NASA Spaceline Current Awareness List #1,011 5 August 2022 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
McNerlin C, Guan F, Bronk L, Lei K, Grosshans D, Young DW, Gaber MW, Maletic-Savatic M.
Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects.
Life Sci Space Res. 2022 Jul 29. Online ahead of print.
https://doi.org/10.1016/j.lssr.2022.07.007
PI: M. Maletic-Savatic
Note: From the abstract: “In this review, we summarize the effects of space-like radiation on hippocampal neurogenesis. We then focus on current advances in drug discovery and development and discuss the nuclear receptor TLX/NR2E1 (oleic acid receptor) as an example of a neurogenic target that might rescue neurogenesis following radiation.”
Journal Impact Factor: 2.73
Funding: “This work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A, grant RAD01013 (M.M.S).”
2
Mao XW, Stanbouly S, Chieu B, Sridharan V, Allen AR, Boerma M.
Low dose space radiation-induced effects on the mouse retina and blood-retinal barrier integrity.
Acta Astronaut. 2022 Jul 30. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2022.07.029
PIs: X.W. Mao, A.R. Allen
Note: From the abstract: “The health risk of flight condition-triggered ocular injury and neurodegeneration has long been a concern. Spaceflight missions will likely expose the astronauts and experiment payloads to greater radiation levels compared to those encountered on the Earth. Knowledge about the susceptibility to adverse effects from low doses of radiation during space missions is very limited. Our present study aims to investigate and compare the effects of whole-body simulated galactic cosmic rays (GCR) on blood-retinal barrier (BRB) integrity, oxidative stress, and apoptosis in the retina of male and female mouse models.” This article may be obtained online without charge.
Journal Impact Factor: 2.954
Funding: “This study was supported by NASA Space Biology grant # NNX15AB41G, NASA 80NSSC18K0310 and LLU Department of Basic Sciences. This work was also supported by the Translational Research Institute through NASA cooperative agreement NNX16AO69A.”
3
Swain P, Mortreux M, Laws JM, Kyriacou H, De Martino E, Winnard A, Caplan N.
Bone deconditioning during partial weight-bearing in rodents – A systematic review and meta-analysis.
Life Sci Space Res. 2022 Aug;34:87-103. Review.
https://doi.org/10.1016/j.lssr.2022.07.003
PI: S. Rutkove
Note: From the abstract: “Space agencies are preparing to send humans to the Moon (16% Earth’s gravity) and Mars (38% Earth’s gravity), however, there is limited evidence regarding the effects of hypogravity on the skeletal system. A novel rodent partial weight-bearing (PWB) model may provide insight into how human bone responds to hypogravity.” This article may be obtained online without charge.
Journal Impact Factor: 2.73
Funding: “M. Mortreux is supported by the National Aeronautics and Space Administration grants NNX16AL36G and 80NSSC19K1598. The funding sources were not involved in the conduct, analysis, or interpretation of the current review.”
4
Swain P, Mortreux M, Laws JM, Kyriacou H, De Martino E, Winnard A, Caplan N.
Skeletal muscle deconditioning during partial weight-bearing in rodents – A systematic review and meta-analysis.
Life Sci Space Res. 2022 Aug;34:68-86. Review.
https://doi.org/10.1016/j.lssr.2022.06.007
PI: S. Rutkove
Note: From the abstract: “Space agencies are planning to send humans back to the Lunar surface, in preparation for crewed exploration of Mars. However, the effect of hypogravity on human skeletal muscle is largely unknown. A recently established rodent partial weight-bearing model has been employed to mimic various levels of hypogravity loading and may provide valuable insights to better understanding how human muscle might respond to this environment.” This article may be obtained online without charge.
Journal Impact Factor: 2.73
Funding: “The work of M. Mortreux is supported by the National Aeronautics and Space Administration grants NNX16AL36G and 80NSSC19K1598. The funding sources were not involved in the conduct, analysis, or interpretation of the current review.”
5
Ng S, Williamson C, van Zee M, Di Carlo D, Santa Maria SR.
Enabling clonal analyses of yeast in outer space by encapsulation and desiccation in hollow microparticles.
Life. 2022 July 31;12(8):1168.
https://doi.org/10.3390/life12081168
PI: S.R. Santa Maria
Note: This article is part of Special Issue “Gravitational Microbiology Research and Applications” (https://www.mdpi.com/journal/life/special_issues/gravitational_microbiology). The Special Issue also includes articles from previous Current Awareness Lists #984 https://doi.org/10.3390/life12010047; and #1,006 https://doi.org/10.3390/life12060774 and https://doi.org/10.3390/life12050660. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.251
Funding: “Funding for S.N. was provided by the NASA Space Biology program through the Space Life Sciences Training Program (SLSTP). S.R.S.M.’s research is supported by NASA Advanced Exploration Systems and NASA Space Biology.”
