring MB.
Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis.
Ther Adv Musculoskelet Dis. 2012 Aug;4(4):269-85.
http://www.ncbi.nlm.nih.gov/pubmed/22859926
NOTE: This article may be obtained online without charge via PubMed Central.

24 Shuryak I, Brenner DJ.
Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death.
Radiat Res. 2012 Jul;178(1):17-24. Epub 2012 Jun 4.
http://www.ncbi.nlm.nih.gov/pubmed/22663149

25 Irons SL, Serra V, Bowler D, Chapman K, Militi S, Lyng F, Kadhim M.
The effect of genetic background and dose on non-targeted effects of radiation.
Int J Radiat Biol. 2012 Aug 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22853854

26 Pinho C, Wong R, Sur RK, Hayward JE, Farrell TJ, Seymour C, Mothersill C.
The involvement of serum serotonin levels producing radiation-induced bystander effects for an in vivo assay with fractionated high dose-rate (HDR) brachytherapy.
Int J Radiat Biol. 2012 Aug 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22849323

27 Goetz JG.
Tumor microenvironment indoctrination: An emerging hallmark of cancer.
Cell Adh Migr. 2012 May-Jun;6(3);190-2.
http://www.ncbi.nlm.nih.gov/pubmed/22863738
NOTE: This letter introduces a special focus section on this topic: http://www.landesbioscience.com/journals/celladhesion/toc/volume/6/issue/3/

28 Chabeauti PY, Assaiante C, Vaugoyeau M.
Extreme short-term environmental constraints do not update internal models of action as assessed from motor imagery in adults.
Neuroscience. 2012 Oct 11;222:69-74.
http://www.ncbi.nlm.nih.gov/pubmed/22796070
NOTE: Parabolic flight results.

29 Sienko KH, Balkwill MD, Wall C 3rd.
Biofeedback improves postural control recovery from multi-axis discrete perturbations.
J Neuroeng Rehabil. 2012 Aug 3;9:53. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22863399
NOTE: This article may be obtained online without charge.

30 Jiang SF, Gao YF.
[Effects of simulated weightlessness on emotional behaviour in rats]
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 May;28(3):205-8. Chinese.
http://www.ncbi.nlm.nih.gov/pubmed/22860415
NOTE: Translated journal title is Chinese Journal of Applied Physiology.

31 Reynolds AC, Dorrian J, Liu PY, Van Dongen HP, Wittert GA, Harmer LJ, Banks S.
Impact of five nights of sleep restriction on glucose metabolism, leptin and testosterone in young adult men.
PLoS One. 2012;7(7):e41218. Epub 2012 Jul 23.
http://www.ncbi.nlm.nih.gov/pubmed/22844441
NOTE: This article may be obtained online without charge.

32 Rupp TL, Wesensten NJ, Balkin TJ.
Trait-like vulnerability to total and partial sleep loss.
Sleep. 2012 Aug 1;35(8):1163-72.
http://www.ncbi.nlm.nih.gov/pubmed/22851812

33 de Vera JP.
Lichens as survivors in space and on Mars.
Fungal Ecol. 2012 Aug;5(4):472-9.
http://dx.doi.org/10.1016/j.funeco.2012.01.008
NOTE: This article briefly summarizes experiments on two Foton flights and EXPOSE experiments on the International Space Station.

34 Nishi M, Matsumoto R, Dong J, Uemura T.
Engineered bone tissue associated with vascularization utilizing a rotating wall vessel bioreactor.
J Biomed Mater Res A. 2012 Aug 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22865391

35 Nugroho WD, Yamagishi Y, Nakaba S, Fukuhara S, Begum S, Marsoem SN, Ko JH, Jin HO, Funada R.
Gibberellin is required for the formation of tension wood and stem gravitropism in Acacia mangium seedlings.
Ann Bot. 2012 Jul 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22843341

36 Zheng L, Huang Y, Song W, Gong X, Liu M, Jia X, Zhou G, Chen L, Li A, Fan Y.
Fluid shear stress regulates metalloproteinase-1 and 2 in human periodontal ligament cells: Involvement of extracellular signal-regulated kinase (ERK) and P38 signaling pathways.
J Biomech. 2012 Aug 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22863019

37 Knoell R, Marston S.
On mechanosensation, acto/myosin interaction, and hypertrophy.
Trends Cardiovasc Med. 2012 Jul 27. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22841838

38 Kim DH, Khatau SB, Feng Y, Walcott S, Sun SX, Longmore GD, Wirtz D.
Actin cap associated focal adhesions and their distinct role in cellular mechanosensing.
Sci Rep. 2012;2:555. Epub 2012 Aug 3.
http://www.ncbi.nlm.nih.gov/pubmed/22870384
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site: http://www.nature.com/srep/2012/120803/srep00555/full/srep00555.html

39 von Castelmur E, Struempfer J, Franke B, Bogomolovas J, Barbieri S, Qadota H, Konarev PV, Svergun DI, Labeit S, Benian GM, Schulten K, Mayans O.
Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase.
Proc Natl Acad Sci U S A. 2012 Aug 6. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/22869697