Status Report

NASA Spaceline Current Awareness 15 November 2013 (Recent Space Life Science Research Results)

By SpaceRef Editor
November 15, 2013
Filed under , ,

Next list:  December 6, 2013

Papers deriving from NASA support:


Jeong SM, Hwang GS, Kim SO, Levine BD, Zhang R.

Dynamic cerebral autoregulation after bed rest: Effects of volume loading and exercise countermeasures.

J Appl Physiol (1985). 2013 Oct 24. [Epub ahead of print]

(PI: B.D. Levine)

NOTE: Bed rest study.


Marzban C, Illian PR, Morison D, Mourad PD.

A double-gaussian, percentile-based method for estimating maximum blood flow velocity.

J Ultrasound Med. 2013 Nov;32(11):1913-20.

(PI: P.D. Mourad)


Prisk GK, Migeotte PF.

Physiological insights from gravity-free ballistocardiography.

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:7282-5.

(PI: G.K. Prisk)


Kufta JM, Dulchavsky SA.

Medical care in outer space: A useful paradigm for underserved regions on the planet.

(PI: S.A. Dulchavsky)

NOTE: By navigating to the ScienceDirect abstract, you can view a photograph that shows Dr. Scott Dulchavsky being admitted into the Space Technology Hall of Fame, as well as the first page of the article.


Blue RS, Hudson JC, Rieders MF, James JT, Stepaniak PC.

Medical management of a potentially toxic accidental trialkylamine ingestion during spaceflight.

Aviat Space Environ Med. 2013 Oct;84(10):1100-4.

NOTE: Shuttle results.


Bigley AB, Rezvani K, Chew C, Sekine T, Pistillo M, Crucian B, Bollard CM, Simpson RJ.

Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells.

Brain Behav Immun. 2013 Nov 5. [Epub ahead of print]

(PI: R.J. Simpson)


LaVoy EC, Bigley AB, Spielmann G, Rector JL, Morrison MR, O’Connor DP, Simpson RJ.

CMV amplifies T-cell redeployment to acute exercise independently of HSV-1 serostatus.

Med Sci Sports Exerc. 2013 Jul 19. [Epub ahead of print]

(PI: R.J. Simpson)


Cotter JA, Yu A, Kreitenberg A, Haddad FH, Baker MJ, Fox JC, Adams GR.

Suction-modified needle biopsy technique for the human soleus muscle.    

Aviat Space Environ Med. 2013 Oct;84(10):1066-73.

(PI: G.R. Adams)


Dib LH, Ortega MT, Fleming SD, Chapes SK, Melgarejo T.

Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice.

(PI: S.K. Chapes)


Puttlitz C, Gadomski BC, McGilvray K, Easley J, Palmer R, Ehrhart EJ, Haussler K, Browning R, Santoni B.

A translational bone model of simulated microgravity.

J Biomech Eng. 2013 Oct 1. [Epub ahead of print]

(PI: C. Puttlitz)


Tate ML, O’Leary J, McNamara E, Cai L, Knothe UR.

Lithotripsy stimulates new bone formation and mitigates loss of bone due to disuse in aged rats.

Technol Health Care. 2013 Nov 5. [Epub ahead of print]


Cucinotta FA, Kim MH, Chappell LJ, Huff JL.

How safe is safe enough? Radiation risk for a human mission to Mars.

PLoS One. 2013 Oct 16;8(10):e74988.

(PI: F.A. Cucinotta)

NOTE: This article may be obtained online without charge.


Shtifman A, Pezone MJ, Sasi SP, Agarwal A, Gee H, Song J, Perepletchikov A, Yan X, Kishore R, Goukassian DA.

Divergent modification of low-dose (56)Fe-particle and proton radiation on skeletal muscle.

Radiat Res. 2013 Oct 17. [Epub ahead of print]

(PI: D.A. Goukassian)


Grabham P, Sharma P.

The effects of radiation on angiogenesis.

Vasc Cell. 2013 Oct 26;5:19. [Epub ahead of print]

(PI: P. Grabham)

NOTE: This article may be obtained online without charge.


Rankine LJ, Newton J, Bache ST, Das SK, Adamovics J, Kirsch DG, Oldham M.

Investigating end-to-end accuracy of image guided radiation treatment delivery using a micro-irradiator.

Phys Med Biol. 2013 Nov 7;58(21):7791-801. Epub 2013 Oct 17.

(PI: D.G. Kirsch/NSCOR)

NOTE: This article may be obtained online without charge.


Kukreja SL, Wallin R, Boyle RD.

An indirect system identification technique for stable estimation of continuous-time parameters of the vestibulo-ocular reflex (VOR).

