NASA Spaceline Current Awareness List #1,057 7 July 2023 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm.
Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Otsuka K, Cornelissen G, Kubo Y, Shibata K, Mizuno K, Aiba T, Furukawa S, Ohshima H, Mukai C.
Methods for assessing change in brain plasticity at night and psychological resilience during daytime between repeated long-duration space missions.
Sci Rep. 2023 Jul 5;13:10909.
https://pubmed.ncbi.nlm.nih.gov/37407662
Note: ISS results. This article may be obtained online without charge.
Journal Impact Factor: 4.996
Funding: “The authors thank I. Tayama, S. Ishida, N. Inoue, K. Murakami and S. Yamada from the Space Biomedical Research Group, Japan Aerospace Exploration Agency (JAXA), for cooperation in our study. The authors also acknowledge the cooperation of the astronauts, the engineers, staff and managers of JAXA and NASA.”
2
Waisberg E, Ong J, Masalkhi M, Zaman N, Kamran SA, Sarker P, Tavakkoli A, Lee AG.
The case for expanding visual assessments during spaceflight.
Prehosp Disaster Med. 2023 Jun 27;1-4. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37365808
PI: A. Tavakkoli
Note: From the abstract: “Spaceflight associated neuro-ocular syndrome (SANS) is one of the potential barriers to human long-duration spaceflight (LDSF), including a manned mission to Mars. While a large barrier, the pathophysiology of SANS is not well understood, and functional and structural findings from SANS continue to be further characterized. Currently on the International Space Station (ISS), scheduled visual assessments are static visual acuity, Amsler grid, and a self-reported survey. Additional visual assessments may help the understanding of this neuro-ophthalmic phenomenon, as well as the effects of spaceflight of overall ocular health. In this paper, a case is made for expanding scheduled visual assessments to include dynamic visual, contrast sensitivity (CS), visual field testing, and virtual reality-based metamorphopsia assessment during spaceflight.” This article may be obtained online without charge.
Journal Impact Factor: 2.866
Funding: “Aeronautics and Space Administration (NASA) Grant [80NSSC20K183]: A Non-Intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-Term Spaceflight.”
3
Sano S, Thel MC, Walsh K.
Mosaic loss of Y chromosome in white blood cells: Its impact on men’s health.
Physiology (Bethesda). 2023 Jul 1;38(4):161-66. Review.
https://pubmed.ncbi.nlm.nih.gov/36976266
PI: K. Walsh
Note: From the abstract: “We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we discuss murine models and the potential mechanisms by which LOY contributes to disease.”
Journal Impact Factor: 8.4
Funding: “This work was supported by the National Institutes of Health Grants AG073249, AG072095, HL142650, and HL152174 and National Aeronautics and Space Administration Grant 80NSSC21K0549 (to K.W.); Grant-in-Aid for Research Activity Start-up 21K20879 (to S.S.); Grant-in-Aid for Scientific Research C 22K08162 (to S.S.); and the MSD Life Science Foundation (to S.S.); the Cardiovascular Research Fund (to S.S.); Kondou Kinen Medical Foundation (to S.S.); and The Japanese Heart Failure Society (to S.S.).”
4
Narayanan SA.
Gravity’s effect on biology.
Front Physiol. 2023 Jul 3;14:1199175.
https://doi.org/10.3389/fphys.2023.1199175
PI: S.A. Narayanan
Note: This article is part of Research Topic “Insights in Environmental, Aviation and Space Physiology: 2022” (https://www.frontiersin.org/research-topics/34248/insights-in-environmental-aviation-and-space-physiology-2022#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,003 https://doi.org/10.3389/fphys.2022.907651; #1,022 https://doi.org/10.3389/fphys.2022.1007316 and https://doi.org/10.3389/fphys.2022.1003073; #1,026 https://doi.org/10.3389/fphys.2022.1029161; and #1,028 https://doi.org/10.3389/fphys.2022.1008508. This article may be obtained online without charge.
Journal Impact Factor: 4
Funding: “SN thanks NASA (80NSSC19K0426, 80NSSC19K1322) for funding support.”
5
Cahill T, Chan S, Overton IM, Hardiman G.
