- Press Release
- Feb 6, 2023
Scientists find clues that the path leading to the origin of life begins in deep space
Mountain View, Calif.– Duplicating the harsh conditions of cold interstellar space in the laboratory, scientists from The Astrochemistry Laboratory at NASA’s Ames Research Center and the Department of Chemistry and Biochemistry at The University of California Santa Cruz have created chemical compounds that may have been important for life’s origin.
In their laboratory, this team regularly make copies of the extremely cold ice particles that make up dense interstellar clouds. These clouds are the birthsites of stars and star systems and the smoke sized ice particles are the building blocks of the planets, asteroids, meteorites and comets which orbit the stars. Even after they are formed, planets continue to collect material from the debris (dust, asteroids, meteorites, and comets) from the star formation process, and life on Earth is thought to have emerged from this primordial chemical soup.
The most common scientific theory for the origin of life on Earth is that somewhere in the vast chemical resources available on the early Earth, conditions favored the formation of chemical compounds and chemical processes which eventually led to life. In contrast, this new work shows that the early chemical steps believed to be important for the origin of life do not necessarily require an already formed planet to occur. Instead, they can readily be taken in the depths of space long before planet formation occurs. This implies that the vastness of space is filled with compounds which, if landing in a hospitable environment, can help jump-start the origin of life.
The main ingredients of interstellar ices are familiar, simple chemicals frozen together. Mostly water, they also contain some ammonia, carbon monoxide, carbon dioxide and the simplest alcohol, methanol. The NASA Ames – University of California Santa Cruz team freezes a mixture of these chemicals into a thin solid ice at temperatures close to absolute zero (-441°F, / -263°C) under extreme vacuum conditions. This ice is then exposed to harsh ultraviolet radiation that mimics the radiation in space produced by neighboring stars. It has been known for a long time that ultraviolet irradiation of icy solids produces chemicals more complex than those originally present in the ice, and there was speculation that some of these chemicals might have played an important role in early Earth chemistry. However, the recent development of Exobiology and Astrobiology as interdisciplinary research fields has brought together astronomers, biologists and funding opportunities in a way that wasn’t possible ten years ago.
"We started this work motivated to find the types of compounds that might be in comets, icy planets and moons, providing guidance for future NASA missions," space scientist and team leader Lou Allamandola said. "Sure, we expected that ultraviolet radiation would make a few molecules that might have some biological interest, but nothing major. Instead, we found that this process transforms some of the simple chemicals that are very common in space into larger molecules which behave in far more complex ways. Ways which many people think are critical for the origin of life, the point in our history when chemistry became biology," he continued.
"Instead of finding a handful of molecules only slightly more complicated than the starting compounds, hundreds of new compounds are produced in every mixed ice we have studied," space scientist Scott Sandford said. He continued, "We are finding that the types of compounds produced in these ices are strikingly similar to many of those brought to Earth today by infalling meteorites and their smaller cousins, the interplanetary dust particles. Every year more than a hundred tons of extraterrestrial stuff falls on the Earth, and much of it is in the form of organic material. In the early life of our solar system, before the debris from its formation was fully cleared away, these materials were deposited on the Earth in far greater quantities than we see today. Thus, much of the organic material found on the Earth in its earliest years probably had an interstellar heritage."
"A number of years ago I found that some of the extraterrestrial organic compounds brought to Earth in the Murchison meteorite could form membranous vesicles when they interacted with water," said team member Dave Deamer, Professor of Chemistry at the University of California at Santa Cruz. Vesicles are microscopic, hollow droplets with sizes, shapes and structures similar to those of certain living cells. "All life today is cellular, and cells are defined by membranes that separate the cytoplasm from the outside world. When life began, at some point it became compartmented in the form of cells. But where did the first cell membranes come from? Maybe they were composed of molecules similar to those we discovered earlier in meteorites," Deamer continued. "When I learned of the ice experiments at NASA Ames, I went to the Astrochemistry Lab intending to find out what would happen when their complex organic mixtures were allowed to interact with water. To our surprise and delight we found that vesicular structures formed that looked very much like those we saw in the Murchison material."
"We now know that of the hundreds of new compounds we make in these interstellar ice simulation experiments, many have properties relevant to the origin of life," said biochemist Jason Dworkin. "Upon the addition of liquid water to the organics produced during ice irradiation, some of these new compounds, with no outside help, organize themselves into tiny vesicles with complicated structures. Other new compounds formed are so much more complex than what we started with that they glow when exposed to UV light. Not only that, but these molecules, which can convert energy from the ultraviolet light to the visible range, become part of the self-formed vesicles," continued Dworkin. "Molecules that do these things are thought to be extremely important for the origin of life. Membrane structures are necessary to separate and protect the chemistry involved in the life process from that in the outside environment, and all known biology uses membranes to capture and generate cellular energy," Dworkin said.
Sandford added, "The ready formation of these and other biologically interesting compounds by irradiating realistic simple interstellar ices shows that some of the organics falling to Earth in meteorites and interplanetary dust particles might have been born in the coldest regions of interstellar space, and that delivery of these compounds by comets, meteorites and interplanetary dust particles could well have been important in the origin of life on Earth."
