NASA Spaceline Current Awareness List #1,060 28 July 2023 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm.
Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Kim H, Lee W, Weisholtz DS, Yoo SS.
Transcranial focused ultrasound stimulation of cortical and thalamic somatosensory areas in human.
PLoS One. 2023 Jul 23;18(7):e0288654.
https://pubmed.ncbi.nlm.nih.gov/37478086
PI: S.S. Yoo
Note: This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work is supported by the Translational Research Institute for Space Health through National Aeronautics and Space Administration (NASA) Cooperative Agreement NNX16AO69A (to SSY).”
2
Stoffle NN, Campbell-Ricketts T, Castro A, Gaza R, Zeitlin C, George S, Abdelmelek M, Schram A.
HERA [Hybrid Electronic Radiation Assessor]: A Timepix-based radiation detection system for Exploration-class space missions.
Life Sci Space Res. 2023 Mar 21. Online ahead of print.
https://doi.org/10.1016/j.lssr.2023.03.004
Note: From the introduction: “The potential impact to astronaut crew resulting from local changes in the radiation environment is a critical hazard for Exploration-class missions to the Moon and beyond. Unlike vehicles within Low Earth Orbit (LEO), missions beyond LEO will not have the benefit of the geomagnetic field to provide shielding sufficient to protect astronauts from Solar Particle Events (SPEs) and to minimize exposure to Galactic Cosmic Rays (GCR). As a result, the ability to monitor, characterize, and respond to radiation events during the missions will be critical in managing impacts to crew health due to increased radiation exposures.”
Journal Impact Factor: 2.5
Funding: “The authors would like to thank Dr. Kerry Lee for his role in the various iterations of the HERA operations, as well as the MCC-H Flight Control Teams for their support of the hardware on ISS and Artemis-I. This work was performed under NASA contract NNJ15HK11B.”
3
Pal Chowdhury R, Stegeman LA, Lund ML, Fry D, Madzunkov S, Bahadori AA.
Hybrid methods of radiation shielding against deep-space radiation.
Life Sci Space Res (Amst). 2023 Aug;38:67-78.
https://pubmed.ncbi.nlm.nih.gov/37481310
Note: From the abstract: “In the last decade, NASA and other space exploration organizations have focused on making crewed missions to different locations in our solar system a priority. To ensure the crewmembers’ safety in a harsh radiation environment outside the protection of the geomagnetic field and atmosphere, a robust radiation protection system needs to be in place. Passive shielding methods, which use mass shielding, are insufficient as a standalone means of radiation protection for long-term deep-space missions. Active shielding methods, which use electromagnetic fields to deflect charged particles, have the potential to be a solution that can be used along with passive shielding to make deep-space travel safer and more feasible. Past active shielding studies have demonstrated that substantial technological advances are required for active shielding to be a reality. However, active shielding has shown potential for near-future implementation when used to protect against solar energetic particles, which are less penetrating than galactic cosmic rays (GCRs). This study uses a novel approach to investigate the impacts of passive and active shielding for protection against extreme solar particle events (SPEs) and free-space GCR spectra under solar minimum and solar maximum conditions.”
Journal Impact Factor: 2.5
Funding: “This work was supported by the NASA Human Health and Performance Contract NNJ15HK11B. Some of the computing for this project was performed on the Beocat Research Cluster at Kansas State University, which is partly funded by NSF grants CNS-1006860, EPS-1006860, and EPS-0919443, respectively ACI-1440548, CHE-1726332, and NIH P20GM113109. The Jet Propulsion Laboratory, California Institute of Technology, carried out work under a contract with the National Aeronautics and Space Administration (80NM0018D0004).”
4
Pasetes LN, Rosendahl-Garcia KM, Goel N.
Cardiovascular measures display robust phenotypic stability across long-duration intervals involving repeated sleep deprivation and recovery.
Front Neurosci. 2023 Jul 20;17:1201637.
https://doi.org/10.3389/fnins.2023.1201637
PI: N. Goel
Note: From the abstract: “We determined whether cardiovascular (CV) measures show trait-like responses after repeated total sleep deprivation (TSD), baseline (BL) and recovery (REC) exposures in two long-duration studies (total N = 11 adults).” This article may be obtained online without charge.
