NASA Spaceline Current Awareness 12 August 2011 (Recent Space Life Science Research Results)

Papers deriving from NASA support:

1
Perrien DS, Nicks KM, Liu L, Akel NS, Bacon AW, Skinner RA, Swain FL, Aronson J, Suva LJ, Gaddy D.
Inhibin A enhances bone formation during distraction osteogenesis.
J Orthop Res. 2011 Aug 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21809377
(PI: D.S. Perrien, NASA Graduate Student Researcher Program)

2
Zeitlin C, Miller J, Guetersloh S, Heilbronn L, Fukumura A, Iwata Y, Murakami T, Blattnig S, Norman R, Mashnik S.
Fragmentation of 14N, 16O, 20Ne, and 24Mg nuclei at 290 to 1000 MeV/nucleon.
Phys Rev C. 2011 Mar;83(3):034909.
http://dx.doi.org/10.1103/PhysRevC.83.034909
(PIs: C. Zeitlin, J. Norbury)

3
Badavi FF, Blattnig SR, Atwell W, Nealy JE, Norman RB.
A deterministic electron, photon, proton and heavy ion transport suite for the study of the Jovian moon Europa.
Nucl Instrum Methods Phys Res B. 2011 Feb 1;269(3):232-8.
http://dx.doi.org/10.1016/j.nimb.2010.12.022
(PIs: J. Norbury, C. Sandridge)

4
Loria R, Beckman M, Contaifer D, Tamariz F, Gibb D, Thompson L, Guida P.
Beta androstenediol mitigates the damage of 1GeV/n Fe ion particle radiation to the hematopoietic system.
Cancer Biother Radiopharm. 2011 Aug;26(4): 453-9. Epub 2011 Jul 26.
http://www.ncbi.nlm.nih.gov/pubmed/21790310

5
Azzam EI.
Exposure to low level environmental agents: The induction of hormesis.
Mutat Res. 2011 Jul 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21807115
(PI: E.I. Azzam)
NOTE: This is a comment on this article: http://www.ncbi.nlm.nih.gov/pubmed/21540124

6
Makowski AL, Lindgren K, Locke JP.
Visual side effects of scopolamine/ dextroamphetamine among parabolic fliers.
Aviat Space Environ Med. 2011 Jul;82(7):683-8.
http://www.ncbi.nlm.nih.gov/pubmed/21748905
NOTE: Parabolic flight results.

7
Bonato F, Bubka A, Ishak S, Graveline V.
The sickening rug: A repeating static pattern that leads to motion-sickness-like symptoms.
Perception. 2011;40(4):493-6.
http://www.ncbi.nlm.nih.gov/pubmed/21805924

8
Mangala LS, Zhang Y, He Z, Emami K, Ramesh GT, Story M, Rohde LH, Wu H.
Effects of simulated microgravity on the expression profile of microRNA in human lymphoblastoid cells.
J Biol Chem. 2011 Jul 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21775437
NOTE: This article may temporarily be obtained online without charge.

9
Castro SL, Nelman-Gonzalez M, Nickerson CA, Ott CM.
Low fluid shear culture of Staphylococcus aureus induces attachment-independent biofilm formation and represses hfq expression.
Appl Environ Microbiol. 2011 Jul 29. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21803898
(PI: S.L. Castro, NASA Human Research Program student grant)

10
Sarker S, Ott CM, Barrila J, Nickerson CA.
Discovery of spaceflight-regulated virulence mechanisms in Salmonella and other microbial pathogens: Novel approaches to commercial vaccine development.
Gravit Space Biol. 2010 Aug;23(2):75-8.
(PI: C.A. Nickerson)
NOTE: This article, a review of C.A. Nickerson’s ground and space flight research, may be obtained online without charge. Scroll to the article: http://asgsb.org/bulletins/v23n2/v23n2.pdf
This issue also includes nine 2-page articles, which are not included in this list. The entire issue may be obtained online without charge at the url above.