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:61-4.


Kim W, Tengra FK, Shong J, Marchand N, Chan HK, Young Z, Pangule RC, Parra M, Dordick JS, Plawsky JL, Collins CH.

Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability.

BMC Microbiol. 2013 Nov 6;13:241. [Epub ahead of print]

(PI: C.H. Collins)

NOTE: STS-135 results. This article may be obtained online without charge.


Yin Y, Damron FH, Withers TR, Pritchett CL, Wang X, Schurr MJ, Yu HD.

Expression of mucoid induction factor MucE is dependent upon the alternate sigma factor AlgU in Pseudomonas aeruginosa.

BMC Microbiol. 2013 Oct 18;13:232. [Epub ahead of print]

(PI: F.H. Damron, NASA Graduate Student Researcher Program)

NOTE: This article may be obtained online without charge.


Chen Y, Aung K, Rolčík J, Walicki K, Friml J, Brandizzi F.

Inter-regulation of the unfolded protein response and auxin signaling.

Plant J. 2013 Nov 4. [Epub ahead of print]

(PI: F. Brandizzi)

Other papers of interest:


Migeotte PF, Deliere Q, Tank J, Funtova I, Baevsky R, Neyt X, Pattyn N.

3D-ballistocardiography in microgravity: Comparison with ground based recordings.

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:7012-6.

NOTE: Parabolic flight results.


Wiard RM, Inan OT, Giovangrandi L, Cuttino CM, Kovacs GT.

Preliminary results from standing ballistocardiography measurements in microgravity.

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:7290-3.

NOTE: Parabolic flight results.


Luchitskaya E, Deliere Q, Diedrich A, Pattyn N, Almorad A, Beck L, Gauger P, Limper U, Funtova I, Baevsky RM, Migeotte PF, Tank J.

Timing and source of the maximum of the transthoracic impedance cardiogram (dZ/dt) in relation to the H-I-J complex of the longitudinal ballistocardiogram under gravity and microgravity conditions.

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:7294-7.

NOTE: Parabolic flight results.


Deliere Q, Migeotte PF, Neyt X, Funtova I, Baevsky RM, Tank J, Pattyn N.

Cardiovascular changes in parabolic flights assessed by ballistocardiography.

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:3801-4.

NOTE: Parabolic flight results.


Alametsa J, Palomaki A, Viik J.

Local ballistocardiographic spectrum studies from signals obtained from limbs and carotid artery with an EMFi sensor induced with a tilt table.

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:7008-11.


Vigo DE, Tuerlinckx F, Ogrinz B, Wan L, Simonelli G, Bersenev E, Van den Bergh O, Aubert AE.

Circadian rhythm of autonomic cardiovascular control during Mars500 simulated mission to Mars.          

Aviat Space Environ Med. 2013 Oct;84(10):1023-8.


de Andrade O, Borghi SM, de Souza HC, Fontes MA, Martins-Pinge MC.

Paraventricular nucleus of hypothalamus participates in the sympathetic modulation and spontaneous fluctuation of baroreflex during head up tilt in unanesthetized rats.

Neurosci Lett. 2013 Oct 28. [Epub ahead of print]


Halliwill JR, Sieck DC, Romero SA, Buck TM, Ely MR.

Blood pressure regulation X: What happens when the muscle pump is lost? Post-exercise hypotension and syncope.

Eur J Appl Physiol. 2013 Nov 7. [Epub ahead of print]


Serravite DH, Edwards D, Edwards ES, Gallo SE, Signorile JF.

Loading and concurrent synchronous whole-body vibration interaction increases oxygen consumption during resistance exercise.

J Sports Sci Med. 2013 Sep 1;12(3):475-80.

NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site:


White CR, Seymour RS.

The role of gravity in the evolution of mammalian blood pressure.


Honda Y, Honda S, Narici M, Szewczyk NJ.

Spaceflight and ageing: Reflecting on Caenorhabditis elegans in space.

NOTE: This article may be obtained online without charge.


Gaydos SJ, Curry IP, Bushby AJ.

Fatigue assessment: Subjective peer-to-peer fatigue scoring.

Aviat Space Environ Med. 2013 Oct;84(10):1105-8.


Lau EM, Bailey DL, Bailey EA, Torzillo PJ, Roach PJ, Schembri GP, Corte TJ, Celermajer DS.

Pulmonary hypertension leads to a loss of gravity dependent redistribution of regional lung perfusion: A SPECT/CT study.


Gattinoni L, Taccone P, Carlesso E, Marini JJ.

Prone position in acute respiratory distress syndrome: Rationale, indications and limits.