Journal Impact Factor: 4.3
Funding: “This research was funded by the National Aeronautics and Space Administration (NASA) [grant numbers NNX14AN49G and 80NSSC20K0243 (to NG)]. This work was also partially supported by the National Institutes of Health [grant number NIH R01DK117488 (to NG)].”
5
Xiao Q, Lyu Y, Zhou M, Lu J, Zhang K, Wang J, Bauer C.
Artificial light at night and social vulnerability: An environmental justice analysis in the U.S. 2012-2019.
Environ Int. 2023 Aug;178:108096.
https://pubmed.ncbi.nlm.nih.gov/37480833
Note: From the abstract: “Artificial Light at Night (ALAN) is an emerging health risk factor that has been linked to a wide range of adverse health effects. Recent study suggested that disadvantaged neighborhoods may be exposed to higher levels of ALAN. Understanding how social disadvantage correlates with ALAN levels is essential for identifying the vulnerable populations and for informing lighting policy.”
Journal Impact Factor: 11.8
Funding: “This work was supported in part by the Terra, Aqua, and Suomi National Polar-orbiting Partnership (SNPP) Program, National Aeronautics and Space Administration (NASA), under Award 80NNSC21L1976. Meng Zhou was supported by the Future Investigators in NASA Earth and Space Science and Technology Program under Grant 80NSSC21K1628. Qian Xiao, Cici Bauer, Jun Wang and Lye Yue are supported by the NASA Health and Air Quality Applied Science Team Program, 80NSSC21K0510.”
6
Min J, Demchyshyn S, Sempionatto JR, Song Y, Hailegnaw B, Xu C, Yang Y, Solomon S, Putz C, Lehner LE, Schwarz JF, Schwarzinger C, Scharber MC, Shirzaei Sani E, Kaltenbrunner M, Gao W.
An autonomous wearable biosensor powered by a perovskite solar cell.
Nat Electron. 2023 Jul 20.
https://doi.org/10.1038/s41928-023-00996-y
PI: W. Gao
Note: From this abstract: “Wearable sweat sensors can potentially be used to continuously and non-invasively monitor physicochemical biomarkers that contain information related to disease diagnostics and fitness tracking. However, the development of such autonomous sensors faces a number of challenges including achieving steady sweat extraction for continuous and prolonged monitoring and addressing the high power demands of multifunctional and complex analysis. Here we report an autonomous wearable biosensor that is powered by a perovskite solar cell and can provide continuous and non-invasive metabolic monitoring.”
Journal Impact Factor: 34.3
Funding: “This project was supported by the National Institutes of Health grants R01HL155815 and R21DK13266, Office of Naval Research grants N00014-21-1-2483 and N00014-21-1-2845, the Translational Research Institute for Space Health through NASA NNX16AO69A, National Science Foundation grant 2145802 (to W.G.) and the European Research Council Starting Grant ‘GEL-SYS’ under grant agreement no. 757931 (to M.K.). S.D. would like to acknowledge the Marshall Plan Foundation that provided financial support for the three months of research visit to California Institute of Technology that initiated this work.”
7
Ballard R, Parkhurst J, Julian K, Pasetes LN, Fawcett A, Li A, Goel N, Sit DK.
Light therapy for adolescent depression: A scoping review.
Curr Psychiatry Rep. 2023 Jul 25. Review.
https://pubmed.ncbi.nlm.nih.gov/37490215
PI: N. Goel
Journal Impact Factor: 6.7
Funding: “R.B., J.P., D.K.S., and K.J. received funding support from a Northwestern Primary Care Practice-Based Research Program (NP3) seed grant. D.K.S. also receives support from the Asher Center for the Study and Treatment of Depressive Disorders based at Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences. A.L. received the 2022 Washington University in St. Louis Career Center Internship Stipend Award. N.G. was supported in part by National Aeronautics and Space Administration (NASA) [grants NNX14AN49G and 80NSSC20K0243 (to N.G.)], and National Institutes of Health [grant NIH R01DK117488 (to N.G.)]. L.N.P. was supported by NASA grant 80NSSC20K0243.”
