Status Report

NASA Spaceline Current Awareness 11 May 2012 (Recent Space Life Science Research Results)

By SpaceRef Editor
May 11, 2012
Filed under , , ,

Papers deriving from NASA support:

Smith SM, Heer MA, Shackelford L, Sibonga JD, Ploutz-Snyder L, Zwart SR.
Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: Evidence from biochemistry and densitometry.
J Bone Miner Res. 2012 May 1. [Epub ahead of print]
(PI: S.M. Smith)
NOTE: ISS results. From Discussion: “The data presented here document that astronauts who have access to sufficient resistance exercise, coupled with adequate energy intake and vitamin D status, can return from spaceflight missions of 4-6 months with measured bone mass and bone mineral densities seemingly no different from baseline measures – for most skeletal regions. Although further work is needed to refine these factors (by developing optimal exercise prescriptions and optimal nutrition), the results provide the first evidence that nutrition and exercise may be able to mitigate bone loss and reduce risk for spaceflight-induced osteoporosis. Comparison of the data from this study with data from crewmembers on earlier ISS missions and from the Russian space station Mir missions (figure) shows that when data are normalized to percentage change per month, the benefits of ARED over those of earlier exercise regimens are clear. Additionally, the nutrition findings document that some of the assumptions about human spaceflight are not always true. Specifically, energy intake, body mass, and lean body mass can be maintained during flight, and the same is true for vitamin D status.”

Ball CG, Kirkpatrick AW, Williams DR, Jones JA, Polk JD, Vanderploeg JM, Talamini MA, Campbell MR, Broderick TJ.
Prophylactic surgery prior to extended-duration space flight: Is the benefit worth the risk?
Can J Surg. 2012 Apr;55(2):125-31.
NOTE: This article may be obtained online without charge.

Ortega MT, Lu N, Chapes SK.
Evaluation of in vitro macrophage differentiation during space flight.
Adv Space Res. 2012 May 15;49(10):1441-55.
(PI: S.K. Chapes)
NOTE: STS-126 (mission to ISS) results.

Wakatsuki M, Magpayo N, Kawamura H, Held KD.
Differential bystander signaling between radioresistant chondrosarcoma cells and fibroblasts after X-ray, proton, iron ion and carbon ion exposures.
Int J Radiat Oncol Biol Phys. 2012 Apr 24. [Epub ahead of print]
(PI: K.D. Held)

Templin T, Young EF, Smilenov LB.
Proton radiation induced miRNA signatures in mouse blood: Characterization and comparison with (56)Fe-ion and gamma radiation.
Int J Radiat Biol. 2012 May 3. [Epub ahead of print]
(PI: L.B. Smilenov)

St Hilaire MA, Gooley JJ, Khalsa SB, Kronauer RE, Czeisler CA, Lockley SW.
Human Phase Response Curve (PRC) to a 1-hour pulse of bright white light.
J Physiol. 2012 Apr 30. [Epub ahead of print]
(PIs: S.W. Lockley, C.A. Czeisler)

Chang AM, Santhi N, St Hilaire MA, Gronfier C, Bradstreet DS, Duffy JF, Lockley SW, Kronauer RE, Czeisler CA.
Human duration responses to bright light.
J Physiol. 2012 Apr 23. [Epub ahead of print]
(PI: C.A. Czeisler)

Grigoryan EN, Anton HJ, Poplinskaya VA, Aleinikova KS, Domaratskaya EI, Novikova YP, Almeida E.
Signs of Mueller cell gliotic response found in the retina of newts exposed to real and simulated microgravity.
Adv Space Res. 2012 May 15;49(10):1465-71.
(PI: E. Almeida)
NOTE: Bion 11, Foton M3 results.

Other papers of interest:

Aletti F, Ferrario M, Xu D, Greaves DK, Shoemaker JK, Arbeille P, Baselli G, Hughson RL.
Short term variability of blood pressure: Effects of lower body negative pressure and long duration bed rest.
Am J Physiol Regul Integr Comp Physiol. 2012 May 2. [Epub ahead of print]
NOTE: WISE-2005 bed rest study.

Alessandri N, Petrassi M, Tufano F, Dei Giudici A, De Angelis S, Urciuoli F, Alessandri C, De Angelis C, Tomao E.
Functional changes cardiovascular: Normobaric activity and microgravity in young healthy human subjects.
Eur Rev Med Pharmacol Sci. 2012 Mar;16(3):310-5.

Gojanovic B, Cutti P, Shultz R, Matheson GO.
Maximal physiologic parameters during partial body-weight support treadmill testing.
Med Sci Sports Exerc. 2012 Apr 24. [Epub ahead of print]
NOTE: Website for antigravity treadmill used in this study:

Ryan KL, Rickards CA, Hinojosa-Laborde C, Cooke WH, Convertino VA.
Sympathetic responses to central hypovolemia: New insights from microneurographic recordings.
Front Physiol. 2012;3:110. Epub 2012 Apr 26.
NOTE: This article may be obtained online without charge.

