Status Report

NASA Spaceline Current Awareness 14 December 2012 (Recent Space Life Science Research Results)

By SpaceRef Editor
December 14, 2012
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NASA Spaceline Current Awareness 14 December 2012 (Recent Space Life Science Research Results)

Next list: January 4, 2013
Papers deriving from NASA support:

Diedrich A, Crossman AA, Beightol LA, Tahvanainen KU, Kuusela TA, Ertl AC, Eckberg DL.
Baroreflex physiology studied in healthy subjects with very infrequent muscle sympathetic bursts.
J Appl Physiol. 2012 Nov 29. [Epub ahead of print]
(PI: D.L. Eckberg)

Prisby RD, Dominguez JM 2nd, Muller-Delp J, Allen MR, Delp MD.
Aging and estrogen status: A possible endothelium-dependent vascular coupling mechanism in bone remodeling.
PLoS One. 2012;7(11):e48564. Epub 2012 Nov 20.
(PI: M.D. Delp)
NOTE: This article may be obtained online without charge.

Clouse A, Deo S, Rampersaud E, Farmer J, Goldschmidt-Clermont PJ, Daunert S.
Defining a molecular portrait of physical fitness.
Anal Bioanal Chem. 2012 Nov 30. [Epub ahead of print]
NOTE: With their web site redesign, some Springer journals (like this one) now permit viewing the first two pages of an article without charge; formerly it was one page. This can be done by clicking on the “Look Inside” link at the publisher’s site.

Grattoni A, Tasciotti E, Fine D, Fernandez-Moure JS, Sakamoto J, Hu Y, Weiner B, Ferrari M, Parazynski S.
Nanotechnologies and regenerative medical approaches for space and terrestrial medicine.
Aviat Space Environ Med. 2012 Nov;83(11):1025-36.

Mijnendonckx K, Provoost A, Ott CM, Venkateswaran K, Mahillon J, Leys N, Van Houdt R.
Characterization of the survival ability of Cupriavidus metallidurans and Ralstonia pickettii from space-related environments.
Microb Ecol. 2012 Dec 5. [Epub ahead of print]
NOTE: Samples from ISS were analyzed. From abstract: “This study demonstrated that extreme resistance is not required to withstand the disinfection and sterilization procedures implemented in the ISS and space industry.” This article may temporarily be obtained online without charge.

Cartreine JA, Chang TE, Seville JL, Sandoval L, Moore JB, Xu S, Hegel MT.
Using self-guided treatment software (ePST) to teach clinicians how to deliver problem-solving treatment for depression.
Depress Res Treat. 2012;2012:309094. Epub 2012 Nov 14.
(PI: J.A. Cartreine)
NOTE: This article may temporarily be obtained online without charge.

Kozlowski SW, Chao GT.
The dynamics of emergence: Cognition and cohesion in work teams.
Managerial Decision Econ. 2012 Jul-Sep;33(5-6):335-54.
(PI: S.W. Kozlowski)

Hoch JE, Kozlowski SW.
Leading virtual teams: Hierarchical leadership, structural supports, and shared team leadership.
J Appl Psychol. 2012 Dec 3. [Epub ahead of print]
(PI: S.W. Kozlowski)

De La Torre GG, van Baarsen B, Ferlazzo F, Kanas N, Weiss K, Schneider S, Whiteley I.
Future perspectives on space psychology: Recommendations on psychosocial and neurobehavioural aspects of human spaceflight.
Acta Astronaut. 2012 Dec;81(2):587-99.
(PI: N. Kanas)
NOTE: Some flight results are presented as part of review.

Casey T, Zakrzewska EI, Maple RL, Lintault L, Wade CE, Baer LA, Ronca AE, Plaut K.
Hypergravity disruption of homeorhetic adaptations to lactation in rat dams include changes in circadian clocks.
Biol Open. 2012 Jun 15;1(6):570-81. Epub 2012 Apr 30.
(PIs: A.E. Ronca, K. Plaut)
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site:

Cooper MR, Catauro P, Perchonok M.
Development and evaluation of bioregenerative menus for Mars habitat missions.
Acta Astronaut. 2012 Dec;81(2):555-62.
(PIs: M.R. Cooper, P. Catauro, M. Perchonok)

Montague M, McArthur GH 4th, Cockell CS, Held J, Marshall W, Sherman LA, Wang N, Nicholson WL, Tarjan DR, Cumbers J.
The role of synthetic biology for In Situ Resource Utilization (ISRU).
Astrobiology. 2012 Dec;12(12):1135-42. Epub 2012 Nov 9.

