NASA Spaceline Current Awareness List #1,053 9 June 2023 (Space Life Science Research Results)

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. 

Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:

1

Singh NK, Wood JM, Patane J, Moura LMS, Lombardino J, Setubal JC, Venkateswaran K.

Characterization of metagenome-assembled genomes from the International Space Station.

Microbiome. 2023 Jun 1;11:125.

https://pubmed.ncbi.nlm.nih.gov/37264385

PI: K. Venkateswaran

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 16.837

Funding: “Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV, which also funded the postdoctoral fellowships for NKS and JMW.”

2

Krittanawong C, Scheuring RA.

Space and precision cardiovascular health: Future perspectives of space travel.

Eur Heart J. 2023 Jun 2. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/37264547

Note: This article may be obtained online without charge.

Journal Impact Factor: 35.855

Funding: R.A. Scheuring is affiliated with NASA Johnson Space Center.

3

Sarker P, Ong J, Zaman N, Kamran SA, Waisberg E, Paladugu P, Lee AG, Tavakkoli A.

Extended reality quantification of pupil reactivity as a non-invasive assessment for the pathogenesis of spaceflight associated neuro-ocular syndrome: A technology validation study for astronaut health.

Life Sci Space Res. 2023 Jun 5. Online ahead of print.

https://doi.org/10.1016/j.lssr.2023.06.001

PI: A. Tavakkoli

Journal Impact Factor: 2.73

Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”

4

Valinia A, Folta D, Hughes K, Hatten N, Vera A, Stone L, Parisi M, McTigue K, Panontin T.

Risk trade-space analysis for safe human expeditions to Mars.

Acta Astronaut. 2023 Jun 8. Online ahead of print.

https://doi.org/10.1016/j.actaastro.2023.05.039

Note: From the abstract: “We assessed the integrated safety, health, and performance risk to crews on long-duration missions, specifically to Mars. Using a systems approach rather than one focused on individual countermeasures, we examined the trade space around several such risks to identify high-potential risk mitigation strategies and characterize aspects of Mars mission architectures that could lower aggregated risk. Current Mars Design Reference missions would require durations well over two years and would increase crew exposure to radiation and microgravity well beyond ISS levels, likely resulting in significantly reduced performance beyond our current capability to mitigate that could jeopardize mission success. A ‘fast Mars transit’ round-trip mission concept was studied using an innovative flight dynamics approach to quantify the minimum total mission energy required for a Mars transit with total mission duration less than 400 days.”

Journal Impact Factor: 2.954

Funding: A. Valinia, D. Folta, K. Hughes, and N. Hatten are affiliated with NASA Goddard Space Flight Center. A. Vera, L. Stone, M. Parisi, and K. McTigue are affiliated with NASA Ames Research Center.

5

Oyefeso FA, Goldberg G, Opoku N, Vazquez M, Bertucci A, Chen Z, Wang C, Muotri AR, Pecaut MJ.

Effects of acute low-moderate dose ionizing radiation to human brain organoids.

PLoS One. 2023 May 31;18(5):e0282958.

https://pubmed.ncbi.nlm.nih.gov/37256873

PI: M.J. Pecaut

Note: This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “M.J.P. received support in part through National Institutes of Health grant U19AI067773, National Aeronautics and Space Administration Research Grant NNX13AN34G, and NSF/CASIS grant 2126309. F.O. received support through the LLU Initiative for Maximizing Student Development under National Institutes of General Medical Sciences grant R25 GM060507. A.R.M. received National Science Foundation / Center for the Advancement of Science in Space grant 2126309. Imaging and analysis was performed in the LLUSM Advanced Imaging and Microscopy Core that is supported by National Science Foundation grant MRI-DBI 0923559.”

6

Waisberg E, Ong J, Masalkhi M, Zaman N, Kamran SA, Sarker P, Lee AG, Tavakkoli A.

Generative Pre-Trained Transformers (GPT) and space health: A potential frontier in astronaut health during exploration missions.

Prehosp Disaster Med. 2023 Jun 2;1-5. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/37264946

PI: A. Tavakkoli

Note: This article is a commentary and may be obtained online without charge.

Journal Impact Factor: 2.866

Funding: “The authors declare no conflicts of interest. Funding was received through NASA Grant [80NSSC20K183]: A Non-Intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-Term Spaceflight.”

