NASA Spaceline Current Awareness List #1,009 22 July 2022 (Space Life Science Research Results)

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:

1
Averesch NJH, Shunk GK, Kern C.
Cultivation of the dematiaceous fungus Cladosporium sphaerospermum aboard the International Space Station and effects of ionizing radiation.
Front Microbiol. 2022 Jul 5;13:877625.
https://doi.org/10.3389/fmicb.2022.877625
Note: ISS results. This article and the two articles below (Blachowicz et al. and Dean et al.) are part of Research Topic “The Impact of the Space Environment on Microbial Growth and Behavior” (https://www.frontiersin.org/research-topics/27130/the-impact-of-the-space-environment-on-microbial-growth-and-behavior#overview). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: 6.064
Funding: “The Higher Orbits Foundation provided funding for the implementation of this project through the Go For Launch! program. NA was partially supported under NASA grant or cooperative agreement award number NNX17AJ31G.”

2
Blachowicz A, Romsdahl J, Chiang AJ, Masonjones S, Kalkum M, Stajich JE, Torok T, Wang CCC, Venkateswaran K.
The International Space Station environment triggers molecular responses in Aspergillus niger.
Front Microbiol. 2022 Jun 30;13:893071.
https://pubmed.ncbi.nlm.nih.gov/35847112
Note: ISS results. This article, the article above (Averesch et al.), and the article below (Dean et al.) are part of Research Topic “The Impact of the Space Environment on Microbial Growth and Behavior” (https://www.frontiersin.org/research-topics/27130/the-impact-of-the-space-environment-on-microbial-growth-and-behavior#overview). This article may be obtained online without charge.
Journal Impact Factor: 6.064
Funding: A. Blachowicz and K. Venkateswaran are affiliated with NASA Jet Propulsion Laboratory.

3
Dean ZS, DiNicola M, Klonicki E, Roberts S, Clement BG, Guan L.
Establishing sterility assurance for Bacillus canaveralius 29669 spores under high heat exposure.
Front Microbiol. 2022 Jul 11;13:909997.
https://doi.org/10.3389/fmicb.2022.909997
Note: This article and the articles above (Averesch et al. and Blachowicz et al.) are part of Research Topic “The Impact of the Space Environment on Microbial Growth and Behavior” (https://www.frontiersin.org/research-topics/27130/the-impact-of-the-space-environment-on-microbial-growth-and-behavior#overview). This article may be obtained online without charge.
Journal Impact Factor: 6.064
Funding: “The research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004).”

4
Cordero RJB, Dragotakes Q, Friello PJ, Casadevall A.
Melanin protects Cryptococcus neoformans from spaceflight effects.
Environ Microbiol Rep. 2022 Jul 19. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35852045
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 4.006
Funding: “This spaceflight opportunity was made available by NanoRacks through its Space Act Agreement with NASA’s U.S. National Lab. We also acknowledge the Young Presidents Organization for their support and the teachers and students of Space Center Houston’s Space Educator Expedition Crew. We thank Andrew Trunek (NASA Glenn) and the Space Radiation and Analysis Group at Johnson Space Center for kindly providing the radiation data records from the International Space Station. We also thank the Reviewers, Dr. John E. Hallsworth and Dr. Kerry T. Lee for their time and effort in providing valuable comments and suggestions that improved the manuscript significantly. A.C. was supported in part by National Institutes of Health grants AI052733, AI15207 and HL059842.”

5
Otsuka K, Cornelissen G, Furukawa S, Shibata K, Kubo Y, Mizuno K, Aiba T, Ohshima H, Mukai C.
Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight.
Sci Rep. 2022 Jul 13;12(1):11862.
https://pubmed.ncbi.nlm.nih.gov/35831420
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 4.996
Funding: “The authors thank Dr. I. Tayama and S. Ishida from the Space Biomedical Research Group, Japan Aerospace Exploration Agency (JAXA), for cooperation in our study. The authors also acknowledge the cooperation of the astronaut, the engineers, staff and managers of JAXA and NASA.”

