New Space and Tech

NASA Spaceline Current Awareness List #1,05 2 June (Space Life Science Research Results)

By Keith Cowing
Status Report
June 2, 2023
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NASA Spaceline Current Awareness List #1,05 2 June (Space Life Science Research Results)
NASA astronaut Kayla Barron sets up the Plant Habitat-05 Growth experiment that is studying cotton genetics in microgravity. — NASA

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at

Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Patel OV, Partridge C, Plaut K.

Space environment impacts homeostasis: Exposure to spaceflight alters mammary gland transportome genes.

Biomolecules. 2023 May 22;13(5):872.

PI: K. Plaut

Note: Space shuttle (STS-70) results. This article is part of Collection “Metabolomics and Integrated Multi-Omics in Health and Disease” ( This article may be obtained online without charge.

Journal Impact Factor: 6.064

Funding: “Supported by NASA Grants NCC2-2870.”


Marquez JJ, Landon LB, Salas E.

The next giant leap for space human factors: The opportunities.

Hum Factors. 2023 May 28;187208231174955. Online ahead of print.

PI: J.J. Marquez

Note: From the abstract: “Deep space, long-duration human spaceflight missions to the Moon and Mars still require advances in space human factors research. Key drivers relate to astronauts living and working in isolation, new novel technologies required to accomplish exploration missions, and the longer durations of these.”

Journal Impact Factor: 3.598

Funding: “JM is supported by NASA Human Research Program’s Human Factors and Behavioral Performance Element, and by the NASA Human Capabilities Assessment for Autonomous Missions (HCAAM) Virtual NASA Specialized Center of Research (VNSCOR) project (NASA award 80JSC017N0001-BPBA; JJM, PI). LBL is supported by KBR’s Human Health and Performance Contract NNJ15HK11 B through the National Aeronautics and Space Administration (NASA) Grants NNX16AP96 G and NNX17AB556 awarded to the William Marsh Rice University.”


Lonner TL, Clark TK.

The efficacy of VR as a countermeasure for astronaut motion sickness in post-flight water landings.

2023 IEEE Aerospace Conference. 2023;1-8.

PI: T.K. Clark

Note: This article is a conference proceeding published by a peer-reviewed journal. From the abstract: “This study evaluated the efficacy of virtual reality as a medium for reducing the effects of motion sickness during wave-like motions following gravity transitions.” This article may be obtained online without charge.

Journal Impact Factor: 0.88

Funding: “This work was supported by the National Aeronautics and Space Administration Human Research Program under Grant No. 80NSSC21K0257.”


Puukila S, Siu O, Rubinstein L, Tahimic CGT, Lowe M, Tabares Ruiz S, Korostenskij I, Semel M, Iyer J, Mhatre SD, Shirazi-Fard Y, Alwood JS, Paul AM, Ronca AE.

Galactic cosmic irradiation alters acute and delayed species-typical behavior in male and female mice.

Life (Basel). 2023 May 19;13(5):1214.

PIs: C.G.T. Tahimic, A.E. Ronca

Note: This article is part of Special Issue “Current Challenges in Space Neuroscience” ( The Special Issue also includes an article from previous Current Awareness List #1,046 Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Journal Impact Factor: 3.253

Funding: “This research was funded by HRP Human Factors Behavioral Performance (HFBP) Element (NASA HRP 80JSC018N0001-FLAGSHIP Grant) and ancillary support by Space Biology’s NASA Postdoctoral Program (L.R., S.P.), Space Life Sciences Training Program SLSTP (O.S.) and Embry Riddle Start Up Fund (A.M.P). CGTT is supported by the NASA HRP (80JSC019N0001-FLAGSHIP).”


Cappuccio G, Khalil SM, Osenberg S, Li F, Maletic-Savatic M.

Mass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids.

Front Mol Biosci. 2023 May 22;10:1181965.

PI: M. Maletic-Savatic

Note: This article is part of Research Topic “3D Models of Disease as Diagnostics and Therapeutic Tools” ( This article may be obtained online without charge.

