NASA Spaceline Current Awareness 11 March 2011 (Recent Space Life Science Research Results)

Papers deriving from NASA support:

1
Brown RA, Schlegel TT.
Diagnostic utility of the spatial versus individual planar QRS-T angles in cardiac disease detection (STAFF Symposium).
J Electrocardiol. 2011 Feb 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21353236

2
Cherubini R, Cucinotta FA, Gerardi S, Menzel HG, O’Neill P.
Fifteenth International Symposium on Microdosimetry.
Radiat Prot Dosimetry. 2011;143(2-4):133-4.
http://www.ncbi.nlm.nih.gov/pubmed/21362696
NOTE: This Editorial introduces an issue of 82 papers deriving from the Fifteenth International Symposium on Microdosimetry, held in Italy in October 2009. Some of the papers were listed in earlier Current Awareness lists as epubs (12/10/10 and 1/21/11 lists). The Table of Contents may be viewed at: http://rpd.oxfordjournals.org/content/143/2-4.toc

3
Slaba TC, Blattnig SR, Badavi FF, Stoffle NN, Rutledge RD, Lee KT, Zapp EN, Dachev TP, Tomov BT.
Statistical validation of HZETRN as a function of vertical cutoff rigidity using ISS measurements.
Adv Space Res. 2011 Feb 15;47(4):600-10.
http://dx.doi.org/10.1016/j.asr.2010.10.021
NOTE: ISS data were used.

4
Norbury JW.
Perspective on space radiation for space flights in 2020-2040.
Adv Space Res. 2011 Feb 15;47(4):611-21.
http://dx.doi.org/10.1016/j.asr.2010.10.012

5
Woellert K, Ehrenfreund P, Ricco AJ, Hertzfeld H.
Cubesats: Cost-effective science and technology platforms for emerging and developing nations.
Adv Space Res. 2011 Feb 15;47(4):663-84.
http://dx.doi.org/10.1016/j.asr.2010.10.009
NOTE: Life sciences satellites that fall in this category include GeneSat (2006 flight) and PharmaSat (2009). They are briefly described in this paper.

6
Heinbockel JH, Slaba TC, Blattnig SR, Tripathi RK, Townsend LW, Handler T, Gabriel TA, Pinsky LS, Reddell B, Clowdsley MS, Singleterry RC, Norbury JW, Badavi FF, Aghara SK.
Comparison of the transport codes HZETRN, HETC and FLUKA for a solar particle event.
Adv Space Res. 2011 Mar 15;47(6):1079-88.
http://dx.doi.org/10.1016/j.asr.2010.11.012

7
Heinbockel JH, Slaba TC, Tripathi RK, Blattnig SR, Norbury JW, Badavi FF, Townsend LW, Handler T, Gabriel TA, Pinsky LS, Reddell B, Aumann AR.
Comparison of the transport codes HZETRN, HETC and FLUKA for galactic cosmic rays.
Adv Space Res. 2011 Mar 15;47(6):1089-105.
http://dx.doi.org/10.1016/j.asr.2010.11.013

8
Metts JG, Nabity JA, Klaus DM.
Theoretical performance analysis of electrochromic radiators for space suit thermal control.
Adv Space Res. 2011 Apr 1;47(7):1256-64.
http://dx.doi.org/10.1016/j.asr.2010.11.018
(PI: J.G. Metts, NASA Graduate Student Researcher Program)

9
Swanson S, Choi WG, Chanoca A, Gilroy S.
In vivo imaging of Ca(2+), pH, and reactive oxygen species using fluorescent probes in plants.
Annu Rev Plant Biol. 2011 Mar 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21370977
(PI: S. Gilroy)

Other papers of interest:

1
Lind-Holst M, Cotter JD, Helge JW, Boushel R, Augustesen H, van Lieshout JJ, Pott FC.
Cerebral autoregulation dynamics in endurance-trained individuals.
J Appl Physiol. 2011 Mar 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21372098