Chung KK, Ryan KL, Rickards CA, Hinojosa-Laborde C, Pamplin JC, Patel SS, Herold TS, Convertino VA.
Progressive reduction in central blood volume is not detected by sublingual capnography.
Shock. 2012 May 1. [Epub ahead of print]

Lindenberger M, Laenne T.
Reduced defense of central blood volume during acute LBNP-induced hypovolemic circulatory stress in aging women.
Shock. 2012 May 1. [Epub ahead of print]

Haranas I, Gkigkitzis I.
One dimensional blood flow in a planetocentric orbit.
Adv Space Res. 2012 May 15;49(10):1456-64.

Masini MA, Albi E, Barmo C, Bonfiglio T, Bruni L, Canesi L, Cataldi S, Curcio F, D’Amora M, Ferri I, Goto K, Kawano F, Lazzarini R, Loreti E, Nakai N, Ohira T, Ohira Y, Palmero S, Prato P, Ricci F, Scarabelli L, Shibaguchi T, Spelat R, Strollo F, Ambesi-Impiombato FS.
The impact of long-term exposure to space environment on adult mammalian organisms: A study on mouse thyroid and testis.
PLoS One. 2012;7(4):e35418. Epub 2012 Apr 25.
NOTE: ISS results. This article may be obtained online without charge.

Rai B, Kaur J, Foing BH.
Salivary amylase and stress during stressful environment: Three Mars analog mission crews study.
Neurosci Lett. 2012 Apr 21. [Epub ahead of print]
NOTE: Mars Desert Research Station study.

Maistrovski Y, Biggar KK, Storey KB.
HIF-1 regulation in mammalian hibernators: Role of non-coding RNA in HIF-1 control during torpor in ground squirrels and bats.
J Comp Physiol B. 2012 Apr 13. [Epub ahead of print]

Rowe WJ.
Correcting magnesium deficiencies may prolong life.
Clin Interv Aging. 2012;7:51-4. Epub 2012 Feb 16.
NOTE: This article may be obtained online without charge.

Knudsen SH, Hansen LS, Pedersen M, Dejgaard T, Hansen J, van Hall G, Thomsen C, Solomon TP, Pedersen BK, Krogh-Madsen R.
Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men.
J Appl Physiol. 2012 May 3. [Epub ahead of print]

Xu PT, Li Q, Sheng JJ, Chang H, Song Z, Yu ZB.
Passive stretch reduces calpain activity through nitric oxide pathway in unloaded soleus muscles.
Mol Cell Biochem. 2012 May 1. [Epub ahead of print]

Ritzmann R, Gollhofer A, Kramer A.
The influence of vibration type, frequency, body position and additional load on the neuromuscular activity during whole body vibration.
Eur J Appl Physiol. 2012 Apr 27. [Epub ahead of print]

Nikolaidis MG, Kyparos A, Spanou C, Paschalis V, Theodorou AA, Vrabas IS.
Redox biology of exercise: An integrative and comparative consideration of some overlooked issues.
J Exp Biol. 2012 May 15;215(Pt 10):1615-25.

Ishii K, Liang N, Oue A, Hirasawa A, Sato K, Sadamoto T, Matsukawa K.
Central command contributes to increased blood flow in the non-contracting muscle at the start of one-legged dynamic exercise in humans.
J Appl Physiol. 2012 Apr 12. [Epub ahead of print]

Kamioka H, Yamashiro T.
[Osteocyte – The instructive role in bone mass regulation – . Mechanosensitivity of osteocytes]
Clin Calcium. 2012 May;22(5):697-704. Japanese.
NOTE: This article and 6 other articles are part of an issue on the topic of the role of osteocytes in bone mass regulation. The citations can be viewed by entering the journal title abbreviation clin calcium [ta] in PubMed. Journal site:

Ushakov IB, Petrov VM, Shafirkin AV, Shtemberg AS.
[Problems of ensuring human radiation safety during interplanetary flights]
Radiats Biol Radioecol. 2011 Sep-Oct;51(5):595-610. Russian.

Hu Y, Lau P, Baumstark-Khan C, Hellweg CE, Reitz G.
X-ray induced alterations in the differentiation and mineralization potential of murine preosteoblastic cells.
Adv Space Res. 2012 May 15;49(10):1422-31.

Loedermann B, Wunderlich R, Frey S, Schorn C, Stangl S, Roedel F, Keilholz L, Fietkau R, Gaipl US, Frey B.
Low dose ionising radiation leads to a NF-B dependent decreased secretion of active IL-1 by activated macrophages with a discontinuous dose-dependency.
Int J Radiat Biol. 2012 Apr 30. [Epub ahead of print]

Dos-Santos-Silva I, De Stavola B, Pizzi C, Evans A, Evans SA.
Cancer incidence in professional flight crew and air traffic control officers: Disentangling the effect of occupational versus lifestyle exposures.
Int J Cancer. 2012 Apr 24. [Epub ahead of print]

