Status Report

NASA Spaceline Current Awareness 12 July 2013 (Recent Space Life Science Research Results)

By SpaceRef Editor
July 12, 2013
Filed under , ,
NASA Spaceline Current Awareness 12 July 2013 (Recent Space Life Science Research Results)

Next list: July 26, 2013

Papers deriving from NASA support:

Eckberg DL, Cooke WH, Diedrich A, Levine BD, Pawelczyk JA, Buckey JC, Ertl AC, Biaggioni I, Cox JF, Robertson D, Baisch FJ, Blomqvist CG, Kuusela TA, Tahvanainen KU.
Human baroreflex rhythms persist during handgrip and muscle ischaemia.
Acta Physiol (Oxf). 2013 Jun 28. [Epub ahead of print]
(PI: D.L. Eckberg)
NOTE: Analyses were conducted on Neurolab (STS-90, 1998) astronauts and backup astronauts prior to the flight.

Zhang B, Cory E, Bhattacharya R, Sah R, Hargens AR.
Fifteen days of microgravity causes growth in calvaria of mice.
Bone. 2013 Jun 20. [Epub ahead of print]
(PI: A.R. Hargens)
NOTE: STS-131 results. From abstract: “Our results indicate that microgravity causes responsive changes in calvarial bones that do not normally bear weight. These findings suggest that fluid shifts alone accompanying microgravity may initiate bone adaptation independent of skeletal loading by tissue.”

Chappell SP, Abercromby AF, Gernhardt ML.
NEEMO 15: Evaluation of human exploration systems for near-Earth asteroids.
Acta Astronaut. 2013 Aug-Sep;89:166-78.

Southern T, Roberts DP, Moiseev N, Ross A, Kim JH.
Space suit glove design with advanced metacarpal phalangeal joints and robotic hand evaluation.
Aviat Space Environ Med. 2013 Jun;84(6):633-8.
NOTE: NASA SBIR funding.

Novotny SC, Perusek GP, Rice AJ, Comstock BA, Bansal A, Cavanagh PR.
A harness for enhanced comfort and loading during treadmill exercise in space.
Acta Astronaut. 2013 Aug-Sep;89:205-14.
(PIs: G.P. Perusek, P.R. Cavanagh)

Yokota H, Hamamura K, Chen A, Dodge TR, Tanjung N, Abedinpoor A, Zhang P.
Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells.
BMC Musculoskelet Disord. 2013 Jul 1;14:197. [Epub ahead of print]
(PI: H. Yokota)
NOTE: This article may be obtained online without charge.

Slaba TC, Blattnig SR, Reddell B, Bahadori A, Norman RB, Badavi FF.
Pion and electromagnetic contribution to dose: Comparisons of HZETRN to Monte Carlo results and ISS data.
Adv Space Res. 2013 Jul 1;52(1):62-78.
(PIs: J.W. Norbury, C. Sandridge)
NOTE: ISS results.

Norman RB, Slaba TC, Blattnig SR.
An extension of HZETRN for cosmic ray initiated electromagnetic cascades.
Adv Space Res. 2013 Jun 15;51(12):2251-60.
(PIs: J.W. Norbury, C. Sandridge)

Tseng B, Giedzinski E, Izadi A, Suarez T, Lan M, Tran K, Acharya M, Nelson G, Raber J, Parihar VK, Limoli C.
Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation.
Antioxid Redox Signal. 2013 Jun 26. [Epub ahead of print]
(PIs: C. Limoli; G. Nelson/J. Raber/C. Limoli/NSCOR)

Rithidech KN, Honikel LM, Reungpatthanaphong P, Tungjai M, Golightly M, Whorton EB.
Effects of 100MeV protons delivered at 0.5 or 1cGy/min on the in vivo induction of early and delayed chromosomal damage.
Mutat Res. 2013 Jun 13. [Epub ahead of print]
(PI: K.N. Rithidech)

Finnberg N, Wambi C, Kennedy AR, El-Deiry WS.
The effects of antioxidants on gene expression following gamma-radiation (GR) and proton radiation (PR) in mice in vivo.
Cell Cycle. 2013 Jul 15;12(14):31-7.
(PI: A.R. Kennedy)
NOTE: This article may be available without charge as a provisional document; see the link below the abstract at the publisher’s site abstract.

