New Space and Tech

NASA Spaceline Current Awareness List #1,047 28 April 2023 (Space Life Science Research Results)

By Keith Cowing
Status Report
April 28, 2023
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NASA Spaceline Current Awareness List #1,047  28 April 2023 (Space Life Science Research Results)
Space Biology on ISS

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, [email protected].

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Bedree JK, Kerns K, Chen T, Lima BP, Liu G, Ha P, Shi J, Pan HC, Kim JK, Tran L, Minot SS, Hendrickson EL, Lamont EI, Schulte F, Hardt M, Stephens D, Patel M, Kokaras A, Stodieck L, Shirazi-Fard Y, Wu B, Kwak JH, Ting K, Soo C, McLean JS, He X, Shi W.

Specific host metabolite and gut microbiome alterations are associated with bone loss during spaceflight.

Cell Rep. 2023 Apr 10;112299. Online ahead of print.

Note: ISS results. From the abstract: “Understanding the axis of the human microbiome and physiological homeostasis is an essential task in managing deep-space-travel-associated health risks. The NASA-led Rodent Research 5 mission enabled an ancillary investigation of the gut microbiome, varying exposure to microgravity (flight) relative to ground controls in the context of previously shown bone mineral density (BMD) loss that was observed in these flight groups. We demonstrate elevated abundance of Lactobacillus murinus and Dorea sp. during microgravity exposure relative to ground control through whole-genome sequencing and 16S rRNA analyses.” This article may be obtained online without charge.

Journal Impact Factor: 9.995

Funding: “The authors would like to thank the NASA Ames Rodent Research Team and the Kennedy Space Center as well as the Space Station Processing Facility Annex Team, especially Ramona Bober, for experimental preparation and facilitation.”


Mao X, Stanbouly S, Holley J, Pecaut M, Crapo J.

Evidence of spaceflight-induced adverse effects on photoreceptors and retinal function in the mouse eye.

Int J Mol Sci. 2023 Apr 17;24(8):7362.

PIs: X. Mao, M. Pecaut

Note: ISS results. This article is part of Section “Molecular Neurobiology” ( and may be obtained online without charge.

Journal Impact Factor: 6.208

Funding: “This study was supported by the NASA Space Biology grant # NNX15AB41G, NASA 80NSSC18K0310, and LLU Department of Basic Sciences.”


Averesch NJH, Berliner AJ, Nangle SN, Zezulka S, Vengerova GL, Ho D, Casale CA, Lehner BAE, Snyder JE, Clark KB, Dartnell LR, Criddle CS, Arkin AP.

Microbial biomanufacturing for space-explorationWhat to take and when to make.

Nat Commun. 2023 Apr 21;14:2311. Review.

Note: This article may be obtained online without charge.

Journal Impact Factor: 17.69

Funding: “We thank the many members of the ‘Center for the Utilization of Biological Engineering in Space’ (CUBES) who were involved in discussions that lead to the conception of the ideas for this this study. As such, this material is partially based upon work supported by NASA under grant or cooperative agreement award number NNX17AJ31G.”


Song Y, Mota FL, Tourret D, Ji K, Billia B, Trivedi R, Bergeon N, Karma A.

Cell invasion during competitive growth of polycrystalline solidification patterns.

Nat Commun. 2023 Apr 19;14(1):2244.

PI: A. Karma

Note: This article may be obtained online without charge.

Journal Impact Factor: 17.69

Funding: “This study was supported by the National Aeronautics and Space Administration Grants NNX16AB54G, 80NSSC19K0135 and 80NSSC22K0664 (Y.S., K.J., R.T., A.K.), and the French Space Agency CNES project MISOL3D Microstructures de solidification 3D (F.M., B.B., N.B.). D.T. acknowledges support from the Spanish Ministry of Science via a Ramon y Cajal fellowship (RYC2019-028233-I). Y.S. acknowledges that this work was partially prepared by LLNL under Contract DE-AC52- 07NA27344.”


Basner M, Smith MG, Jones CW, Ecker AJ, Howard K, Schneller V, Cordoza M, Kaizi-Lutu M, Park-Chavar S, Stahn AC, Dinges DF, Shou H, Mitchell JA, Bhatnagar A, Smith T, Smith AE, Stopforth CK, Yeager R, Keith RJ.