6
Ho D, Makrygiorgos G, Hill A, Berliner AJ.
Towards an extension of equivalent system mass for human exploration missions on Mars.
npj Microgravity. 2022 Aug 2;8:30.
https://doi.org/10.1038/s41526-022-00214-7
Note: From the introduction: “Travel to space is limited by the expense of transporting resources beyond Earth’s gravity well. As a result, early metrics of usability for space systems, especially life support, favored mass as the primary decision factor. Following a request to ‘provide the designers of future missions with mature technologies and hardware designs, as well as extensive performance data justifying confidence that highly reliable Advanced Life Support Systems (ALS) that meet mission constraints can be developed’ by the 1997 NASA Research Council (NRC), the scope of the Equivalent System Mass (ESM) framework was broadened to account for differences in the cost of resources. The general principle behind this early metric was to calculate the mass of all of the resources required to make the system work. ESM was expanded from theory to the practice of accounting for processes ranging from controls, agriculture, and recycling. Currently, ESM remains the standard metric for evaluating ALS technology development and systems. It has been adopted for use in trade studies, as the metric for life support sizing, and has been incorporated into several tools.”
Journal Impact Factor: 4.97
Funding: “This material is based upon work supported by NASA under a grant or cooperative agreement award number NNX17AJ31G. We thank I. Lipsky for his edits. We thank H. Jones (NASA Ames), O. de Weck (MIT) for their initial review.”
7
Seidler RD, Stern C, Basner M, Stahn AC, Wuyts FL, zu Eulenburg P.
Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report.
Front Neural Circuits. 2022 Aug 4;16:876789.
https://doi.org/10.3389/fncir.2022.876789
PI: M. Basner
Note: From the introduction: “This document is the result of discussions and work by the NASA-ESA Brain and SANS (Spaceflight-Associated Neuro-ocular Syndrome) Expert Team, which was convened in 2020–2022 by NASA and ESA.” This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior” (https://www.frontiersin.org/research-topics/19134/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior#articles). The Research Topic also includes articles from previous Current Awareness Lists #956 https://doi.org/10.3389/fncir.2021.659557; #967 https://doi.org/10.3389/fphys.2021.654906; #969 https://doi.org/10.3389/fphys.2021.746509; #973 https://doi.org/10.3389/fncir.2021.723504; #975 https://doi.org/10.3389/fncir.2021.757817, https://doi.org/10.3389/fncir.2021.760313, and https://doi.org/10.3389/fphys.2021.750414; #976 https://doi.org/10.3389/fphys.2021.770502; #977 https://doi.org/10.3389/fphys.2021.782860; #979 https://doi.org/10.3389/fncir.2021.750176; #982 https://doi.org/10.3389/fphys.2021.795321; #985 https://doi.org/10.3389/fphys.2022.806357; #987 https://doi.org/10.3389/fphys.2021.751016; #988 https://doi.org/10.3389/fncir.2022.815838; #991 https://doi.org/10.3389/fphys.2022.743855; and #992 https://doi.org/10.3389/fncir.2022.784280. This article may be obtained online without charge.
Journal Impact Factor: 3.342
Funding: “The authors thank Jancy C. Mcphee (NASA) and Angelique van Ombergen (ESA) very much for reviewing the manuscript and improving its quality. Reviewers from the NASA Human Factors and Behavioral Performance and Human Health Countermeasures Elements provided helpful feedback on the document. And finally, the authors acknowledge that MB received funding through NASA grants 80NSSC19K1046 and 80NSSC21K1698 as well as through the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A.”
8
Holmes ZC, Villa MM, Durand HK, Jiang S, Dallow EP, Petrone BL, Silverman JD, Lin PH, David LA.
Microbiota responses to different prebiotics are conserved within individuals and associated with habitual fiber intake.
Microbiome. 2022 Jul 29;10:114.
https://pubmed.ncbi.nlm.nih.gov/35902900
PI: L.A. David
Note: This article may be obtained online without charge.