Khan SY, Tariq MA, Perrott JP, Brumbaugh CD, Kim HJ, Shabbir MI, Ramesh GT, Pourmand N.
Distinctive microRNA expression signatures in proton-irradiated mice.
Mol Cell Biochem. 2013 Jul 2. [Epub ahead of print]

Park D, Magis AT, Li R, Owonikoko TK, Sica GL, Sun SY, Ramalingam SS, Khuri FR, Curran WJ, Deng X.
Novel small molecule inhibitors of Bcl-XL to treat lung cancer.
Cancer Res. 2013 Jul 3. [Epub ahead of print]
(PI: X. Deng)

Zeitlin C, Case AW, Spence HE, Schwadron NA, Golightly M, Wilson JK, Kasper JC, Blake JB, Looper MD, Mazur JE, Townsend LW, Iwata Y.
Measurements of galactic cosmic ray shielding with the CRaTER instrument.
Space Weather. 2013 May;11(5):284-96. Epub 2013 May 22.
NOTE: This paper and the following three papers constitute a special issue, entitled: “The CRaTER Special Issue of Space Weather: Building the observational foundation to deduce biological effects of space radiation”:
CRaTER stands for the Cosmic Ray Telescope for the Effects of Radiation, an instrument on the Lunar Reconnaissance Orbiter that has been measuring galactic cosmic radiation and solar particle events in lunar orbit. A news release describes how this space research confirms ground-based results of the value of plastics for radiation shielding:

Looper MD, Mazur JE, Blake JB, Spence HE, Schwadron NA, Golightly MJ, Case AW, Kasper JC, Townsend LW.
The radiation environment near the lunar surface: CRaTER observations and Geant4 simulations.
Space Weather. 2013 Apr;11(4):142-52. Epub 2013 Apr 3.

Case AW, Kasper JC, Spence HE, Zeitlin CJ, Looper MD, Golightly MJ, Schwadron NA, Townsend LW, Mazur JE, Blake JB, Iwata Y.
The deep space galactic cosmic ray lineal energy spectrum at solar minimum.
Space Weather. 2013 Jun;11(6):361-8. Epub 2013 Jun 18.

Joyce CJ, Schwadron NA, Wilson JK, Spence HE, Kasper JC, Golightly M, Blake JB, Mazur J, Townsend LW, Case AW, Semones E, Smith S, Zeitlin CJ.
Validation of PREDICCS using LRO/CRaTER observations during three major solar events in 2012.
Space Weather. 2013 Jun;11(6):350-60. Epub 2013 Jun 6.

Tirumalai MR, Rastogi R, Zamani N, O’Bryant Williams E, Allen S, Diouf F, Kwende S, Weinstock GM, Venkateswaran KJ, Fox GE.
Candidate genes that may be responsible for the unusual resistances exhibited by Bacillus pumilus SAFR-032 spores.
PLoS One. 2013 Jun 14;8(6):e66012.
NOTE: This article may be obtained online without charge.

Tirumalai MR, Fox GE.
An ICEBs1-like element may be associated with the extreme radiation and desiccation resistance of Bacillus pumilus SAFR-032 spores.
Extremophiles. 2013 Jun 28. [Epub ahead of print]

Peters BT, Brady RA, Batson CD, Guined JR, Ploutz-Snyder RJ, Mulavara AP, Bloomberg JJ.
Adaptation in locomotor stability, cognition, and metabolic cost during sensory discordance.
Aviat Space Environ Med. 2013 Jun;84(6):567-72.
(PI: J.J. Bloomberg)

Liston DB, Stone LS.
Saccadic brightness decisions do not use a difference model.
J Vis. 2013 Jul 1;13(8):1.
(PI: L.S. Stone)
NOTE: This article may be obtained online without charge:

Spaeth AM, Dinges DF, Goel N.
Effects of experimental sleep restriction on weight gain, caloric intake, and meal timing in healthy adults.
Sleep. 2013 Jul 1;36(7):981-90.
(PI: D.F. Dinges)

Baard SK, Rench TA, Kozlowski SW.
Performance adaptation: A theoretical integration and review.
J Management. 2013 May 29. [Epub ahead of print]
(PI: S.W. Kozlowski)

Svalina G, Forsman AD.
The effect of the space flight environment on mucin production in the mouse uterine tube.
Adv Space Res. 2013 Jun 15;51(12):2229-34.
NOTE: STS-118 results.

