NASA Spaceline Current Awareness List #1,018 23 September 2022 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Please note: The next issue of SPACELINE Current Awareness (List #1,019) will be sent on Friday, October 7, 2022.
Papers deriving from NASA support:
1
McMackin P, Adam J, Griffin S, Hirsa A.
Amyloidogenesis via interfacial shear in a containerless biochemical reactor aboard the International Space Station.
npj Microgravity. 2022 Sep 20;8:41.
https://doi.org/10.1038/s41526-022-00227-2
PI: A. Hirsa
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 4.97
Funding: “The authors would like to thank Louise Littles, Sridhar Gorti, Hong Q. Yang, Kevin Depew, Michael Hall, James McClellan, Heidi Parris, Shawn Reagan, Ryan Reeves, Shawn Stephens, Paul Galloway, Ben Murphy, and Fran Chiramonte for their continued support of both the RSD project and the operations team at Rensselaer Polytechnic Institute. The authors also thank astronauts Raja Chari, Shane Kimbrough, Christina Koch, Akihiko Hoshide, Megan McArthur, Luca Parmitano, Thomas Pasquet, and Mark Vande Hei for their excellence and flexibility during real-time space operations. The authors are also grateful for the support to this study given by NASA BPS, NASA MSFC, NASA JSC, NSF-CASIS, and Teledyne-Brown Engineering. This work was supported by NASA Grant 80NSSC20K1726 and NSF Grant 1929134.”
2
Rosenberg MJ, Reschke MF, Tomilovskaya ES, Wood SJ.
Multiple field tests on landing day: Early mobility may improve postural recovery following spaceflight.
Front Physiol. 2022 Sep 14;
13:921368.
https://doi.org/10.3389/fphys.2022.921368
PI: M.F. Reschke
Note: From the introduction: “The purpose of this paper was to determine if these early, multiple testing on landing day improved postural recovery in the participating crewmembers compared to those who did not participate. Specifically, we compared measures between groups using Computerized Dynamic Posturography (CDP) measures conducted the day after landing. Based on the most challenging CDP test conditions requiring effective use of vestibular input (standing eyes closed on unstable surface with head erect or performing pitch head tilts), post flight postural recovery appeared improved in some field test participants versus non-participant controls. However, the bimodal nature of responses suggest that others may have pushed beyond their motion tolerance limit in an effort to complete more Field Test (FT) objectives. These observations are consistent with encouraging early movement to drive adaptation but performed in a constrained fashion to minimize movements above aversive thresholds.” This article and an article below in the “Other” section (Rozanvov et al.) are part of Research Topic “Space Countermeasures and Medicine – Implementation into Earth medicine and Rehabilitation” (https://www.frontiersin.org/research-topics/29370/space-countermeasures-and-medicine—implementation-into-earth-medicine-and-rehabilitation#overview). The Research Topic also includes articles from previous Current Awareness Lists #997 https://doi.org/10.3389/fphys.2022.897694, #1,004 https://doi.org/10.3389/fphys.2022.921862, #1,009 https://doi.org/10.3389/fphys.2022.921434, #1,012 https://doi.org/10.3389/fphys.2022.928313, #1,014 https://doi.org/10.3389/fphys.2022.943443, and #1,015 https://doi.org/10.3389/fphys.2022.952723. This article may be obtained online without charge.
Journal Impact Factor: 4.755
Funding: “This work was funded by the NASA Human Research Program Field Test, Principal Investigator (PI) Millard Reschke and the Russian Academy of Sciences (project 63.1, PI Inessa Kozlovskaya).”
3
Kumar K, Moon B-H, Datta K, Fornace AJ, Suman S.
Simulated galactic cosmic radiation (GCR)-induced expression of Spp1 coincide with mammary ductal cell proliferation and preneoplastic changes in ApcMin/+
mouse.
Life Sci Space Res. 2022 Sep 18. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.09.006
Journal Impact Factor: 2.730
Funding: “This study is partly supported in part by NASA grant #80NSSC18K1649, and institutional funds.”
4
Roldan P, Ravi S, Hodovan J, Belcik JT, Heitner SB, Masri A, Lindner JR.