6
Ebnali M, Goldsmith A, Burian B, Atamna B, Duggan N, Fischetti C, Yule S, Dias R.
AR-coach: Using augmented reality (AR) for real-time clinical guidance during medical emergencies on deep space exploration missions.
In: Jay Kalra and Nancy Lightner (eds). Healthcare and Medical Devices. AHFE International, 2022. p. 67-75.
http://doi.org/10.54941/ahfe1002100
PI: R. Dias
Note: From the abstract: “Space travel imposes significant risks to crew health due to physiological adaptations, exposure to physical and psychological stressors, and limited capabilities to provide medical care. When medical emergencies occur, appropriate use of diagnostic and procedural guidance tools are crucial countermeasures against the risks of injury and mission failure. Point-of-care ultrasound (POCUS) is the only portable imaging modality available during exploration missions that can provide critical and dynamic medical information. Developing competency in POCUS is time-consuming and it is usually achieved through years of medical residency or clinical fellowship training programs. Due to the amount of astronaut training currently required, it is not feasible to also provide them with in-depth POCUS training. Current cognitive aids for POCUS-based procedures are either paper-based or static electronic checklists, which can be cumbersome to use, non-intuitive, and sometimes distracting; applying their written guidance to real actions can be difficult. To overcome these limitations, we developed a proof of concept of an augmented reality (AR) Coach (AR-Coach) as an Augmented Clinical Tool (ACT): a hands-free virtual coach system that guides the crew in real-time on how to perform POCUS during medical emergencies in space.” A free download is available at the link above.
Funding: “We would like to thank all the experts who participated in our panel activities and discussions. This work was funded by the Translational Research Institute for Space Health (TRISH) through NASA Cooperative Agreement NNX16AO69A (Grant # T0506).”

7
Whittle RS, Keller N, Hall EA, Vellore HS, Stapleton LM, Findlay KH, Dunbar BJ, Diaz‐Artiles A.
Gravitational dose-response curves for acute cardiovascular hemodynamics and autonomic responses in a tilt paradigm.
J Am Heart Assoc 2022 Jul 19;11(14):e024175.
https://doi.org/10.1161/JAHA.121.024175
PI: A. Diaz‐Artiles
Note: Head-down and head-up tilt study. This article may be obtained online without charge.
Journal Impact Factor: 5.501
Funding: “This work was supported by the National Aeronautics and Space Administration Human Research Program, grant 80NSSC20K1521.”

8
Anderson CP, Park SY.
Assessing pulse transit time to the skeletal muscle microcirculation using near-infrared spectroscopy.
J Appl Physiol (1985). 2022 Jul 14. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35834626
Journal Impact Factor: 3.880
Funding: “U54 GM115458/GM/NIGMS NIH HHS/United States; P20GM109090/HHS | National Institutes of Health (NIH); 80NSSC20M0112/NASA Nebraska Space Grant Consortium.”

9
Sletten TL, Sullivan JP, Arendt J, Palinkas LA, Barger LK, Fletcher L, Arnold M, Wallace J, Strauss C, Baker RJS, Kloza K, Kennaway DJ, Rajaratnam SMW, Ayton J, Lockley SW.
The role of circadian phase in sleep and performance during Antarctic winter expeditions.
J Pineal Res. 2022 Jul 14. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35833316
PI: S.W. Lockley
Note: This article may be obtained online without charge.
Journal Impact Factor: 13.007
Funding: “The study was supported by NASA Headquarters Moon and Mars Analog Mission Activities 2008 Research Opportunities in Space and Earth Sciences (ROSES) Planetary Science Division Research Program grant to S.W. Lockley (08-MMAMA08-0035). Additional support was provided by the NHMRC Centre for Integrated Research and Understanding of Sleep (CIRUS) and the Australian Antarctic Division. T.L. Sletten was also supported by the Australasian Sleep Association Helen Bearpark Scholarship. J. Sullivan and L.K. Barger were supported in part by R01OH011773.”