Chu H, Li MH, Juan SH, Chiou WY.
Effects of transcutaneous electrical nerve stimulation on motion sickness induced by rotary chair: A crossover study.
J Altern Complement Med. 2012 Apr 26. [Epub ahead of print]

Schubert MC, Migliaccio AA, Ng TW, Shaikh AG, Zee DS.
The under-compensatory roll aVOR does not affect dynamic visual acuity.
J Assoc Res Otolaryngol. 2012 Apr 24. [Epub ahead of print]

Weber KP, Rosengren SM, Michels R, Sturm V, Straumann D, Landau K.
Single motor unit activity in human extraocular muscles during the vestibulo-ocular reflex.
J Physiol. 2012 Apr 23. [Epub ahead of print]

Zheng B, Jiang X, Tien G, Meneghetti A, Panton ON, Atkins MS.
Workload assessment of surgeons: Correlation between NASA TLX and blinks.
Surg Endosc. 2012 Apr 24. [Epub ahead of print]

Ansdell M.
Language protocols in international human spaceflight: Time for a common tongue?
Space Policy. 2012 Feb;28(1):2-6.
NOTE: This article may be obtained online without charge.

Yamazaki T, Yoshimoto M, Nishiyama Y, Okubo Y, Makimura K.
Phenotypic characterization of Aspergillus niger and Candida albicans grown under simulated microgravity using a three-dimensional clinostat.
Microbiol Immunol. 2012 Apr 27. [Epub ahead of print]

Bearon RN.
Helical swimming can provide robust upwards transport for gravitactic single-cell algae; a mechanistic model.
J Math Biol. 2012 Apr 21. [Epub ahead of print]

Chiang MC, Lin H, Cheng YC, Yen CH, Huang RN, Lin KH.
Beta-adrenoceptor pathway enhances mitochondrial function in human neural stem cells via rotary cell culture system.
J Neurosci Methods. 2012 Apr 13;207(2):130-6. [Epub ahead of print]

Siti-Ismail N, Samadikuchaksaraei A, Bishop AE, Polak JM, Mantalaris A.
Development of a novel three-dimensional, automatable and integrated bioprocess for the differentiation of embryonic stem cells into pulmonary alveolar cells in a rotating vessel bioreactor system.
Tissue Eng Part C Methods. 2012 Apr;18(4):263-72. Epub 2012 Feb 10.

Zheng HX, Tian WM, Yan HJ, Jiang HD, Liu SS, Yue L, Han F, Wei LJ, Chen XB, Li Y.
Expression of estrogen receptor in human breast cancer cells regulates mitochondrial oxidative stress under simulated microgravity.
Adv Space Res. 2012 May 15;49(10):1432-40.

Haranas I, Gkigkitzis I, Zouganelis GD.
Intracellular molecular distributions in spacecraft experiments in orbit around Earth.
Adv Space Res. 2012 Apr 1;49(7):1203-11.

Goldmann WH.
Mechanotransduction and focal adhesions.
Cell Biol Int. 2012 Apr 24. [Epub ahead of print]
NOTE: This article may be obtained online without charge.

Kardas D, Nackenhorst U, Balzani D.
Computational model for the cell-mechanical response of the osteocyte cytoskeleton based on self-stabilizing tensegrity structures.
Biomech Model Mechanobiol. 2012 Apr 21. [Epub ahead of print]

Lim SM, Trzeciakowski JP, Sreenivasappa H, Dangott LJ, Trache A.
RhoA-induced cytoskeletal tension controls adaptive cellular remodeling to mechanical signaling.
Integr Biol (Camb). 2012 May 1. [Epub ahead of print]

Hwang Y, Barakat AI.
Dynamics of mechanical signal transmission through prestressed stress fibers.
PLoS One. 2012;7(4):e35343. Epub 2012 Apr 13.
NOTE: This article may be obtained online without charge.

Cao HL, Yin DC, Guo YZ, Ma XL, He J, Guo WH, Xie XZ, Zhou BR.
Rapid crystallization from acoustically levitated droplets.
J Acoust Soc Am. 2012 Apr;131(4):3164-72.

Guyomarc’h S, Leran S, Auzon-Cape M, Perrine-Walker F, Lucas M, Laplaze L.
Early development and gravitropic response of lateral roots in Arabidopsis thaliana.
Philos Trans R Soc Lond B Biol Sci. 2012 Jun 5;367(1595):1509-16.
NOTE: This article may temporarily be obtained online without charge.

Nakayama M, Kaneko Y, Miyazawa Y, Fujii N, Higashitani N, Wada S, Ishida H, Yoshimoto K, Shirasu K, Yamada K, Nishimura M, Takahashi H.
A possible involvement of autophagy in amyloplast degradation in columella cells during hydrotropic response of Arabidopsis roots.
Planta. 2012 Apr 25. [Epub ahead of print]

De Micco V, Buonomo R, Paradiso R, De Pascale S, Aronne G.
Soybean cultivar selection for Bioregenerative Life Support Systems (BLSS) – Theoretical selection.
Adv Space Res. 2012 May 15;49(10):1415-21.

SpaceRef staff editor.