NASA Spaceline Current Awareness 1 February 2013 (Recent Space Life Science Research Results)

Next list: February 22, 2013
Papers deriving from NASA support:

1
LeBlanc A, Matsumoto T, Jones J, Shapiro J, Lang T, Shackelford L, Smith SM, Evans H, Spector E, Ploutz-Snyder R, Sibonga J, Keyak J, Nakamura T, Kohri K, Ohshima H.
Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight.
Osteoporos Int. 2013 Jan 19. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23334732
(PI: A. LeBlanc)
NOTE: ISS results. The first two pages of this article may be obtained online without charge. This is the current policy for many Springer journals.

2
Davis RT 3rd, Stabley JN, Dominguez JM, Ramsey MW, McCullough DJ, Lesniewski LA, Delp MD, Behnke BJ.
Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation.
J Appl Physiol. 2013 Jan 24. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23349454
(PI: M.D. Delp)

3
Sorensen MD, Harper JD, Hsi RS, Shah AR, Dighe MK, Carter SJ, Moshiri M, Paun M, Lu W, Bailey MR.
B-mode ultrasound versus color Doppler twinkling artifact in detecting kidney stones.
J Endourol. 2013 Jan 30. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23067207
(PI: L.A. Crum)

4
Sorensen MD, Bailey MR, Shah AR, Hsi RS, Paun M, Harper JD.
Quantitative assessment of shockwave lithotripsy accuracy and the effect of respiratory motion.
J Endourol. 2012 Aug;26(8):1070-4. Epub 2012 Jun 13.
http://www.ncbi.nlm.nih.gov/pubmed/22471349
(PI: L.A. Crum)

5
Feldman G, Zayfert C, Sandoval L, Dunn E, Cartreine JA.
Reward responsiveness and anxiety predict performance of Mount Everest climbers.
J Res Personality. 2013 Feb;47(1):111-5.
http://dx.doi.org/10.1016/j.jrp.2012.10.001
(PI: J.A. Cartreine)

6
Choi S, Chang MS, Stuecker T, Chung C, Newcombe DA, Venkateswaran K.
A fosmid cloning strategy for detecting the widest possible spectrum of microbes from the International Space Station drinking water system.
Genomics Inform. 2012 Dec;10(4):249-55. Epub 2012 Dec 31.
http://www.ncbi.nlm.nih.gov/pubmed/23346038
NOTE: This article, which may be obtained online without charge, contains an analysis of samples taken from sources considered part of the ISS drinking water system. From Methods: “Two drinking water samples from the Kennedy Space Center, Orlando, Florida, USA – namely, water samples from the ground service equipment tank (Prebiocide) and the space shuttle water tank (iodine-treated water; Tank A) – were collected for microbial diversity assessment.”

7
Drolia R, Von Ohlen T, Chapes SK.
Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster.
Int J Med Microbiol. 2013 Jan;303(1):40-9. Epub 2013 Jan 8.
http://www.ncbi.nlm.nih.gov/pubmed/23306065
(PI: S.K. Chapes)
NOTE: This article may be obtained online without charge if accessed via the Table of Contents of the issue.

8
Loucas BD, Durante M, Bailey SM, Cornforth MN.
Chromosome damage in human cells by rays, particles and heavy ions: Track interactions in basic dose-response relationships.
Radiat Res. 2013 Jan;179(1):9-20. Epub 2012 Nov 30.
http://www.ncbi.nlm.nih.gov/pubmed/23198992
(PIs: S.M. Bailey, M.N. Cornforth)

9
Waters KM, Stenoien DL, Sowa MB, von Neubeck C, Chrisler WB, Tan R, Sontag RL, Weber TJ.
Annexin A2 modulates radiation-sensitive transcriptional programming and cell fate.
Radiat Res. 2013 Jan;179(1):53-61. Epub 2012 Nov 13.
http://www.ncbi.nlm.nih.gov/pubmed/23148505
(PI: M.B. Sowa)

10
Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH.
Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes.
Clin Cancer Res. 2013 Jan 21. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23339125
(PI: M.H. Barcellos-Hoff/NSCOR)

11
Barcellos-Hoff MH.
Does microenvironment contribute to the etiology of estrogen receptor-negative breast cancer?
Clin Cancer Res. 2013 Jan 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23325583
(PI: M.H. Barcellos-Hoff/NSCOR)

12
Barcellos-Hoff MH.
New biological insights on the link between radiation exposure and breast cancer risk.
J Mammary Gland Biol Neoplasia. 2013 Jan 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23325014
(PI: M.H. Barcellos-Hoff/NSCOR)

13
Eisch AJ, Petrik D.
Depression and hippocampal neurogenesis: A road to remission?
Science. 2012 Oct 5;338(6103):72-5.
http://www.ncbi.nlm.nih.gov/pubmed/23042885
(PIs: A.J. Eisch, B.P. Chen)
NOTE: This article is part of a special section on Depression.

