NASA Spaceline Current Awareness List #1,048 5 May 2023 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm.
Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Chan K, Arumugam A, Markham C, Jenson R, Wu H-W, Wong S.
The development of a 3D printer-inspired, microgravity-compatible sample preparation device for future use inside the International Space Station.
Micromachines. 2023 Apr 26;14(5):937.
https://doi.org/10.3390/mi14050937
Note: From the abstract: “Biological testing on the International Space Station (ISS) is necessary in order to monitor the microbial burden and identify risks to crew health. With support from a NASA Phase I Small Business Innovative Research contract, we have developed a compact prototype of a microgravity-compatible, automated versatile sample preparation platform (VSPP).” This article is part of Special Issue “3D-Printed Microdevices: From Design to Applications” (https://www.mdpi.com/journal/micromachines/special_issues/0O2GBE7066). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.523
Funding: “This research was supported by a NASA SBIR Contract (NNX17CP21P) awarded to SW as the Principal Investigator and through a NASA Translational Research Institute for Space Health (TRISH) Cooperative Agreement NNX16AO69A.”
2
Rosa-Caldwell ME, Mortreux M, Wadhwa A, Kaiser UB, Sung DM, Bouxsein ML, Rutkove SB.
Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats.
J Appl Physiol (1985). 2023 Apr 27. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37102698
PIs: M.E. Rosa-Caldwell, S.B. Rutkove
Note: Hindlimb unloading study.
Journal Impact Factor: 3.880
Funding: “This study was funded by NASA Awards: 80NSSC21K0311 (M.E.R/S.B.R) and 80NSSC19K1598, 80NSSC19K9518 (S.B.R) as well as NIH Award: R37HD019938 (U.B.K.), and T32GM144273 (A.W.) from the National Institute of General Medical Sciences.”
3
Lenarczyk M, Kronenberg A, Mäder M, Komorowski R, Hopewell JW, Baker JE.
Exposure to multiple ion beams, broadly representative of galactic cosmic rays, causes perivascular cardiac fibrosis in mature male rats.
PLoS One. 2023 Apr 26;18(4):e0283877.
https://pubmed.ncbi.nlm.nih.gov/37099482
PI: J.E. Baker
Note: From the abstract: “Long-duration space exploratory missions to the Earth’s moon and the planet Mars are actively being planned. Such missions will require humans to live for prolonged periods beyond low earth orbit where astronauts will be continuously exposed to high-energy galactic cosmic rays (GCRs). A major unknown is the potential impact of GCRs on the risks of developing degenerative cardiovascular disease, which is a concern to NASA. A ground-based rat model has been used to provide a detailed characterization of the risk of long-term cardiovascular disease from components of GCRs at radiation doses relevant to future human missions beyond low earth orbit.” This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “The work was supported by grants from the National Aeronautics and Space Administration, NNX15AD69G, Dr. John E. Baker National Aeronautics and Space Administration, 80NSSC19K0498, Dr. John E. Baker and an unrestricted grant from the Foundation for Heart Science, Dr. John E. Baker.”
4
Austermann K, Baecker N, Zwart SR, Fimmers R, Stehle P, Smith SM, Heer M.
Effects of antioxidant supplementation on bone mineral density, bone mineral content and bone structure in healthy men during 60 days of 6° head-down tilt bedrest: Results from a randomized controlled trial.
Nutr Bull. 2023 Apr 27.
https://pubmed.ncbi.nlm.nih.gov/37106504
Note: Head-down tilt bedrest study. This article may be obtained online without charge.
Journal Impact Factor: 3.737
Funding: “Funded by the DLR Space Program with allocation of funds from the Federal Ministry of Economy and Technology (BMWi) under the support code 50WB1535 (KA, NB, MH, PS), the University of Bonn (RF) and by the European Space Agency (ESA), the Centre National d’Etudes Spatiales (CNES), and the Human Health Countermeasures Element of the NASA Human Research Program (SRZ, SMS).”