Allamandola concluded, "The spell is now breaking that interstellar chemistry is a chemistry of relatively small and simple molecules. We are just now beginning to realize that we are only seeing the tip of the iceberg in terms of extraterrestrial molecular complexity. Since these experiments were designed to simulate the conditions in all dense molecular clouds, the birthsites of new stars and planetary systems, very complex organic molecules that might be important for the origin of life could well be falling on the surfaces of newly formed planets everywhere in the universe. For example, of the things which bring extraterrestrial chemicals to the Earth, comets are thought to be closely related to interstellar ices. I know I hold a minority view on this nowadays, but I suspect that even deep inside a comet, which is mainly water ice after all, reactions are much further along than we think and the chemistry quite complex."
Their results are published in the current, special Astrobiology issue of the "Proceedings of The National Academy of Sciences, USA". The authors include Drs. Dworkin, Sandford, and Allamandola of NASA’s Ames Research Center and Professor Deamer of the Chemistry and Biochemistry Department of the University of California, Santa Cruz.
This research is supported by the Space Science Division at NASA Ames Research Center and the Offices of Exobiology and Astrobiology at NASA Headquarters, Washington, D.C.
These droplets (~10 µm across) show structures reminiscent of cells (although they are not alive). They are from a chemically separated fraction of the bulk residue. [Larger image]
These droplets (small ones are ~10 µm across) glowing under black light in the microscope show internal structure and suggest chemical complexity. They are from a chemically separated fraction of the bulk residue. [Larger image]
This is a vesicle (~10 µm across) glowing under black light in the microscope made from the bulk residue. Proof that it is a hollow vesicle, rather than a simple drop of oil, is the green pyranine dye which we have trapped inside of it. [Larger image]
The equipment used to simulate space (center image)
Related material in the July 1999 issue of Scientific American
NASA Scientists Find Clues That Life Began in Deep Space
Duplicating the harsh conditions of cold interstellar space in their laboratory, NASA scientists have created primitive cells that mimic the membranous structures found in all living things. These chemical compounds may have played a part in the origin of life.
This breakthrough by scientists at NASA Ames Research Center in California’s Silicon Valley is important because some scientists believe that the delivery – by comets, meteorites and interplanetary dust – of similar organic compounds born in interstellar space might have “kick-started” life on Earth.
“Scientists believe the molecules needed to make a cell’s membrane, and thus for the origin of life, are all over space. This discovery implies that life could be everywhere in the universe,” said Dr. Louis Allamandola, the team’s leader.
Using simple, everyday chemicals, researchers from Ames’ Astrochemistry Laboratory and the Department of Chemistry and Biochemistry at the University of California, Santa Cruz, have created, for the first time, “proto”-cells. These are the primitive cells that mimic the membranous structures found in all life forms. “This process happens all the time in the dense molecular clouds of space,” Allamandola said.
This discovery has important implications for NASA’s astrobiology mission. “The formation of these biologically interesting compounds by irradiating simple interstellar ices shows that some of the organics falling to Earth in meteorites and interplanetary dust might have been born in the coldest regions of interstellar space,” Allamandola said. “The delivery of these compounds could well have been critical to the origin of life on Earth.”
Their results will be published Jan. 30 in the special astrobiology issue of the “Proceedings of the National Academy of Sciences, USA.”
Scientists do not yet know whether life began as naked RNA or as genetic material encapsulated in membranes. But at some point, membranes became important. “All life as we know it on Earth uses membrane structures to separate and protect the chemistry involved in the life process from the outside,” said Dr. Jason Dworkin of the SETI Institute, the paper’s lead author and a team member. “All known biology uses membranes to capture and generate cellular energy.”
“Membranes are like a house,” Dworkin added. “Maybe these molecules were just the raw lumber lying around that allowed origin-of-life chemicals to move in and set up housekeeping or construct their own houses.”
In the lab, the scientists recreated the conditions found in space — which is a cold vacuum — zapping a series of simple ices with the ultraviolet radiation found everywhere. They created solid materials which, when immersed in water, spontaneously created soap bubble-like membranous structures that contained both an “inside” and an “outside” layer.
In contrast to current thinking, this new work shows that the early chemical steps believed to be important for the origin of life do not require an already-formed planet. Instead, they seem to take place in deep space long before planet formation occurs. This implies that the vastness of space is filled with chemical compounds which, if they land in a hospitable environment like our Earth, can readily jump-start life.
Interstellar ices are made of familiar everyday chemicals such as water, methanol (wood alcohol), ammonia and carbon monoxide that are frozen together.
The astrobiology research team also included Dr. Scott Sandford of Ames and David Deamer of the Chemistry and Biochemistry Department of UC Santa Cruz.
Further information about this research is available at: http://web99.arc.nasa.gov/~astrochm/vesicle.html
The research was supported by the Space Science Division at Ames and the Offices of Exobiology and Astrobiology at NASA Headquarters, Washington, D.C. NASA Ames is the agency’s lead center for astrobiology and the location of the central office of the NASA Astrobiology Institute, an international research consortium. Astrobiology is the study of the origin, evolution, dispersion and future of life in the universe.