Saldanha JN, Parashar A, Pandey S, Powell-Coffman JA.
Multi-parameter behavioral analyses provide insights to mechanisms of cyanide resistance in Caenorhabditis elegans.
Toxicol Sci. 2013 Jun 26. [Epub ahead of print]
(PI: S. Pandey)

Warren P, Golden A, Hanover J, Love D, Shephard F, Szewczyk NJ.
Evaluation of the fluids mixing enclosure system for life science experiments during a commercial Caenorhabditis elegans spaceflight experiment.
Adv Space Res. 2013 Jun 15;51(12):2241-50.
NOTE: The flight experiment, which was not successfully activated inflight, was delivered to ISS by SpaceX Dragon and returned by Soyuz.

Other papers of interest:

Kapitonova MY, Kuznetsov SL, Froemming GR, Muid S, Nor-Ashikin MN, Otman S, Shahir AR, Nawawi H.
Effects of space mission factors on the morphology and function of endothelial cells.
Bull Exp Biol Med. 2013 Apr;154(6):796-801.
NOTE: ISS results. This paper is an English translation from Byulleten’ Eksperimental’noi Biologii i Meditsiny 2012 Dec;154(12):766-71.

Durga Prasad K, Murty SV.
Performance of a small and low-cost chamber to simulate lunar surface environment.
Acta Astronaut. 2013 Aug-Sep;89:149-53.

Pletser V.
Are aircraft parabolic flights really parabolic?
Acta Astronaut. 2013 Aug-Sep;89:226-8.

Parsaik AK, Singh B, Altayar O, Mascarenhas SS, Singh SK, Erwin PJ, Murad MH.
Midodrine for orthostatic hypotension: A systematic review and meta-analysis of clinical trials.
J Gen Intern Med. 2013 Jun 18. [Epub ahead of print]

Strey KA, Baertsch NA, Baker-Herman TL.
Inactivity-induced respiratory plasticity: Protecting the drive to breathe in disorders that reduce respiratory neural activity.
Respir Physiol Neurobiol. 2013 Jun 28. [Epub ahead of print]

Oliver SJ, Macdonald JH, Harper Smith AD, Lawley JS, Gallagher CA, Di Felice U, Walsh NP.
High altitude impairs in vivo immunity in humans.
High Alt Med Biol. 2013 Jun;14(2):144-9.

MacLeod KE, MacInnis MJ, Manokhina I, Rupert JL.
Twin studies in altitude and hypoxia research.
Aviat Space Environ Med. 2013 Jun;84(6):613-9.

Arendt T, Bullmann T.
Neuronal plasticity in hibernation and the role of the microtubule-associated protein tau as a ‘master switch’ regulating synaptic gain in neuronal networks.
Am J Physiol Regul Integr Comp Physiol. 2013 Jul 3. [Epub ahead of print]

Mutin-Carnino M, Carnino A, Roffino S, Chopard A.
Effect of muscle unloading, reloading and exercise on inflammation during a head-down bed rest.
Int J Sports Med. 2013 Jul 3. [Epub ahead of print]
NOTE: WISE-2005 bed rest study.

Gordon BS, Kelleher AR, Kimball SR.
Regulation of muscle protein synthesis and the effects of catabolic states.
Int J Biochem Cell Biol. 2013 Jun 12. [Epub ahead of print]
NOTE: This article and the following article will be part of a Directed Issue on the topic Muscle Wasting.

Bodine SC.
Disuse-induced muscle wasting.
Int J Biochem Cell Biol. 2013 Jun 22. [Epub ahead of print]

Bodine SC.
Hibernation: The search for treatments to prevent disuse-induced skeletal muscle atrophy.
Exp Neurol. 2013 Jun 12;248C:129-35. [Epub ahead of print]

Turczyska KM, Hellstrand P, Swaerd K, Albinsson S.
Regulation of vascular smooth muscle mechanotransduction by microRNAs and L-type calcium channels.
Commun Integr Biol. 2013 Jan/Feb;6(1):e22278.
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site:

Demontis F, Piccirillo R, Goldberg AL, Perrimon N.
The influence of skeletal muscle on systemic aging and lifespan.
Aging Cell. 2013 Jun 26. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Ritzmann R, Kramer A, Gollhofer A, Taube W.
The effect of whole body vibration on the H-reflex, the stretch reflex, and the short-latency response during hopping.
Scand J Med Sci Sports. 2013 Jun;23(3):331-9.

Miyamoto N, Wakahara T, Ema R, Kawakami Y.
Further potentiation of dynamic muscle strength after resistance training.
Med Sci Sports Exerc. 2013 Jul;45(7):1323-30.