Myocardial contrast echocardiography assessment of perfusion abnormalities in hypertrophic cardiomyopathy.
Cardiovasc Ultrasound. 2022 Sep 19;20:23.
https://pubmed.ncbi.nlm.nih.gov/36117179
PI: J.R. Lindner
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.263
Funding: “Dr. Lindner is supported by grants R01-HL078610, R01-HL130046, and P51-OD011092 from the National Institutes of Health (NIH); and by grant 18-18HCFBP_2-0009 from NASA.”
5
Suman S, Fornace AJ.
Countermeasure development against space radiation-induced gastrointestinal carcinogenesis: Current and future perspectives.
Life Sci Space Res. 2022 Sep 15. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.09.005
PI: A.J. Fornace/NSCOR
Journal Impact Factor: 2.730
Funding: “This study is supported by NASA grant # 80NSSC22K1279, NNX09AU95G and 80NSSC18K1649.”
6
Xiong Y, Hirano H, Lane NE, Nandi S, McDonald KA.
Plant-based production and characterization of a promising Fc-fusion protein against microgravity-induced bone density loss.
Front bioeng biotechnol. 2022 Sep 12;10:962292.
https://doi.org/10.3389/fbioe.2022.962292
PI: K.A. McDonald
Note: This article may be obtained online without charge.
Journal Impact Factor: 6.064
Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) under grant or cooperative agreement award number NNX17AJ31G and the Translational Research Institute through NASA NNX16AO69A.”
7
Lalwala M, Devane KS, Koya B, Vu LQ, Dolick K, Yates KM, Newby NJ, Somers JT, Gayzik FS, Stitzel JD, Weaver AA.
Development and validation of an active muscle simplified finite element human body model in a standing posture.
Ann Biomed Eng. 2022 Sep 20.
https://pubmed.ncbi.nlm.nih.gov/36125604
PI: A.A. Weaver
Journal Impact Factor: 4.219
Funding: “This study was supported by a NASA Human Research Program Student Augmentation Award to NASA Grant No. NNX16AP89G.”
8
Liao S, Macharoen K, McDonald KA, Nandi S, Paul D.
Analysis of variability of functionals of recombinant protein production trajectories based on limited data.
Int J Mol Sci. 2022;23(14):7628.
https://pubmed.ncbi.nlm.nih.gov/35886973
PI: K.A. McDonald
Note: This article is part of Special Issue “Recombinant Proteins 3.0” (https://www.mdpi.com/journal/ijms/special_issues/recombinant_proteins_3). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 6.208
Funding: “This work was supported by the Translational Research Institute through NASA NNX16AO69A.”
9
Rahman SA, Kent BA, Grant LK, Clark T, Hanifin JP, Barger LK, Czeisler CA, Brainard GC, St Hilaire MA, Lockley SW.
Effects of dynamic lighting on circadian phase, self-reported sleep and performance during a 45-day space analog mission with chronic variable sleep deficiency.
J Pineal Res. 2022 Aug 23. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35996978
PIs: S.W. Lockley, G.C. Brainard
Journal Impact Factor: 13.007
Funding: “The authors wish to thank the NASA Flight Analog Planning team and HERA project personnel and staff at Johnson Space Center, Houston Texas, for coordinating and executing the missions. The authors also wish to thank Scott M. Smith, Ph.D. and Sara R. Zwart, Ph.D. in the Nutritional Biochemistry Laboratory at the NASA Johnson Space Center for their support of the urine sample collection; Alexandra Whitmire, Ph.D., and Kristine K. Ohnesorge, Jessie Fuentes, Terrell M. Guess, Lorrie Primeaux and Elizabeth A Spence in the NASA Johnson Space Center and Andrei Kolomenski at MEI Technologies for their support in installing and managing the lighting intervention. Matthias Basner, PhD, University of Pennsylvania for provision of the Cognition battery; Erin Flynn‐Evans, Ph.D., NASA Ames for additional mission information; and Matthew Mayer, Brigham and Women’s Hospital for assistance in data processing. This study was supported by the National Aeronautics and Space Administration under Grant NNX15AM28G (Steven W. Lockley). George C. Brainard and Steven W. Lockley were supported in part by NASA grant NNX15AC14G. In addition, George C. Brainard was supported, in part, by a grant from The Nova Institute for Health (The Institute for Integrative Health). John P. Hanifin was supported, in part, by DOE grant DE‐ EE0008207, NAS Award #HR 05‐23 UNIT 905; NASA grant NNX15AC14G; NSF Award #2037357; Rensselaer Polytechnic Institute; BIOS, Toshiba Materials Science, The Institute for Integrative Health; and the Philadelphia Section of the Illuminating Engineering Society. Melissa A. St. Hilaire and Shadab A. Rahman were supported in part by an NIH‐NHLBI training grant T32‐HL07901, Brianne A. Kent by NIH‐NINDS K99/R00 NS109909‐01, and Melissa A. St. Hilaire by NIH‐NINR R21NR018974. Toni Clark was supported by a Human Health & Performance Contract held by Leidos Inc. in support of the Lighting Lab at NASA Johnson Space Center, Houston, TX.”
