New Space and Tech

NASA Spaceline Current Awareness List #1,049 12 Mat 2023 (Space Life Science Research Results)

By Keith Cowing
Status Report
May 12, 2023
Filed under , , , , ,
NASA Spaceline Current Awareness List #1,049 12 Mat 2023 (Space Life Science Research Results)
Astronaut Kate Rubins working with Wet Lab-2, a tool for quantitative gene expression analysis set for further testing this year. Credits: NASA

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at

Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Reichard JF, Phelps SE, Lehnhardt KR, Young M, Easter BD.

The effect of long-term spaceflight on drug potency and the risk of medication failure.

npj Microgravity. 2023 May 5;9(1):35.

Note: From the article: “A literature search was performed to identify all English language spaceflight drug stability studies (summarized in the accompanying Supplemental Methods) and ensure a complete dataset and inclusion of data. Active pharmaceutical ingredient (API) content was quantified across the majority of spaceflight drug stability studies. Additional measures of drug stability, including impurities and physical characteristics, were only available in some studies and only for a few drugs. For this reason, this paper focuses on API content as the measure of drug stability.” This article may be obtained online without charge.

Journal Impact Factor: 4.97

Funding: “Patrick J. Faustino, US EPA Center for Drug Evaluation and Research, for expert advice and guidance in preparing this manuscript. Alan H Feiveson, Statistician, Johnson Space Center, for statistical help and support, particularly for the Generalized Estimating Equations (GEE) model. J.R., K.L., and B.E. received funding support through an Intergovernmental Personnel Agreement (IPA) between NASA and their affiliated institutions.”


Rahmanian S, Slaba TC.

Applicability of the NASA galactic cosmic ray simulator for mice, rats, and minipigs.

Acta Astronaut. 2023 July;208:111-23.

Journal Impact Factor: 2.954

Funding: “This work is supported by the NASA Langley Research Center Cooperative Agreement 80LARC17C0004 (Shirin Rahmanian) and by the Human Research Program under the Space Operations Mission Directorate (SOMP) at NASA (Tony C. Slaba)…”


Diaz J, Kuhlman BM, Edenhoffer NP, Evans AC, Martin KA, Guida P, Rusek A, Atala A, Coleman MA, Wilson PF, Almeida-Porada G, Porada CD.

Immediate effects of acute Mars mission equivalent doses of SEP and GCR radiation on the murine gastrointestinal system-protective effects of curcumin-loaded nanolipoprotein particles (cNLPs).

Front Astron Space Sci. 2023 May 5;10:1117811.

PI: C.D. Porada

Note: This article is part of Research Topic “Astroparticle Experiments to Improve the Biological Risk Assessment of Exposure to Ionizing Radiation in the Exploratory Space Missions” ( The Research Topic also includes articles from previous Current Awareness Lists #993 #1,027 This article may be obtained online without charge.

Journal Impact Factor: 4.055

Funding: “This work was supported by the NASA Translational Research Institute for Space Health (TRISH) through Cooperative Agreement NNX16AO69A. Work was also performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344 and supported with funding from the LLNL Laboratory Directed Research and Development program (LDRD-19-SI-003) at LLNL and by Pacific Northwest National Laboratory under contract DE-AC05-76RL01830.”


Stephenson S, Liu A, Blackwell AA, Britten RA.

Multiple decrements in switch task performance in female rats exposed to space radiation.

Behav Brain Res. 2023 May 2;114465. Online ahead of print.

PIs: R.A. Britten; C. Limoli/R.A. Britten/NSCOR

Journal Impact Factor: 3.352

Funding: “This work was funded by NASA grant support NNX14AE73G and NNX15AI22G.”


Hoffman JA, Hinterman ER, Hecht MH, Rapp D, Hartvigsen JJ.

18 Months of MOXIE (Mars Oxygen ISRU experiment) operations on the surface of Mars – Preparing for human Mars exploration.

Acta Astronaut. 2023 May 6. Online ahead of print.

Note: From the abstract: “By the time of the 2022 IAC, NASA’s Mars2020 Perseverance rover will have spent 18 months on the surface of Mars, during which time the MOXIE experiment (Mars Oxygen ISRU Experiment) will have produced oxygen at night and in the day during both the annual maximum and minimum atmospheric density periods, as well as at many other times during the year. MOXIE is the first demonstration of the use of indigenous resources (ISRU = In Situ Resource Utilization) on the surface of another planet. This paper will present a summary of what MOXIE has accomplished, how its performance on Mars has changed with time, and plans for the future. The paper will also present results from an optimization study of a human-scale MOXIE-type system capable of providing the oxidizer for a 6–person Mars Ascent Vehicle.”

Journal Impact Factor: 2.954

Funding: “Portions of this research were carried out at MIT under a contract with the National Aeronautics and Space Administration (NNH17CH01C) and at the Jet Propulsion Laboratory, California Institute of Technology, under NASA contract 80NM0018D0004. Eric Hinterman was supported by a NSTGRO fellowship…”


Other papers of interest:


Han Y, Shi S, Liu S, Gu X.

Effects of spaceflight on the spleen and thymus of mice: Gene pathway analysis and immune infiltration analysis.

Math Biosci Eng. 2023 Mar 3;20(5):8531-45.

Note: ISS results. This article may be obtained online without charge.


Karlsson LL, Van Muylem A, Linnarsson D.

Lung diffusing capacity for nitric oxide in space: Microgravity gas density interactions.

Front Physiol. 2023 May 9;14:1161062.