_______________________________________________________
Other papers of interest:
1
Egashira K, Ino Y, Nakai Y, Ohira T, Akiyama T, Moriyama K, Yamamoto Y, Kimura M, Ryo A, Saito T, Inaba Y, Hirano H, Kumagai K, Kimura Y.
Identification of gravity-responsive proteins in the femur of spaceflight mice using a quantitative proteomic approach.
J Proteomics. 2023 Jul 21;104976. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37482271
Note: ISS results.
2
Yin Y, Wu X, Zhu Y, Liu J, Fan Q, Zhao S, Wang J, Liu Y, Li Y, Lu W.
Protective effect of Baoyuan Jieyu Formula on long-term spaceflight composite stress-induced depressive-like behavior and memory deficits through regulation of Ca2+
channel currents.
Life Sci Space Res. 2023 Jul 24. Online ahead of print.
https://doi.org/10.1016/j.lssr.2023.07.002
Note: From the abstract: “Long-term spaceflight composite stress (LSCS) can cause adverse effects on human systems, especially the central nervous system. This study aimed to identify the underlying mechanisms of the protective effect of Baoyuan Jieyu Formula (BYJYF) on LSCS-induced depressive-like behavior and memory deficits. In this experiment, we simulated the real space station environment for a period of 42 days. Novel object recognition test and forced swimming test were used to assess the memory abilities and depression level of rats as well as test the therapeutic effects of BYJYF treatment. Results showed LSCS could induce depressive-like behavior and damage short-term memory in the behavioral level, and BYJYF could enhance the ability to resist LSCS.”
3
Carvajal-Agudelo JD, McNeil A, Franz-Odendaal TA.
Effects of simulated microgravity and vibration on osteoblast and osteoclast activity in cultured zebrafish scales.
Life Sci Space Res (Amst). 2023 Aug;38:39-45.
https://pubmed.ncbi.nlm.nih.gov/37481306
Note: From the abstract: “Zebrafish cultured scales have been used effectively to study cellular and molecular responses of bone cells. In order to expose zebrafish scales to simulated microgravity (SMG) and/or vibration, we first determined via apoptosis staining whether cells of the scale survive in culture for two days and hence, we restricted our analyses to two-day durations. Next, we measured the effects of SMG and vibration on cell death, osteoclast tartrate-resistant acid phosphatase, and osteoblast alkaline phosphatase activity and on the number of Runx2a positive cells. We found that during the SMG treatment, osteoclast tartrate-resistant acid phosphatase activity increased on average, while the number of Runx2a positive cells decreased significantly. In contrast, SMG exposure caused a decrease in osteoblast activity. The vibration treatment showed an increase, on average, in the osteoblast alkaline phosphatase activity. This study demonstrates the effect of SMG and vibration on zebrafish scales and the effects of SMG on bone cells. We also show that zebrafish scales can be used to examine the effects of SMG on bone maintenance.”
4
Stern C, Yücel YH, Zu Eulenburg P, Pavy-Le Traon A, Petersen LG.
Eye-brain axis in microgravity and its implications for Spaceflight Associated Neuro-ocular Syndrome.
npj Microgravity. 2023 Jul 20;9:56. Review.
https://pubmed.ncbi.nlm.nih.gov/37474624
Note: This article may be obtained online without charge.
5
Malhan D, Schoenrock B, Yalçin M, Blottner D, Relόgio A.
Circadian regulation in aging: Implications for spaceflight and life on Earth.
Aging Cell. 2023 Jul 26;e13935. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37493006
Note: This article may be obtained online without charge.
6
Klos B, Steinbach C, Ketel J, Lambert C, Penders J, Doré J, Enck P, Mack I.
Effects of isolation and confinement on gastrointestinal microbiota-A systematic review.