Associations of bedroom PM2.5

, CO2

, temperature, humidity, and noise with sleep: An observational actigraphy study.

Sleep Health. 2023 Apr 10;S2352-7218(23)00043-8. Online ahead of print.

PI: M. Basner

Journal Impact Factor: 4.207

Funding: “This study was supported in part by grants from the National Institutes of Health, ES029846 and ES023716 (PI: A. Bhatnagar), the Christina Lee Brown Envirome Institute, and the National Aviation and Space Administration (NASA) through grant NNX14AM81G (PI: M. Basner). C.W.J. is supported by NIH/NHLBI 5T32HL007713. M.C. is supported by NIH/NINR K99 NR019862. R.Y. is supported by NIH P30ES030283.”


Rabin BM, Miller MG, Shukitt-Hale B.

Effects of preexposure to a subthreshold dose of helium particles on the changes in performance produced by exposure to helium particles.

Life Sci Space Res (Amst). 2023 May;37:88-96.

PI: B.M. Rabin

Note: From the abstract: “On exploratory class missions, such as a mission to Mars, astronauts will be exposed to doses of particles of high energy and charge and protons up to 30 – 40 cGy. These exposures will most likely occur at random intervals across the estimated 3-yr duration of the mission. As such, the possibility of an interaction between particles must be taken into account: a prior subthreshold exposure to one particle may prevent or minimize the effect of a subsequent exposure (adaptation), or there may be an additive effect such that the prior exposure may sensitize the individual to a subsequent exposure of the same or different radiations.”

Journal Impact Factor: 2.73

Funding: “This research was supported by NASA Grant NNX16AE06G and by intramural funding from ARS, USDA.”


Guez-Barber D, Eisch A, Cristancho AG.

Developmental brain injury and social determinants of health: Opportunities to combine preclinical models for mechanistic insights into recovery.

Dev Neurosci. 2023 Apr 20. Review. Online ahead of print.

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.421

Funding: “DGB is supported by the Child Neurologist Career Development Program-K12 from the National Institutes of Health (NIH) and institutional grants from the Children’s Hospital of Philadelphia Research Institute (Foerderer Grant and K-readiness Pilot award). AJE is supported by NASA 19- 19OMNI3_2-0061 (PI: S Yun), NIH grants NS126279 (PI: RA Ahrens-Nicklas), NS 088555 (PI: AM Stowe), and NS 007413 (PI: AJ Eisch & ED Marsh), the Peter F. McManus Charitable Trust, the University of Pennsylvania Perelman School of Medicine Department of Radiation Oncology Pilot Grant (PI: AJE & Y Fan), and direct philanthropic support for the Eisch Neuroscience Lab. AGC is supported by the Robert Wood Johnson Foundation Harold Amos Medical Faculty Development Program and NIH grant K08 NS119797 (PI: AGC). DGB and AGC are also supported by the Division of Child Neurology at the CHOP. DGB, AJE, and AGC are additionally supported by various grants from the CHOP Research Institute.”


Other papers of interest:


Hayashi T, Fujita R, Okada R, Hamada M, Suzuki R, Fuseya S, Leckey J, Kanai M, Inoue Y, Sadaki S, Nakamura A, Okamura Y, Abe C, Morita H, Aiba T, Senkoji T, Shimomura M, Okada M, Kamimura D, Yumoto A, Muratani M, Kudo T, Shiba D, Takahashi S.

Lunar gravity prevents skeletal muscle atrophy but not myofiber type shift in mice.

Commun Biol. 2023 Apr 21;6:424.

Note: ISS results. This article may be obtained online without charge.


Orlov OI, Popova IIR, Yu. G.

Improvement of methodology and hardware and software for obtaining telemedicine video information in spaceflight.

Aviakosm Ekolog Med. 2023;57(2):14-19. Russian.

Note: ISS results.


Roggan MD, Kronenberg J, Wollert E, Hoffmann S, Nisar H, Konda B, Diegeler S, Liemersdorf C, Hellweg CE.

Unraveling astrocyte behavior in the space brain: Radiation response of primary astrocytes.

Front Public Health. 2023 Apr 6;11:1063250.

Note: This article is part of Research Topic “Emerging Talents in Non-Neuronal Cells” ( and may be obtained online without charge.


Shirah BH, Sen J, Naaman NK, Pandya S.

Automated pupillometry in space neuroscience.

Life Sci Space Res (Amst). 2023 May;37:1-2.