Journal Impact Factor: 6.113

Funding: “This work was supported in part by grants from the National Institute of Mental Health (1R01MH130356 to MM-S), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R61/R33HD099995 to FL), the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (P50HD103555) for use of the Microscopy Core facility, the Pathology Core facility, and the Human Disease Cellular Models Core facility. In addition, the support was provided by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A, grant RAD01013 (MM-S), NASA grant 21-3DTMPS_2-0020 (MM-S), Autism Speaks (GC), Simons Foundation Pilot Award (MM-S) and Cynthia and Antony Petrello Endowment (MM-S).”


Waisberg E, Ong J, Zaman N, Kamran SA, Sarker P, Tavakkoli A, Lee AG.

GPT-4 for triaging ophthalmic symptoms.

Eye (Lond). 2023 May 25.

PI: A. Tavakkoli

Journal Impact Factor: 4.456

Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”


Naithani S, Mohanty B, Elser J, D’Eustachio P, Jaiswal P.

Biocuration of a transcription factors network involved in submergence tolerance during seed germination and coleoptile elongation in rice (Oryza sativa).

Plants. 2023 May 29;12(11):2146.

PIs: S. Naithani, P. Jaiswal

Note: This article is part of Special Issue “The Impacts of Abiotic Stresses on Plant Development 2.0” ( This article may be obtained online without charge.

Journal Impact Factor: 4.658

Funding: “We acknowledge funding from National Aeronautics and Space Administration (NASA) #80NSSC22K0891 to S.N. and in-kind infrastructure and intellectual support from the National Institute of Health-funded Reactome database project (U24 HG012198).”


Other papers of interest:


Bhuyan N, Ghose S, Bhattacharya S, Chakraborty T.

Prolonged spaceflight: Adverse health effects and treatment options with medicinal plants and natural products.

Sciences of Phytochemistry. 2023 May 24;2(1):82-97. Review.

Note: This article may be obtained online without charge.


Cavallaro U.

Spaceflight participants.

In: Cavallaro U, ed. To The Stars: Women Spacefarers’ Legacy. Cham, Switzerland: Springer International Publishing, 2023. p. 505-73.


Cavallaro U.

Outside the spacecraft.

In: Cavallaro U, ed. To The Stars: Women Spacefarers’ Legacy. Cham, Switzerland: Springer International Publishing, 2023. p. 187-269.

Note: From the abstract: “The first female to conduct an Extravehicular Activity (EVA, or spacewalk) was the Soviet Union’s Svetlana Savitskaya, who spent three hours and 33 minutes outside the Salyut 7 space station in July 1984, testing a space welding tool.”


Kiwanuka O, Marcano A, Grip J, Sundblad P.

[Challenges and possibilities with space travel].

Lakartidningen. 2023 May 31;120:22135. Swedish. Review.


Pannkuk EL, Laiakis EC, Garty GY, Ponnaiya B, Wu X, Shuryak I, Ghandhi SA, Amundson SA, Brenner DJ, Fornace AJ.

Variable dose rates in realistic radiation exposures: Effects on small molecule markers of ionizing radiation in the murine model.

Radiat Res. 2023 May 22. Online ahead of print.


Pernigoni L, Lafont U, Grande AM.

Self-healing polymers for space: A study on autonomous repair performance and response to space radiation.

Acta Astronaut. 2023 May 27. Onine ahead of print.

Note: From the abstract: “This study focuses on a first example of application to a space suit, analyzing the healing performance of a set of candidate self-healing polymers before and after exposure to simulated space radiation.”


Straube U, Berger T, Dieckmann M.

The ESA Active Dosimeter (EAD) system onboard the International Space Station (ISS).

Z Med Phys. 2023 May 22:S0939-3889(23)00038-7. Online ahead of print.

Note: From the abstract: “Ionizing radiation in general and mixed fields of space radiation in particular pose a risk of serious harm to human health. The risk of such adverse effects increases with the duration of the mission, and for all missions outside the protective properties of the Earth’s magnetic field and atmosphere. Accordingly, radiation protection is of central importance for all human spaceflight, which is recognized by all international space agencies.” This article may be obtained online without charge.