Note: ISS results. From the article: “The present experiments were performed in parallel with a study on exhaled NO [nitric oxide], which will be reported elsewhere. Experiments in normal gravity [1G, Baseline data collection (BDC)] mostly took place at the Johnson Space Center, Houston, TX, United States, with two trials at the European Astronaut Centre, Cologne, Germany and one at Skrydsrup Air Force Base, Denmark. Procedures were performed at normal atmospheric pressure [1.0 atmosphere absolute (ata)] and at 0.7 ata in hypobaric chambers, which is equivalent to an altitude of 3,000 m (10,000 ft). The experiments in weightlessness (microgravity, µG) were performed on the ISS, at normal pressure and at 0.7 ata, with the latter in the US Air Lock that normally is used for preparations before extravehicular activity.” This article may be obtained online without charge.


Popova OV, Rusanov VB.

Is space flight arrhythmogenic?

Front Physiol. 2023 May 12;14:1162355.

Note: Opinion article. This article is part of Research Topic “Women in Space Physiology 2022” ( The Research Topic also includes articles from previous Current Awareness Lists #1,021, #1,038, and #1,047 This article may be obtained online without charge.


Shishkin N, Kitov V, Sayenko D, Tomilovskaya E.

Sensory organization of postural control after long-term spaceflight.

Front Neural Circuits. 2023 Apr 17;17:1135434.

Note: ISS results. This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior-Volume II” (—volume-ii#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,041 and #1,046 This article may be obtained online without charge.


Rezapour Sarabi M, Yetisen AK, Tasoglu S.

Bioprinting in microgravity.

ACS Biomater Sci Eng. 2023 May 8. Review. Online ahead of print.

Note: From the abstract: “Bioprinting as an extension of 3D printing offers capabilities for printing tissues and organs for application in biomedical engineering. Conducting bioprinting in space, where the gravity is zero, can enable new frontiers in tissue engineering. Fabrication of soft tissues, which usually collapse under their own weight, can be accelerated in microgravity conditions as the external forces are eliminated. Furthermore, human colonization in space can be supported by providing critical needs of life and ecosystems by 3D bioprinting without relying on cargos from Earth, e.g., by development and long-term employment of living engineered filters (such as sea sponges-known as critical for initiating and maintaining an ecosystem). This review covers bioprinting methods in microgravity along with providing an analysis on the process of shipping bioprinters to space and presenting a perspective on the prospects of zero-gravity bioprinting.”


Lipshits MI, Levik YS.

Cognitive functions of the brain: A review of research in weightlessness.

Human Physiology. 2023 Apr 27;49(2):165-75.


Deng A, Wang T, Wang J, Li L, Wang X, Liu L, Wen T.

Adaptive mechanisms of Bacillus to near space extreme environments.

Sci Total Environ. 2023 Aug;886:163952.

Note: From the abstract: “In this study, we investigated microbial survival and adaptive strategies in near space using a scientific balloon fight mission and multi-omics analyses.”


Lu Y, Fu Y, Chen L, Cui J, Huang M, Fu Y, Liu H.

Combined effect of simulated microgravity and low-dose ionizing radiation on structure and antibiotic resistance of a synthetic community model of bacteria isolated from spacecraft assembly room.

Life Sci Space Res. 2023 Aug;38:29-38.

Note: From the abstract: “Understanding the structural and antibiotic resistance changes of microbial communities in space environments is critical for identifying potential pathogens that may pose health risks to astronauts and for preventing and controlling microbial contamination. The research to date on microbes under simulated space factors has primarily been carried out on single bacterial species under the individual effects of microgravity or low-dose radiation. However, microgravity (MG) and low-dose ionizing radiation (LDIR) coexist in the actual spacecraft environment, and microorganisms coexist as communities in the spacecraft environment. Thus, the microbial response to the real changes present during space habitation has not been adequately explored. To address this knowledge gap, we compared the dynamics of community composition and antibiotic resistance of synthetic bacterial communities under simulated microgravit, low-dose ionizing radiation, and the conditions combined, as it occurs in spacecraft.”


Wang G, Hurr C.

Effects of cutaneous administration of an over-the-counter menthol cream during temperate-water immersion for exercise-induced hyperthermia in men.

Front Physiol. 2023 May 10;14:1161240.

Note: This article and the article below (Liu et al.) are part of Research Topic “Cold, Heat, and Hypoxia as a Medical Tool: The Use in a Healthy and Diseased Population” ( The Research Topic also includes an article from previous Current Awareness List #1,042 This article may be obtained online without charge.


Liu C, Guo G, Li X, Shen Y, Xu X, Chen Y, Li H, Hao J, He K.

Identification of novel urine proteomic biomarkers for high stamina in high-altitude adaptation.

Front Physiol. 2023 May 3;14:1153166.

Note: This article and the article above (Wang et al.) are part of Research Topic “Cold, Heat, and Hypoxia as a Medical Tool: The Use in a Healthy and Diseased Population” ( This article may be obtained online without charge.


Carvil P, Russomano T, Baptisa RR, Jain V, Lindsay K, Waldie J, Andrew Green D.

Axial reloading during body weight unloading: Relationship between g-level and cardiorespiratory responses to running – A case study.

Acta Astronaut. 2023 May 10. Online ahead of print.

Note: From the abstract: “Prolonged microgravity exposure induces physiological de-conditioning that is partially mitigated by aerobic exercise. De-conditioning is also anticipated during partial gravity habitation (e.g., Moon or Mars). However, the relationship between gravity, resultant running speed, associated biomechanics, and the cardiorespiratory response is unknown. Thus, this case study evaluated responses to self-selected running across a continuum of simulated gravity levels generated by bodyweight unloading and axial loading via the Mk III Gravity Loading Countermeasure SkinSuit (GLCS).”

SpaceRef co-founder, Explorers Club Fellow, ex-NASA, Away Teams, Journalist, Space & Astrobiology, Lapsed climber.