NASA Spaceline Current Awareness List #1,056 30 June 2023 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm
Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Hanshaw BC, Ryder VE, Johansen BD, Pattarini JM, Nguyen HN, Nowadly CD, Blue RS.
Spaceflight recovery considerations for acute inhalational exposure to hydrazines.
Aerosp Med Hum Perform. 2023 Jul 1;94(7):532-43. Review.
https://pubmed.ncbi.nlm.nih.gov/37349930
Journal Impact Factor: 0.889
Funding: V.E. Ryder, B.D. Johansen, and J.M. Pattarini are affiliated with NASA Johnson Space Center.
2
Impey S, Pelz C, Riparip L-K, Tafessu A, Fareh F, Zuloaga DG, Marzulla T, Stewart B, Rosi S, Turker MS, Raber J.
Postsynaptic density radiation signature following space irradiation.
Front Physiol. 2023 Jun 27;14:1215535.
https://doi.org/10.3389/fphys.2023.1215535
PI: J. Raber
Note: This article is part of Research Topic “Multi-omics Approaches for Understanding Space Flight Impact” (https://www.frontiersin.org/research-topics/36594/multi-omics-approaches-for-understanding-space-flight-impact#overview). The Research Topic also includes an article from previous Current Awareness List #1,014 https://doi.org/10.3389/fphys.2022.971282. This article may be obtained online without charge.
Journal Impact Factor: 4.755
Funding: “This work was supported by NASA grants NNJ12ZSA001N, 80NSSC19K0498-P00001, NIDA T32DA007262, the Legacy Good Samaritan Foundation, and the development accounts of JR and SI.”
3
Iyer J, Mhatre SD, Gilbert R, Bhattacharya S.
Multi-system responses to altered gravity and spaceflight: Insights from Drosophila melanogaster.
Neurosci Biobehav Rev. 2022 Nov;142:104880. Review.
https://pubmed.ncbi.nlm.nih.gov/36126744
Note: From the abstract: “This review discusses the advancements in gravitational biology using Drosophila melanogaster, one of the first organisms to be launched into space.”
Journal Impact Factor: 9.052
Funding: “Special thanks to Drs. April Ronca and Joshua Alwood for their critical review of the manuscript; NASA’s Biological and Physical Sciences Division for the following grants to S.B.: NNX13AN38G and NNX15AB42G; and NASA Postdoctoral Program for an award to RG.”
4
Koehle AP, Brumwell SL, Seto EP, Lynch AM, Urbaniak C.
Microbial applications for sustainable space exploration beyond low Earth orbit.
npj Microgravity. 2023 Jun 21;9:47. Reviewl
https://pubmed.ncbi.nlm.nih.gov/37344487
PI: C. Urbaniak
Note: From the abstract: “In this review, information will be presented on the beneficial use of microbes in bioregenerative life support systems, their applicability to bISRU, and their capability to be genetically engineered for biotechnological space applications. In addition, we discuss the negative effect microbes and microbial communities may have on long-duration space travel and provide mitigation strategies to reduce their impact. Utilizing the benefits of microbes, while understanding their limitations, will help us explore deeper into space and develop sustainable human habitats on the Moon, Mars and beyond.” This article may be obtained online without charge.
Journal Impact Factor: 4.97
Funding: “The authors acknowledge funds from a NASA 2020 Space Biology (NNH18ZTT001NFG2) grant (80NSSC21K0320) awarded to C.U.”
5
Kreykes AJ, Suresh R, Levin D, Hilmers DC.
Selecting medical conditions relevant to exploration spaceflight to create the IMPACT 1.0 Medical Condition List.
Aerosp Med Hum Perform. 2023 Jul 1;94(7):550-7.
https://pubmed.ncbi.nlm.nih.gov/37349929
Note: From the abstract: “Medical conditions occurring in spaceflight pose risks to the crew and the mission and these risks will be exacerbated during exploration-class missions. Probabilistic risk assessment is a method used at NASA to quantify this risk for low-Earth orbit operations. Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) is a next-generation tool suite that will perform these assessments for exploration-class missions. It will require a robust list of medical conditions of significant likelihood and/or consequence to exploration-class missions to accurately inform the tool suite.”
Journal Impact Factor: 0.889
Funding: “This work was funded by the Exploration Medical Capability Element of the Human Research Program, NASA Johnson Space Center.”
6
Russell BK, Burian BK, Hilmers DC, Beard BL, Martin K, Pletcher DL, Easter B, Lehnhardt K, Levin D.
The value of a spaceflight clinical decision support system for Earth-independent medical operations.
npj Microgravity. 2023 Jun 21;9:46. Review.
https://pubmed.ncbi.nlm.nih.gov/37344482
Note: This article is a perspective and may be obtained online without charge.
