NASA Spaceline Current Awareness List #1,054 16 June 2023 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm.
Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Castro CL, Velez-Justiniano YA, Stahl-Rommel S, Nguyen HN, Almengor A, Dunbar B, McLean RJC, Sysoeva TA, Castro-Wallace SL.
Genome sequences of bacteria isolated from the International Space Station water systems.
Microbiol Resour Announc. 2023 Jun 7:e0015823. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37284768
Note: ISS results. From the abstract: “We report draft genomes of five bacteria recovered from the U.S. and Russian water systems onboard the International Space Station. The five genera include Ralstonia, Burkholderia, Cupriavidus, Methylobacterium, and Pseudomonas. These sequences will help further the understanding of water reclamation and environmental control and life support systems in space.” This article may be obtained online without charge.
Journal Impact Factor: 3.03
Funding: Y-A. Velez-Justiniano is affiliated with NASA Marshall Space Flight Center. Miss Velez-Justiniano is part of the NASA Polaris project. S.L. Castro-Wallace is affiliated with NASA Johnson Space Center. From the article acknowledgments: “This research was carried out at the NASA Lyndon B. Johnson Space Center. We thank the ISS crew members for sample collection and the Microbiology Laboratory for isolating and archiving the bacteria. This work was supported in part by research funds from NASA Polaris grant 663323.08.62.01. The JSC contract team acknowledges funding through NASA contract NNJ15HK11B, made possible by the NASA Polaris grant and the JSC Office of the Chief Technologist R. Clayton and C. Westhelle.”
2
McGregor HR, Hupfeld KE, Pasternak O, Beltran NE, De Dios YE, Bloomberg JJ, Wood SJ, Mulavara AP, Riascos RF, Reuter-Lorenz PA, Seidler RD.
Impacts of spaceflight experience on human brain structure.
Sci Rep. 2023 Jun 8;13:7878.
https://pubmed.ncbi.nlm.nih.gov/37291238
PIs: H.R. McGregor, R.D. Seidler
Note: ISS results. From the article: “T1-weighted and diffusion-weighted MRI (dMRI) scans collected from a total of 30 astronauts were included in this study. Data from 15 of the astronauts were collected as part of a prospective study conducted between 2014 and 2020. Astronauts in the prospective group completed a long-duration mission to the ISS lasting approximately 6 (n = 13) or 12 months (n = 2). Data from the remaining 15 astronauts were obtained from the NASA Lifetime Surveillance of Astronaut Health Repository.” This article may be obtained online without charge.
Journal Impact Factor: 4.996
Funding: “This study was supported by NASA grant #NNX11AR02G awarded to RDS, AM, PARL, SJW and JJB. HRM was supported by a NSERC postdoctoral fellowship and a NASA Human Research Program augmentation grant. KEH was supported by a National Institute on Aging fellowship 1F99AG068440.”
3
Estlack Z, Golozar M, Butterworth AL, Mathies RA, Kim J.
Operation of a programmable microfluidic organic analyzer under microgravity conditions simulating spaceflight environments.
npj Microgravity. 2023 Jun 8;9:41.
https://pubmed.ncbi.nlm.nih.gov/37286631
Note: This article is a Brief Communication. From the abstract: “A programmable microfluidic organic analyzer was developed for detecting life signatures beyond Earth and clinical monitoring of astronaut health. Extensive environmental tests, including various gravitational environments, are required to confirm the functionality of this analyzer and advance its overall Technology Readiness Level. This work examines how the programmable microfluidic analyzer performed under simulated Lunar, Martian, zero, and hypergravity conditions during a parabolic flight.” This article may be obtained online without charge.
Journal Impact Factor: 4.97
Funding: “This work was primarily supported by NASA SpaceTech–REDDI Tech Flights 2020 through grant 80NSSC21K0447 from the Space Technology Mission Directorate / Flight Opportunities. Z.”
4
Thamer S, Stevanovic M, Buckey JC Jr.
Pre-flight body weight effects on urinary calcium excretion in space.
npj Microgravity. 2023 Jun 14;9:45.
https://pubmed.ncbi.nlm.nih.gov/37316529
PI: J.C. Buckey Jr
Note: From the abstract: “Microgravity-induced bone loss increases urinary calcium excretion which increases kidney stone formation risk. Not all individuals show the same degree of increase in urinary calcium and some pre-flight characteristics may help identify individuals who may benefit from in-flight monitoring. In weightlessness, the bone is unloaded, and the effect of this unloading may be greater for those who weigh more. We studied whether pre-flight body weight was associated with increased in-flight urinary calcium excretion using data from Skylab and the International Space Station (ISS). The study was reviewed and approved by the National Aeronautics and Space Administration (NASA) electronic Institutional Review Board (eIRB) and data were sourced from the Longitudinal Study of Astronaut Health (LSAH) database.” This article may be obtained online without charge.