11
Wheeler RM.
Plants for human life support in space: From Myers to Mars.
Gravit Space Biol. 2010 Aug;23(2):25-35.
This article may be obtained online without charge. Scroll to the article: http://asgsb.org/bulletins/v23n2/v23n2.pdf

13
Im YJ, Killens R, Lee A, Ji M, Lowder C, Grunden AM, Boss WF.
Redesigning plants for spaceflight and beyond: Transfer of genes from Pyrococcus.
Gravit Space Biol. 2010 Aug;23(2):39-48.
NOTE: This article may be obtained online without charge. Scroll to the article: http://asgsb.org/bulletins/v23n2/v23n2.pdf

13
Uhran ML.
Status of US national laboratory on the ISS.
Gravit Space Biol. 2010 Aug;23(2):67-74.
NOTE: This article may be obtained online without charge. Scroll to the article: http://asgsb.org/bulletins/v23n2/v23n2.pdf

Other papers of interest:

1
Zhuravleva OA, Morukov BV, Markin AA, Vostrikova LV, Zabolotskay IV.
Lipid peroxidation rate and the antioxidant protection system during the readaptation period after long-term space flights on board the International Space Station.
Hum Physiol. 2011 May;37(3):347-50.
http://dx.doi.org/10.1134/S0362119711030170
NOTE: ISS results. This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2011 May-Jun;37(3):92-7: http://www.ncbi.nlm.nih.gov/pubmed/21780685

2
Yao YJ, Zhu YS, Yang CB, Zhou XD, Sun XQ.
Artificial gravity with ergometric exercise can prevent enhancement of popliteal vein compliance due to 4-day head-down bed rest.
Eur J Appl Physiol. 2011 Jul 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21786130
NOTE: Bed rest study.

3
Wan L, Ogrinz B, Vigo D, Bersenev E, Tuerlinckx F, Van den Bergh O, Aubert AE.
Cardiovascular autonomic adaptation to long-term confinement during a 105-day simulated Mars mission.
Aviat Space Environ Med. 2011 Jul;82(7):711-6.
http://www.ncbi.nlm.nih.gov/pubmed/21748910

4
Valeeva OA, Pastushkova LK, Pakharukova NA, Dobrokhotov IV, Larina IM.
Variability of urine proteome in healthy humans during a 105-day isolation in a pressurized compartment.
Hum Physiol. 2011 May;37(3):351-4.
http://dx.doi.org/10.1134/S0362119711030157
NOTE: This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2011 May-Jun;37(3):98-102: http://www.ncbi.nlm.nih.gov/pubmed/21780686

5
Kuzichkin DS, Markin AA, Morukov BV.
Hemostasis system indices in the course of a 105-day hermetic chamber isolation experiment.
Hum Physiol. 2011 May;37(3):379-81.
http://dx.doi.org/10.1134/S0362119711020125
NOTE: This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2011 May-Jun;37(3):129-31: http://www.ncbi.nlm.nih.gov/pubmed/21780689

6
Muid S, Froemming GR, Manaf A, Muszaphar S, Yusoff K, Nawawi H.
Changes in protein and gene expression of adhesion molecules and cytokines of endothelial cells immediately following short-term spaceflight travel.
Gravit Space Biol. 2010 Aug;23(2 Supp.):S1-S11.
NOTE: ISS results. This article may be obtained online without charge. Scroll to the article: http://asgsb.org/bulletins/v23n2/v23n2.pdf

7
Kotanen C, Guiseppi-Elie A.
Development of an implantable biosensor system for physiological status monitoring during long duration space exploration.
Gravit Space Biol. 2010 Aug;23(2):55-63.
NOTE: This article may be obtained online without charge. Scroll to the article: http://asgsb.org/bulletins/v23n2/v23n2.pdf

8
Turianikova Z, Javorka K, Baumert M, Calkovska A, Javorka M.
The effect of orthostatic stress on multiscale entropy of heart rate and blood pressure.
Physiol Meas. 2011 Jul 28;32(9):1425-37. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21799239

9
Novak P.
Quantitative autonomic testing.
J Vis Exp. 2011 Jul 19;(53). pii: 2502.
http://www.ncbi.nlm.nih.gov/pubmed/21788940
NOTE: This article and video may be obtained online without charge.

10
Wittwer ED, Liu Z, Warner ND, Schroeder DR, Nadeau AM, Allen AR, Murillo CJ, Elvebak RL, Aakre BM, Eisenach JH.
Beta-1 and beta-2 adrenergic receptor polymorphism and association with cardiovascular response to orthostatic screening.
Auton Neurosci. 2011 Jul 31. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21807569

11
Rickards CA, Ryan KL, Cooke WH, Convertino VA.
Tolerance to central hypovolemia: The influence of oscillations in arterial pressure and cerebral blood velocity.
J Appl Physiol. 2011 Jul 28. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21799129

12
Steiner JL, Murphy EA, McClellan JL, Carmichael MD, Davis JM.
Exercise training increases mitochondrial biogenesis in the brain.
J Appl Physiol. 2011 Aug 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21817111

13
Garunova KA, Grigorenko DE, Aminova GG.
[Morphological peculiarities of mesenteric lymph nodes in hypokinesia modeling]
Morfologiia. 2011;139(1):49-52. Russian.
http://www.ncbi.nlm.nih.gov/pubmed/21539086