Journal Impact Factor: 4.97
Funding: B.K. Russell, B.K. Burian, B.L. Beard, K. Martin, and D.L. Pletcher are affiliated with NASA Ames Research Center. D.C. Hilmers, B. Easter, K. Lehnhardt, and D. Levin are affiliated with NASA Johnson Space Center.
7
Ryder VE, Williams ES.
Revisions to acute/off-nominal limits for benzene in spacecraft air.
Aerosp Med Hum Perform. 2023 Jul 1;94(7):544-5.
https://pubmed.ncbi.nlm.nih.gov/37349924
Note: This article is a short communication.
Journal Impact Factor: 0.889
Funding: V.E. Ryder and E.S. Williams are affiliated with NASA Johnson Space Center.
8
McDonagh F, Cormican M, Morris D, Burke L, Singh NK, Venkateswaran K, Miliotis G.
Medical astro-microbiology: Current role and future challenges.
J Indian Inst Sci. 2023 Apr 8;1-26. Review.
https://pubmed.ncbi.nlm.nih.gov/37362850
Note: This article may be obtained online without charge.
Journal Impact Factor: 2.456
Funding: N.K. Singh and K. Venkateswaran are affiliated with NASA Jet Propulsion Laboratory.
9
Hoenemann JN, Moestl S, van Herwaarden AE, Diedrich A, Mulder E, Frett T, Petrat G, Pustowalow W, Arz M, Heusser K, Lee S, Jordan J, Tank J, Hoffmann F.
Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest.
Clin Auton Res. 2023 Jun 22.
https://pubmed.ncbi.nlm.nih.gov/37347452
Note: Head-down tilt bedrest study.
Journal Impact Factor: 5.625
Funding: “This work was supported by NASA, ESA, the Belgian Federal Scientific Policy Office (PRODEX PEA 4000110826), and programmatic funding of the German Aerospace Center (DLR). J.H. received funding from the German Aerospace Center (DLR) and the German Federal Ministry of Economy and Technology (BMWi; 50WB1816).”
10
Sherman SO, Jonsen A, Lewis Q, Schlittenhart M, Szafir D, Clark TK, Anderson AP.
Training augmentation using additive sensory noise in a lunar rover navigation task.
Front Neurosci. 2023 Jun 23;17:1180314.
https://doi.org/10.3389/fnins.2023.1180314
PI: A.P. Anderson
Note: This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior-Volume II” (https://www.frontiersin.org/research-topics/47491/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior—volume-ii#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,041 https://doi.org/10.3389/fphys.2023.1141078, #1,046 https://doi.org/10.3389/fncir.2023.1135434, #1,051 https://doi.org/10.3389/fphys.2023.1146096, and # 1,053 https://doi.org/10.3389/fphys.2023.1141015. This article may be obtained online without charge.
Journal Impact Factor: 5.152
Funding: “This study was funded by the Translational Research Institute for Space Health (TRISH) through NASA Cooperative Agreement NNX16AO69A (award number T0402).”
11
Petersen L.
Arterial and intracranial hypotension during and following exercise.
Physiology. 2023 May;38(S1):5793685.
https://doi.org/10.1152/physiol.2023.38.S1.5793685
PI: L. Petersen
Note: This is a meeting abstract published by a peer-reviewed journal.
Journal Impact Factor: 8.4
Funding: “This work was supported by NASA grant no 80NSSC19K0020 and the Novo Nordic Foundation grant no NNF15OC0019196.”
12
Arguelles J, Lee J, Cardenas LV, Govind S, Singh S.
In silico analysis of a Drosophila parasitoid venom peptide reveals prevalence of the Cation-Polar-Cation clip motif in knottin proteins.
Pathogens. 2023 Jan 14;12(1):143.
https://pubmed.ncbi.nlm.nih.gov/36678491
PI: S. Govind
Note: This article is part of Special Issue “‘Behavior’ of Fungi—A Themed Issue in Honor of Dr. Peter N. Lipke” (https://www.mdpi.com/journal/pathogens/special_issues/fungi_behavior). This article may be obtained online without charge.
Journal Impact Factor: 3.7
Funding: PI reports NASA grant NNX15AB42G funding.
13
Waisberg E, Ong J, Masalkhi M, Zaman N, Sarker P, Lee AG, Tavakkoli A.
Apple Vision Pro and why extended reality will revolutionize the future of medicine.
Ir J Med Sci. 2023 Jun 27.
https://pubmed.ncbi.nlm.nih.gov/37365445
PI: A. Tavakkoli
Note: This is a letter to the editor.
Journal Impact Factor: 2.089
Funding: “This work was supported by NASA Grant (80NSSC20K183)—a non-intrusive ocular monitoring framework to model ocular structure and functional changes due to long-term spaceflight.”
_______________________________________________________
Other papers of interest:
1
Abitante TJ, Alemi MM, Newman DJ, Duda KR.