Am J Respir Crit Care Med. 2013 Oct 17. [Epub ahead of print]


Stepanek J, Cocco D, Pradhan GN, Smith BE, Bartlett J, Studer M, Kuhn F, Cevette MJ.

Early detection of hypoxia-induced cognitive impairment using the King-Devick test.      

Aviat Space Environ Med. 2013 Oct;84(10):1017-22.


Winklewski PJ, Kot J, Frydrychowski AF, Nuckowska MK, Tkachenko Y.

Effects of diving and oxygen on autonomic nervous system and cerebral blood flow.

Diving Hyperb Med. 2013 Sep;43(3):148-56.


Rose WC.

Computational simulation to understand vision changes during prolonged weightlessness.

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:4094-7.


Durantin G, Gagnon JF, Tremblay S, Dehais F.

Using near infrared spectroscopy and heart rate variability to detect mental overload.

Behav Brain Res. 2013 Oct 31. [Epub ahead of print]


Krogh-Madsen R, Pedersen M, Solomon TP, Knudsen SH, Hansen LS, Karstoft K, Lehrskov-Schmidt L, Pedersen KK, Thomsen C, Holst JJ, Pedersen BK.

Normal physical activity obliterates the deleterious effects of a high-caloric intake.

J Appl Physiol (1985). 2013 Nov 7. [Epub ahead of print]


Stevens L, Bastide B, Hedou J, Cieniewski-Bernard C, Montel V, Cochon L, Dupont E, Mounier Y.

Potential regulation of human muscle plasticity by MLC2 post-translational modifications during bed rest and countermeasures.

Arch Biochem Biophys. 2013 Oct 31. [Epub ahead of print]

NOTE: WISE-2005 bed rest study.


Wall BT, Dirks ML, Snijders T, Senden JM, Dolmans J, van Loon LJ.

Substantial skeletal muscle loss occurs during only 5 days of disuse.

Acta Physiol (Oxf). 2013 Oct 30. [Epub ahead of print]


Essers JM, Meijer K, Murgia A, Bergsma A, Verstegen P.

An inverse dynamic analysis on the influence of upper limb gravity compensation during reaching.

IEEE Int Conf Rehabil Robot. 2013 Jun;2013:1-5.


de Oliveira Nunes Teixeira V, Filippin LI, Viacava PR, de Oliveira PG, Xavier RM.

Muscle wasting in collagen-induced arthritis and disuse atrophy.

Exp Biol Med (Maywood). 2013 Nov 1. [Epub ahead of print]


Mettlach G, Polo-Parada L, Peca L, Rubin CT, Plattner F, Bibb JA.

Enhancement of neuromuscular dynamics and strength behavior using extremely low magnitude mechanical signals in mice.

J Biomech. 2013 Oct 8. [Epub ahead of print]


Powers SK, Smuder AJ, Fuller D, Levine S.

CrossTalk proposal: Mechanical ventilation-induced diaphragm atrophy is primarily due to inactivity.

J Physiol. 2013 Nov 1;591(Pt 21):5255-7.

NOTE: See the citation below. There are also two rebuttals, which may be accessed via the Table of Contents. These articles may be obtained online without charge.


Sieck GC, Mantilla CB.

CrossTalk opposing view: The diaphragm muscle does not atrophy as a result of inactivity.

J Physiol. 2013 Nov 1;591(Pt 21):5259-62.


Wing SS.

Deubiquitinases in skeletal muscle atrophy.

Int J Biochem Cell Biol. 2013 Oct;45(10):2130-5. Epub 2013 May 13.

NOTE: This article is in an issue on the topic “Molecular Basis of Muscle Wasting”; the issue is dedicated to Alfred L. Goldberg. Some of the articles in the issue appeared in previous lists as epubs.


Beasley JM, Shikany JM, Thomson CA.

The role of dietary protein intake in the prevention of sarcopenia of aging.

Nutr Clin Pract. 2013 Oct 25. [Epub ahead of print]


Islamov RR, Lannik NI, Shaimardanova GF, Rezvyakov PN, Tyapkina OV, Rizvanov AA, Chelyshev YA, Kozlovskaya IB, Nikolskii EE.

Effect of hindlimb unloading on myelinated fibers in the mouse lumbar spinal cord.

Dokl Biol Sci. 2013 Sep;452(1):266-8. Epub 2013 Oct 23.

NOTE: This paper is a translation in English of the Russian original published in Doklady Akademii Nauk 2013;452(3):339-41.


Dideriksen K.

Muscle and tendon connective tissue adaptation to unloading, exercise, and NSAID.