Transcriptome profiling reveals enhanced mitochondrial activity as a cold adaptive strategy to hypothermia in zebrafish muscle.
Cells. 2023 May 11;12(10):1366.
https://pubmed.ncbi.nlm.nih.gov/37408201
Note: This article may be obtained online without charge.
Journal Impact Factor: 6.0
Funding: “This research was funded by NASA EPSCoR 521192MUHARDIMANS. GH Acknowledges support from NIH U54MD010706, U01DA045300, and QUB start-up funds. TC was supported by an NI Department for the Economy (DfE) Research Studentship.”
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Other papers of interest:
1
Baranowski RW, Braun JL, Hockey BL, Yumol JL, Geromella MS, Watson CJF, Kurgan N, Messner HN, Whitley KC, MacNeil AJ, Gauquelin-Koch G, Bertile F, Gittings W, Vandenboom R, Ward WE, Fajardo VA.
Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target.
iScience. 2023 Jul 21;26(7):107047.
https://pubmed.ncbi.nlm.nih.gov/37360691
Note: ISS results. From the introduction: “The purpose of this study was to investigate the effects of spaceflight on murine muscle and bone GSK3 content and activation status. We obtained samples from various missions/payloads where male or female mice were exposed to microgravity for 30-37 days aboard the International Space Station (ISS) or the BION-M1 biosatellite.” This article may be obtained online without charge.
2
De la Torre GG, Gonzalez-Torre S.
Neurocognitive assessment in microgravity: Review of tools and benefits of increasing their clinical validity for long duration missions.
J Clin Exp Neuropsychol. 2023 Jun 26;1-22. Review.
https://pubmed.ncbi.nlm.nih.gov/37357681
3
ElGindi M, Sapudom J, Garcia Sabate A, Chesney Quartey B, Alatoom A, Al-Sayegh M, Li R, Chen W, Teo J.
Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity.
npj Aging. 2023 Jul 1;9(1):14.
https://pubmed.ncbi.nlm.nih.gov/37393393
Note: From the abstract: “Here, we address a significantly outstanding research gap by examining the effects of simulated microgravity via a random positioning machine on both immature and mature DCs cultured in biomimetic collagen hydrogels, a surrogate for tissue matrices.” This article may be obtained online without charge.
4
Jacob P, Oertlin C, Baselet B, Westerberg LS, Frippiat JP, Baatout S.
Next generation of astronauts or ESA [European Space Agency] astronaut 2.0 concept and spotlight on immunity.
npj Microgravity. 2023 Jun 28;9(1):51. Review.
https://pubmed.ncbi.nlm.nih.gov/37380641
Note: This article may be obtained online without charge.
5
Jenkin H, Jenkin M, Harris LR, Herpers R.
Neutral buoyancy and the static perception of upright.
npj Microgravity. 2023 Jun 28;9(1):52.
https://pubmed.ncbi.nlm.nih.gov/37380706
Note: From the abstract: “The perceptual upright results from the multisensory integration of the directions indicated by vision and gravity as well as a prior assumption that upright is towards the head. The direction of gravity is signaled by multiple cues, the predominant of which are the otoliths of the vestibular system and somatosensory information from contact with the support surface. Here, we used neutral buoyancy to remove somatosensory information while retaining vestibular cues, thus “splitting the gravity vector” leaving only the vestibular component. In this way, neutral buoyancy can be used as a microgravity analogue. We assessed spatial orientation using the oriented character recognition test (OChaRT, which yields the perceptual upright, PU) under both neutrally buoyant and terrestrial conditions.” This article may be obtained online without charge.
6
Kuya N, Nishijima R, Kitomi Y, Kawakatsu T, Uga Y.
Transcriptome profiles of rice roots under simulated microgravity conditions and following gravistimulation.
Front Plant Sci. 2023 Jun 9;14:1193042.
https://pubmed.ncbi.nlm.nih.gov/37360733
Note: A 3D clinostat was used in this study. This article may be obtained online without charge.
7
Shtemberg AS, Lebedeva-Georgievskaya KB, Perevezentsev AA, Kudrin VS.