Metabolic cost of a proposed NMES spaceflight countermeasure compared to walking in active adults.
Aerosp Med Hum Perform. 2023 Jul 1;94(7):523-31.
https://pubmed.ncbi.nlm.nih.gov/37349933
2
Li C, Sun T, Zhang Y, Gao Y, Sun Z, Li W, Cheng H, Gu Y, Abumaria N.
A neural circuit for regulating a behavioral switch in response to prolonged uncontrollability in mice.
Neuron. 2023 Jun 16. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37352858
3
Ata SO, Ata N, Yazgan E, Akkor T, Ugurlutan R.
Push-out bond strength of fiber posts in long-term hypobaric pressure changes.
Aerosp Med Hum Perform. 2023 Jul 1;94(7):508-13.
https://doi.org/10.3357/AMHP.6173.2023
Note: From the abstract: “The purpose of this study was to evaluate the bond strength of fiber posts with different mixing methods and insertion into root canal techniques in long-term hypobaric pressure changes.”
4
Mayes RS, Keirns CJ, Hicks AG, Menner LD, Lee MS, Wagner JH, Baltzer RL.
USAFSAM Aeromedical Consultation Service Medical Risk Assessment and Airworthiness Matrix.
Aerosp Med Hum Perform. 2023 Jul 1;94(7):514-22.
https://doi.org/10.3357/AMHP.6154.2023
Note: From the abstract: “The 1% rule has long been a standard threshold for aerospace medical risk acceptance, but medical literature has noted multiple shortcomings with this threshold. Previous studies have suggested a risk matrix approach in aeromedical decision-making. General use of risk matrices for risk assessment is already codified in the U.S. Air Force (USAF). Based on this, the USAF School of Aerospace Medicine (USAFSAM) Aeromedical Consultation Service (ACS) generated and evaluated the ACS Medical Risk Assessment and Airworthiness Matrix (AMRAAM).”
5
National Academies of Sciences, Engineering, Medicine.
Nonhuman primate models in biomedical research: State of the science and future needs.
Ramos KS, Downey A, Yost OC, editors.
Washington, DC: The National Academies Press, 2023. 268 p.
6
Nicoll PM, Ali JI, Silveira K, Harper NJ, Smart CM.
Psychological growth following exposure to isolated, confined, and extreme environments: A systematic review.
Acta Astronaut. 2023 Jun 24. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2023.06.038
7
Tegern M, Aasa U, Larsson H.
A prospective cohort study on risk factors for cervico-thoracic pain in military aircrew.
Aerosp Med Hum Perform. 2023 Jul 1;94(7):500-7.
https://doi.org/10.3357/AMHP.6218.2023
8
Garcia G, Arauz PG, Alvarez I, Encalada N, Vega S, Martin BJ.
Impact of a passive upper-body exoskeleton on muscle activity, heart rate, and discomfort during a carrying task.
PLoS One. 2023 Jun 23;18(6):e0287588.
https://pubmed.ncbi.nlm.nih.gov/37352272
Note: This article may be obtained online without charge.
9
Norris AM, Appu AB, Johnson CD, Zhou LY, McKellar DW, Renault MA, Hammers D, Cosgrove BD, Kopinke D.
Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration.
Nat Commun. 2023 Jun 24;14:3766.
https://pubmed.ncbi.nlm.nih.gov/37355632
Note: From the abstract: “In this work, we reveal crucial post-developmental functions of Hh signaling in balancing tissue regeneration and fatty fibrosis. Moreover, they provide the exciting possibility that mis-regulation of the Hh pathway with age and disease could be a major driver of pathological IMAT formation.”
10
Srinivasan SS, Gfrerer L, Karandikar P, Som A, Alshareef A, Liu S, Higginbotham H, Ishida K, Hayward A, Kalva SP, Langer R, Traverso G.
Adaptive conductive electrotherapeutic scaffolds for enhanced peripheral nerve regeneration and stimulation.
Med. 2023 Jun 9;S2666-6340(23)00165-4. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37339635
11
Rabotin A, Epstein Y, Ketko I.
Heat intolerance, body size, and return to duty.
Aerosp Med Hum Perform. 2023 Jul 1;94(7):546-9.
https://pubmed.ncbi.nlm.nih.gov/37349917
12
Thompson J.
NASA resilience and leadership: Examining the phenomenon of awe.
Front Psychol. 2023 Jun 9;14:1158437.
https://pubmed.ncbi.nlm.nih.gov/37359869
Note: This article is part of Research Topic “Searching for Meaning in Work and Life: Happiness, Wellbeing and the Future of Organizations” (https://www.frontiersin.org/research-topics/45203/searching-for-meaning-in-work-and-life-happiness-wellbeing-and-the-future-of-organisations#overview) and may be obtained online without charge.