7

Sherman SO, Greenstein M, Basner M, Clark TK, Anderson AP.

Effects of additive sensory noise on cognition.

Front Hum Neurosci. 2023 Jun 1;17:1092154.

https://doi.org/10.3389/fnhum.2023.1092154

PI: A.P. Anderson

Note: This article is part of Research Topic “Affective Processing and Non-invasive Brain Stimulation, Volume II” (https://www.frontiersin.org/research-topics/30720/affective-processing-and-non-invasive-brain-stimulation-volume-ii#overview) and may be obtained online without charge.

Journal Impact Factor: 3.473

Funding: “This study was funded by the Translational Research Institute for Space Health (TRISH) through NASA Cooperative Agreement NNX16AO69A (award number: T0402).”

8

Lutz WE, Azadmanesh J, Lovelace JJ, Kolar C, Coates L, Weiss KL, Borgstahl GEO.

Perfect crystals: Microgravity capillary counterdiffusion crystallization of human manganese superoxide dismutase for neutron crystallography.

npj Microgravity. 2023 Jun 3;9:39.

https://pubmed.ncbi.nlm.nih.gov/37270576

PI: G.E.O. Borgstahl

Note: From the abstract: “The NASA mission Perfect Crystals used the microgravity environment on the International Space Station (ISS) to grow crystals of human manganese superoxide dismutase (MnSOD)—an oxidoreductase critical for mitochondrial vitality and human health. The mission’s overarching aim is to perform neutron protein crystallography (NPC) on MnSOD to directly visualize proton positions and derive a chemical understanding of the concerted proton electron transfers performed by the enzyme.” This article may be obtained online without charge.

Journal Impact Factor: 4.97

Funding: “This research was supported by NIGMS (R01GM145647-01), NASA EPSCoR (NE-80NSSC17M0030 and NE-NNX15AM82A), and NASA space grant fellowships to Jahaun Azadmanesh. The UNMC Structural Biology Core Facility was funded by the Fred and Pamela Buffett NCI Cancer Center Support Grant (P30CA036727). Leighton Coates acknowledges support by the NIH (R01-GM071939). The research at Oak Ridge National Laboratory (ORNL) Spallation Neutron Source was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, US Department of Energy. The Office of Biological and Environmental Research supported research at ORNL Center for Structural Molecular Biology (CSMB) using facilities supported by the Scientific User Facilities Division, Office of Basic Energy Sciences, US Department of Energy.”

9

Britten RA, Limoli CL.

New radiobiological principles for the CNS arising from space radiation research.

Life. 2023 May 31;13(6):1293.

https://doi.org/10.3390/life13061293

PIs: C.L. Limoli/R.A. Britten/NSCOR

Note: This article is part of Special Issue “Current Challenges in Space Neuroscience” (https://www.mdpi.com/journal/life/special_issues/XR00G704U3). The Special Issue also includes an article from previous Current Awareness List #1,042 https://doi.org/10.3390/life13030826, #1,046 https://doi.org/10.3390/life13041002, and #1,052 https://doi.org/10.3390/life13051214. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 3.253

Funding: “NASA NSCOR grant NNX15AI22G.”

10

Rocha-Rangel J, Liang MTC, Tsai AH, Auslander AT, Robles P, Kwoh YL, Arnaud SB.

Bone bending strength and BMD [bone mineral density] of female athletes in volleyball, soccer, and long-distance running.

Eur J Appl Physiol. 2023 May 31.

https://pubmed.ncbi.nlm.nih.gov/37256294

Journal Impact Factor: 3.346

Funding: “This project was supported by the Provost’s Teacher-Scholar Award 2017 to M.T.C.L. The authors express their great appreciation to our graduate students, the coaches for their assistance in the project, and the participants for their time, effort, and commitment in completing the study. We also express our appreciation to NASA Ames Research Center, Life Science Division for lending us the MRTA instrument to conduct the study.”

11

Sanders LM, Chok H, Samson F, Acuna AU, Polo S-HL, Boyko V, Chen Y-C, Dinh M, Gebre S, Galazka JM, Costes SV, Saravia-Butler AM.

Batch effect correction methods for NASA GeneLab transcriptomic datasets.