Journal Impact Factor: 4.97
Funding: “This research was supported by NASA Grant 80NSSC19K1632. We thank the NASA office of the Life Sciences Data Archive for their time in providing the dataset used in this study. This research was supported by NASA Grant 80NSSC19K1632. We thank the NASA office of the Life Sciences Data Archive for their time in providing the dataset used in this study.”
5
Kamal KY, Lawler JM.
Cellular and molecular signaling meet the space environment.
Int J Mol Sci. 2023 Mar 22;24(6):5955.
https://doi.org/10.3390/ijms24065955
PI: J.M. Lawler
Note: This article is the editorial to Special Issue “Cellular and Molecular Signaling Meet the Space Environment” (https://www.mdpi.com/journal/ijms/special_issues/Cellular_molecular_signaling_space). The editorial includes articles from Current Awareness lists #983 https://doi.org/10.3390/ijms23010075; #1,002 https://doi.org/10.3390/ijms23105593 and https://doi.org/10.3390/ijms23105489; and #1,008 https://doi.org/10.3390/ijms23137465and https://doi.org/10.3390/ijms23137133. This article may be obtained online without charge.
Journal Impact Factor: 6.208
Funding: PI reports funding from all of their Task Book submissions and ongoing, funded projects.
6
Kumar K, Kumar S, Datta K, Fornace AJ Jr, Suman S.
High-LET-radiation-induced persistent DNA damage response signaling and gastrointestinal cancer development.
Curr Oncol. 2023 Jun 7;30(6):5497-514. Review.
https://doi.org/10.3390/curroncol30060416
PI: A.J. Fornace Jr/NSCOR
Note: This article is part of Section “Gastrointestinal Oncology” (https://www.mdpi.com/journal/curroncol/sections/Gastrointestinal_Oncology) and may be obtained online without charge.
Journal Impact Factor: 3.109
Funding: “This research was funded by the National Aeronautics and Space Administration (NASA), grant number NNX15AI21G and 80NSSC22K1279.”
7
Yun S, Soler I, Tran FH, Haas HA, Shi R, Bancroft GL, Suarez MD, de Santis CR, Reynolds RP, Eisch AJ.
Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity.
Front Behav Neurosci. 2023 Jun 1;17:1151877.
https://doi.org/10.3389/fnbeh.2023.1151877
PIs: S. Yun, A.J. Eisch
Note: This article may be obtained online without charge.
Journal Impact Factor: 3.617
Funding: “SY support: NIH [Training Grant MH076690 (PI: Tamminga), R21MH107945 (PI: AE), R15 MH117628 (PI: Lambert) NS088555 (PI: Stowe)], a 2018 PENN McCabe Pilot grant, a 2019 IBRO travel grant, the PENN Undergraduate Research Foundation (PI: SY), a 2019 NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation, a 2021 NASA HERO grant (80NSSC21K0814, PI: SY), and CHOP [Foerderer Fund for Excellence (PI: Van Batavia)], and philanthropic funds to the Eisch Lab. IS support: by the Penn Post Baccalaureate Research Education Program (PennPREP) which was supported by a grant from the NIH (R25GM071745, PI: KL Jordan-Sciutto) and additional funding from Biomedical Graduate Studies at the University of Pennsylvania. AE support: NASA [NNX07AP84G and NNX12AB55G (co-I AE) and NNX15AE09G (PI: AE)], NIH [DA007290, DA023555, DA016765, and MH107945 (PI: AE), R15 MH117628 (PI: Lambert) T, 32NS007413-25 (PI: AE and Marsh), NS088555 (PI: Stowe), and NS126279 (PI: Ahrens-Nicklas], CHOP [Foerderer Fund for Excellence (PI: Van Batavia)], Perelman School of Medicine’s Department of Radiation Oncology Pilot Grant (PI: AE and Fan), and philanthropic funds to the Eisch Lab (PI: AE and Fan).”
8
Dwivedi R, Farrag M, Sharma P, Shi D, Shami AA, Misra SK, Ray P, Shukla J, Zhang F, Linhardt RJ, Sharp JS, Tandon R, Pomin VH.
The sea cucumber Thyonella gemmata contains a low anticoagulant sulfated fucan with high anti-SARS-CoV-2 actions against wild-type and delta variants.
J Nat Prod. 2023 Jun 12. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37306476
PI: R. Tandon
Journal Impact Factor: 4.803
Funding: “Grant ID: 80NSSC19K1603.”
9
Sarker P, Zaman N, Ong J, Paladugu P, Aldred M, Waisberg E, Lee AG, Tavakkoli A.
Test-retest reliability of virtual reality devices in quantifying for relative afferent pupillary defect.