14
Maentysaari M, Joutsi-Korhonen L, Siimes MA, Siitonen S, Parkkola K, Lemponen M, Lassila R.
Unaltered blood coagulation and platelet function in healthy subjects exposed to acute hypoxia.
Aviat Space Environ Med. 2011 Jul;82(7):699-703.
http://www.ncbi.nlm.nih.gov/pubmed/21748908

15
Curry TB, Lundgren CE.
Nitrogen washout during a fatty meal while breathing nitrogen-free gas at sea level.
Aviat Space Environ Med. 2011 Jul;82(7):725-8.
http://www.ncbi.nlm.nih.gov/pubmed/21748912

16
Armbrecht G, Belav DL, Backstroem M, Beller G, Alexandre C, Rizzoli R, Felsenberg D.
Trabecular and cortical bone density and architecture in women after 60-days of bed-rest using high-resolution pQCT: WISE 2005.
J Bone Miner Res. 2011 Aug 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21812030
NOTE: WISE-2005 bed rest study.

17
Belavy DL, Bansmann PM, Boehme G, Frings-Meuthen P, Heer M, Rittweger J, Zange J, Felsenberg D.
Changes in intervertebral disc morphology persist 5 months after 21-days bed-rest.
J Appl Physiol. 2011 Jul 28. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21799122
NOTE: Bed rest study.

18
O’Connell GD, Jacobs NT, Sen S, Vresilovic EJ, Elliott DM.
Axial creep loading and unloaded recovery of the human intervertebral disc and the effect of degeneration.
J Mech Behav Biomed Mater. 2011 Oct;4(7):933-42. Epub 2011 Feb 22.
http://www.ncbi.nlm.nih.gov/pubmed/21783103

19
Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, Komori T.
Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis.
Bone. 2011 Jul 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21803180

20
Matsumoto T.
[Progress and perspectives in bone research]
Nihon Rinsho. 2011 Jul;69(7):1175-80. Japanese.
http://www.ncbi.nlm.nih.gov/pubmed/21774354
NOTE: This issue appears to focus on bone research and osteoporosis. Enter Nihon Rinsho[ta] 69[vi] 7[ip] in the PubMed search box to see the article citations.

21
Sun HB, Cardoso L, Yokota H.
Mechanical intervention for maintenance of cartilage and bone.
Clin Med Insights Arthritis Musculoskelet Disord. 2011;4:65-70. Epub 2011 Jun 29.
http://www.ncbi.nlm.nih.gov/pubmed/21792344
NOTE: This article may be obtained online without charge.

22
Bikle DD, Wang Y.
Insulin like growth factor-I: A critical mediator of the skeletal response to parathyroid hormone.
Curr Mol Pharmacol. 2011 Jun 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21787292
NOTE: This article and the next three articles are part of a “Hot Topic Issue: Molecular and Pharmacological Aspects of Existing and Experimental Bone Anabolic Therapies.” The articles are listed here: http://www.benthamscience.com/cmp/E-Pub-Ahead-of-Schedule.htm
An editorial summarizing the issue by N. Chattopadhyay is available without charge.

23
Greenfield EM.
Anabolic effects of intermittent PTH on osteoblasts.
Curr Mol Pharmacol. 2011 Jun 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21787293

24
Riccardi D.
Antagonizing the calcium-sensing receptor: Towards new bone anabolics?
Curr Mol Pharmacol. 2011 Jun 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21787287

25
Lotinun S, Pearsall RS, Horne WC, Baron R.
Activin receptor signaling: A potential therapeutic target for osteoporosis.
Curr Mol Pharmacol. 2011 Jun 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21787285

26
Itzstein C, Coxon FP, Rogers MJ.
The regulation of osteoclast function and bone resorption by small GTPases.
Small Gtpases. 2011 May-Jun;2(3):117-30.
http://www.ncbi.nlm.nih.gov/pubmed/21776413
NOTE: This article may be obtained online without charge via PubMed Central.

