Space Stations

NASA Spaceline Current Awareness List #1,012 12 August 2022 (Space Life Science Research Results)

By Keith Cowing
Press Release
August 12, 2022
Filed under , , , , , , , ,
NASA Spaceline Current Awareness List #1,012 12 August 2022 (Space Life Science Research Results)
Space Biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Franco Meléndez K, Crenshaw K, Barrila J, Yang J, Gangaraju S, Davis RR, Forsyth RJ, Ott CM, Kader R, Curtiss R, Roland K, Nickerson CA.

Role of RpoS in regulating stationary phase Salmonella Typhimurium pathogenesis-related stress responses under physiological low fluid shear force conditions.

mSphere. Aug 1;e00210-22.

PI: C. Nickerson

Note: From the abstract: “The discovery that biomechanical forces regulate microbial virulence was established with the finding that physiological low fluid shear (LFS) forces altered gene expression, stress responses, and virulence of the enteric pathogen Salmonella enterica serovar Typhimurium during the log phase. These log phase LFS-induced phenotypes were independent of the master stress response regulator, RpoS. Given the central importance of RpoS in regulating stationary-phase stress responses of S. Typhimurium cultured under conventional shake flask and static conditions, we examined its role in stationary-phase cultures grown under physiological LFS. We constructed an isogenic rpoS mutant derivative of wild-type S. Typhimurium and compared the ability of these strains to survive in vitro pathogenesis-related stresses that mimic those encountered in the infected host and environment.” This article may be obtained online without charge.

Journal Impact Factor: 4.389

Funding: C.M. Ott is affiliated with NASA Johnson Space Center.


Holley JM, Stanbouly S, Pecaut MJ, Willey JS, Delp M, Mao XW.

Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission.

npj Microgravity. 2022 Aug 10;8:35.

PIs: M.J. Pecaut, X.W. Mao

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 4.97

Funding: “This study was supported by NASA Space Biology grant #NNX15AB41G and the LLU Department of Basic Sciences.”


Bokhari RS, Beheshti A, Blutt SE, Bowles DE, Brenner D, Britton R, Bronk L, Cao X, Chatterjee A, Clay DE, Courtney C, Fox DT, Gaber MW, Gerecht S, Grabham P, Grosshans D, Guan F, Jezuit EA, Kirsch DG, Liu Z, Maletic-Savatic M, Miller KM, Montague RA, Nagpal P, Osenberg S, Parkitny L, Pierce NA, Porada C, Rosenberg SM, Sargunas P, Sharma S, Spangler J, Tavakol DN, Thomas D, Vunjak-Novakovic G, Wang C, Whitcomb L, Young DW, Donoviel D.

Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel.

Life Sci Space Res. 2022 Aug 7. Online ahead of print.

PIs: A. Beheshti, S.E. Blutt, D.E. Bowles, A. Chatterjee, D.T. Fox, S. Gerecht, M. Maletic-Savatic, N.A. Pierce, C. Porada, S.M. Rosenberg, G. Vunjak-Novakovic, M. Weil

Note: From the abstract: “Future lunar missions and beyond will require new and innovative approaches to radiation countermeasures. The Translational Research Institute for Space Health (TRISH) is focused on identifying and supporting unique approaches to reduce risks to human health and performance on future missions beyond low Earth orbit. This paper will describe three funded and complementary avenues for reducing the risk to humans from radiation exposure experienced in deep space.” This article may be obtained online without charge.

Journal Impact Factor: 2.730

Funding: “This work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A.”


Johnson B, Sierra-Sastre Y, Gifford S.

Health, hygiene, and microbial monitoring during long-duration space simulations.

Acta Astronaut. 2022 Oct;199:249-258.

Note: From the abstract: “The significance of the human-microbe relationship is amplified in long duration space exploration (LDSE), where isolated and confined microbial environments degenerate space habitat integrity, compromise planetary protection goals, and have largely unknown and potentially deleterious effects on astronaut health. While environmental surveillance is assumed to be a key component of future deep space missions, the optimal modality, frequency, and location of such surveillance is not yet defined. In order to investigate strategies of microbial surveillance, a series of experiments, conducted at a long-duration, isolated and confined (ICE) Mars simulation, furthered our understanding of the microbiome sampling challenges presented by food, environment, and crewmembers.”

Journal Impact Factor: 2.954

Funding: “The studies described herein did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. They were part of opportunitistic research activities conducted during HI-SEAS M1 and M4, which were funded by NASA Human Research Program grants NNX11AE53G and NNX13AM78G, respectively.”


Kerry O’Banion M.

Microglia: Rheostats of space radiation effects in the CNS [central nervous system] microenvironment.

Life Sci Space Res. 2022 Aug 9. Online ahead of print.

PI: M. Kerry O’Banion

Note: This article may be obtained online without charge.