Front Nutr. 2023;10:1214016. Review.
https://pubmed.ncbi.nlm.nih.gov/37492598
Note: This article is part of Research Topic “Microbiota, Nutrition and Stress: Modulators of Immunity” (https://www.frontiersin.org/research-topics/41957/microbiota-nutrition-and-stress-modulators-of-immunity#articles). This article may be obtained online without charge.
7
Jagtap S, Kumar A, Mahale B, Dixit J, Kalange AE, Kanawade R, Gangal S, Vidyasagar P.
Response of cardiac pulse parameters in humans at various inclinations via 360° rotating platform for simulated microgravity perspective.
npj Microgravity. 2023 Jul 18;9:54.
https://pubmed.ncbi.nlm.nih.gov/37463938
Note: From the abstract: “On the Earth, the human body is designed and adapted to function under uniform gravitational acceleration. However, exposure to microgravity or weightlessness as experienced by astronauts in space causes significant alterations in the functioning of the human cardiovascular system. Due to limitations in using real microgravity platforms, researchers opted for various ground-based microgravity analogs including head-down tilt (HDT) at fixed inclination. However, in the present study, an investigation of response of various cardiac parameters and their circulatory adaptation in 18 healthy male subjects was undertaken by using an indigenously developed 360° rotating platform.” This article may be obtained online without charge.
8
Opsomer L, Delhaye BP, Théate V, Thonnard JL, Lefèvre P.
A haptic illusion created by gravity.
iScience. 2023 Jul 21;26(7):107246.
https://pubmed.ncbi.nlm.nih.gov/37485356
Note: From the abstract: “Human dexterity requires very fine and efficient control of fingertip forces, which relies on the integration of cutaneous and proprioceptive feedback. Here, we examined the influence of gravity on isometric force control.” This article may be obtained online without charge.
9
Ren Z, Harriot AD, Mair DB, Chung MK, Lee PHU, Kim DH.
Biomanufacturing of 3D tissue constructs in microgravity and their applications in human pathophysiological studies.
Adv Healthc Mater. 2023 Jul 22;e2300157. Review. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37483106
10
Shirzad M, Van Riesen J, Behboodpour N, Heath M.
10-min exposure to a 2.5% hypercapnic environment increases cerebral blood flow but does not impact executive function.
Life Sci Space Res. 2023 Jul 24. Online ahead of print.
https://doi.org/10.1016/j.lssr.2023.07.003
Note: From the abstract: “Here, we employed the anti-saccade task to evaluate whether transient exposure to a hypercapnic environment influences top-down executive function (EF).”
11
Su X, Fang T, Fang L, Wang D, Jiang X, Liu C, Zhang H, Guo R, Wang J.
Effects of short-term exposure to simulated microgravity on the physiology of Bacillus subtilis and multiomic analysis.
Can J Microbiol. 2023 Jul 18. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37463516
Note: A high-aspect rotating wall vessel was used in this study.
12
Swanenburg J, Easthope CA, Meinke A, Langenfeld A, Green DA, Schweinhardt P.
Lunar and Mars gravity induce similar changes in spinal motor control as microgravity.
Front Physiol. 2023 Jul 26;14:1196929.
https://doi.org/10.3389/fphys.2023.1196929
Note: From the abstract: “Spinal motor control measurements were performed during Earth, Lunar, Mars, and micro-gravity conditions and two hypergravity conditions of a parabola. Three proxy measures of spinal motor control were recorded: spinal stiffness of lumbar L3 vertebra using the impulse response, muscle activity of lumbar flexors and extensors using surface electromyography, and lumbar curvature using two curvature distance sensors placed at the upper and lower lumbar spine. The participants were six females and six males, with a mean age of 33 years (standard deviation: 7 years).”
13
Bloomfield SA, Swift SN, Metzger CE, Baek K, De Souza MJ, Lenfest S, Shirazi-Fard Y, Hogan HA.
Exercise training modifies the bone and endocrine response to graded reductions in energy availability in skeletally mature female rodents.
Front Endocrinol (Lausanne). 2023 Jun 27;14:1141906.
https://pubmed.ncbi.nlm.nih.gov/37455901
Note: This article may be obtained online without charge.