10
Duncan MA, Welch D, Shuryak I, Brenner DJ.
Ocular and facial far-UVC doses from ceiling-mounted 222 nm far-UVC fixtures.
Photochem Photobiol. 2022 Jul 12. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35818780
Note: From the abstract: “Far-UVC radiation, defined in this paper as ultraviolet (UV) radiation with wavelengths from 200 nm – 235 nm, is a promising tool to help prevent the spread of disease. The unique advantage of far-UVC technology over traditional UV germicidal irradiation lies in the potential for direct application of far-UVC into occupied spaces since antimicrobial doses of far-UVC are significantly below the recommended daily safe exposure limits. This study used a ceiling-mounted far-UVC fixture emitting at 222 nm to directly irradiate an indoor space and then evaluated the doses received upon a manikin. Radiation sensitive film was affixed to the head, nose, lip, and eyes of the manikin, and the 8-hour equivalent exposure dose was determined.”
Journal Impact Factor: 3.521
Funding: “Funding for this work was provided by NIH grant 5R42AI125006, NASA grant 80NSSC22K0211, Columbia University Urban Tech Award: Technology Innovations for Better Urban Living, and the Shostack Foundation.”

11
Zheng M, Piermarocchi C, Mias GI.
Temporal response characterization across individual multiomics profiles of prediabetic and diabetic subjects.
Sci Rep. 2022 Jul 15;12:12098.
https://pubmed.ncbi.nlm.nih.gov/35840765
PI: G.I. Mias
Note: This article may be obtained online without charge.
Journal Impact Factor: 4.996
Funding: “This work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (project T0412). CP acknowledges support by NIH R01GM122085.”

12
Santos M, Luna M, Reyes DL, Traylor A, Lacerenza CN, Salas E.
How to be an inclusive leader for gender-diverse teams.
Organ Dyn. 2022 Jun 2;100914. Online ahead of print.
https://doi.org/10.1016/j.orgdyn.2022.100914
PIs: E. Salas, S. Burke
Journal Impact Factor: 1.133
Funding: “This work was partially supported by NASA grants NNX16AB08G, NNX16AP96G, National Science Foundation grant #1853528 to Rice University, and the U.S. Army Research Institute (ARI) for the Behavioral and Social Sciences and was accomplished under Cooperative Agreement Number W911NF-19-2-0173.”

Other papers of interest:

1
Bourdier P, Zahariev A, Schoeller DA, Chery I, Le Roux E, Thevenot C, Maillet A, Garnotel M, Gauquelin-Koch G, Bergouignan A, Blanc S, Simon C.
Effect of exercise on energy expenditure and body composition in astronauts onboard the International Space Station: Considerations for interplanetary travel.
Sports Med. 2022 Jul 13.
https://pubmed.ncbi.nlm.nih.gov/35829995
Note: ISS results.

2
Jordan SL, Kern J, Chilek DR, Moore AD.
Critical power (CP) testing: An accurate rapid method of fitness assessment during space missions.
Acta Astronaut. 2022 Sep;198:69-75.
https://doi.org/10.1016/j.actaastro.2022.05.049
Note: From the abstract: “Current aerobic fitness testing during ISS flight does not assess either critical power (CP) or work capacity above CP (W′). Both CP and W′ have been demonstrated to be highly related to time of performance during ground analogues of lunar or planetary work tasks. This study was conducted to determine if CP measures differ between trials performed without (Control) and with (WMD) metabolic gas exchange data collection during 3-min supramaximal cycle ergometer tests. A secondary aim was to determine if peak oxygen consumption (VO2peak) can be ascertained from a 3-min CP test.”

3
Amirova L, Avdeeva M, Shishkin N, Gudkova A, Guekht A, Tomilovskaya E.
Effect of modulated electromyostimulation on the motor system of elderly neurological patients. Pilot study of Russian currents also known as Kotz currents.
Front Physiol. 2022 Jul 18;13:921434.
https://doi.org/10.3389/fphys.2022.921434
Note: This article is part of Research Topic “Space Countermeasures and Medicine – Implementation into Earth medicine and Rehabilitation” (https://www.frontiersin.org/research-topics/29370/space-countermeasures-and-medicine—implementation-into-earth-medicine-and-rehabilitation#articles). The Research Topic also includes articles from previous Current Awareness Lists #997 https://doi.org/10.3389/fphys.2022.897694 and #1,004 https://doi.org/10.3389/fphys.2022.921862. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

4
Doolette DJ, Mitchell SJ.
Extended lifetimes of bubbles at hyperbaric pressure may contribute to inner ear decompression sickness during saturation diving.
J Appl Physiol (1985). 2022 Jul 14. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35834629