Other papers of interest:

Pastushkova LKh, Valeeva OA, Kononikhin AS, Nikolaev EN, Larina IM, Dobrokhotov IV, Popov IA, Pochuev VI, Kireev KS, Grigoriev AI.
Changes in urine protein composition in human organism during long term space flights.
Acta Astronaut. 2012 Dec;81(2):430-4.
NOTE: ISS results.

Metzler M, Duerr S, Granata R, Krismer F, Robertson D, Wenning GK.
Neurogenic orthostatic hypotension: Pathophysiology, evaluation, and management.
J Neurol. 2012 Nov 20. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Mounier-Vehier C.
[Orthostatic hypotension: A potential independant cardiovascular risk factor]
Presse Med. 2012 Nov;41(11):1090-1. Epub 2012 Aug 27. French.
NOTE: This article introduces a special section on orthostatic hypotension:

LeBlanc AJ, Chen B, Dougherty PJ, Reyes RA, Shipley RD, Korzick DH, Muller-Delp JM.
Divergent effects of aging and sex on vasoconstriction to endothelin in coronary arterioles.
Microcirculation. 2012 Dec 1. [Epub ahead of print]

Ogawa Y, Aoki K, Kato J, Iwasaki KI.
Differential effects of mild central hypovolemia with furosemide administration versus lower body suction on dynamic cerebral autoregulation.
J Appl Physiol. 2012 Nov 29. [Epub ahead of print]

Mueller PJ, Mischel NA.
Selective enhancement of glutamate-mediated pressor responses after GABA(A) receptor blockade in the RVLM of sedentary versus spontaneous wheel running rats.
Front Physiol. 2012;3:447. Epub 2012 Nov 26.
NOTE: This article may be obtained online without charge.

Kim HS, Kim YW.
Expression of phosphorylated extracellular signal-regulated kinase in rat kidneys exposed to high +Gz.
Bosn J Basic Med Sci. 2012 Nov;12(4):269-72.
NOTE: This article may be obtained online without charge:

Sonnenfeld G.
Editorial: Space flight modifies T cell activation–role of microgravity.
J Leukoc Biol. 2012 Dec;92(6):1125-6.
NOTE: This editorial comments on an ISS flight paper by M. Hughes-Fulford and others that was first listed in Current Awareness list #564:

Astakhov DA, Baranov MV, Panchenkov DN.
[Physiological effects of microgravity as risk factors of diseases during space flight]
Patol Fiziol Eksp Ter. 2012 Apr-Jun;(2):70-6. Russian.

Brinckmann E.
Centrifuges and their application for biological experiments in space.
Microgravity Sci Technol. 2012 Dec;24(6):365-72.
NOTE: Some Shuttle-Mir and Shuttle flight results are reviewed.

Pletser V, Winter J, Duclos F, Bret-Dibat T, Friedrich U, Clervoy JF, Gharib T, Gai F, Minster O, Sundblad P.
The first Joint European Partial-G Parabolic Flight Campaign at Moon and Mars gravity levels for science and exploration.
Microgravity Sci Technol. 2012 Dec;24(6):383-95.
NOTE: Description of parabolic flight campaign and experiments.

Karakucuk S, Mujdeci M, Baskol G, Arda H, Gumus K, Oner A.
Changes in central corneal thickness, intraocular pressure, and oxidation/antioxidation parameters at high altitude.
Aviat Space Environ Med. 2012 Nov;83(11):1044-8.

Weenink RP, Hollmann MW, van Hulst RA.
Acute neurological symptoms during hypobaric exposure: Consider cerebral air embolism.
Aviat Space Environ Med. 2012 Nov;83(11):1084-91.

Bouma HR, Henning RH, Kroese FG, Carey HV.
Hibernation is associated with depression of T-cell independent humoral immune responses in the 13-lined ground squirrel.
Dev Comp Immunol. 2012 Nov 24. [Epub ahead of print]

Chen CN, Thompson LV.
Interplay between aging and unloading on oxidative stress in fast-twitch muscles.
J Gerontol A Biol Sci Med Sci. 2012 Dec 4. [Epub ahead of print]

Li S, Yang Z, Gao Y, Li G, Wang H, Hinghofer-Szalkay HG.
Ligustrazine and the contractile properties of soleus muscle in hindlimb-unloaded rats.
Aviat Space Environ Med. 2012 Nov;83(11):1049-54.

Koriak IuA.
[Contraction properties and musculo-tendinous stiffness of the human triceps surae muscle and their change as a result of a long-term bed-rest]
Fiziol Zh. 2012;58(2):66-79. Russian.

