NASA Spaceline Current Awareness List #1,063 25 August 2023 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Nakashima J, Pattathil S, Avci U, Chin S, Alan Sparks J, Hahn MG, Gilroy S, Blancaflor EB.
Glycome profiling and immunohistochemistry uncover changes in cell walls of Arabidopsis thaliana roots during spaceflight.
npj Microgravity. 2023 Aug 22;9:68.
https://doi.org/10.1038/s41526-023-00312-0
PIs: S. Gilroy, E.B. Blancaflor
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 5.1
Funding: “This work was supported by NASA grants NNX12AM94G and 80NSSC19K0129 (to E.B.B.), 80NSSC18K1462 and 80NSSC22K0024 (to S.G. and S.C.). Plant cell wall glycan-directed antibodies used here were generated with funsding from the National Science Foundation Plant Genome Program (DBI-0421683, to M.G.H.). Glycome profiling of samples described here was supported by a grant to MGH from the NSF Plant Genome Program (IOS-0923992). We thank Allison Mjoen, Howard Levine, Bryan Onate, Jose Camacho, Trent Smith, Gioia Massa, Colleen Huber, John Carver, Shawn Stephens, Gerald Newsham, David Reed, and Stacy Engel at NASA-Kennedy Space Center for technical support during ground and spaceflight operations.”
2
Shibata S, Wakeham DJ, Thomas JD, Abdullah SM, Platts S, Bungo MW, Levine BD.
Cardiac effects of long-duration spaceflight.
J Am Coll Cardiol. 2023 Aug 22;82(8):674-84.
https://pubmed.ncbi.nlm.nih.gov/37587578
PI: B.D. Levine
Note: ISS results.
Journal Impact Factor: 24
Funding: “This study was funded by NASA grant NNJ04HH01A to Drs. Levine and Bungo.”
3
Stepaniak PC, Blue RS, Gilmore S, Beven GE, Chough NG, Tsung A, McMonigal KA, Mazuchowski EL, 2nd
, Bytheway JA, Lindgren KN, Barratt MR.
Operational considerations for crew fatality on the International Space Station.
Aerosp Med Hum Perform. 2023 Sep 1;94(9):705-14.
https://pubmed.ncbi.nlm.nih.gov/37587636
Note: From the abstract: “Here, we detail the operational considerations for a crew fatality should it occur during spaceflight onboard the ISS, including forensic and timeline constraints, behavioral health factors, and considerations for final disposition of decedent remains.”
Journal Impact Factor: 0.889
Funding: “This project was funded by the NASA/JSC HH&P Directorate and the active data collection phases were undertaken from November 2017 through December 2019. Efforts were coordinated with multiple stakeholders, including NASA JSC (Houston, TX), the Armed Forces Medical Examiner System (AFMES) and Air Force Mortuary Affairs Operation (Dover Air Force Base, DE); the Sam Houston State University (SHSU) Department of Chemistry and their Applied Anatomical Research Center/Southeast Texas Applied Forensic Science (STAFS) Facility (Huntsville, TX); the University of Texas Medical Branch (UTMB) School of Preventive Medicine and Population Health (Galveston, TX); Kellogg-Brown-Root (KBR) (Houston, TX); Isovac Products LLC (Romeoville, IL); and the NASA Multilateral Medical Operations Panel (MMOP) international partners from the Russian Federation Space Agency (RFSA), European Space Agency (ESA), Japan Aerospace Exploration Agency (JAXA), and the Canadian Space Agency (CSA).”
4
Hughes AM, Vandenbrink JP, Kiss JZ.
Efficacy of the random positioning machine as a terrestrial analogue to microgravity in studies of seedling phototropism.
Microgravity Sci Technol. 2023 Aug 14;35:43.
https://doi.org/10.1007/s12217-023-10066-9
PI: J.Z. Kiss
Note: From the abstract: “In this study, we compare the results from experiments conducted on the International Space Station with those conducted using the random positioning machine (in the 3D clinostat mode) on the ground.”
Journal Impact Factor: 1.8
Funding: “Funding for this research was provided by a grant from NASA (National Aeronautics and Space Administration) to John Z. Kiss (grant number 80NSSC17K0546).”
5
Allred AR, Clark TK.
A computational model of motion sickness dynamics during passive self-motion in the dark.
Exp Brain Res. 2023 Aug 17.
https://pubmed.ncbi.nlm.nih.gov/37589937
Note: From the abstract: “Predicting the time course of motion sickness symptoms enables the evaluation of provocative stimuli and the development of countermeasures for reducing symptom severity. In pursuit of this goal, we present an observer-driven model of motion sickness for passive motions in the dark. Constructed in two stages, this model predicts motion sickness symptoms by bridging sensory conflict (i.e., differences between actual and expected sensory signals) arising from the observer model of spatial orientation perception (stage 1) to Oman’s model of motion sickness symptom dynamics (stage 2; presented in 1982 and 1990) through a proposed ‘Normalized innovation squared statistic.'”