Transl Vis Sci Technol. 2023 Jun 1;12(6):2.
https://pubmed.ncbi.nlm.nih.gov/37279393
PI: A. Tavakkoli
Note: From the abstract: “Our study demonstrates the critical necessity of establishing test–retest reliability measures when bridging virtual reality technology into the clinical setting for relevant afferent pupillary defect.” This article may be obtained online without charge.
Journal Impact Factor: 3.048
Funding: “Supported by a NASA grant (80NSSC20K183: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes Due to Long-term Spaceflight).”
_______________________________________________________
Other papers of interest:
1
Pusil S, Zegarra-Valdivia J, Cuesta P, Laohathai C, Cebolla AM, Haueisen J, Fiedler P, Funke M, Maestú F, Cheron G.
Effects of spaceflight on the EEG [electroencephalography] alpha power and functional connectivity.
Sci Rep. 2023 Jun 11;13:9489.
https://pubmed.ncbi.nlm.nih.gov/37303002
Note: ISS results. This article may be obtained online without charge.
2
Qu X, Wang H, Lodhi AF, Deng YL, Zhang Y.
Evaluation of decontamination potential of wet wipes against microbial contamination of Chinese spacecraft materials.
Astrobiology. 2023 Jun 6.
https://pubmed.ncbi.nlm.nih.gov/37279031
Note: From the abstract: “There are many kinds of microorganisms that inhabit the environment of crewed space stations. Wet wipes are a common tool used in space stations to clean and reduce microorganisms on surfaces. Here, we compared the performance of five types of wipes used by the Chinese Space Station (CSS) on orbit before 2021 in terms of microbial decontamination. In previous studies, we found that Bacillus sp. TJ-1-1 and Staphylococcus sp. HN-5 were the most abundant microorganisms in the assembly environment of the CSS. In this study, we used these two bacteria to build different microbial load models to represent the occurrence and non-occurrence of microbial outbreaks in the on-orbit CSS.”
3
Zhang Z, Wang Z, Zhou Z, Li H, Zhang Q, Zhou Y, Li X, Liu W.
Omnidirectional continuous movement method of dual-arm robot in a space station.
Sensors (Basel). 2023 May 24;23(11):5025.
https://pubmed.ncbi.nlm.nih.gov/37299752
Note: From the abstract: “The burgeoning complexity of space missions has amplified the research focus on robots that are capable of assisting astronauts in accomplishing tasks within space stations. Nevertheless, these robots grapple with substantial mobility challenges in a weightless environment. This study proposed an omnidirectional continuous movement method for a dual-arm robot, inspired by the movement patterns of astronauts within space stations.” This article is part of Special Issue “Human-Robot Collaborations in Industrial Automation II” (https://www.mdpi.com/journal/sensors/special_issues/V1NL10G1N5). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
4
Bury NA, Jenkin M, Allison RS, Herpers R, Harris LR.
Vection underwater illustrates the limitations of neutral buoyancy as a microgravity analog.
npj Microgravity. 2023 Jun 10;9:42.
https://pubmed.ncbi.nlm.nih.gov/37301926
Note: From the article: “Participants were tested in two environmental conditions (in a laboratory and underwater in the German Sport University Swimming Facility in Cologne, Germany) and in two body postures (upright and supine). The order in which a participant experienced the environmental condition was randomized but once in that environment the participant completed all of the in-pool or all of the in-lab data collection sessions in a group. The order of the body postures was randomized within either the in-lab or the in-pool group.”
5
Dwi Setiawan G, Thiravetyan P, Treesubsuntorn C.
Gaseous toluene phytoremediation by Vigna radiata seedlings under simulated microgravity: Effect of hypocotyl, auxin, and gibberellic acid.
Acta Astronaut. 2023 Oct;211. Online ahead of print.
https://doi.org/10.1016/j.actaastro.2023.06.002
Note: From the abstract: “Air phytoremediation is one of the sustainable and eco-friendly biotechnology to remedy polluted atmospheric environment. The microgravity environment in International Space Station (ISS) cabin is contaminated with various traces of volatile organic compounds (VOCs), such as toluene. The mature plant showed the capability to remove air pollution under simulated microgravity (μG). However, generally, plants are brought to space in seed form. In this study, we tried to observe gaseous toluene phytoremediation by
Vigna radiata seedlings grown under μG started from the seeds form and evaluate its effect on seedling’s growth an
d plant stress response through endogenous hormones auxin and gibberellin.”
6
Service RF.
Let there be dark.
Science. 2023 Jun 9;380(6649):1004-7.
https://pubmed.ncbi.nlm.nih.gov/37289883
Note: From the article: “For the first astronauts to visit Mars, what to eat on their 3-year mission will be one of the most critical questions. It’s not just a matter of taste. According to one recent estimate, a crew of six would require an estimated 10,000 kilograms of food for the trip. NASA—which plans to send people to Mars within 2 decades—could stuff a spacecraft with prepackaged meals and launch additional supplies to the Red Planet in advance for the voyage home. But even that wouldn’t completely solve the problem.” This article may be obtained online without charge.