___________________________________________________
Other papers of interest:
1
Kunitskaya A, Piret JM, Buckley N, Low-Décarie E.
Meta-analysis of health research data from greater than three months ISS missions.
Acta Astronaut. 2022 Sep 16. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2022.09.019
Note: ISS results.
2
Aliberti F, Paolin E, Benedetti L, Cusella G, Ceccarelli G.
3D bioprinting and Rigenera®
micrografting technology: A possible countermeasure for wound healing in spaceflight.
Front Bioeng Biotechnol. 2022 Aug 30;10:937709.
https://pubmed.ncbi.nlm.nih.gov/36110324
Note: From the introduction: “The aim of this work is to discuss the forthcoming experiments that need to be carried out to study and characterize potential countermeasures to guarantee new, effective, and successful medical treatments for astronauts.” This article is part of Research Topic “Wound Management and Healing in Space” (https://www.frontiersin.org/research-topics/14877/wound-management-and-healing-in-space#overview). The Research Topic also includes articles from previous Current Awareness Lists #958 https://doi.org/10.3389/fbioe.2021.679650, #972 https://doi.org/10.3389/fbioe.2021.720091, #973 https://doi.org/10.3389/fbioe.2021.720217 and https://doi.org/10.3389/fbioe.2021.716184, #995 https://doi.org/10.3389/fbioe.2022.666434, #998 https://doi.org/10.3389/fbioe.2022.873384, and #1,008 https://doi.org/10.3389/fbioe.2022.780553. This article may be obtained online without charge.
3
Caswell G, Eshelby B.
Skin microbiome considerations for long haul space flights.
Front Cell Dev Biol. 2022 Sep 8;10:956432.
Note: This article and the article below (Zhang et al.) are part of Research Topic “Space Mechanobiology and Medicine – Volume II” (https://www.frontiersin.org/research-topics/29064/space-mechanobiology-and-medicine—volume-ii#overview). The Research Topic also includes articles from previous Current Awareness List #1,008 https://doi.org/10.3389/fcell.2022.933984 and https://doi.org/10.3389/fcell.2022.896014. This article may be obtained online without charge.
4
Zhang S, Adachi T, Zhang S, Yoshida Y, Takahashi A.
A new type of simulated partial gravity apparatus for rats based on a pully-spring system.
Front Cell Dev Biol. 2022 Aug 31;10:965656.
https://pubmed.ncbi.nlm.nih.gov/36120559
Note: Hindlimb unloading results. This article and the article above (Caswell et al.) are part of Research Topic “Space Mechanobiology and Medicine – Volume II” (https://www.frontiersin.org/research-topics/29064/space-mechanobiology-and-medicine—volume-ii#overview). This article may be obtained online without charge.
5
Mikheeva I, Mikhailova G, Zhujkova N, Shtanchaev R, Arkhipov V, Pavlik L.
Studying the structure of the nucleus of the trochlear nerve in mice through 7 days of readaptation to Earth gravity after spaceflight.