Journal Impact Factor: 2.0
Funding: “This work was supported by a NASA Space Technology Graduate Research Opportunities Award. Space Technology Mission Directorate, 80NSSC20K1202, Aaron Allred.”
6
Hoppock GA, Buettmann EG, Denisco JA, Goldscheitter GM, Condyles SN, Juhl OJ 4th
, Friedman MA, Zhang Y, Donahue HJ.
Connexin 43 and cell culture substrate differentially regulate OCY454 osteocytic differentiation and signaling to primary bone cells.
Am J Physiol Cell Physiol. 2023 Aug 21. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37602413
PIs: E.G. Buettmann, M.A. Friedman
Note: From the abstract: “Connexin 43 (Cx43), the predominate gap junction protein in bone, is essential for intercellular communication and skeletal homeostasis. Previous work suggests osteocyte-specific deletion of Cx43 leads to increased bone formation and resorption; however, the cell-autonomous role of osteocytic Cx43 in promoting increased bone remodeling is unknown. Recent studies using 3D culture substrates in OCY454 cells suggest 3D cultures may offer increased bone remodeling factor expression and secretion, such as sclerostin and RANKL. In this study, we compared culturing OCY454 osteocytes on 3D Alvetex scaffolds to traditional 2D tissue culture, both with (WT) and without Cx43 (Cx43 KO).”
Journal Impact Factor: 5.5
Funding: “80NSSC18KK1473/National Aeronautics and Space Administration (NASA); R01AR068132/HHS | National Institutes of Health (NIH); NNX16AO69A/National Aeronautics and Space Administration (NASA).”
7
Thompson EA, Fowlkes NW, Jacobsen MC, Layman RR, Cressman ENK.
Quantitative dual-energy CT image guidance for thermochemical ablation: In vivo results in the rabbit VX2 model.
J Vasc Interv Radiol. 2023 May;34(5):782-9.
https://doi.org/10.1016/j.jvir.2022.12.026
Journal Impact Factor: 2.9
Funding: “E.A.T. reports a Society of Interventional Radiology (SIR) Foundation Allied Scientist Training Grant, a Cancer Prevention and Research Institute of Texas Graduate Scholar Award (RP210028), and a grant (R01CA201127) from the National Institutes of Health. R.R.L. reports receiving the following grants: NIH S10 1S10OD028621-01A1, Cancer Prevention and Research Institute of Texas RP220366, USDA Small Business Innovation Research NIFA Phase II, MDACC Institutional Research Grant, NIH 5R01HL141831-04, NASA 80NSSC18K1639, T32 FP 13417, and SIR FP10908; speaking honoraria from American College of Radiology Regional Chapter; advisory board participation in GE Healthcare; leadership role as American Association of Physicists in Medicine Task Group Co-Chair; and receipt of research materials from Siemens Healthineers and MARS Bioimaging Ltd. E.N.K.C. reports leadership roles in the SIR Annual Meeting Committee and Global Embolization and Technologies Meeting Research Committee.”
8
Naruse M, Vincenty CS, Konopka AR, Trappe SW, Harber MP, Trappe TA.
Cycle exercise training and muscle mass: A preliminary investigation of 17 lower limb muscles in older men.
Physiol Rep. 2023 Aug 22;11(16):e15781.
https://pubmed.ncbi.nlm.nih.gov/37606179
Note: This article may be obtained online without charge.
Journal Impact Factor: 0.78
Funding: “This study was supported by NIH Grant AG032127 and NASA Grant NNJ06HF59G.”
9
Wong CP, Iwaniec UT, Turner RT.
Brown adipose tissue but not tibia exhibits a dramatic response to acute reduction in environmental temperature in growing male mice.
Bone Rep. 2023 Dec 19;101706.
https://doi.org/10.1016/j.bonr.2023.101706
PI: R.T. Turner
Journal Impact Factor: 2.5
Funding: “This work was supported by the National Aeronautics and Space Administration (80NSSC19K0430).”
10
Soroczynski J, Risca VI.
Technological advances in probing 4D genome organization.
Curr Opin Cell Biol. 2023 Oct 23;84:102211.
https://doi.org/10.1016/j.ceb.2023.102211
PI: V.I. Risca
Journal Impact Factor: 7.5
Funding: “This work was supported by grants from the Rita Allen Foundation (Scholar Grant), the Irma T. Hirschl/Monique Weill-Caulier Trust (Career Scientist Award), the Starr Cancer Consortium (grant number I16-0058), the National Aeronautics and Space Administration (grant number 80NSSC21K0565) and the National Institutes of Health (grant number DP2GM150021). …”
_______________________________________________________
Other papers of interest:
1
De Micco V, Aronne G, Caplin N, Carnero-Diaz E, Herranz R, Horemans N, Legué V, Medina FJ, Pereda-Loth V, Schiefloe M, De Francesco S, Izzo LG, Le Disquet I, Kittang Jost AI.