7
Jin H, Zhu L, Li M, Duffy VG.
Recognition and evaluation of mental workload in different stages of perceptual and cognitive information processing using a multimodal approach.
Ergonomics. 2023 Jun 8;1-27. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37289000
Note: From the abstract: “This study explores the effects of different perceptual and cognitive information processing stages on mental workload by assessing multimodal indicators of mental workload such as the NASA Task Load Index, task performance, ERPs, and eye movements.”
8
Meier MM, Berger T, Jahn T, Matthiä D, Plettenberg MC, Scheibinger M, Schennetten K, Wirtz M.
Impact of the South Atlantic Anomaly on radiation exposure at flight altitudes during solar minimum.
Sci Rep. 2023 Jun 8;13:9348.
https://pubmed.ncbi.nlm.nih.gov/37291163
Note: From the abstract: “The South Atlantic Anomaly (SAA) is a geographical region over the South Atlantic Ocean where the inner Van Allen radiation belt extends down particularly close to Earth. This leads to highly increased levels of ionizing radiation and related impacts on spacecraft in Low Earth Orbits, e.g., correspondingly increased radiation exposure of astronauts and electronic components on the International Space Station.” This article may be obtained online without charge.
9
Sakae T, Takada K, Kamizawa S, Terunuma T, Ando K.
Formulation of time-dependent cell survival with saturable repairability of radiation damage.
Radiat Res. 2023 Jun 6. Online ahead of print.
https://doi.org/10.1667/RADE-21-00066.1
10
Srivastava T, Chirikova E, Birk S, Xiong F, Benzouak T, Liu JY, Villeneuve PJ, Zablotska LB.
Exposure to ionizing radiation and risk of dementia: A systematic review and meta-analysis.
Radiat Res. 2023;199(5):490-505.
https://pubmed.ncbi.nlm.nih.gov/37293601
Note: This article may be obtained online without charge.
11
Prideaux M, Smargiassi A, Peng G, Brotto M, Robling AG, Bonewald LF.
L-BAIBA synergizes with sub-optimal mechanical loading to promote new bone formation.
JBMR Plus. 2023 Apr 24;7(6):e10746. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37283651
Note: This article may be obtained online without charge.
12
Saver JL, Klerman EB, Buchan AM, Calleja P, Lizasoain I, Bahr-Hosseini M, Lee S, Liebeskind DS, Mergenthaler P, Mun KT, Ning M, Pelz D, Ray D, Rothwell PM, Seners P, Sreekrishnan A, Sung EM, Tiedt S, Webb AJS, Wölfer TA, Albers GW.
Consensus recommendations for standardized data elements, scales, and time segmentations in studies of human circadian/diurnal biology and stroke.
Stroke. 2023 Jun 5. Online ahead of print. Review.
https://pubmed.ncbi.nlm.nih.gov/37272394
13
Shirure VS, Yechikov S, Shergill BS, Dehghani T, Block AV, Sodhi H, Panitch A, George SC.
Mitigating neutrophil trafficking and cardiotoxicity with DS-IkL in a microphysiological system of a cytokine storm.
Lab Chip. 2023 Jun 6. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37278194
Note: From the abstract: “A feature of severe COVID-19 is the onset of an acute and intense systemic inflammatory response referred to as the “cytokine storm”. The cytokine storm is characterized by high serum levels of inflammatory cytokines and the subsequent transport of inflammatory cells to damaging levels in vital organs (e.g., myocarditis). Immune trafficking and its effect on underlying tissues (e.g., myocardium) are challenging to observe at a high spatial and temporal resolution in mouse models. In this study, we created a vascularized organ-on-a-chip system to mimic cytokine storm-like conditions and tested the effectiveness of a novel multivalent selectin-targeting carbohydrate conjugate (composed of DS – dermatan sulfate and IkL – a selectin-binding peptide, termed DS–IkL) in blocking infiltration of polymorphonuclear leukocytes (PMN).”
14
Thamer SB, Bello J, Stevanovic M, Obat D, Buckey JC.
Nationwide survey of medical student interest in and exposure to aerospace medicine.
npj Microgravity. 2023 Jun 14;9:44.
https://pubmed.ncbi.nlm.nih.gov/37316520
Note: From the abstract: “Aerospace Medicine is experiencing a renaissance. Commercial spaceflight is now a reality, meaning that individuals with a variety of medical conditions will be flying in space. NASA has Mars plans, and SpaceX plans to send humans to Mars within the next decade, so today’s medical students may be future physicians on these crews. Considering these developments, we evaluated interest in and exposure to Aerospace Medicine among medical students in the United States (US).”