Journal Impact Factor: 2.730

Funding: “Dr. O’Banion’s current research is funding by NASA (80NSSC21K0542) and the National Institutes of Health (R56 AG066397).”


Stankovic AS, Pryputniewicz A, Holder S, York SP, Handley PM, Karasinski JA, Robinson SK, West JJ, Duda KR.

Longitudinal impacts of simulated long-duration spaceflight missions on operationally relevant measures of human performance using a portable simulation platform.

Hum Factors. 2022 Aug 4;187208221113629. Online ahead of print.

PI: K.R. Duda

Note: From the article: “Each mission was completed in NASA’s Human Exploration Research Analog (HERA), a self-contained, two-story, four-port habitat unit designed for isolation and confinement studies, which is housed in Building 220 at the Johnson Space Center (JSC). The cylindrical habitat has a vertical axis, with a connecting simulated airlock and hygiene module, and a total space of 148.6 m3


Journal Impact Factor: 3.598

Funding: “This work was supported by the NASA HRP (NNX16A029G).”


Guo G, Gong K, Beckley N, Zhang Y, Yang X, Chkheidze R, Hatanpaa KJ, Garzon-Muvdi T, Koduru P, Nayab A, Jenks J, Sathe AA, Liu Y, Xing C, Wu S-Y, Chiang C-M, Mukherjee B, Burma S, Wohlfeld B, Patel T, Mickey B, Abdullah K, Youssef M, Pan E, Gerber DE, Tian S, Sarkaria JN, McBrayer SK, Zhao D, Habib AA.

EGFR [epidermal growth factor receptor] ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation.

Nat Cell Biol. 2022 Aug 1;24:1291-305.

PI: S. Burma

Journal Impact Factor: 28.213

Funding: “This work was supported in part by funding from the Department of Veteran’s Affairs (grant no. 2I01BX002559-08) and the National Institutes of Health (grant nos 1R01CA244212-01A1 and 1R01NS119225-01A1) to A.A.H. D.E.G. is supported by a National Cancer Institute (NCI) Midcareer Investigator Award in Patient-Oriented Research (grant no. K24CA201543-01). S.B. is supported by grants from the National Institutes of Health (grant nos R01CA258381 and R01CA246807) and the National Aeronautics and Space Administration (grant no. 80NSSC20K0732). C.-M.C.’s research is supported by NIH grant no. 1RO1CA251698 and CPRIT grant no. RP190077. D.Z. was supported by NIH grant no. R01 CA194578, S.K.M. is supported by awards from the Cancer Prevention and Research Institute of Texas (grant no. RR190034) and the NCI (grant no. K22CA237752). Research reported in this publication was supported in part by the Harold C. Simmons Comprehensive Cancer Center’s Biomarker Research Core, which are supported by NCI Cancer Center Support Grant 1P30 CA142543–03. J.N.S. was supported by the MIT/Mayo Physical Sciences Center for Drug Distribution and Efficacy in Brain Tumours (grant no. U54CA210180). We acknowledge NIH shared instrumentation grant no. 1S10OD023552-01 that funded the MRI equipment.”


Boutros SW, Krenik D, Holden S, Unni VK, Raber J.

Common cancer treatments targeting DNA double strand breaks affect long-term memory and relate to immediate early gene expression in a sex-dependent manner.

Oncotarget. 2022;13:198-213.

PIs: M. Weil, J. Raber

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.168

Funding: PIs report NASA grant #NNX15AK13G funding.


Waid M, Narici L, Girgenrath M, Stang K, Marcil I, Johnson-Green P, Ngo-Anh TJ, Kotov O, Murakami K, Dempsey R, McPhee J, Sato K, Siegel B, Scimemi S, Robinson J.

Enabling innovative research on the International Space Station to solve the challenges of a human mission to Mars: Results of the ISS4Mars International Workshops 2020-2021.

REACH. 2022 Aug 10;100047.

Note: From the abstract: “During the ISS4Mars workshops in 2020-2021, personnel from the International Space Station (ISS) partner agencies convened to reflect on scenarios for how the ISS could be used and its operations possibly modified to simulate aspects of a human mission to Mars. Scientific leaders, operations experts, crewmembers, managers, and flight surgeons discussed the 5 hazards of human spaceflight—gravity transitions, radiation, isolation and confinement, distance from Earth, and hostile closed environments—and considered how an ISS-based analog of Mars transit could benefit assessments and mitigations of these hazards.”

Journal Impact Factor: Not available for this journal

Funding: M. Waid, R. Dempsey, and J. Mcphee are affiliated with NASA Johnson Space Center; K. Sato is affiliated with NASA Ames Research Center; B. Siegel, S. Scimemi, and J. Robinson are affiliated with NASA Headquarters.