Perspectives for plant biology in space and analogue environments.
npj Microgravity. 2023 Aug 21;9(1):67. Review.
https://pubmed.ncbi.nlm.nih.gov/37604914
Note: This article may be obtained online without charge.
2
Cucinotta FA.
Non-targeted effects and space radiation risks for astronauts on multiple International Space Station and Lunar missions.
Life Sci Space Res. 2023 Aug 23. Online ahead of print.
https://doi.org/10.1016/j.lssr.2023.08.003
Note: Opinion/Position article.
3
Tommaso CL.
Long-duration spaceflight and cardiac morphology: To boldly go where no man has gone before.
J Am Coll Cardiol. 2023 Aug 22;82(8):685-6.
https://doi.org/10.1016/j.jacc.2023.06.030
Note: This article is an editorial.
4
Goto M, Shibata Y, Ishiyama S, Matsumaru Y, Ishikawa E.
Brain microstructure and brain function changes in space headache by head-down-tilted bedrest.
Aerosp Med Hum Perform. 2023 Sep;94(9):678-85.
https://doi.org/10.3357/AMHP.6177.2023
Note: Head-down tilt bedrest.
5
Santhoshkumar P, Negi A, Moses JA.
3D printing for space food applications: Advancements, challenges, and prospects.
Life Sci Space Res. 2023 Aug 22. Online ahead of print.
https://doi.org/10.1016/j.lssr.2023.08.002
Note: From the abstract: “Space foods closely associate with the performance and mental health of astronauts. Over the years, a range of manufacturing technologies have been explored and advancements in food 3D printing can provide answers to certain existing challenges and revolutionize the way foods are prepared for space exploration missions. Apart from the nutrition and satiety perspective, product shelf-life, variety, personalization, and the need for customized diets are critical considerations. In such long-duration human-crewed space missions, under microgravity conditions and exposure to space, psychological factors heavily affect food consumption patterns. Therefore, there has been a surge in research funding for developing products and methods that offer safe, nutritionally balanced, and delightful food options. 3D food printing could be a creative solution for such requirements.”
6
Dwi Setiawan G, Thiravetyan P, Treesubsuntorn C.
Gaseous toluene phytoremediation by Vigna radiata seedlings under simulated microgravity: Effect of hypocotyl, auxin, and gibberellic acid.
Acta Astronaut. 2023 Oct;211:88-96.
https://doi.org/10.1016/j.actaastro.2023.06.002
Note: A random positioning machine was used in this study.
7
Shi Q, Gui J, Sun L, Song Y, Na J, Zhang J, Fan Y, Zheng L.
Frizzled-9 triggers actin polymerization and activates mechano-transducer YAP to rescue simulated microgravity-induced osteoblast dysfunction.
Faseb j. 2023 Sep;37(9):e23147.
https://pubmed.ncbi.nlm.nih.gov/37585277
Note: Hindlimb unloading study.
8
Varis N, Leinonen A, Perälä J, Leino TK, Husa L, Sovelius R.
Delayed drowsiness after normobaric hypoxia training in an F/A-18 hornet simulator.
Aerosp Med Hum Perform. 2023 Sep;94(9):715-8.
https://doi.org/10.3357/AMHP.6238.2023
Note: From the abstract: “This case report demonstrates the danger of deep hypoxia. Hypoxia training instructions should include restrictions related to driving a car immediately after hypoxia training. In addition, hypoxia may lower the brain threshold for sopite syndrome.”
9
Connolly DM, D’Oyly TJ, Harridge SDR, Smith TG, Lee VM.
Decompression sickness risk in parachutist dispatchers exposed repeatedly to high altitude.
Aerosp Med Hum Perform. 2023 Sep;94(9):666-77.
https://doi.org/10.3357/AMHP.6231.2023
10
Vallée N, Dugrenot E, Desruelle A-V, Richard S, Coupé S, Ramdani C, Guieu R, Risso J-J, Gaillard S, Guerrero F.
Highlighting of the interactions of MYD88 and NFKB1 SNPs in rats resistant to decompression sickness: Toward an autoimmune response.
Front Physiol. 2023 Aug 17;14:1253856.
https://doi.org/10.3389/fphys.2023.1253856
Note: This article may be obtained online without charge.
11
Brighton EM, Klaus DM.
Categorization of select cockpit performance evaluation techniques.
Aerosp Med Hum Perform. 2023 Sep;94(9):696-704.
https://doi.org/10.3357/AMHP.6185.2023
Note: From the abstract: “The modern aircraft cockpit has evolved into a complex system of systems. Numerous performance evaluation metrics and techniques exist that can measure the effectiveness of cockpit components in terms of how they influence the human operator’s ability to perform tasks relevant to mission success. As no prior review of these metrics has been found in the literature, this effort attempts to do so, albeit without applying the metrics to a novel cockpit evaluation.”
12
Chu V, Newman DG.
Exercise effect on mental health in isolating or quarantining adults.
Aerosp Med Hum Perform. 2023 Sep;94(9):686-95.