2
Liu J, Fang P, Liu Y, Lu G, Li Z, Li X, Wang Y.
Duration of head-up tilt test for patients with suspected vasovagal syncope.
Europace. 2011 Feb 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21357590

3
Panigada M, Berra L.
Gravity. It’s not just a good idea. It’s the law.
Minerva Anestesiol. 2011 Feb;77(2):127-8.
http://www.ncbi.nlm.nih.gov/pubmed/21368725
NOTE: This article comments on a paper by Dave et al. (PMID 21283067) that describes different endotracheal tube cuff materials and procedures. The comment emphasizes positioning of the patient to direct secretions away from the lungs and lessen the chance of ventilator associated pneumonia. From the comment: “Making Sir Issac Newton physics simple: what goes up must come down. Secretions travel according to the laws of gravity and this in-vitro study by Dave et al. proves once again that gravity is the main determinant of fluid aspiration no matter what solution you find to countereliminate it.” This comment may be obtained online without charge: http://www.minervamedica.it/en/journals/minerva-anestesiologica/article….

4
Rehders M, Grosshaeuser BB, Smarandache A, Sadhukhan A, Mirastschijski U, Kempf J, Duenne M, Slenzka K, Brix K.
Effects of lunar and Mars dust simulants on HaCaT keratinocytes and CHO-K1 fibroblasts.
Adv Space Res. 2011 Apr 1;47(7):1200-13.
http://dx.doi.org/10.1016/j.asr.2010.11.033

5
Makimura K, Satoh K, Sugita T, Yamazaki T.
[Fungal biota in manned space environment and impact on human health]
Nippon Eiseigaku Zasshi. 2011 Jan;66(1):77-82. Japanese.
http://www.ncbi.nlm.nih.gov/pubmed/21358138
NOTE: Journal title in English is Japanese Journal of Hygiene. This article may be obtained online without charge.

6
Deogenov VA, Kakuris KK, Zorbas YG, Luzhkov AG.
Vanadium supplementation effect on vanadium metabolism during hypokinesia in rats.
Tokai J Exp Clin Med. 2010 Apr 20;35(1):40-5.
http://www.ncbi.nlm.nih.gov/pubmed/21319025
NOTE: This article may be obtained online without charge. The link to it cannot be provided at this time due to internet connection problems, possibly due to the earthquake in Japan.

7
Oe K, Ueha T, Sakai Y, Niikura T, Lee SY, Koh A, Hasegawa T, Tanaka M, Miwa M, Kurosaka M.
The effect of transcutaneous application of carbon dioxide (CO(2)) on skeletal muscle.
Biochem Biophys Res Commun. 2011 Mar 1. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21371433

8
Ogneva IV, Shenkman BS, Kozlovskaya IB.
The contents of desmin and alpha-actinin-1 in the human soleus muscle after seven-day “dry” immersion.
Dokl Biol Sci. 2011 Jan-Feb;436(1):20-2. Epub 2011 Mar 5.
http://www.ncbi.nlm.nih.gov/pubmed/21374005
NOTE: This paper is a translation in English of the Russian original published in Doklady Akademii Nauk 2011;436(5):709-11.

9
Pedersen BK.
Exercise-induced myokines and their role in chronic diseases.
Brain Behav Immun. 2011 Feb 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21354469

10
Sverdlova N.
Tensile trabeculae – Myth or reality?
J Musculoskelet Neuronal Interact. 2011 Mar;11(1):1-7.
http://www.ncbi.nlm.nih.gov/pubmed/21364269
NOTE: This article may be obtained online without charge.

11
Yang PF, Brueggemann GP, Rittweger J.
What do we currently know from in vivo bone strain measurements in humans?
J Musculoskelet Neuronal Interact. 2011 Mar;11(1):8-20.
http://www.ncbi.nlm.nih.gov/pubmed/21364270
NOTE: This article may be obtained online without charge.