Long dated changes in behavior and neurochemical features of the work of rat’s cerebral brain after combined exposure to hypogravity and ionizing radiations modeled in a ground-based experiment.
Aviakosm Ekolog Med. 2023;57(3):57-67. Russian.
http://journal.imbp.ru/eng/content2023_3.html
8Smolianina SO, Korshunov DV, Morozova YuA, Berkovich YuA, Ivanova АА, Erokhin AN, Ilyin VK.
Dynamics of microbiological community properties in the root zone of Chinese cabbage grown on hydrophilic porous membranes combined with a fiber ion-exchange artificial soil.
Aviakosm Ekolog Med. 2023;57(3):77-84. Russian.
http://journal.imbp.ru/eng/content2023_3.html
Note: From the abstract: “One of the methods to deliver nutrients to roots in microgravity is to grow plants on a fiber ion-exchange salted artificial soil (AS) and control the watering potential by a tensiometer made of porous metals. Five experiments with Chinese cabbage crops raised on AS BIONA-V3 laid upon titanic porous membranes provided insight into dynamics of size and composition of a microbial community in the root zone and on roots.”
9
Sukhinov DV, Gotovtsev PM, Sergeeva YE.
Phototrophic microorganisms in bioregenerative life support systems for long-term crewed expeditions: Prospects and challenges.
Acta Astronaut. 2023 Jul 5. Review. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2023.07.006
Note: From the abstract: “The review considers modern research and development in bioregenerative life support systems (BLSS) for crewed spacecrafts, summarizes the information obtained in scientific research in this field, evaluates of current status of the astronaut life support problems, frames unsolved questions and determines areas for future study. This review shows that the most promising life support systems include phototrophic microorganisms which can be used to create carbon, oxygen and nitrogen cycles within one system, which, in turn, allows reducing the level of resupplied and/or stored stocks of resources and, therefore, total crewed expedition cost.”
10
Jackman JS, Bell PG, Van Someren K, Gondek MB, Hills FA, Wilson LJ, Cockburn E.
Effect of hot water immersion on acute physiological responses following resistance exercise.
Front Physiol. 2023 Jul 5;14:1213733.
https://doi.org/10.3389/fphys.2023.1213733
Note: This article is part of Special Issue “Cold, Heat and Hypoxia as a Medical Tool: The Use in a Healthy and Diseased Population” (https://www.frontiersin.org/research-topics/48889/cold-heat-and-hypoxia-as-a-medical-tool-the-use-in-a-healthy-and-diseased-population#overview). The Special Issue also includes an article from previous Current Awareness List #1,050 https://doi.org/10.3389/fphys.2023.1173171. This article may be obtained online without charge.
11
Kuzichkin DS, Nichiporuk IA, Rykova MP, Zhuravleva OA, Markin AA, Zhuravleva TV, Sadova AA, Chistokhodova SA, Kutko OV, Ponomarev SA.
Immunological, hormonal, and hemostasis parameters in cosmonauts’ blood after long-term orbital missions.
Acta Astronaut. 2023 Jul 1. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2023.06.050
12
Shi H, Li F, Zhang F, Wei X, Liu C, Duan R.
An electrical stimulation intervention protocol to prevent disuse atrophy and muscle strength decline: An experimental study in rat.
J Neuroeng Rehabil. 2023 Jun 29;20:84.
https://pubmed.ncbi.nlm.nih.gov/37386493
Note: This article may be obtained online without charge.
13
Belova SP, Zaripova KA, Tyganov SA, Turtikova OV, Shenkman BS.
Expression of E3-ubiquitin ligases MURF-1 and MAFBX in human postural and locomotor muscles during head-down hypokinesia.
Aviakosm Ekolog Med. 2023;57(3):29-36. Russian.
http://journal.imbp.ru/eng/content2023_3.html
14
Stepanova SI, Koroleva MV, Galichiy VA, Karpova OI.
Interdependence of basic components of the sleep-wakefulness cycle and cosmonauts’ work-rest schedule.
Aviakosm Ekolog Med. 2023;57(3):5-17. Russian.
http://journal.imbp.ru/eng/content2023_3.htm
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