Brain Res. 2022 Nov;1795:148077.
https://pubmed.ncbi.nlm.nih.gov/36096199
Note: From the abstract: “The negative effect of hypogravity on the human organism is manifested to a greater extent after the astronauts return to the conditions of habitual gravity. In this work, to elucidate the causes underlying atypical nystagmus, arising after the flight, we studied structural changes in the motoneurons of the trochlear nerve after a 7-day readaptation of mice to the conditions of Earth’s gravity.”
6
Camy C, Brioche T, Senni K, Bertaud A, Genovesio C, Lamy E, Fovet T, Chopard A, Pithioux M, Roffino S.
Effects of hindlimb unloading and subsequent reloading on the structure and mechanical properties of Achilles tendon-to-bone attachment.
Faseb j. 2022 Oct;36(10):e22548.
https://pubmed.ncbi.nlm.nih.gov/36121701
Note: Hindlimb unloading results.
7
Sucosky P, Kalaiarasan VV, Quasebarth GB, Strack P, Shar JA.
Atherogenic potential of microgravity hemodynamics in the carotid bifurcation: A numerical investigation.
npj Microgravity. 2022 Sep 9;8:39.
https://pubmed.ncbi.nlm.nih.gov/36085153
Note: From the abstract: “Long-duration spaceflight poses multiple hazards to human health, including physiological changes associated with microgravity. The hemodynamic adaptations occurring upon entry into weightlessness have been associated with retrograde stagnant flow conditions and thromboembolic events in the venous vasculature but the impact of microgravity on cerebral arterial hemodynamics and function remains poorly understood. The objective of this study was to quantify the effects of microgravity on hemodynamics and wall shear stress (WSS) characteristics in 16 carotid bifurcation geometries reconstructed from ultrasonography images using computational fluid dynamics modeling.” This article may be obtained online without charge.
8
Rozanov IA, Ryumin O, Karpova O, Shved D, Savinkina A, Kuznetsova P, Diaz Rey N, Shishenina K, Gushin V.
Applications of methods of psychological support developed for astronauts for use in medical settings.
Front Physiol. 2022 Sep 14;13:926597.
https://doi.org/10.3389/fphys.2022.926597
Note: This article and an article above in the “NASA” section (Rosenberg et al.) are part of Research Topic “Space Countermeasures and Medicine – Implementation into Earth medicine and Rehabilitation” (https://www.frontiersin.org/research-topics/29370/space-countermeasures-and-medicine—implementation-into-earth-medicine-and-rehabilitation#overview). This article may be obtained online without charge.
9
de Korte M, Keating A, Wang C.
Culturing lymphocytes in simulated microgravity using a rotary cell culture system.
J Vis Exp. 2022 Aug 25;(186):e63296.
https://pubmed.ncbi.nlm.nih.gov/36094288
Note: A rotary cell culture system was used in this study.
10
Jiang C, Yang S, Guo D, Song P, Tian G, Wang Y, Tian Y, Shao D, Shang L, Shi J.
Simulated microgravity accelerates alloy corrosion by Aspergillus sp. via the enhanced production of organic acids.
Appl Environ Microbiol. 2022 Sep 13:e0091222. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36098535
Note: From the abstract: “The Space Station and other long-term crewed spacecrafts will experience the risk of microbial corrosion, especially mold, which will be harmful to the platform system and astronauts. Aspergillus sp. has been widely reported to produce organic acids that corrode and destroy materials, and the ability of these crafts to fly through space can be significantly affected. Research on the mechanism that causes enhanced corrosion ability of fungi in space stations is important to control their growth. Our research focuses on the interaction between mold and metals. In particular, it is found that metal ions promote mold growth and produce organic acids, thus accelerating mold corrosion of metals. Our results provide a new perspective for the control of fungal corrosion under simulated microgravity.”
11
Shen J, Lin M, Ding M, Yu N, Yang C, Kong D, Sun H, Xie Z.
Tumor immunosuppressive microenvironment modulating hydrogels for second near-infrared photothermal-immunotherapy of cancer.
Mater Today Bio. 2022 Dec;16:100416.
https://pubmed.ncbi.nlm.nih.gov/36105677
12
Wang J, Han Y, Li Y, Zhang F, Cai M, Zhang X, Chen J, Ji C, Ma J, Xu F.