5
Rahmanian S, Slaba TC, Braby LA, Santa Maria SR, Bhattacharya S, Straume T.
Galactic cosmic ray environment predictions for the NASA BioSentinel mission.
Life Sci Space Res. 2023 May 2. Online ahead of print.
https://doi.org/10.1016/j.lssr.2023.05.001
Note: From the abstract: “BioSentinel is a nanosatellite deployed from Artemis-I designed to conduct in-situ biological measurements on yeast cells in the deep space radiation environment. Along with the primary goal of measuring damage and response in cells exposed during spaceflight, on-board active dosimetry will provide measurements of the radiation field encountered behind moderate shielding provided by the BioSentinel housing and internal components.”
Journal Impact Factor: 2.73
Funding: “This work is supported by the NASA Langley Research Center Cooperative Agreement 80LARC17C0004 and by the Human Research Program under the Space Operations Mission Directorate (SOMP) at NASA. The BioSentinel program at the NASA Ames Research Center (ARC) is supported in part by the NASA Advanced Exploration Systems (AES) Division/Exploration Systems Development Mission Directorate (ESDMD).”
6
Winkelmaier G, Jabbari K, Chien LC, Grabham P, Parvin B, Pluth J.
Influence of simulated microgravity on mammary epithelial cells grown as 2D and 3D cultures.
Int J Mol Sci. 2023 Apr 20;24(8):7615.
https://pubmed.ncbi.nlm.nih.gov/37108776
PI: J. Pluth
Note: This article is part of Section “Molecular Biology” (https://www.mdpi.com/journal/ijms/sections/Molecular_Biology) and may be obtained online without charge.
Journal Impact Factor: 6.208
Funding: “This research was funded by National Aeronautics and Space Administration (NASA), Grant Number 80NSSC18K1464.”
7
Asencio R, Mesmer-Magnus J, DeChurch L, Contractor N.
Boundary transitions in dynamic teamwork.
Acad Manage Rev. 2023.
https://doi.org/10.5465/amr.2019.0471
PI: L. DeChurch
Journal Impact Factor: 13.865
Funding: “Support for this research was provided by the National Aeronautics and Space Administration grant 80NSSC18K0276 and the Army Research Office contract no. W911NF1710444.”
8
Li M, Erickson IM, Cross EV, Lee JD.
It’s not only what you say, but also how you say it: Machine learning approach to estimate trust from conversation.
Hum Factors. 2023 Apr 28:187208231166624. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37116009
PI: J.D. Lee
Note: From the abstract: “As NASA moves to long-duration space exploration operations, the increasing need for cooperation between humans and virtual agents requires real-time trust estimation by virtual agents. Measuring trust through conversation is a novel and unintrusive approach.” This article may be obtained online without charge.
Journal Impact Factor: 3.598
Funding: “This work was supported by NASA Human Research Program No.80NSSC19K0654.”
9
Li M, Kamaraj AV, Lee JD.
Modeling trust dimensions and dynamics in human-agent conversation: A trajectory epistemic network analysis approach.
Int J Hum-Comput Interact. 2023 Apr 27;1-12.
https://doi.org/10.1080/10447318.2023.2201555
PI: J.D. Lee
Note: From the abstract: “Human-AI conversation provides a natural, unobtrusive, yet under-explored way to investigate trust dynamics in human-AI teams (HATs). In this paper, we modeled dynamic trust evolution in conversations using a novel method, trajectory epistemic network analysis (T-ENA).”
Journal Impact Factor: 4.920
Funding: “This work was supported by NASA Human Research Program No. 80NSSC19K0654.”
_______________________________________________________
Other papers of interest:
1
Xie D, Huang Q, Zhou P.
Drug discovery targeting post-translational modifications in response to DNA damages induced by space radiation.
