Press Release

Breaking Research on Space Travel’s Effects on Immune System Presented at The 56th Annual Meeting of The American Academy of Allergy, Asthma and Immun

By SpaceRef Editor
March 6, 2000
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Three new research studies presented
today at the American Academy of Allergy, Asthma and Immunology (AAAAI) Annual
Meeting offer the latest information on the effects of space travel on the
human immune system, which may some day offer new treatments for allergic and
immunologic diseases here on Earth.

Three leading scientists have stepped away from conventional thinking to
find answers about how the immune system changes during space travel. Desmond
Lugg, M.D., FAFOM, Director of Polar Medicine for the Australian National
Antarctic Research Expedition in Tasmania spoke on his 25 years of research on
the effects of isolation and containment on T-cells in subjects during the
long 10-month Antarctic winter. This isolation and lack of sunlight is
considered to be an earth-bound equivalent of space travel. Lugg’s research is
based on the fact that when humans are literally cut off from the world,
whether in space or the Antarctic, the body’s T-lymphocyte system is weakened,
predisposing them to infection with both common and latent viruses. One such
virus is the Epstein-Barr virus, which has been associated with malignancies
in immunosuppressed patients.

Gerald Sonnenfeld, Ph.D., Vice-Dean and Chair of Microbiology and
Immunology at the Morehouse University School of Medicine in Atlanta, shared
his insight on his numerous studies on the effects of space travel on human
and animal immunity. His research has found alterations in T-lymphocyte
changes in small animals during space travel. Sonnenfeld has further explored
these bodily changes in immunity studies of astronauts and Russian cosmonauts.

David F. Dinges, Ph.D., Head of the Unit for Experimental Psychiatry at
the University of Pennsylvania School of Medicine in Philadelphia, addressed
the effects of sleep deprivation on human immune function, another
acknowledged equivalent model of the effects of space travel. His studies of
subjects deprived of sleep in special isolation chambers at the University of
Pennsylvania have found that as the human body is deprived of sleep, the
body’s ability to fight off disease is lessened. An increased susceptibility
to infection, combined with the small living space within a space station,
could also facilitate the rapid spread of infections between crew members.
Dinges’ research has aimed to find possible prevention and control measures to
lessen the risk of infectious diseases among astronauts, which could seriously
comprise individual health and the entire space mission. The Department of
Defense and the Federal Aviation Administration have been major supporters of
his research due to its implications for military and commercial airline
pilots and the safety of passengers.

The research offered by these three scientists was spearheaded through the
National Space Biomedical Research Institute, which aims to find
countermeasures useful for astronauts experiencing allergies, hypersensitivity
conditions and immunodeficiencies that might occur on a future highly
stressful voyage to Mars. Evidence currently indicates that space flight may
make astronauts more prone to infection by microorganisms, such as bacteria,
viruses and fungi, and possibly reactivate viruses already present in the
body. Simply, the absence of gravity, stress, loss of sleep and changes in
various bodily functions due to space travel may lessen the body’s ability to
defend itself against disease, including allergic and immunologic conditions.

Besides their application for astronauts, new medications or treatments
created for space travel conditions could also potentially aid patients with
allergic and immunologic disorders on Earth, said William T. Shearer, M.D.,
Ph.D., FAAAAI, Professor of Pediatrics and Microbiology and Immunology at
Baylor College of Medicine and Chief of Allergy and Immunology Service at
Texas Children’s Hospital in Houston.

“It has been common knowledge that people who feel run-down because of
being overworked or an emotional crisis often suffer from an increase in
symptoms of infection or bad allergies,” Shearer said. “This area of medicine
has been overlooked in scientific circles because of the lack of ability to
quantitatively measure the connections between the nervous system and the
immune system. And the conditions of space travel as reflected in an
earth-bound equivalent model certainly are associated with alterations in
immune responses that are likely to produce allergic and immunologic diseases.
These studies may provide valuable clues for the diseases that people on Earth

These studies were presented at the 56th Annual Meeting of the American
Academy of Allergy, Asthma and Immunology. The American Academy of Allergy,
Asthma and Immunology is the largest professional medical specialty
organization in the United States representing allergists, asthma specialists,
clinical immunologists, allied health professionals and others with a special
interest in the research and treatment of allergic disease. Allergy/immunology
specialists are pediatric or internal medicine physicians who have elected an
additional two years of training to become specialized in the treatment of
asthma, allergy and immunologic disease. Established in 1943, the Academy has
more than 6,000 members in the U.S., Canada and 60 other countries.
Academy serves as an advocate to the public by providing educational
information through its toll-free line at 800-822-2762 and its Web site at

SpaceRef staff editor.