Front Astron Space Sci. 2023 Jun 1;10:120013.

https://doi.org/10.3389/fspas.2023.1200132

Note: This article is part of Research Topic “Multi-omics Approaches for Understanding Space Flight Impact” (https://www.frontiersin.org/research-topics/36594/multi-omics-approaches-for-understanding-space-flight-impact#overview). The Research Topic also includes an article from previous Current Awareness List #1,014 https://doi.org/10.3389/fphys.2022.971282. GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.

Journal Impact Factor: 4.055

Funding: “This work was funded by the NASA Space Biology Program within the NASA Science Mission Directorate’s (SMD) Biological and Physical Sciences (BPS) Division.”

12

Mehta SK, Diak DM, Rooney BV, Krieger SS, Nelman-Gonzalez M, Locke JP, Nagel MA, Young M, Crucian BE.

Antiviral treatment with valacyclovir reduces virus shedding in saliva of Antarctic expeditioners.

Front Virol. 2023 Jun 2;3:1157659.

https://doi.org/10.3389/fviro.2023.1157659

Note: From the abstract: “Reactivation of herpes viruses, such as Epstein–Barr virus (EBV), herpes simplex virus 1 (HSV1), and varicella zoster virus (VZV), increases in astronauts during spaceflight, compared with their preflight and post flight levels. Reactivations can increase the risk of associated clinical conditions, such as herpes zoster, chronic neuropathic pain, vision loss, stroke, cognitive impairment, and cold sores. Furthermore, continued viral shedding for longer periods after space travel may increase the risk of viral transmission to uninfected crew contacts, including, but not limited to, the immunocompromised and newborn infants. Thus, it is essential to develop spaceflight countermeasures to prevent herpes viral reactivations to ensure the health of crewmembers and their contacts.” This article may be obtained online without charge.

Journal Impact Factor: Not available for this journal

Funding: “The study was funded by Human Research Program of NASA grant # 80JSC017N0001-OMNIBUS. Authors acknowledge the National Science Foundation and UTMB, Galveston, Texas staff for coordinating the study and the subjects who participated in the study at McMurdo and South Pole Stations.”

_______________________________________________________

Other papers of interest:

1

Grigoryan EN.

Impact of microgravity and other spaceflight factors on retina of vertebrates and humans in vivo and in vitro.

Life. 2023 May 26;13(6):1263. Review.

https://doi.org/10.3390/life13061263

Note: This article is part of Special Issue “The Space Environment on Human Health and Disease” (https://www.mdpi.com/journal/life/special_issues/space_microbiome). The Special Issue also includes articles from previous Current Awareness Lists #997 https://doi.org/10.3390/life12040495; #1,011 https://doi.org/10.3390/life12071060 and https://doi.org/10.3390/life12081163; #1,015 https://doi.org/10.3390/life12091301; #1,026 https://doi.org/10.3390/life12111865; and #1,038 https://doi.org/10.3390/life13020588. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

2

Fagliarone C, Mosca C, Di Stefano G, Leuko S, Moeller R, Rabbow E, Rettberg P, Billi D.

Enabling deep-space experimentations on cyanobacteria by monitoring cell division resumption in dried Chroococcidiopsis sp. 029 with accumulated DNA damage.

Front Microbiol. 2023 May 17;14:1150224.

https://pubmed.ncbi.nlm.nih.gov/37266021

Note: This article is part of Research Topic “The Impact of the Space Environment on Microbial Growth and Behavior” (https://www.frontiersin.org/research-topics/27130/the-impact-of-the-space-environment-on-microbial-growth-and-behavior#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,009 https://doi.org/10.3389/fmicb.2022.877625, https://doi.org/10.3389/fmicb.2022.893071, and https://doi.org/10.3389/fmicb.2022.909997; #1,041 https://doi.org/10.3389/fmicb.2023.1090740; #1,046 https://doi.org/10.3389/fmicb.2023.1155726; and #1,050 https://doi.org/10.3389/fmicb.2023.1150224. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

3

Ruprecht NA, Singhal S, Schaefer K, Gill JS, Bansal B, Sens D, Singhal SK.

Establishing a genomic radiation-age association for space exploration supplements lung disease differentiation.