Targeting tumor physical microenvironment for improved radiotherapy.
Small Methods. 2022 Sep 18;e2200570. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36116123
13
Kumar S, Das S, Sun J, Huang Y, Singh SK, Srivastava P, Sondarva G, Nair RS, Viswakarma N, Ganesh BB, Duan L, Maki CG, Hoskins K, Danciu O, Rana B, Li S, Rana A.
Mixed lineage kinase 3 and CD70 cooperation sensitize trastuzumab-resistant HER2+
breast cancer by ceramide-loaded nanoparticles.
Proc Natl Acad Sci USA. 2022 Sep 12;119(38):e2205454119.
https://pubmed.ncbi.nlm.nih.gov/36095190
14
Katerji M, Bertucci A, Filippov V, Vazquez M, Chen X, Duerksen-Hughes PJ.
Proton-induced DNA damage promotes integration of foreign plasmid DNA into human genome.
Front Oncol. 2022 Sep 2;12:928545.
https://pubmed.ncbi.nlm.nih.gov/36119491
Note: This article may be obtained online without charge.
15
Alva R, Mirza M, Baiton A, Lazuran L, Samokysh L, Bobinski A, Cowan C, Jaimon A, Obioru D, Al Makhoul T, Stuart JA.
Oxygen toxicity: Cellular mechanisms in normobaric hyperoxia.
Cell Biol Toxicol. 2022 Sep 16;1-33. Review.
https://pubmed.ncbi.nlm.nih.gov/36112262
Note: This article may be obtained online without charge.
16
Washington TA, Haynie WS, Schrems ER, Perry RA Jr, Brown LA, Williams BM, Rosa-Caldwell ME, Lee DE, Brown JL.Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration.
Sports Med Health Sci. 2022 Sep;4(3):198-208.
https://pubmed.ncbi.nlm.nih.gov/36090923
17
Mulas O, Caocci G, Efficace F, Piras E, Targhetta C, Frau V, Barella S, Piroddi A, Orofino MG, Vacca A, La Nasa G.Long-term health-related quality of life in patients with β-thalassemia after unrelated hematopoietic stem cell transplantation.
Bone Marrow Transplant. 2022 Sep 16.
https://pubmed.ncbi.nlm.nih.gov/36114248
18
Meyer N, Harvey AG, Lockley SW, Dijk DJ.
Circadian rhythms and disorders of the timing of sleep.
Lancet. 2022 Sep 14;400(10357):1061-78. Review.
https://pubmed.ncbi.nlm.nih.gov/36115370
19
Korthas HT, Main BS, Harvey AC, Buenaventura RG, Wicker E, Forcelli PA, Burns MP.
The effect of traumatic brain injury on sleep architecture and circadian rhythms in mice-A comparison of high-frequency head impact and controlled cortical injury.
Biology (Basel). 2022 Jul 8;11(7):1031.
https://pubmed.ncbi.nlm.nih.gov/36101412
Note: This article is part of Special Issue “Advances in Sleep and Inflammation” (https://www.mdpi.com/journal/biology/special_issues/sleep_inflammation). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
20
Robin A, Wang L, Custaud MA, Liu J, Yuan M, Li Z, Lloret JC, Liu S, Dai X, Zhang J, Lv K, Li W, Gauquelin-Koch G, Wang H, Li K, Li X, Qu L, Navasiolava N, Li Y.
Running vs. resistance exercise to counteract deconditioning induced by 90-day head-down bedrest.
Front Physiol. 2022 Aug 31;13:902983.
Note: This article is part of Research Topic “Rising Stars in Environmental, Aviation and Space Physiology: 2022” (https://www.frontiersin.org/research-topics/29535/rising-stars-in-environmental-aviation-and-space-physiology-2022#articles). The Research Topic also includes articles from previous Current Awareness Lists #993 https://doi.org/10.3389/fphys.2022.846229, #1,010 https://doi.org/10.3389/fphys.2022.899830, and #1,015 https://doi.org/10.3389/fphys.2022.933450 and https://doi.org/10.3389/fphys.2022.902983. This article may be obtained online without charge.