Waisberg E, Ong J, Masalkhi M, Lee AG, Berdahl J.

Anatomical considerations for reducing ocular emergencies during spaceflight.

Ir J Med Sci. 2023 May 27. Review.

Note: From the abstract: “In this paper, we describe the anatomic, physiologic, and pharmacologic factors to consider that impact acute angle-closure glaucoma risk during spaceflight.” This article may be obtained online without charge.


Lan R, Li Y, Zhao X, Shen R, Wang R, Mao R, Guo S.

Low-molecular-weight chondroitin sulfates alleviate simulated microgravity-induced oxidative stress and bone loss in mice.

Curr Issues Mol Biol. 2023 May 10;45(5):4214-27.

Note: Hindlimb unloading study. This article is part of Section “Molecular Medicine” ( This article may be obtained online without charge.


Yough M, Hanna K, Yakovenko S, Gritsenko V.

Surface electromyography provides neuromuscular insights for skill acquisition in microgravity.

Proc Int Astronaut Congr. 2022 Sep;73:68484.

Note: From the abstract: “The human motor system has evolved to perform efficient motor control in Earth’s gravity. Altered gravity environments, such as microgravity and hypergravity, pose unique challenges for performing fine motor tasks with object manipulation. Altered gravity has been shown to reduce the speed and accuracy of complex manual tasks. This study aims to leverage electromyography (EMG) and virtual reality (VR) technologies to provide insights into the neuromuscular mechanism of object weight compensation.” This article may be obtained online without charge.


Kim S, Caporaso NE, Gu F, Klerman EB, Albert PS.

Uncovering circadian rhythms in metabolic longitudinal data: A Bayesian latent class modeling approach.

Stat Med. 2023 May 26. Online ahead of print.


Lombini M, Schreiber L, Albertini R, Alessi EM, Attinà P, Bianco A, Cascone E, Colucci ME, Cortecchia F, De Caprio V, Diolaiti E, Fiorini M, Lessio L, Macchi A, Malaguti G, Mongelluzzo G, Pareschi G, Pelizzo MG, Pasquarella C.

Solar ultraviolet light collector for germicidal irradiation on the Moon.

Sci Rep. 2023 May 23;13(1):8326.

Note: From the abstract: “Prolonged human-crewed missions on the Moon are foreseen as a gateway for Mars and asteroid colonization in the next decades. Health risks related to long-time permanence in space have been partially investigated. Hazards due to airborne biological contaminants represent a relevant problem in space missions. A possible way to perform pathogens’ inactivation is by employing the shortest wavelength range of solar ultraviolet radiation, the so-called germicidal range. On Earth, it is totally absorbed by the atmosphere and does not reach the surface. In space, such Ultraviolet solar component is present and effective germicidal irradiation for airborne pathogens’ inactivation can be achieved inside habitable outposts through a combination of highly reflective internal coating and optimized geometry of the air ducts.” This article may be obtained online without charge.


Li Y, Liu Z, Luo G, Lan H, Chen P, Du R, Jing G, Liu L, Cui X, Li Y, Han Y, Xu J, Zhu H, Ling S, Li Y.

Effects of 60 days of 6° head-down bedrest on the composition and function of the human gut microbiota.

iScience. 2023 May 19;26(5):106615.

Note: Head-down bedrest study. This article may be obtained online without charge.


Louis LL, Moussaoui S, Van Langhenhove A, Ravoux S, Le Jan T, Roualdes V, Milleville-Pennel I.

Cognitive tasks and combined statistical methods to evaluate, model, and predict mental workload.

Front Psychol. 2023 May 12;14:1122793.

Note: This article is part of Research Topic “Cognitive Load Research, Theories, Models and Applications: Volume II” (

SpaceRef co-founder, Explorers Club Fellow, ex-NASA, Away Teams, Journalist, Space & Astrobiology, Lapsed climber.