Connect Tissue Res. 2013 Nov 6. [Epub ahead of print]


Giannotti S, Bottai V, Dell’osso G, De Paola G, Bugelli G, Pini E, Guido G.

Disuse osteoporosis of the upper limb: Assessment of thirty patients.

Clin Cases Miner Bone Metab. 2013 May-Aug;10(2):129-32.

NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site:


Yamada K, Nishii K, Sakai K, Teranishi T.

Stimulus in the form of rotation and shaking of a platform and its effect on the formation of trabecular bone in the lumbar vertebrae of mice.

Aging Clin Exp Res. 2013 Oct 22. [Epub ahead of print]


Krueger D, Vallarta-Ast N, Libber J, Gangnon R, Binkley N.

Does the precision of dual-energy X-ray absorptiometry for bone mineral density differ by sex?

J Clin Densitom. 2013 Oct 26. [Epub ahead of print]


Buzmakov A, Chukalina M, Nikolaev D, Schaefer G, Gulimova V, Saveliev S, Tereschenko E, Seregin A, Senin R, Prun V, Zolotov D, Asadchikov V.

Computed microtomography and x-ray fluorescence analysis for comprehensive analysis of structural changes in bone.

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:2340-3.


Durante M.

New challenges in high-energy particle radiobiology.

Br J Radiol. 2013 Nov 6. [Epub ahead of print]


Allen AR, Eilertson K, Chakraborti A, Sharma S, Baure J, Habdank-Kolaczkowski J, Allen B, Rosi S, Raber J, Fike JR.

Radiation exposure prior to traumatic brain injury induces responses that differ as a function of animal age.

Int J Radiat Biol. 2013 Oct 29. [Epub ahead of print]


Atri D, Hariharan B, Grießmeier JM.

Galactic cosmic ray-induced radiation dose on terrestrial exoplanets.


Autsavapromporn N, Suzuki M, Funayama T, Usami N, Plante I, Yokota Y, Mutou Y, Ikeda H, Kobayashi K, Kobayashi Y, Uchihori Y, Hei TK, Azzam EI, Murakami T.

Gap junction communication and the propagation of bystander effects induced by microbeam irradiation in human fibroblast cultures: The impact of radiation quality.

Radiat Res. 2013 Oct;180(4):367-75. Epub 2013 Aug 29.


Zhang XH, Lou ZC, Wang AL, Zhang HQ.

Detection of DNA strand breaks in gamma-irradiated lymphocytes using surface plasmon resonance.

Radiat Res. 2013 Oct;180(4):351-9. Epub 2013 Sep 6.


Vogt T, Abeln V, Strüder HK, Schneider S.

Artificial gravity exposure impairs exercise-related neurophysiological benefits.

Physiol Behav. 2014 Jan 17;123:156-61.


Tarnutzer AA, Bertolini G, Bockisch CJ, Straumann D, Marti S.

Modulation of internal estimates of gravity during and after prolonged roll-tilts.

PLoS One. 2013 Oct 10;8(10):e78079.

NOTE: This article may be obtained online without charge.


Gaveau J, Berret B, Demougeot L, Fadiga L, Pozzo T, Papaxanthis C.

Energy-related optimal control accounts for gravitational load: Comparing shoulder, elbow and wrist rotations.

J Neurophysiol. 2013 Oct 16. [Epub ahead of print]


Nishiike S, Okazaki S, Watanabe H, Akizuki H, Imai T, Uno A, Kitahara T, Horii A, Takeda N, Inohara H.

The effect of visual-vestibulosomatosensory conflict induced by virtual reality on postural stability in humans.

J Med Invest. 2013;60(3-4):236-9.

NOTE: This article may be obtained online without charge.


Nesti A, Barnett-Cowan M, Macneilage PR, Bülthoff HH.

Human sensitivity to vertical self-motion.

Exp Brain Res. 2013 Oct 25. [Epub ahead of print]

NOTE: This article may be obtained online without charge.


Smith PF, Darlington CL.

Personality changes in patients with vestibular dysfunction.

Front Hum Neurosci. 2013 Oct 29;7:678.

NOTE: This article may be obtained online without charge.


Winter L, Wollmer MA, Laurens J, Straumann D, Kruger TH.

Cox’s chair revisited: Can spinning alter mood states?

Front Psychiatry. 2013 Oct 15;4:132.

NOTE: This article may be obtained online without charge.


Ferrè ER, Longo MR, Fiori F, Haggard P.

Vestibular modulation of spatial perception.

Front Hum Neurosci. 2013 Oct 10;7:660.

NOTE: This article may be obtained online without charge.


Preuss N, Harris LR, Mast FW.

Allocentric visual cues influence mental transformation of bodies.