27
Du F, Wang J, Gao Y, Wang H, Wang Q, Jiang S, Goswami N.
A hind limb disuse model inducing extensor digitorum longus atrophy in rats: Tail suspension-immobilization.
Aviat Space Environ Med. 2011 Jul;82(7):689-93.
http://www.ncbi.nlm.nih.gov/pubmed/21748906

28
Min K, Smuder AJ, Kwon OS, Kavazis AN, Szeto HH, Powers SK.
Mitochondrial-targeted antioxidants protect the skeletal muscle against immobilization-induced muscle atrophy.
J Appl Physiol. 2011 Aug 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21817113

29
Powers SK, Hudson MB, Nelson WB, Talbert EE, Min K, Szeto HH, Kavazis AN, Smuder AJ.
Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness.
Crit Care Med. 2011 Jul;39(7):1749-59.
http://www.ncbi.nlm.nih.gov/pubmed/21460706

30
Yasuhara K, Ohno Y, Kojima A, Uehara K, Beppu M, Sugiura T, Fujimoto M, Nakai A, Ohira Y, Yoshioka T, Goto K.
Absence of heat shock transcription factor 1 retards the regrowth of atrophied soleus muscle in mice.
J Appl Physiol. 2011 Aug 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21817109

31
Bialek P, Morris CA, Parkington J, St.Andre M, Owens J, Yaworsky P, Seeherman H, Jelinsky SA.
Distinct protein degradation profiles are induced by different disuse models of skeletal muscle atrophy.
Physiol Genomics. 2011 Jul 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21791639
NOTE: From abstract: “The degradation following casting was ubiquitin-proteasome-mediated, while degradation following tenotomy was lysosomal and matrix-metalloproteinase (MMP)-mediated, suggesting a possible role for autophagy. These data suggest that there are multiple mechanisms leading to muscle atrophy and that specific therapeutic agents may be necessary to combat atrophy resulting from different conditions.”

32
Dobrowolny G, Aucello M, Musaro A.
Muscle atrophy induced by SOD1G93A expression does not involve the activation of caspase in the absence of denervation.
Skelet Muscle. 2011 Jan 24;1:3.
http://www.ncbi.nlm.nih.gov/pubmed/21798081
NOTE: This is a new journal. This article may be obtained online without charge.

33
Ohlendieck K.
Skeletal muscle proteomics: Current approaches, technical challenges and emerging techniques.
Skelet Muscle. 2011 Feb 1;1:6.
http://www.ncbi.nlm.nih.gov/pubmed/21798084
NOTE: This article may be obtained online without charge.

34
Eliasson P, Andersson T, Aspenberg P.
Achilles tendon healing in rats is improved by intermittent mechanical loading during the inflammatory phase.
J Orthop Res. 2011 Aug 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21809382

35
Artero EG, Espada-Fuentes JC, Argueelles-Cienfuegos J, Roman A, Gomez-Lopez PJ, Gutierrez A.
Effects of whole-body vibration and resistance training on knee extensors muscular performance.
Eur J Appl Physiol. 2011 Aug 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21809090

36
Claflin DR, Larkin LM, Cederna PS, Horowitz JF, Alexander NB, Cole NM, Galecki AT, Chen S, Nyquist LV, Carlson BM, Faulkner JA, Ashton-Miller JA.
Effects of high- and low-velocity resistance training on the contractile properties of skeletal muscle fibers from young and older humans.
J Appl Physiol. 2011 Jul 28. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21799130

37
Zou K, Meador BM, Johnson B, Huntsman HD, Mahmassani Z, Valero MC, Huey KA, Boppart MD.
The 71 integrin increases muscle hypertrophy following multiple bouts of eccentric exercise.
J Appl Physiol. 2011 Aug 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21817112

38
Nelson FE, Ortega JD, Jubrias SA, Conley KE, Kushmerick MJ.
High efficiency in human muscle: An anomaly and an opportunity?
J Exp Biol. 2011 Aug 15;214(Pt 16):2649-53.
http://www.ncbi.nlm.nih.gov/pubmed/21795559

39
Jinka TR, Toien O, Drew KL.
Season primes the brain in an arctic hibernator to facilitate entrance into torpor mediated by adenosine A1 receptors.
J Neurosci. 2011 Jul 27;31(30):10752-8.
http://www.ncbi.nlm.nih.gov/pubmed/21795527
NOTE: This article is featured on the cover of the issue and is highlighted in “This Week in the Journal”: http://www.jneurosci.org/content/31/30.toc

40
Konishi T, Takeyasu A, Natsume T, Furusawa Y, Hieda K.
Visualization of heavy ion tracks by labeling 3′-OH termini of induced DNA strand breaks.
J Radiat Res (Tokyo). 2011;52(4):433-40.
http://www.ncbi.nlm.nih.gov/pubmed/21785232
NOTE: This article may be obtained online without charge.