14
Kolb EM, Rezende EL, Holness L, Radtke A, Lee SK, Obenaus A, Garland T Jr.
Mice selectively bred for high voluntary wheel running have larger midbrains: Support for the mosaic model of brain evolution.
J Exp Biol. 2013 Feb 1;216(Pt 3):515-23.
http://www.ncbi.nlm.nih.gov/pubmed/23325861
(PI: A. Obenaus)

15
Eckstein MP, Mack SC, Liston DB, Bogush L, Menzel R, Krauzlis RJ.
Rethinking human visual attention: Spatial cueing effects and optimality of decisions by honeybees, monkeys and humans.
Vision Res. 2013 Jan 5. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23298793

16
Czeisler CA, Pellegrini CA, Sade RM.
Should sleep-deprived surgeons be prohibited from operating without patients’ consent?
Ann Thorac Surg. 2013 Feb;95(2):757-66.
http://www.ncbi.nlm.nih.gov/pubmed/23336899
(PI: C.A. Czeisler)

Other papers of interest:

1
Rakova N, Juettner K, Dahlmann A, Schroeder A, Linz P, Kopp C, Rauh M, Goller U, Beck L, Agureev A, Vassilieva G, Lenkova L, Johannes B, Wabel P, Moissl U, Vienken J, Gerzer R, Eckardt KU, Mueller DN, Kirsch K, Morukov B, Luft FC, Titze J.
Long-term space flight simulation reveals infradian rhythmicity in human Na(+) balance.
Cell Metab. 2013 Jan 8;17(1):125-31.
http://www.ncbi.nlm.nih.gov/pubmed/23312287
NOTE: This article reports on results from Mars105 and Mars520 simulations (data for 105 and 205 days), part of the Mars500 program. This article is described in a comment “A trip to inner space: Insights into salt balance from cosmonauts”: http://www.ncbi.nlm.nih.gov/pubmed/23312276
The article is also featured on the cover of the journal: http://www.cell.com/cell-metabolism/issue?pii=S1550-4131(12)X0013-5#

2
Moffitt JA, Henry MK, Welliver KC, Jepson AJ, Garnett ER.
Hindlimb unloading results in increased predisposition to cardiac arrhythmias and alters left ventricular connexin43 expression.
Am J Physiol Regul Integr Comp Physiol. 2013 Jan 9. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23302960

3
Li TZ, Yuan M, Chen ZH, Guo YH, Kang CY, Wang JY, Li ZL, Wang DS, Wang HJ, Yuan M, Liu CT.
Effect of simulated microgravity and its associated mechanism on pulmonary circulation in rats.
Biomed Environ Sci. 2013 Feb;26(2):118-27.
http://www.ncbi.nlm.nih.gov/pubmed/23336135
NOTE: This article may be obtained online without charge.

4
Schneider S, Abeln V, Askew CD, Vogt T, Hoffmann U, Denise P, Strueder HK.
Changes in cerebral oxygenation during parabolic flight.
Eur J Appl Physiol. 2013 Jan 20. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23334389
NOTE: Parabolic flight results.

5
Ogoh S, Nakahara H, Okazaki K, Bailey DM, Miyamoto T.
Cerebral hypoperfusion modifies the respiratory chemoreflex during orthostatic stress.
Clin Sci (Lond). 2013 Jan 21. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23330653

6
Gmitrov J.
Static magnetic field effect on microcirculation, direct versus baroreflex-mediated approach.
Electromagn Biol Med. 2013 Jan 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23323761

7
Dos Santos RQ, Smidt L, Suzigan BH, De Souza LV, Barbisan JN.
Efficacy of lower limb compression in the management of vasovagal syncope-randomized, crossover study.
Pacing Clin Electrophysiol. 2013 Jan 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23305349

8
Wu CW, Biggar KK, Storey KB.
Biochemical adaptations of mammalian hibernation: Exploring squirrels as a perspective model for naturally induced reversible insulin resistance.
Braz J Med Biol Res. 2013 Jan 11:0. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23314346
NOTE: This article may be obtained online without charge.