Front Public Health. 2023 May 11;11:1161124.

https://pubmed.ncbi.nlm.nih.gov/37250098

Note: This article is part of Research Topic “Fast Transit, Crew Health, and Performance on Extended Duration Space Missions” (https://www.frontiersin.org/research-topics/46048/fast-transit-crew-health-and-performance-on-extended-duration-space-missions#overview). This article may be obtained online without charge.

4

Farjoud Kouhanjani M, Akbarialiabad H, Asadi-Pooya AA.

Science or fiction; living in extremes of the universe (space and under the sea) even with epilepsy: A systematic review.

Epilepsy & Behavior. 2023 Jul;144:109261.

https://doi.org/10.1016/j.yebeh.2023.109261

Note: From the abstract: “The current systematic review aimed to investigate whether living under the sea or in space is detrimental for patients with epilepsy (PWE). We hypothesized that living under such conditions may predispose PWE to experience seizure recurrence by altering their brain function in a way that predisposes them to seizures.”

5

Fournier R, Persad AH.

A low-cost adapter for the rehydration of commercially available food and beverages for spaceflight.

Acta Astronaut. 2023 Apr 18. Online ahead of print.

https://doi.org/10.1016/j.actaastro.2023.04.023

Note: From the abstract: “All current rehydratable food and drink items prepared for U.S. astronauts on missions to the International Space Station (ISS) must be compatible with the station’s potable water dispenser, called the rehydration station. This highly validated system ensures that water is compartmentalized and safely transferred to custom-made food and beverage pouches to prevent free-floating food particles and water in microgravity. However, the food and beverages packaged in these single-purpose pouches require complex, time-consuming, and costly procedures before flight, which is not feasible for future commercial space stations seeking more affordable life-support systems. Furthermore, even though a vast number of rehydratable food and beverage items available at supermarkets have appropriate nutritional content and shelf life for spaceflight, their incompatible consumer packaging renders them unusable by astronauts. In this paper, we present a low-cost solution that draws on NASA technology to adapt these commercially developed food and drink items for spaceflight and makes them compatible with the water dispensing unit and consumption in a microgravity environment.”

6

Jiang N, Zhang Y, Yao C, Chen F, Liu Y, Chen Y, Wang Y, Choudhary MI, Liu X.

Hemerocallis citrina Baroni ameliorates chronic sleep deprivation-induced cognitive deficits and depressive-like behaviors in mice.

Life Sci Space Res. 2023 Jun 2. Online ahead of print.

https://doi.org/10.1016/j.lssr.2023.04.001

Note: From the abstract: “Sleep deprivation (SD) is common during spaceflight. SD is known to cause cognitive deficits and depression, requiring treatment and prevention. Hemerocallis citrina Baroni (Liliaceae) is a perennial herb with antidepressant, antioxidant, antitumor, anti-inflammatory, and neuroprotective effects.The aim of our study was to investigate the effects of H. citrina extract (HCE) on SD-induced cognitive decline and depression-like behavior and possible neuroinflammation-related mechanisms.”

7

Malaya CA, Parikh PJ, Smith DL, Riaz A, Chandrasekaran S, Layne CS.

Effects of simulated hypo-gravity on lower limb kinematic and electromyographic variables during anti-gravitational treadmill walking.

Front Physiol. 2023 Jun 8;14:1141015.

https://doi.org/10.3389/fphys.2023.1141015

Note: This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior-Volume II” (https://www.frontiersin.org/research-topics/47491/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior—volume-ii#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,041 https://doi.org/10.3389/fphys.2023.1141078, #1,046 https://doi.org/10.3389/fncir.2023.1135434, and #1,051 https://doi.org/10.3389/fphys.2023.1146096. This article may be obtained online without charge.

8

Zhuang H, Xia Y, Wang N, Li W, Dong L, Li B.

Interactive method research of dual mode information coordination integration for astronaut gesture and eye movement signals based on hybrid model.

Sci China Technol Sci. 2023 Jun;66(6):1717-33.

https://doi.org/10.1007/s11431-022-2368-y

Note: This article may be obtained online without charge.

9

Escamilla-Nunez R, Gouda A, Andrysek J.

Evaluation of a vibrotactile biofeedback system targeting stance time symmetry ratio of individuals with lower-limb amputation: A pilot study.

IEEE Trans Neural Syst Rehabil Eng. 2023 Jun 2;3282216.

https://pubmed.ncbi.nlm.nih.gov/37267134

Note: This article may be obtained online without charge.