Vanderburg CR, Clarke MS.
Laser capture microdissection of metachromatically stained skeletal muscle allows quantification of fiber type specific gene expression.
Mol Cell Biochem. 2012 Nov 30. [Epub ahead of print]
NOTE: Hindlimb suspension was used.

Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS.
The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.
Am J Physiol Endocrinol Metab. 2012 Nov 27. [Epub ahead of print]

Dumont NA, Frenette J.
Macrophage colony-stimulating factor-induced macrophage differentiation promotes regrowth in atrophied skeletal muscles and C2C12 myotubes.
Am J Pathol. 2012 Nov 27. [Epub ahead of print]
NOTE: Hindlimb suspension was used.

Mantilla CB, Greising SM, Zhan WZ, Seven YB, Sieck GC.
Prolonged C2 spinal hemisection-induced inactivity reduces diaphragm muscle specific force with modest, selective atrophy of type IIx and/or IIb fibers.
J Appl Physiol. 2012 Nov 29. [Epub ahead of print]

Nonaka I.
Muscle fiber atrophy.
Rinsho Shinkeigaku. 2012;52(11):1315-7.

Ito N, Ruegg UT, Kudo A, Miyagoe-Suzuki Y, Takeda S.
Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy.
Nat Med. 2012 Dec 2. [Epub ahead of print]

Driss T, Lambertz D, Rouis M, Vandewalle H.
Influence of musculo-tendinous stiffness of the plantar ankle flexor muscles upon maximal power output on a cycle ergometre.
Eur J Appl Physiol. 2012 Nov;112(11):3721-8. Epub 2012 Feb 22.
NOTE: This article may temporarily be obtained online without charge:

Chaudhary P, Suryakumar G, Sharma YK, Ilavazhagan G.
Differential response of the gastrocnemius and soleus muscles of rats to chronic hypobaric hypoxia.
Aviat Space Environ Med. 2012 Nov;83(11):1037-43.

Kornfeld SF, Biggar KK, Storey KB.
Differential expression of mature microRNAs involved in muscle maintenance of hibernating little brown bats, Myotis lucifugus: A model of muscle atrophy resistance.
Genomics Proteomics Bioinformatics. 2012 Oct;10(5):295-301. Epub 2012 Sep 29.

Sonza A, Maurer C, Achaval M, Zaro MA, Nigg BM.
Human cutaneous sensors on the sole of the foot: Altered sensitivity and recovery time after whole body vibration.
Neurosci Lett. 2012 Nov 29. [Epub ahead of print]

Ohshima H, Matsumoto T.
[Space Flight/Bedrest Immobilization and Bone. Bone metabolism in space flight and long-duration bed rest]
Clin Calcium. 2012 Dec;22(12):1803-12. Japanese.
NOTE: This article is the first of 13 articles in an issue on the topic: Space Flight/Bedrest Immobilization and Bone. Five articles related to space flight are listed below. Citations to all of the articles may be viewed by pasting these characters into the PubMed search box: clin calcium [ta] 22 [vi] 12 [ip]
Journal site:

Ikeda C, Abe T, Sakai A, Hirasaka K, Nikawa T.
[Space Flight/Bedrest Immobilization and Bone. Space flight and bed rest-mediated muscle atrophy]
Clin Calcium. 2012 Dec;22(12):1813-20. Japanese.

Kohri K, Yasui T, Okada A.
[Space Flight/Bedrest Immobilization and Bone. Urolithiasis formation during space flight and long-term bed rest]
Clin Calcium. 2012 Dec;22(12):1821-7. Japanese.

Endo I, Matsumoto T.
[Space Flight/Bedrest Immobilization and Bone. Bisphosphonate and the loss of bone mineral due to space flight or prolonged bed rest]
Clin Calcium. 2012 Dec;22(12):1863-70. Japanese.

Shiba N, Matsuse H, Nago T, Masayuki O, Kawaguchi T, Tagawa Y.
[Space Flight/Bedrest Immobilization and Bone. Development a devise to maintain the skeletal muscles in space]
Clin Calcium. 2012 Dec;22(12):1871-8. Japanese.

Mukai C, Ohshima H.
[Space Flight/Bedrest Immobilization and Bone. In-flight exercise device to support a health of astronauts]
Clin Calcium. 2012 Dec;22(12):1887-93. Japanese.

Wasserman E, Webster D, Kuhn G, Attar-Namdar M, Mueller R, Bab I.
Differential load-regulated global gene expression in mouse trabecular osteocytes.
Bone. 2012 Nov 28. [Epub ahead of print]

Regard JB, Zhong Z, Williams BO, Yang Y.
Wnt signaling in bone development and disease: Making stronger bone with Wnts.
Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12).