Eslinger PJ, Anders S, Ballarini T, Boutros S, Krach S, Mayer AV, Moll J, Newton TL, Schroeter ML, de Oliveira-Souza R, Raber J, Sullivan GB, Swain JE, Lowe L, Zahn R.

The neuroscience of social feelings: Mechanisms of adaptive social functioning.

Neurosci Biobehav Rev. 2021 Sep;128:592-620. Review.

PIs: M. Weil, J. Raber

Journal Impact Factor: 9.052

Funding: PIs report NASA grant #NNX15AK13G funding.


Other papers of interest:


Abdeljelil N, Ben Miloud Yahia N, Landoulsi A, Chatti A, Wattiez R, Van Houdt R, Gillan D.

Growth and biofilm formation of Cupriavidus metallidurans CH34 on different metallic and polymeric materials used in spaceflight applications.

Biofouling. 2022 Aug 4;1-13. Online ahead of print.

Note: ISS results.


Hedge ET, Patterson CA, Mastrandrea CJ, Sonjak V, Hajj-Boutros G, Faust A, Morais JA, Hughson RL.

Implementation of exercise countermeasures during spaceflight and microgravity analogue studies: Developing countermeasure protocols for bedrest in older adults (BROA).

Front Physiol. 2022 Aug 9;13.

Note: This article is part of Research Topic “Space Countermeasures and Medicine – Implementation into Earth medicine and Rehabilitation” (—implementation-into-earth-medicine-and-rehabilitation#articles). The Research Topic also includes articles from previous Current Awareness Lists #997, #1,004, and #1,009 This article may be obtained online without charge.


Kozbenko T, Adam N, Lai V, Sandhu S, Kuan J, Flores D, Appleby M, Parker H, Hocking R, Tsaioun K, Yauk C, Wilkins R, Chauhan V.

Deploying elements of scoping review methods for adverse outcome pathway development: A space travel case example.

Int J Radiat Biol. 2022 Aug 8;1-38. Online ahead of print.

Note: From the abstract: “Health protection agencies require scientific information for evidence-based decision-making and guideline development. However, vetting and collating large quantities of published research to identify relevant high-quality studies is a challenge. One approach to address this issue is the use of Adverse Outcome Pathways (AOPs) that provide a framework to assemble toxicological knowledge into causally linked chains of key events across levels of biological organization to culminate in an adverse health outcome of significance. Traditionally, AOPs have been constructed using a narrative review approach where the collection of evidence that supports each pathway is based on prior knowledge of influential studies that can also be supplemented by individually selecting and reviewing relevant references.”


Li C, Ma B, Li X.

The decision-making process of China’s human spaceflight program.

Space Policy. 2022 Jun 9;101492.


Luoni F, Boscolo D, Fiore G, Bocchini L, Horst F, Reidel CA, Schuy C, Cipriani C, Binello A, Baricco M, Giraudo M, Santin G, Durante M, Weber U.

Dose attenuation in innovative shielding materials for radiation protection in space: Measurements and simulations.

Radiat Res. 2022 Aug 1;198(2):107-19.


Xu L, Zhang X, Li G, Zhang L, Zhang S, Shi F, Hu Z.

Inhibition of SIRT1 by miR-138-5p provides a mechanism for inhibiting osteoblast proliferation and promoting apoptosis under simulated microgravity.

Life Sci Space Res. 2022 Aug 7. Online ahead of print.

Note: A 2D clinostat was used in this study. This article may be obtained online without charge.


van Loon LM, Steins A, Schulte K-M, Gruen R, Tucker EM.

Computational modeling of orthostatic intolerance for travel to Mars.

npj Microgravity. 2022 Aug 9;8:34.

Note: From the abstract: “Astronauts in a microgravity environment will experience significant changes in their cardiopulmonary system. Up until now, there has always been the reassurance that they have real-time contact with experts on Earth. Mars crew however will have gaps in their communication of 20 min or more. In silico experiments are therefore needed to assess fitness to fly for those on future spaceflights to Mars. In this study, we present an open-source controlled lumped mathematical model of the cardiopulmonary system that is able simulate the short-term adaptations of key hemodynamic parameters to an active stand test after being exposed to microgravity.” This article may be obtained online without charge.


Lemelle L, Rouquette S, Mottin E, Le Tourneau D, Marcoux PR, Thévenot C, Maillet A, Nonglaton G, Place C.

Passive limitation of surface contamination by perFluoroDecylTrichloroSilane coatings in the ISS during the MATISS experiments.

npj Microgravity. 2022 Aug 4;8:31.