Journal Impact Factor: 16.837
Funding: “This study was supported by funding from the Beckman Young Investigator program, the Damon Runyon Cancer Research Foundation, the NASA Translational Research Institute through Cooperative Agreement NNX16AO69A, and NIH 1R01DK116187-01. This work used a high-performance computing facility partially supported by grant 2016-IDG-1013 (HARDAC+: Reproducible HPC for Next-generation Genomics). ZH was funded by the National Defense Science and Engineering Graduate fellowship. MV was funded by a Postdoctoral Enrichment Program Award from the Burroughs Wellcome Fund. JS and BP were funded by the Duke School of Medicine Medical Scientist Training Program. BP was additionally funded by the Integrative Bioinformatics for Investigating and Engineering Microbiomes (IBIEM) program.”
9
Yoo SS, Kim HC, Kim J, Kim E, Kowsari K, Van Reet J, Yoon K.
Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound.
Sci Rep. 2022 Jul 28;12:12940.
https://pubmed.ncbi.nlm.nih.gov/35902724
PI: S.S. Yoo
Journal Impact Factor: 4.996
Funding: “We thank work was partially supported by National Aeronautics and Space Administration (NASA) grant NNX16AO69A-T0415 (to SSY).”
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Other papers of interest:
1
Aleksander M, Danil I, Natalia S, Uliana M, Elena F.
Passive-mode treadmill test effectively reveals neuromuscular modification of a lower limb muscle: sEMG-based study from experiments on ISS.
Acta Astronaut. 2022 Aug 3. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2022.07.045
Note: ISS results.
2
Al KF, Chmiel JA, Stuivenberg GA, Reid G, Burton JP.
Long-duration space travel support must consider wider influences to conserve microbiota composition and function.
Life. 2022 Jul 30;12(8):1163.
https://doi.org/10.3390/life12081163
Note: This article and the article below (Dinatolo et al.) are part of Special Issue “The Effect of Space Travel on the Microbiome and Physiology of Astronauts” (https://www.mdpi.com/journal/life/special_issues/space_microbiome). The Special Issue also includes an article from previous Current Awareness List #997 https://doi.org/10.3390/life12040495. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
3
Dinatolo MF, Cohen LY.
Monitoring the impact of spaceflight on the human brain.
Life (Basel). 2022 Jul 15;12(7):1060. Review.
https://pubmed.ncbi.nlm.nih.gov/35888147
Note: This article and the article above (Al et al.) are part of Special Issue “The Effect of Space Travel on the Microbiome and Physiology of Astronauts” (https://www.mdpi.com/journal/life/special_issues/space_microbiome). This article may be obtained online without charge.
4
Richardson RB.
The role of oxygen and the Goldilocks range in the development of cataracts induced by space radiation in US astronauts.
Exp Eye Res. 2022 Jul 30;109192.
https://pubmed.ncbi.nlm.nih.gov/35917999
Note: From the abstract: “This article explores the role that oxygen levels in US spacecraft from 1961 to 1998 have on the development of cataracts induced by space radiation in astronauts and whether oxygen levels are well accounted for in experimental studies examining cataractogenesis.”
5
Guo Z, Zhou G, Hu W.
Carcinogenesis induced by space radiation: A systematic review.
Neoplasia. 2022 Oct;32:100828. Review.
https://pubmed.ncbi.nlm.nih.gov/35908380
Note: This article may be obtained online without charge.
6
Jiang A, Yao X, Westland S, Hemingray C, Foing B, Lin J.
The effect of correlated colour temperature on physiological, emotional and subjective satisfaction in the hygiene area of a space station.
Int J Environ Res Public Health. 2022 Jul 27;19(15):9090.
https://pubmed.ncbi.nlm.nih.gov/35897510
Note: From the abstract: “The hygiene area is one of the most important facilities in a space station. If its environmental lighting is appropriately designed, it can significantly reduce the psychological pressure on astronauts. This study investigates the effect of correlated colour temperature (CCT) on heart rate, galvanic skin response, emotion and satisfaction in the hygiene area of a space station. Forty subjects participated in experiments in a hygiene area simulator with a controlled lighting environment. The lighting conditions included 2700 K, 3300 K, 3600 K, 5000 K and 6300 K; physiological responses (heart rate, galvanic skin response), as well as emotion and satisfaction, were recorded.” This article may be obtained online without charge.
7
Yamamoto T, Ikegame M, Kuroda K, Kobayashi-Sun J, Hirayama J, Kobayashi I, Kawamura R, Endo M, Tabuchi Y, Furusawa Y, Yachiguchi K, Sekiguchi T, Matsubara H, Yano S, Hattori A, Suzuki N.
Activation of RANKL-producing cells under simulated microgravity with a three-dimensional clinostat in regenerating goldfish scales.