Ikeda T, Gonda Y, Tatsukawa E, Shibata Y, Kamitakahara M, Okuda T, Yonezawa I, Kurosawa H, Ioku K.
Stimulation of osteogenesis in bone defects implanted with biodegradable hydroxyapatite composed of rod-shaped particles under mechanical unloading.
Acta Histochem Cytochem. 2012 Oct 31;45(5):283-92. Epub 2012 Sep 8.
NOTE: This article may be obtained online without charge.

Kashino G, Suzuki K, Kodama S, Watanabe M, Prise KM.
Increased susceptibility to delayed genetic effects of low dose X-irradiation in DNA repair deficient cells.
Int J Radiat Biol. 2012 Nov 23. [Epub ahead of print]

Park HS, Seong KM, Kim JY, Kim CS, Yang KH, Jin YW, Nam SY.
Chronic low-dose radiation inhibits the cells death by cytotoxic high-dose radiation increasing the level of AKT and acinus proteins via NF-B activation.
Int J Radiat Biol. 2012 Dec 3. [Epub ahead of print]

Vukich M, Ganga PL, Cavalieri D, Rizzetto L, Rivero D, Pollastri S, Mugnai S, Mancuso S, Pastorelli S, Lambreva M, Antonacci A, Margonelli A, Bertalan I, Johanningmeier U, Giardi MT, Rea G, Pugliese M, Quarto M, Roca V, Zanini A, Borla O, Rebecchi L, Altiero T, Guidetti R, Cesari M, Marchioro T, Bertolani R, Pace E, De Sio A, Casarosa M, Tozzetti L, Branciamore S, Gallori E, Scarigella M, Bruzzi M, Bucciolini M, Talamonti C, Donati A, Zolesi V.
BIOKIS: A model payload for multidisciplinary experiments in microgravity.
Microgravity Sci Technol. 2012 Dec;24(6):397-409.
NOTE: STS-134 results.

Rai B, Kaur J.
Human factor studies on a Mars analogue during Crew 100B International Lunar Exploration Working Group EuroMoonMars Crew: Proposed new approaches for future human space and interplanetary missions.
N Am J Med Sci. 2012 Nov;4(11):548-57.
NOTE: Mars Desert Research Station study. This article may be obtained online without charge via PubMed Central or at the publisher’s site:

Rai B, Kaur J.
Mental and physical workload, salivary stress biomarkers and taste perception: Mars Desert Research Station expedition.
N Am J Med Sci. 2012 Nov;4(11):577-81.
NOTE: Mars Desert Research Station study. This article may be obtained online without charge via PubMed Central or at the publisher’s site:

Liu S, Gu Y, DeAngelis GC, Angelaki DE.
Choice-related activity and correlated noise in subcortical vestibular neurons.
Nat Neurosci. 2012 Nov 25. [Epub ahead of print]

Winter L, Kruger TH, Laurens J, Engler H, Schedlowski M, Straumann D, Wollmer MA.
Vestibular stimulation on a motion-simulator impacts on mood states.
Front Psychol. 2012;3:499. Epub 2012 Nov 20.
NOTE: This article may be obtained online without charge.

Koizuka I.
Spatial orientation under microgravity.
Rinsho Shinkeigaku. 2012;52(11):1318-20.

Barra J, Laou L, Poline JB, Lebihan D, Berthoz A.
Does an oblique/slanted perspective during virtual navigation engage both egocentric and allocentric brain strategies?
PLoS One. 2012;7(11):e49537. Epub 2012 Nov 28.
NOTE: This article may be obtained online without charge.

Migliaccio AA, Schubert MC.
Unilateral adaptation of the human angular vestibulo-ocular reflex.
J Assoc Res Otolaryngol. 2012 Nov 21. [Epub ahead of print]

Takatsu-Coleman AL, Patti CL, Zanin KA, Zager A, Carvalho RC, Borcoi AR, Ceccon LM, Berro LF, Tufik S, Andersen ML, Frussa-Filho R.
Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: Mood-congruent memory in male mice?
J Psychiatry Neurosci. 2012 Nov 26;37(6):120050. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Cha YH, Chakrapani S, Craig A, Baloh RW.
Metabolic and functional connectivity changes in mal de debarquement syndrome.
PLoS One. 2012;7(11):e49560. Epub 2012 Nov 29.
NOTE: This article may be obtained online without charge.

Mishima K.
Sleep and biological rhythm in space.
Rinsho Shinkeigaku. 2012;52(11):1321-4.

Romeijn N, Verweij IM, Koeleman A, Mooij A, Steimke R, Virkkala J, van der Werf Y, Van Someren EJ.
Cold hands, warm feet: Sleep deprivation disrupts thermoregulation and its association with vigilance.
Sleep. 2012 Dec 1;35(12):1673-83.