5
Du JR, Wang Y, Yue ZH, Zhang HY, Wang H, Sui GQ, Sun ZX.
Recent advances in sonodynamic immunotherapy.
J Cancer Res Clin Oncol. 2022 Jul 13. Review.
https://pubmed.ncbi.nlm.nih.gov/35831762
Note: From the abstract: “Tumor immunotherapy has become an important means of tumor therapy by enhancing the immune response and triggering the activation of immune cells. However, currently, only a small number of patients respond to immunotherapy alone, and patients may experience immune-related adverse events (irAEs) during the course of treatment. Sonodynamic therapy (SDT) can produce cytotoxic substances to tumor tissue, induce apoptosis and enhance immunity. SDT combined with immunotherapy is considered a promising strategy for cancer treatment. In this mini review, we summarize the role of SDT in immunotherapy in recent years, including the application of SDT-triggered immunotherapy and the combination of SDT and immunotherapy.”

6
Li N, Zhang X, Zhou J, Li W, Shu X, Wu Y, Long M.
Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer.
Adv Drug Deliv Rev. 2022 Jul 9;188:114448. Review.
https://pubmed.ncbi.nlm.nih.gov/35820602

7
Zhang Q, Jia Q, Zhang J, Zhu B.
Neoantigens in precision cancer immunotherapy: From identification to clinical applications.
Chin Med J (Engl). 2022 Jul 15. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35838545
Note: This article may be obtained online without charge.

8
Jiang S, Qian YM, Jiang Y, Cao ZQ, Xin BM, Wang YC, Wu B.
Effects of 15-days -6° head-down bed rest on the attention bias of threatening stimulus.
Front Psychol. 2022 Jun 27;13:730820.
https://pubmed.ncbi.nlm.nih.gov/35832905
Note: Head-down bed rest study. This article may be obtained online without charge.

9
Khan AA, Gul MT, Karim A, Ranade A, Azeem M, Ibrahim Z, Ramachandran G, Nair VA, Ahmad F, Elmoselhi A, Qaisar R.
Mitigating sarcoplasmic reticulum stress limits disuse-induced muscle loss in hindlimb unloaded mice.
npj Microgravity. 2022 Jul 11;8(1):24.
https://pubmed.ncbi.nlm.nih.gov/35817772
Note: Hindlimb unloading results. This article may be obtained online without charge.

10
Wu MI, Stegall P, Siu HC, Stirling L.
Impact of haptic cues and an active ankle exoskeleton on gait characteristics.
Hum Factors. 2022 Jul 11:187208221113625. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35815866
Note: From the abstract: “This study examined the interaction of gait-synchronized vibrotactile cues with an active ankle exoskeleton that provides plantarflexion assistance.”

11
Patterson AM, Vemula S, Plett PA, Sampson CH, Chua HL, Fisher A, Wu T, Sellamuthu R, Feng H, Katz BP, DesRosiers CM, Pelus LM, Cox GN, MacVittie TJ, Orschell CM.
Age and sex divergence in hematopoietic radiosensitivity in aged mouse models of the hematopoietic acute radiation syndrome.
Radiat Res. 2022 Jul 14. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35834823

12
Shi L, Herrmann J, Bou Jawde S, Bates JHT, Nia HT, Suki B.
Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure-volume curves.
Sci Rep. 2022 Jul 19;12:12280.
https://pubmed.ncbi.nlm.nih.gov/35853981
Note: From the abstract: “The relationship between pressure (P) and volume (V) in the human lung has been extensively studied. However, the combined effects of gravity and the mechanical properties of elastin and collagen on alveolar and lung P-V curves during breathing are not well understood. Here, we extended a previously established thick-walled spherical model of a single alveolus with wavy collagen fibers during positive pressure inflation.” This article may be obtained online without charge.

13
Li X, Ling X, Li Z, Song N, Ba X, Yang B, Yang X, Sui R.
Clinical characteristics of patients with dizziness/vertigo showing a dissociation between caloric and video head impulse test results.
Ear Nose Throat J. 2022 Jul 11;1455613221113790. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35817592
Note: This article may be obtained online without charge.