Int J Mol Sci. 2023 Apr 21;24(8):7656.
https://pubmed.ncbi.nlm.nih.gov/37108815
Note: From the abstract: “DNA damage in astronauts induced by cosmic radiation poses a major barrier to human space exploration. Cellular responses and repair of the most lethal DNA double-strand breaks (DSBs) are crucial for genomic integrity and cell survival. Post-translational modifications (PTMs), including phosphorylation, ubiquitylation, and SUMOylation, are among the regulatory factors modulating a delicate balance and choice between predominant DSB repair pathways, such as non-homologous end joining (NHEJ) and homologous recombination (HR). In this review, we focused on the engagement of proteins in the DNA damage response (DDR) modulated by phosphorylation and ubiquitylation, including ATM, DNA-PKcs, CtIP, MDM2, and ubiquitin ligases.” This article may be obtained online without charge.
2
Achilles S, Olson JD, Dugan GO, Cline JM.
Assessment of blood pressure in irradiated rhesus macaques (Macaca mulatta).
Radiat Res. 2023 Apr 21. Online ahead of print.
https://doi.org/10.1667/RADE-22-00117.1
3
Wu T, Pelus LM, Plett PA, Sampson CH, Chua HL, Fisher A, Feng H, Liu L, Li H, Ortiz M, Chittajallu S, Luo Q, Bhatwadekar AD, Meyer TB, Zhang X, Zhou D, Fischer KD, McKinzie DL, Miller SJ, Orschell CM.
Further characterization of multi-organ DEARE and protection by 16,16 dimethyl prostaglandin E2
in a mouse model of the hematopoietic acute radiation syndrome.
Radiat Res. 2023 Apr 4. Online ahead of print.
https://doi.org/10.1667/RADE-22-00208.1
4
Yuan Y, Chai D, Zhang R, Cheng J, Dong J, Liu H, Zhang Z, Dang X, Ning K.
Effects of neutron and gamma rays combined irradiation on the transcriptional profile of human peripheral blood.
Radiat Res. 2023 Apr 4. Online ahead of print.
https://doi.org/10.1667/RADE-22-00147.2
5
Pineau J, Moreau H, Duménil AL, Pierobon P.
Polarity in immune cells.
In: U. Tepass, ed. Current Topics in Developmental Biology.
Vol. 154. Elsevier, 2023. p. 197-222.
https://pubmed.ncbi.nlm.nih.gov/37100518
6
Popov DV, Makhnovskii PA, Zgoda VG, Gazizova GR, Vepkhvadze TF, Lednev EM, Motanova ES, Lysenko EA, Orlov OI, Tomilovskaya ES.
Rapid changes in transcriptomic profile and mitochondrial function in human soleus muscle after 3-day dry immersion.
J Appl Physiol (1985). 2023 May 2;134(5):1256-64.
https://pubmed.ncbi.nlm.nih.gov/37055032
7
Roberts K, Kim JT, Huynh T, Schluns J, Dunlap G, Hestekin J, Wolchok JC.
Transcriptome profiling of a synergistic volumetric muscle loss repair strategy.
BMC Musculoskelet Disord. 2023 Apr 24;24:321.
https://pubmed.ncbi.nlm.nih.gov/37095469
Note: This article may be obtained online without charge.
8
Picard-Deland C, Konkoly K, Raider R, Paller KA, Nielsen T, Pigeon WR, Carr M.
The memory sources of dreams: Serial awakenings across sleep stages and time of night.
Sleep. 2022 Apr;46(4):zsac292.
https://doi.org/10.1093/sleep/zsac292
Note: This article may be obtained online without charge.
9
Shih HT, Gregor R, Lee SP.
Description, reliability and utility of a ground-reaction-force triggered protocol for precise delivery of unilateral trip-like perturbations during gait.
PLoS One. 2023 Apr 25;18(4):e0284384.
https://pubmed.ncbi.nlm.nih.gov/37098086
Note: This article may be obtained online without charge.