Richard S, Henggeler D, Ille F, Beck SV, Moeckli M, Forster IC, Franco-Obregon A, Egli M.
A semi-automated electrophysiology system for recording from Xenopus oocytes under microgravity conditions.
Microgravity Sci Technol. 2012 Sep;24(4):237-44.
NOTE: Parabolic flight results.

Auletta G, Adell T, Colage I, D’Ambrosio P, Salo E.
Space research program on planarian Schmidtea mediterranea’s establishment of the anterior-posterior axis in altered gravity conditions.
Microgravity Sci Technol. 2012 Dec;24(6):419-25.
NOTE: The authors describe and analyze an earlier ISS experiment in preparation for a future space experiment.

Dai Y, Chen J, Li H, Li S, Chen J, Ding Y, Wu J, Wang C, Tan M.
Characterizing the effects of VPA, VC and RCCS on rabbit keratocytes onto decellularized bovine cornea.
PLoS One. 2012;7(11):e50114. Epub 2012 Nov 29.
NOTE: This article may be obtained online without charge.

Vukanti R, Leff LG.
Expression of multiple stress response genes by Escherichia coli under modeled reduced gravity.
Microgravity Sci Technol. 2012 Sep;24(4):267-79.

Zhang Y, Li XY, Wang GH, Hu CX, Liu YD.
Physiological responses of Synechocystis sp. PCC 6803 under clinorotation.
Microgravity Sci Technol. 2012 Sep;24(4):281-6.

Wei L, Han F, Yue L, Zheng H, Yu D, Ma X, Cheng H, Li Y.
Synergistic effects of incubation in rotating bioreactors and cumulative low dose 60Co -ray irradiation on human immortal lymphoblastoid cells.
Microgravity Sci Technol. 2012 Nov;24(5):335-44.

Patino-Lopez LD, Decanniere K, Gavira JA, Maes D, Otalora F.
Protein experiment: Scientific data processing platform for on-flight experiment tuning.
Microgravity Sci Technol. 2012 Nov;24(5):327-34.
NOTE: Describes ISS experiment.

Sedelnikov AV.
Fractal quality of microaccelerations.
Microgravity Sci Technol. 2012 Nov;24(5):345-50.

Barroso A, Woerdemann M, Vollmer A, von Bally G, Kemper B, Denz C.
Three-dimensional exploration and mechano-biophysical analysis of the inner structure of living cells.
Small. 2012 Nov 23. [Epub ahead of print]

Thosar S, Johnson B, Johnston J, Wallace J.
Sitting and endothelial dysfunction: The role of shear stress.
Med Sci Monit. 2012 Dec 1;18(12):RA173-80.

Nguyen AM, Jacobs CR.
Emerging role of primary cilia in osteocytes.
Bone. 2012 Nov 28. [Epub ahead of print]

Bamsey M, Graham T, Thompson C, Berinstain A, Scott A, Dixon M.
Ion-specific nutrient management in closed systems: The necessity for ion-selective sensors in terrestrial and space-based agriculture and water management systems.
Sensors (Basel). 2012 Oct 1;12(10):13349-92.
NOTE: This article includes a discussion of water monitoring on ISS. It may be obtained online without charge:

Millar KD, Kiss JZ.
Analyses of tropistic responses using metabolomics.
Am J Bot. 2012 Nov 28. [Epub ahead of print]
NOTE: This article may temporarily be obtained online without charge.

Baster P, Robert S, Kleine-Vehn J, Vanneste S, Kania U, Grunewald W, De Rybel B, Beeckman T, Friml J.
SCF(TIR1/AFB)-auxin signalling regulates PIN vacuolar trafficking and auxin fluxes during root gravitropism.
EMBO J. 2012 Dec 4. [Epub ahead of print]

Schmidt W.
Differential gravity induced absorption changes in coleoptiles of Zea mays as measured with the Single Wavelength Space Discriminator (SWSD).
Microgravity Sci Technol. 2012 Mar;24(2):103-12.
NOTE: Parabolic flight results.

Manzano AI, Herranz R, van Loon JJ, Medina FJ.
A hypergravity environment induced by centrifugation alters plant cell proliferation and growth in an opposite way to microgravity.
Microgravity Sci Technol. 2012 Dec;24(6):373-81.
NOTE: This article may be obtained online without charge.

Shevchenko G.
Actin microfilament organization in the transition zone of Arabidopsis-ABD2-GFP roots under clinorotation.
Microgravity Sci Technol. 2012 Dec;24(6):427-33.

SpaceRef staff editor.