9
Schellart NA, van Rees Vellinga TP, van Hulst RA.
Body fat does not affect venous bubble formation after air dives of moderate severity: Theory and experiment.
J Appl Physiol. 2013 Jan 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23305985

10
Nakamura H, Aoki K, Masuda W, Alles N, Nagano K, Fukushima H, Osawa K, Yasuda H, Nakamura I, Mikuni-Takagaki Y, Ohya K, Maki K, Jimi E.
Disruption of NF-B1 prevents bone loss caused by mechanical unloading.
J Bone Miner Res. 2013 Jan 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23322687

11
Gerbaix M, Metz L, Mac-Way F, Lavet C, Guillet C, Walrand S, Masgrau A, Vico L, Courteix D.
A well-balanced diet combined or not with exercise induces fat mass loss without any decrease of bone mass despite bone micro-architecture alterations in obese rat.
Bone. 2013 Jan 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23318975

12
Macias BR, Aspenberg P, Agholme F.
Paradoxical Sost gene expression response to mechanical unloading in metaphyseal bone.
Bone. 2013 Jan 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23337040

13
Komori T.
Functions of the osteocyte network in the regulation of bone mass.
Cell Tissue Res. 2013 Jan 18. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23329124
NOTE: This article may be obtained online without charge.

14
Ko CY, Kang H, Ryu Y, Jung B, Kim H, Jeong D, Shin HI, Lim D, Kim HS.
The effects of minimally invasive laser needle system on suppression of trabecular bone loss induced by skeletal unloading.
Lasers Med Sci. 2013 Jan 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23324954

15
Nguyen J, Tang SY, Nguyen D, Alliston T.
Load regulates bone formation and Sclerostin expression through a TGF-dependent mechanism.
PLoS One. 2013;8(1):e53813. Epub 2013 Jan 7.
http://www.ncbi.nlm.nih.gov/pubmed/23308287
NOTE: This article may be obtained online without charge.

16
Xu R, Andres-Mateos E, Mejias R, MacDonald EM, Leinwand LA, Merriman DK, Fink RH, Cohn RD.
Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization.
Exp Neurol. 2013 Jan 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23333568

17
Tikkanen O, Haakana P, Pesola AJ, Haekkinen K, Rantalainen T, Havu M, Pullinen T, Finni T.
Muscle activity and inactivity periods during normal daily life.
PLoS One. 2013;8(1):e52228. Epub 2013 Jan 18.
http://www.ncbi.nlm.nih.gov/pubmed/23349681
NOTE: This article may be obtained online without charge.

18
Britten RA, Nazaryan V, Davis LK, Klein SB, Nichiporov D, Mendonca MS, Wolanski M, Nie X, George J, Keppel C.
Variations in the RBE for cell killing along the depth-dose profile of a modulated proton therapy beam.
Radiat Res. 2013 Jan;179(1):21-8. Epub 2012 Nov 13.
http://www.ncbi.nlm.nih.gov/pubmed/23148508

19
Ma L, Nie L, Liu J, Zhang B, Song S, Sun M, Yang J, Yang Y, Fang X, Hu S, Zhao Y, Yu J.
An RNA-seq-based gene expression profiling of radiation-induced tumorigenic mammary epithelial cells.
Genomics Proteomics Bioinformatics. 2012 Dec;10(6):326-35. Epub 2012 Dec 4.
http://www.ncbi.nlm.nih.gov/pubmed/23317700
NOTE: This article may be obtained online without charge.

20
Davis AJ, Lee KJ, Chen DJ.
The amino-terminal region of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is required for its DNA double-strand break-mediated activation.
J Biol Chem. 2013 Jan 15. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23322783
NOTE: This article may temporarily be obtained online without charge.