12
Felsenberg D, Bock O, Boerst H, Armbrecht G, Beller G, Degner C, Stephan-Oelkers M, Schacht E, Mazor Z, Hashimoto J, Roth HJ, Martus P, Runge M.
Additive impact of alfacalcidol on bone mineral density and bone strength in alendronate treated postmenopausal women with reduced bone mass.
J Musculoskelet Neuronal Interact. 2011 Mar;11(1):34-45.
http://www.ncbi.nlm.nih.gov/pubmed/21364273
NOTE: This article may be obtained online without charge.

13
Ikawa T, Kawaguchi A, Okabe T, Ninomiya T, Nakamichi Y, Nakamura M, Uehara S, Nakamura H, Udagawa N, Takahashi N, Nakamura H, Wakitani S.
Hypergravity suppresses bone resorption in ovariectomized rats.
Adv Space Res. 2011 Apr 1;47(7):1214-24.
http://dx.doi.org/10.1016/j.asr.2010.12.004

14
McBride SH, Dolejs S, Knothe U, Knothe Tate ML.
Major and minor centroidal axes serve as objective, automatable reference points to test mechanobiological hypotheses using histomorphometry.
J Biomech. 2011 Feb 25. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21353676

15
Papapoulos SE.
Targeting sclerostin as potential treatment of osteoporosis.
Ann Rheum Dis. 2011 Mar;70 Suppl 1:i119-22.
http://www.ncbi.nlm.nih.gov/pubmed/21339215

16
Mitchell BD, Yerges-Armstrong LM.
The genetics of bone loss: Challenges and prospects.
J Clin Endocrinol Metab. 2011 Feb 23. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21346070

17
Avanzino L, Bassolino M, Pozzo T, Bove M.
Use-dependent hemispheric balance.
J Neurosci. 2011 Mar 2;31(9):3423-8.
http://www.ncbi.nlm.nih.gov/pubmed/21368053

18
Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, van Vliet N, Kuster B, Mann M, Ciechanover A, Dahm-Daphi J, Kanaar R, Hu MC, Chen DJ, Oren M, Shiloh Y.
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.
Mol Cell. 2011 Mar 4;41(5):529-42.
http://www.ncbi.nlm.nih.gov/pubmed/21362549
NOTE: This article may be obtained online without charge.

19
Nakamura K, Kato A, Kobayashi J, Yanagihara H, Sakamoto S, Oliveira DV, Shimada M, Tauchi H, Suzuki H, Tashiro S, Zou L, Komatsu K.
Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.
Mol Cell. 2011 Mar 4;41(5):515-28.
http://www.ncbi.nlm.nih.gov/pubmed/21362548
NOTE: This article may be obtained online without charge.

20
Dicello JF, Gersey BB, Gridley DS, Coutrakon GB, Lesyna D, Pisacane VL, Robertson JB, Schulte RW, Slater JD, Wroe AJ, Slater JM.
Microdosimetric comparison of scanned and conventional proton beams used in radiation therapy.
Radiat Prot Dosimetry. 2011;143(2-4):513-8.
http://www.ncbi.nlm.nih.gov/pubmed/21362697

21
Caffrey JA, Hamby DM.
A review of instruments and methods for dosimetry in space.
Adv Space Res. 2011 Feb 15;47(4):563-74.
http://dx.doi.org/10.1016/j.asr.2010.10.005

22
Zhang M, Liang S, Hang X, Xiang Y, Cheng Z, Li W, Shi J, Huang L, Sun Y.
Identification of heavy-ion radiation-induced microRNAs in rice.
Adv Space Res. 2011 Mar 15;47(6):1054-61.
http://dx.doi.org/10.1016/j.asr.2010.10.024

23
Mancusi D, Boudard A, Cugnon J, David JC, Leray S.
Influence of nuclear de-excitation on observables relevant for space exploration.
Adv Space Res. 2011 Apr 1;47(7):1194-9.
http://dx.doi.org/10.1016/j.asr.2010.11.031