Note: From the introduction: “Long-duration human spaceflights, like missions to Mars, and those involving a continuous presence in low Earth orbit (LEO), require reconsideration of risk management, in particular of biohazardous risks to astronauts and equipment integrity. Over long periods, unknown mutations, resistance, and virulence can develop and be favored in response to recurrent disinfectant application and adaptation to microgravity. Besides, biocontamination of spacecraft and in particular their surfaces by crew flora is inevitable. As sources of holders, the surfaces in the ISS may retain and favor microbial biofilms in which microorganisms are protected from inhospitable environmental variations and from killing by antibiotics and disinfectants. In this respect, surfaces then become infection foci and transmission routes of pathogens by contact. Equipment degradation due to surface corrosion related to microbial metabolic activities observed on MIR and in the early days of the ISS (International Space Station) are also sources of concern. The development of smart surface designs with optimized performances in microgravity is part of a strategic upstream step for constructing novel spacecrafts for long-term exploration.” This article may be obtained online without charge.


Jin X, Wang H, Li F, Liang X, Deng X, Gao S, Ru K, Qiu W, Huai Y, Zhang J, Lai L, Miao Z, Zhang W, Qian A.

Formononetin ameliorates simulated microgravity-induced bone loss by suppressing bone turnover in rats.

Acta Astronaut. 2022 Aug 10. Online ahead of print.

Note: Hindlimb unloading results.


Li S, Song Q, Wu B, Kan G, Wang F, Yang J, Zhu S.

Structural damage to the rat eye following long-term simulated weightlessness.

Exp Eye Res. 2022 Aug 3;223:109200.

Note: Hindlimb unloading results.


Yao J, Li Z, Li Y, Fan Y.

Weightless musculoskeletal injury and protection.

In: Fan Y, Wang L, eds. Biomechanics of Injury and Prevention. Singapore: Springer Nature Singapore; 2022. p. 395-415.


Pascual Izquierdo MC, Mingot-Castellano ME, Kerguelen Fuentes AE, García-Arroba Peinado J, Cid J, Jiménez M, Valcarcel D, Gomez-Segui I, de la Rubia J, Martin P, Goterris R, Hernández-Mateo LM, Tallón Ruiz I, Varea S, Fernández-Docampp M, García-Muñoz N, Vara M, Fernández Zarzoso M, García-Candel F, Paciello ML, García-García I, Zalba S, Campuzano Saavedra V, Garcia-Gala JMM, Vidan J, Moreno G, Lopez Lorenzo JL, González Arias E, Freiría C, Solé M, Ávila Idrovo LF, Hernández Castellet JC, Cruz N, Lavilla E, Pérez-Montaña A, Atucha JA, Moreno Beltrán ME, Romero Macías JR, Salinas Argente R, Del Rio-Garma J.

Real-world effectiveness of caplacizumab vs. standard of care in immune thrombotic thrombocytopenic purpura.

Blood Adv. 2022 Aug 5.

Note: This article may be obtained online without charge.


Yu L, Liu X, Wang X, Yan H, Pu Q, Xie Y, Du J, Yang Z.

Glycometabolism-related gene signature of hepatocellular carcinoma predicts prognosis and guides immunotherapy.

Front Cell Dev Biol. 2022 Jul 22;10:940551.

Note: This article is part of Research Topic “Epigenetics of Metabolism, Immunology and Aging” ( Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.


Melnikov IY, Tyganov SA, Sharlo KA, Ulanova AD, Vikhlyantsev IM, Mirzoev TM, Shenkman BS.

Calpain-dependent degradation of cytoskeletal proteins as a key mechanism for a reduction in intrinsic passive stiffness of unloaded rat postural muscle.

Pflugers Arch. 2022 Aug 6.


Maïmoun L, Mahadea KK, Boudousq V, Mura T, Mariano-Goulart D.

Comparison of the Lunar Prodigy and Stratos DR dual-energy X-ray absorptiometers to assess regional bone mineral density.

J Clin Densitom. 2022 Jul 16. Online ahead of print.

16Wolynski JG, Ilić MM, Labus KM, Notaroš BM, Puttlitz CM, McGilvray KC.

Direct electromagnetic coupling to determine diagnostic bone fracture stiffness.

Ann Transl Med. 2022 May;10(9):510.

Note: This article may be obtained online without charge.


Zhang H, Zhang Y, Ren R, Yang L, Shi Y, Vitiello MV, Sanford LD, Tang X.

Polysomnographic features of idiopathic restless legs syndrome: A systematic review and meta-analysis of 13 sleep parameters and 23 leg movement parameters.

J Clin Sleep Med. 2022 Jul 29. Online ahead of print.


Sasu R.

Infra-low frequency neurofeedback in persistent postural-perceptual dizziness-Case report.

Front Hum Neurosci. 2022 Jul 22;16:959579.

Note: This article is part of Research Topic “Endogenous Neuromodulation in the Infra-Low Frequency Regime” ( This article may be obtained online without charge.

SpaceRef co-founder, Explorers Club Fellow, ex-NASA, Away Teams, Journalist, Space & Astrobiology, Lapsed climber.