Ito M, Arakawa T, Okayama M, Shitara A, Mizoguchi I, Takuma T.
Gravity loading induces adenosine triphosphate release and phosphorylation of extracellular signal-regulated kinases in human periodontal ligament cells.
J Investig Clin Dent. 2013 Jun 24. [Epub ahead of print]

Belavy DL, Miokovic T, Armbrecht G, Felsenberg D.
Hypertrophy in the cervical muscles and thoracic discs in bed-rest?
J Appl Physiol. 2013 Jun 27. [Epub ahead of print]
NOTE: Second Berlin Bed Rest Study.

Jiang SD, Yang YH, Chen JW, Jiang LS.
Isolated osteoblasts from spinal cord-injured rats respond less to mechanical loading as compared with those from hindlimb-immobilized rats.
J Spinal Cord Med. 2013 May;36(3):220-4.

Wu D, Schaffler MB, Weinbaum S, Spray DC.
Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process.
Proc Natl Acad Sci U S A. 2013 Jul 1. [Epub ahead of print]

Rochefort GY, Benhamou CL.
Osteocytes are not only mechanoreceptive cells.
Int J Numer Method Biomed Eng. 2013 Jun 17. [Epub ahead of print]

Preston RJ, Boice Jr JD, Brill AB, Chakraborty R, Conolly R, Hoffman FO, Hornung RW, Kocher DC, Land CE, Shore RE, Woloschak GE.
Uncertainties in estimating health risks associated with exposure to ionising radiation.
J Radiol Prot. 2013 Sep;33(3):573-88.
NOTE: This article, which may be obtained online without charge, is an overview of the topics covered by the following report: National Council on Radiation Protection and Measurements 2012. Uncertainties in the estimation of radiation risks and probability of disease causation. NCRP Report No. 171, Bethesda, MD.
From abstract: “NASA’s approach to radiation protection for astronauts, although a unique occupational group, indicates the possible applicability of estimates of risk and their uncertainty in a broader context for developing recommendations on: (1) dose limits for occupational exposure and exposure of members of the public; (2) criteria to limit exposures of workers and members of the public to radon and its short-lived decay products; and (3) the dosimetric quantity (effective dose) used in radiation protection.”

Sato T, Endo A, Niita K.
Comparison of the mean quality factors for astronauts calculated using the Q-functions proposed by ICRP, ICRU, and NASA.
Adv Space Res. 2013 Jul 1;52(1):79-85.
NOTE: Research described in the article includes calculations of galactic cosmic ray fluxes for a simplified geometry of ISS.

Townsend LW, Anderson JA, Adamczyk AM, Werneth CM.
Estimates of Carrington-class solar particle event radiation exposures as a function of altitude in the atmosphere of Mars.
Acta Astronaut. 2013 Aug-Sep;89:189-94.

Yang Y, Cai J.
Molecular hydrogen protects human lymphocyte AHH-1 cells against (12)C(6+) heavy ion radiation.
Int J Radiat Biol. 2013 Jun 20. [Epub ahead of print]

Muka V, Blaha P, uba V, ervenak J.
Influence of various scavengers of OH radicals on the radiation sensitivity of yeast and bacteria.
Int J Radiat Biol. 2013 Jun 20. [Epub ahead of print]

Sun C, Wang Z, Liu Y, Liu Y, Li H, Di C, Wu Z, Gan L, Zhang H.
Carbon ion beams induce hepatoma cell death by NADPH oxidase-mediated mitochondrial damage.
J Cell Physiol. 2013 Jun 26. [Epub ahead of print]

Schipler A, Iliakis G.
DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice.
Nucleic Acids Res. 2013 Jun 26. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Clarke AH, Just K, Krzok W, Schoenfeld U.
Listing’s plane and the 3D-VOR in microgravity – The role of the otolith afferences.
J Vestib Res. 2013 Jan 1;23(2):61-70.
NOTE: ISS results.

Verheij R, Brenner E, Smeets JB.
Gravity affects the vertical curvature in human grasping movements.
J Mot Behav. 2013;45(4):325-32. Epub 2013 Jun 19.

Indovina I, Maffei V, Lacquaniti F.
Anticipating the effects of visual gravity during simulated self-motion: Estimates of time-to-passage along vertical and horizontal paths.
Exp Brain Res. 2013 Jun 27. [Epub ahead of print]

Tal D, Hershkovitz D, Kaminski-Graif G, Wiener G, Samuel O, Shupak A.
Vestibular evoked myogenic potentials and habituation to seasickness.
Clin Neurophysiol. 2013 Jun 22. [Epub ahead of print]

Jamali M, Carriot J, Chacron MJ, Cullen KE.
Strong correlations between sensitivity and variability give rise to constant discrimination thresholds across the otolith afferent population.
J Neurosci. 2013 Jul 3;33(27):11302-13.