24
Cohen B, Martinelli GP, Ogorodnikov D, Xiang Y, Raphan T, Holstein GR, Yakushin SB.
Sinusoidal galvanic vestibular stimulation (sGVS) induces a vasovagal response in the rat.
Exp Brain Res. 2011 Mar 4. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21374078

25
Anagnostou E, Heimberger J, Sklavos S, Anastasopoulos D.
Alexander’s law during high-acceleration head rotations in humans.
Neuroreport. 2011 Mar 30;22(5):239-43.
http://www.ncbi.nlm.nih.gov/pubmed/21346643

26
Merfeld DM.
Signal detection theory and vestibular thresholds: I. Basic theory and practical considerations.
Exp Brain Res. 2011 Feb 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21359662

27
Robillard R, Lanfranchi PA, Prince F, Filipini D, Carrier J.
Sleep deprivation increases blood pressure in healthy normotensive elderly and attenuates the blood pressure response to orthostatic challenge.
Sleep. 2011 Mar 1;34(3):335-9.
http://www.ncbi.nlm.nih.gov/pubmed/21358850

28
Zhang H, Landmann F, Zahreddine H, Rodriguez D, Koch M, Labouesse M.
A tension-induced mechanotransduction pathway promotes epithelial morphogenesis.
Nature. 2011 Mar 3;471(7336):99-103.
http://www.ncbi.nlm.nih.gov/pubmed/21368832

29
Schmidt S, Nakchbandi I, Ruppert R, Kawelke N, Hess MW, Pfaller K, Jurdic P, Faessler R, Moser M.
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption.
J Cell Biol. 2011 Mar 7;192(5):883-97. Epub 2011 Feb 28.
http://www.ncbi.nlm.nih.gov/pubmed/21357746

30
Knauer T, Duemmer M, Landgraf F, Forreiter C.
A negative effector of blue light-induced and gravitropic bending in Arabidopsis thaliana.
Plant Physiol. 2011 Mar 2. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/21367967
NOTE: This article may be obtained online without charge.

31
Masini MA, Prato P, Scarabelli L, Lanza C, Palmero S, Pointis G, Ricci F, Strollo F.
In vitro effects of simulated microgravity on Sertoli cell function.
Adv Space Res. 2011 Feb 15;47(4):575-81.
http://dx.doi.org/10.1016/j.asr.2010.10.004

32
Wu Y, Yang DY, Tu PF, Tian YZ, Guo YH, Wang XM, Li XB.
Genetic differentiation induced by spaceflight treatment of Cistanche deserticola and identification of inter-simple sequence repeat markers associated with its medicinal constituent contents.
Adv Space Res. 2011 Feb 15;47(4):591-9.
http://dx.doi.org/10.1016/j.asr.2010.10.010
NOTE: Results from plants grown from seeds flown on a Chinese space flight.

33
Takahashi A, Suzuki H, Omori K, Seki M, Hashizume T, Shimazu T, Ishioka N, Ohnishi T.
Expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines after spaceflight in a frozen state.
Adv Space Res. 2011 Mar 15;47(6):1062-70.
http://dx.doi.org/10.1016/j.asr.2010.11.002
NOTE: ISS results.

34
Nelson M, Wolverton BC.
Plants + soil/wetland microbes: Food crop systems that also clean air and water.
Adv Space Res. 2011 Feb 15;47(4):582-90.
http://dx.doi.org/10.1016/j.asr.2010.10.007

35
Zaets I, Burlak O, Rogutskyy I, Vasilenko A, Mytrokhyn O, Lukashov D, Foing B, Kozyrovska N.
Bioaugmentation in growing plants for lunar bases.
Adv Space Res. 2011 Mar 15;47(6):1071-8.
http://dx.doi.org/10.1016/j.asr.2010.11.014