Note: From the article: “Modern pupillometers are automated, thereby providing an objective, accurate, and reliable evaluation of various aspects of the pupillary light reflex at precision levels that were previously unobtainable. There are many gaps in knowledge regarding pupil size and pupillary light reflex in nervous system changes related to space travel, given the previous lack of a precise method to quantitatively measure it. Automated pupillometry has not been used previously in space. This novel tool has promising uses in altered gravity environments as a sensitive non-invasive tool to determine alterations due to headward fluid shifts and elevated intracranial pressure. This article discusses the potential use of automated pupillometry in space for monitoring astronaut health and neurological pathology.”

5Artamonov АА, Molodtsova DV, Smirnova TA, Konstantinova NА.

Systematic analysis of the electromagnetic radiation effect on expression of the heat shock gene with regard to the goals of space medicine.

Aviakosm Ekolog Med. 2023;57(2):5-13. Russian.

Note: From the abstract: “Based on scientific publications, a systematic analysis of the effect of electromagnetic radiation (EMR) on the expression of the heat shock gene in various biological objects was carried out.”


Moser D, Biere K, Liemersdorf C, Tuschen M, Hemmersbach R, Choukér A.

Differential effects of hypergravity on immune dysfunctions induced by simulated microgravity.

Faseb J. 2023 May;37(5):e22910. Online ahead of print.

Note: A clinostat was used in this study.


Hao Z, Meng C, Li L, Feng S, Zhu Y, Yang J, Han L, Sun L, Lv W, Figeys D, Liu H.

Positive mood-related gut microbiota in a long-term closed environment: A multiomics study based on the “Lunar Palace 365” experiment.

Microbiome. 2023 Apr 24;11:88.

Note: This article may be obtained online without charge.


Fomina GA, Salnikov AV, Koloteva MI, Glebova TM, Lobanov KA.

Evaluation of the peripheral hemodynamics reaction to g-loads in the head-to-legs direction (+Gz) on a short-arm centrifuge with the method of doppler flowmetry.

Aviakosm Ekolog Med. 2023;57(2):27-32. Russian.

Note: A short-arm centrifuge was used in this study.


Vlasova DD, Sadova AA, Germanov, NS, Galina VS, Shmarov VA, Kutko OV, Rykova MP, Antropova EN, Lysenko EA, Orlova KD, Ponomarev SA.

The impact of artificial gravity modeled in short-arm centrifuge on the expression of Tlr-associated genes of innate immunity.

Aviakosm Ekolog Med. 2023;57(2):20-6. Russian.

Note: A short-arm centrifuge was used in this study.


Perevedentsev OV, Orlov OI, Chernogorov RV.

Application of recurrent neuron networks for prognostic assessment of medical monitoring data from participants in isolation study in the SIRIUS-21.

Aviakosm Ekolog Med. 2023;57(2):33-8. Russian.

11Kashirina DN, Pastushkova LKh, Brzhozovsky, AG, Kononikhin АS, Nikolaev EN, Larina IM.

Effects of 3-day immersion on blood proteome in female volunteers.

Aviakosm Ekolog Med. 2023;57(2):47-56. Russian.


Pastushkova LK, Goncharova AG, Kashirina DN, Larina IM.

Changes in the body fluids proteome as a reflection of the physiological effects of dry immersion.

Front Physiol. 2023 Apr 24;14:1178077.

Note: This article is part of Research Topic “Women in Space Physiology 2022” ( The Research Topic also includes articles from previous Current Awareness Lists #1,021 and #1,038 This article may be obtained online without charge.


Kriushev ES.

Cerebral blood flow and state of some cognitive functions in healthy human subjects following 520-day isolation.

Aviakosm Ekolog Med. 2023;57(2):57-64. Russian.

14Pashkova DV, Popova YuA. Fedorovich АА.

Functional state of the skin microcirculation bed in healthy females in the condition of dry immersion.

Aviakosm Ekolog Med. 2023;57(2):39-46. Russian.


Shi Y, Liu J, Zhang R, Zhang M, Cui H, Wang L, Cui Y, Wang W, Sun Y, Wang C.

Targeting endothelial ENO1 (Alpha-Enolase) -PI3K-Akt-mTOR axis alleviates hypoxic pulmonary hypertension.

Hypertension. 2023 May;80(5):1035-47.

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