Biological Sciences in Space. 2022;36:9-14.
https://doi.org/10.2187/bss.36.9
Note: A 3D clinostat was used in this study. This article may be obtained online without charge.
8
Cleather DJ, Price PDB, Kennett JE.
Repeated horizontal jumping is a feasible exercise countermeasure for microgravity.
Microgravity Sci Technol. 2022 Jul 28;34:68.
https://doi.org/10.1007/s12217-022-09987-8
Note: Parabolic flight results.
9
Abe C, Katayama C, Horii K, Ogawa B, Ohbayashi K, Iwasaki Y, Nin F, Morita H.
Hypergravity load-induced hyperglycemia occurs due to hypothermia and increased plasma corticosterone level in mice.
J Physiol Sci. 2022 Aug 1;72:18.
https://pubmed.ncbi.nlm.nih.gov/35915429
Note: From the abstract: “Hypothermia has been observed during hypergravity load in mice and rats. This response is beneficial for maintaining blood glucose level, although food intake decreases. However, saving glucose is not enough to maintain blood glucose level during hypergravity load. In this study, we examined the contribution of humoral factors related to glycolysis in maintaining blood glucose level in a 2 G environment. Increased plasma corticosterone levels were observed in mice with intact peripheral vestibular organs, but not in mice with vestibular lesions. Plasma glucagon levels did not change, and decrease in plasma adrenaline levels was observed in mice with intact peripheral vestibular organs. Accordingly, it is possible that increase in plasma corticosterone level and hypothermia contribute to prevent hypoglycemia in a 2 G environment.” This article may be obtained online without charge.
10
Lei J-C, Sun H, Liu S, Feng S, Lu TJ.
Hypergravity effect on dynamic capillary flow in inclined conical tubes with undulated inner walls.
Microgravity Sci Technol. 2022 Aug 2;34:71.
https://doi.org/10.1007/s12217-022-09996-7
Note: From the abstract: “Capillaries in human brain and plants are often neither straight nor smooth, but exhibit conical tubes with numerous wall undulations. Under hypergravity, the dynamics of blood/water flow in such roughened conical capillaries remains elusive, which may affect the performance and health of pilots/astronauts and the growth of plants. This study aims to establish a theoretical model to characterize dynamic capillary rise in inclined conical tubes having idealized cosine-type undulated inner walls, with hypergravity effect duly accounted for.”
11
Cebolla AM, Petieau M, Palmero-Soler E, Cheron G.
Brain potential responses involved in decision-making in weightlessness.
Sci Rep. 2022 Jul 29;12:12992.
https://pubmed.ncbi.nlm.nih.gov/35906468
Note: This article may be obtained online without charge.
12
Hill C, Brunello E, Fusi L, Ovejero JG, Irving M.
Activation of the myosin motors in fast-twitch muscle of the mouse is controlled by mechano-sensing in the myosin filaments.
J Physiol. 2022 Aug 1. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35912434
13
Iwamoto T, Torimoto K, Gotoh D, Onishi S, Hori S, Morizawa Y, Nakai Y, Miyake M, Fujimoto K.
Reduced salt intake partially restores the circadian rhythm of bladder clock genes in Dahl salt-sensitive rats.
Life Sci. 2022 Jul 29;120842.
https://pubmed.ncbi.nlm.nih.gov/35908618
14
Liu X, Gao X, Tong J, Yu L, Xu M, Zhang J.
Improvement of osteoporosis in rats with hind-limb unloading treated with pulsed electromagnetic field and whole-body vibration.
Phys Ther. 2022 Jul 30;pzac097. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35906872
Note: Hindlimb unloading results.
15
Moore JP, Simpson LL, Drinkhill MJ.
Differential contributions of cardiac, coronary and pulmonary artery vagal mechanoreceptors to reflex control of the circulation.
J Physiol. 2022 Jul 28. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35903901
16
Saqr KM, Zidane IF.
On non-Kolmogorov turbulence in blood flow and its possible role in mechanobiological stimulation.
Sci Rep. 2022 Aug 1;12:13166.
https://pubmed.ncbi.nlm.nih.gov/35915207
Note: This article may be obtained online without charge.
17
Tanaka K, Fujiki S, Atomi T, Takano W, Hasegawa K, Nagano A, Shimizu M, Atomi Y.
Control of structural redundancy from the head to trunk in the human upright standing revealed using a data-driven approach.
Sci Rep. 2022 Aug 1;12:13164.
https://pubmed.ncbi.nlm.nih.gov/35915210
Note: This article may be obtained online without charge.