21
Kim JH, Kolozsvary AJ, Jenrow KA, Brown SL.
Mechanisms of radiation-induced skin injury and implications for future clinical trials.
Int J Radiat Biol. 2013 Jan 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23305180

22
Causse M, Peran P, Dehais F, Caravasso CF, Zeffiro T, Sabatini U, Pastor J.
Affective decision making under uncertainty during a plausible aviation task: An fMRI study.
Neuroimage. 2013 Jan 9;71C:19-29. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23313780

23
Indovina I, Maffei V, Pauwels K, Macaluso E, Orban GA, Lacquaniti F.
Simulated self-motion in a visual gravity field: Sensitivity to vertical and horizontal heading in the human brain.
Neuroimage. 2013 Jan 13. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23321153

24
Furman JM, Redfern MS, Fuhrman SI, Jennings JR.
Visual-vestibular stimulation influences spatial and non-spatial cognitive processing.
J Vestib Res. 2012 Jan 1;22(5-6):253-9.
http://www.ncbi.nlm.nih.gov/pubmed/23302706

25
Pettorossi VE, Panichi R, Botti FM, Kyriakareli A, Ferraresi A, Faralli M, Schieppati M, Bronstein AM.
Prolonged asymmetric vestibular stimulation induces opposite, long-term effects on self-motion perception and ocular responses.
J Physiol. 2013 Jan 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23318876

26
Dale A, Cullen KE.
The nucleus prepositus predominantly outputs eye movement-related information during passive and active self-motion.
J Neurophysiol. 2013 Jan 16. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23324318

27
Bronstein AM, Pavlou M.
Balance.
Handb Clin Neurol. 2013;110:189-208.
http://www.ncbi.nlm.nih.gov/pubmed/23312641

28
Hubbard TL, Ruppel SE.
A Froehlich effect and representational gravity in memory for auditory pitch.
J Exp Psychol Hum Percept Perform. 2013 Jan 14. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23317117

29
Lopez C, Falconer CJ, Mast FW.
Being moved by the self and others: Influence of empathy on self-motion perception.
PLoS One. 2013;8(1):e48293. Epub 2013 Jan 11.
http://www.ncbi.nlm.nih.gov/pubmed/23326302
NOTE: This article may be obtained online without charge.

30
Yuan CQ, Li YF, Sun P, Sun YH, Zhang GJ, Yang MS, Zhang YY, Li Y, Wang L.
Assessment of genetic diversity and variation of Robinia pseudoacacia seeds induced by short-term spaceflight based on two molecular marker systems and morphological traits.
Genet Mol Res. 2012 Dec 17;11(4):4268-77.
http://www.ncbi.nlm.nih.gov/pubmed/23315806
NOTE: Results from plants grown from seeds flown on a Chinese satellite (Shijian 8). This article may be obtained online without charge (direct link to pdf): http://geneticsmr.com//year2012/vol11-4/pdf/gmr2024.pdf

31
Okumura E, Tanaka R, Yoshiga T.
Negative gravitactic behavior of Caenorhabditis japonica dauer larvae.
J Exp Biol. 2013 Jan 10. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23307800

32
Yoshihara T, Spalding EP, Iino M.
AtLAZY1 is a signaling component required for gravitropism of the Arabidopsis thaliana inflorescence.
Plant J. 2013 Jan 17. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23331961

33
Chambliss AB, Khatau SB, Erdenberger N, Robinson DK, Hodzic D, Longmore GD, Wirtz D.
The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction.
Sci Rep. 2013;3:1087. Epub 2013 Jan 18.
http://www.ncbi.nlm.nih.gov/pubmed/23336069
NOTE: This article may be obtained online without charge.

34
Zhang Y, Li XY, Ge HM, Wu L, Xia L, Wang GH, Hu CX, Liu Y.
Influence of clinorotation on cellular structure, photosynthetic activity, carbohydrate and astaxanthin metabolism of Haematococcus pluvialis.
Fresenius Environ Bull. 2012 Aug;21(8):2017-26.
http://www.psp-parlar.de/feb_auswahl.asp

35
Hayakawa K, Tatsumi H, Sokabe M.
Mechano-sensing by actin filaments and focal adhesion proteins.
Commun Integr Biol. 2012 Nov/Dec;5(6):572-7.
http://www.ncbi.nlm.nih.gov/pubmed/23336027
NOTE: This article may be obtained online without charge via PubMed Central or at the publisher’s site: http://www.landesbioscience.com/journals/cib/article/21891/

36
Jonietz E.
Mechanics: The forces of cancer.
Nature. 2012 Nov 22;491(7425):S56-7.
http://www.ncbi.nlm.nih.gov/pubmed/23320288
NOTE: This article is in a supplement to Nature on the topic “Physical scientists take on cancer.” An increased emphasis on mechanobiology and cancer is part of this effort. The articles are available online without charge: http://www.nature.com/nature/journal/v491/n7425_supp/index.html

37
Nick P.
Microtubules, signalling and abiotic stress.
Plant J. 2013 Jan 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23311499