J Vis. 2013 Oct 16;13(12):14.

NOTE: This article may be obtained online without charge.


Lejeune L, Casellato C, Pattyn N, Neyt X, Migeotte PF.

Estimating the center of mass of a free-floating body in microgravity.

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:4919-22.

NOTE: Parabolic flight results.


Ranjbaran M, Galiana HL.

Hybrid nonlinear model of the angular vestibulo-ocular reflex.

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:5630-3.


Naqvi SA, Badruddin N, Malik AS, Hazabbah W, Abdullah B.

Does 3D produce more symptoms of visually induced motion sickness?

Conf Proc IEEE Eng Med Biol Soc. 2013 Jul;2013:6405-8.


Tafforin C.

Time effects, cultural influences, and individual differences in crew behavior during the Mars-500 experiment.

Aviat Space Environ Med. 2013 Oct;84(10):1082-6.


Tarabová L, Almášiová V, Holovská K, Cigánková V.

Influence of long-term hypodynamy on spongy bone tissue in Japanese quails.

Acta Vet Brno. 2013 Jun;82(2):225-7.

NOTE: Microgravity was simulated by placing each bird in a suspended sling. This article may be obtained online without charge.


Ma X, Pietsch J, Wehland M, Schulz H, Saar K, Hübner N, Bauer J, Braun M, Schwarzwälder A, Segerer J, Birlem M, Horn A, Hemmersbach R, Waßer K, Grosse J, Infanger M, Grimm D.

Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.

FASEB J. 2013 Nov 6. [Epub ahead of print]

NOTE: Parabolic flight, Shenzhou 8, and random positioning machine (ground) results.


Khuong A, Lecheval V, Fournier R, Blanco S, Weitz S, Bezian JJ, Gautrais J.

How do ants make sense of gravity? A Boltzmann Walker analysis of Lasius niger trajectories on various inclines.

PLoS One. 2013 Oct 29;8(10):e76531.

NOTE: This article may be obtained online without charge.


Kawaguchi Y, Yang Y, Kawashiri N, Shiraishi K, Takasu M, Narumi I, Satoh K, Hashimoto H, Nakagawa K, Tanigawa Y, Momoki YH, Tanabe M, Sugino T, Takahashi Y, Shimizu Y, Yoshida S, Kobayashi K, Yokobori SI, Yamagishi A.

The possible interplanetary transfer of microbes: Assessing the viability of Deinococcus spp. under the ISS environmental conditions for performing exposure experiments of microbes in the Tanpopo mission.

Orig Life Evol Biosph. 2013 Oct 15. [Epub ahead of print]

NOTE: Bacteria were tested under ISS environmental conditions.


Wang C, Luo H, Zhu L, Yang F, Chu Z, Tian H, Feng M, Zhao Y, Shang P.

Microgravity inhibition of lipopolysaccharide-induced tumor necrosis factor-α expression in macrophage cells.

Inflamm Res. 2013 Nov 6. [Epub ahead of print]

NOTE: Microgravity was simulated.


Yoshizaki I, Tsukamoto K, Yamazaki T, Murayama K, Oshi K, Fukuyama S, Shimaoka T, Suzuki Y, Tachibana M.

Growth rate measurements of lysozyme crystals under microgravity conditions by laser interferometry.

Rev Sci Instrum. 2013 Oct;84(10):103707.

NOTE: ISS results.


Giegé R.

A historical perspective on the advances in biocrystallogenesis from 1840 till present.

FEBS J. 2013 Oct 24. [Epub ahead of print]

NOTE: This article, which may be obtained online without charge, includes a section on microgravity research.


Luo T, Mohan K, Iglesias PA, Robinson DN.

Molecular mechanisms of cellular mechanosensing.

Nat Mater. 2013 Nov;12(11):1064-71.

NOTE: There is a comment on this article:


Stroka KM, Konstantopoulos K.

Theme: Physical Biology in Cancer. 4. Physical cues guide tumor cell adhesion and migration.

Am J Physiol Cell Physiol. 2013 Oct 16. [Epub ahead of print]


Scherer GF, Pietrzyk P.

Gravity-dependent differentiation and root coils in Arabidopsis thaliana wild type and phospholipase-A-I knockdown mutant grown on the International Space Station.

Plant Biol (Stuttg). 2013 Nov 8. [Epub ahead of print]

NOTE: ISS results.


Moulia B.

Plant biomechanics and mechanobiology are convergent paths to flourishing interdisciplinary research.

J Exp Bot. 2013 Nov;64(15):4617-33.

NOTE: This article is in an issue on the topic of plant biomechanics and mechanobiology:

SpaceRef staff editor.