Clement G, Tilikete C, Courjon JH.
Influence of stimulus interval on the habituation of vestibulo-ocular reflex and sensation of rotation in humans.
Neurosci Lett. 2013 Jul 1. [Epub ahead of print]

Pigeon P, DiZio P, Lackner JR.
Immediate compensation for variations in self-generated Coriolis torques related to body dynamics and carried objects.
J Neurophysiol. 2013 Jun 26. [Epub ahead of print]

Tung VW, Di Marco S, Lim R, Brichta AM, Camp AJ.
An isolated semi-intact preparation of the mouse vestibular sensory epithelium for electrophysiology and high-resolution two-photon microscopy.
J Vis Exp. 2013 Jun 13;(76):e50471.

Messerotti Benvenuti S, Bianchin M, Angrilli A.
Posture affects emotional responses: A Head Down Bed Rest and ERP study.
Brain Cogn. 2013 Jun 19;82(3):313-8. [Epub ahead of print]
NOTE: Bed rest study.

Jiang CM, Zheng R, Zhou Y, Liang ZY, Rao LL, Sun Y, Tan C, Chen XP, Tian ZQ, Bai YQ, Chen SG, Li S.
Effect of 45-day simulated microgravity on the evaluation of orally reported emergencies.
Ergonomics. 2013 Jun 24. [Epub ahead of print]
NOTE: Bed rest study. The first page of the article, which can be obtained online without charge by clicking Preview at the publisher’s site, recounts a potential emergency during a Chinese space flight as part of the rationale for this research.

Herranz R, Larkin OJ, Hill RJ, Lopez-Vidriero I, van Loon JJ, Medina FJ.
Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis.
BMC Evol Biol. 2013 Jun 27;13:133. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Pan KM, Zhou HC, Zhang Z, Gao Y, Xu XP.
[Evaluation of co-cultured CL-1 hepatocytes and hepatic stellate cells in rotatory cell culture system]
Nan Fang Yi Ke Da Xue Xue Bao. 2013 Jun 20;33(6):902-5. Chinese.
NOTE: This article, which is in Chinese, may be obtained online without charge. Translated title of journal is Journal of Southern Medical University.

Lorin C, Mailfert A, Jeandey C, Masson PJ.
Perfect magnetic compensation of gravity along a vertical axis.
J Appl. Physics. 2013:113(14):143909.
NOTE: This article may be obtained online without charge.

Huang C, Holfeld J, Schaden W, Orgill D, Ogawa R.
Mechanotherapy: Revisiting physical therapy and recruiting mechanobiology for a new era in medicine.
Trends Mol Med. 2013 Jun 18. [Epub ahead of print]

Borau C, Kamm RD, Garcia-Aznar JM.
A time-dependent phenomenological model for cell mechano-sensing.
Biomech Model Mechanobiol. 2013 Jun 20. [Epub ahead of print]

Ross TD, Coon BG, Yun S, Baeyens N, Tanaka K, Ouyang M, Schwartz MA.
Integrins in mechanotransduction.
Curr Opin Cell Biol. 2013 Jun 21. [Epub ahead of print]

Bouffanais R, Sun J, Yue DK.
Physical limits on cellular directional mechanosensing.
Phys Rev E Stat Nonlin Soft Matter Phys. 2013 May;87(5):052716. Epub 2013 May 29.

Zou N, Li B, Chen H, Su Y, Kronzucker HJ, Xiong L, Baluka F, Shi W.
GSA-1/ARG1 protects root gravitropism in Arabidopsis under ammonium stress.
New Phytol. 2013 Jun 20. [Epub ahead of print]

Fu Y, Liu H, Shao L, Wang M, Berkovich YuA, Erokhin AN, Liu H.
A high-performance ground-based prototype of horn-type sequential vegetable production facility for life support system in space.
Adv Space Res. 2013 Jul 1;52(1):97-104.
NOTE: From paper: “To simulate microgravity effect and get morphologically normal plants in the growth chamber, the root modules assembled on stainless steel tube were rotated with rotation velocity of 12 rotations per hour.”

SpaceRef staff editor.