41
Dartnell LR.
Ionizing radiation and life.
Astrobiology. 2011 Jul-Aug;11(6):551-82. Epub 2011 Jul 20.
http://www.ncbi.nlm.nih.gov/pubmed/21774684

42
Mert A, Bles W.
Impact of alignment to gravito-inertial force on motion sickness and cardiopulmonary variables.
Aviat Space Environ Med. 2011 Jul;82(7):694-8.
http://www.ncbi.nlm.nih.gov/pubmed/21748907

43
Xie SJ, Xu Y, Bi HZ, Jia HB, Zheng YJ, Zhang YG.
Ocular vestibular-evoked myogenic potentials in healthy pilots and student pilots.
Aviat Space Environ Med. 2011 Jul;82(7):729-33.
http://www.ncbi.nlm.nih.gov/pubmed/21748913

44
Groen E, Bos JE, Nooij SA.
A rationale for space motion sickness.
Aviat Space Environ Med. 2011 Jul;82(7):737; author reply 737-8.
http://www.ncbi.nlm.nih.gov/pubmed/21748915
NOTE: This letter, commenting on an earlier article, and the response may be obtained online without charge: http://www.ingentaconnect.com/content/asma/asem/2011/00000082/00000007/a…
and http://www.ingentaconnect.com/content/asma/asem/2011/00000082/00000007/a…

45
Cohen B, Dai M, Ogorodnikov D, Laurens J, Raphan T, Mueller P, Athanasios A, Edmaier J, Grossenbacher T, Stadtmueller K, Brugger U, Hauser G, Straumann D.
Motion sickness on tilting trains.
FASEB J. 2011 Jul 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21788449

46
Barnett-Cowan M, Harris LR.
Temporal processing of active and passive head movement.
Exp Brain Res. 2011 Jul 30. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21805199

47
Lipshits MI.
Internal reference frame for the representation and storage of visual information during standing.
Hum Physiol. 2011 May;37(3):299-303.
http://dx.doi.org/10.1134/S0362119711030091
NOTE: This is a translation in English of the Russian original published in Fiziologiya Cheloveka 2011 May-Jun;37(3):36-41: http://www.ncbi.nlm.nih.gov/pubmed/21780677

48
Van Barneveld DC, Kiemeneij AC, Van Opstal AJ.
Absence of spatial updating when the visuomotor system is unsure about stimulus motion.
J Neurosci. 2011 Jul 20;31(29):10558-68.
http://www.ncbi.nlm.nih.gov/pubmed/21775600

49
Della Santina CC, Migliaccio AA, Hayden R, Melvin TA, Fridman GY, Chiang B, Davidovics NS, Dai C, Carey JP, Minor LB, Anderson IC, Park H, Lyford-Pike S, Tang S.
Current and future management of bilateral loss of vestibular sensation – an update on the Johns Hopkins Multichannel Vestibular Prosthesis Project.
Cochlear Implants Int. 2010 Sep;11 Suppl 2:2-11.
http://www.ncbi.nlm.nih.gov/pubmed/21756683
NOTE: This article may be obtained online without charge.

50
Askew GN, Formenti F, Minetti AE.
Limitations imposed by wearing armour on Medieval soldiers’ locomotor performance.
Proc Biol Sci. 2011 Jul 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21775328
NOTE: Perhaps space suits are not so bad?

51
Hoffman BD, Grashoff C, Schwartz MA.
Dynamic molecular processes mediate cellular mechanotransduction.
Nature. 2011 Jul 20;475(7356):316-23.
http://www.ncbi.nlm.nih.gov/pubmed/21776077

52
Hoey DA, Kelly DJ, Jacobs CR.
A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells.
Biochem Biophys Res Commun. 2011 Jul 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21810408

53
Lasseur C, Brunet J, de Weever H, Dixon M, Dussap G, Godia F, Leys N, Mergeay M, Van Der Straeten D.
MELISSA: The European project of closed life support system.
Gravit Space Biol. 2010 Aug;23(2):3-12.
NOTE: This article may be obtained online without charge. Scroll to the article: http://asgsb.org/bulletins/v23n2/v23n2.pdf

54
Tako Y, Arai R, Tsuga SI, Komatsubara O, Masuda T, Nozoe S, Nitta K.
CEEF: Closed Ecology Experiment Facilities.
Gravit Space Biol. 2010 Aug;23(2):13-23.
NOTE: This article may be obtained online without charge. Scroll to the article: http://asgsb.org/bulletins/v23n2/v23n2.pdf

55
Prather KL, McLamore ES, Porterfield DM.
Synthetic biology and the rational design of microbial chemical factories.
Gravit Space Biol. 2010 Aug;23(2):49-54.
NOTE: This article may be obtained online without charge. Scroll to the article: http://asgsb.org/bulletins/v23n2/v23n2.pdf