NASA Spaceline Current Awareness List #1,046 21 April 2023 (Space Life Science Research Results)
SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1
Hupka M, Kedia R, Schauer R, Shepard B, Granados-Presa M, Vande Hei M, Flores P, Zea L.
Morphology of Penicillium rubens biofilms formed in space.
Life. 2023 Apr 13;13(4):1001.
https://doi.org/10.3390/life13041001
PI: L. Zea
Note: ISS results. This article is part of Special Issue “Gravitational Microbiology Research and Applications” (https://www.mdpi.com/journal/life/special_issues/gravitational_microbiology). The Special Issue also includes articles from previous Current Awareness Lists #984 https://doi.org/10.3390/life12010047; #1,006 https://doi.org/10.3390/life12060774 and https://doi.org/10.3390/life12050660; #1,011 https://doi.org/10.3390/life12081168; #1,016 https://doi.org/10.3390/life12091399; #1,022 https://doi.org/10.3390/life12101522; #1,039 https://doi.org/10.3390/life13030656; and #1,040 https://doi.org/10.3390/life13030727. This article may be obtained online without charge.
Journal Impact Factor: 3.253
Funding: “This research was funded by the National Aeronautics and Space Administration as our funding source under grants no. 80NSSC17K0036 to L.Z. and 80NSSC21K1950 to L.Z. and P.F.”
2
Ong J, Mader TH, Gibson CR, Mason SS, Lee AG.
Spaceflight associated neuro-ocular syndrome (SANS): An update on potential microgravity-based pathophysiology and mitigation development.
Eye (Lond). 2023 Apr 18.
https://pubmed.ncbi.nlm.nih.gov/37072472
Note: From the abstract: “Long-duration spaceflight is associated with neurologic and ophthalmic clinical and imaging findings in astronauts termed spaceflight associated neuro-ocular syndrome (SANS). These microgravity-induced findings have been well documented by the National Aeronautics and Space Administration (NASA) and are clearly a potential risk for future human space exploration. The underlying pathogenesis of SANS is not well understood, although multiple hypotheses have emerged. Terrestrial analogues and potential countermeasures have also been studied to further understand and potentially mitigate SANS. In this manuscript, we review the current understanding of SANS, discuss the prevailing hypotheses for pathogenesis, and describe current developments in terrestrial analogues and potential countermeasures for SANS.”
Journal Impact Factor: 4.456
Funding: C.R. Gibson is affiliated with NASA Johnson Space Center.
3
Houser T, Lindgren KN, Mazuchowski EL, Barratt MR, Haines DC, Jayakody M, Blue RS, Bytheway JA, Stepaniak PC.
Remains containment considerations for death in low-earth orbit.
Aerosp Med Hum Perform. 2023 May;94(5):368-76.
https://doi.org/10.3357/AMHP.6146.2023
Note: From the abstract: “Commercial off-the-shelf containment units were modified to meet the needs of a microgravity spaceflight environment and to offer the best likelihood of successful containment and management of remains. A subsequent evaluation of modified containment unit performance was undertaken utilizing human cadavers, with measurement and analysis of volatile off-gassing over time followed by impact testing of the units containing cadaverous remains in a simulated spaceflight vehicle seat.”
Journal Impact Factor: 0.889
Funding: “T. Houser, K.N. Lindgren, E. Mazuchowski, and M.R. Barratt are affiliated with NASA Johnson Space Center.”
4
Sanford LD, Adkins AM, Boden AF, Gotthold JD, Harris RD, Shuboni-Mulligan D, Wellman LL, Britten RA.
Sleep and core body temperature alterations induced by space radiation in rats.
Life. 2023; Apr 13;13(4):1002.
https://doi.org/10.3390/life13041002
PIs: L.D. Sanford, R.A. Britten
Note: This article is part of Special Issue “Current Challenges in Space Neuroscience” (https://www.mdpi.com/journal/life/special_issues/XR00G704U3). This article may be obtained online without charge.
Journal Impact Factor: 3.253
Funding: “This work was supported by the NASA CBS VNSCOR grant 80NSSC19K1582 and the NASA research grant NNX16AC40G.”
5
Zhang F, Blackburn D, Hosea CN, Assié A, Samuel BS.
Application of flow vermimetry for quantification and analysis of the Caenorhabditis elegans gut microbiome.
JoVE. 2023 Mar 31;(193):e64605.
Note: A video to accompany this article will be available soon on the publisher’s website.
Journal Impact Factor: 1.4
Funding: “This work was supported by NIH grants DP2DK116645 (to B.S.S.), Dunn Foundation pilot award and NASA grant 80NSSC22K0250 (to B.S.S.). This project was also supported by the Cytometry and Cell Sorting Core at Baylor College of Medicine with funding from the CPRIT Core Facility Support Award (CPRIT-RP180672), the NIH (S10 OD025251, CA125123, and RR024574), and the assistance of Joel M. Sederstrom, plus an instrumentation grant for the LPS NIH grant (S10 OD025251).”
6
Gesztesi J, Broddrick JT, Lannin T, Lee JA.
The chemical neighborhood of cells in a diffusion-limited system.
Front Microbiol. 2023 Apr 18;14:1155726.
https://doi.org/10.3389/fmicb.2023.1155726
PI: J.A. Lee
Note: This article is part of Research Topic “The Impact of the Space Environment on Microbial Growth and Behavior” (https://www.frontiersin.org/research-topics/27130/the-impact-of-the-space-environment-on-microbial-growth-and-behavior#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,009 https://doi.org/10.3389/fmicb.2022.877625, https://doi.org/10.3389/fmicb.2022.893071, and https://doi.org/10.3389/fmicb.2022.909997; and #1,041 https://doi.org/10.3389/fmicb.2023.1090740. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: 6.064
Funding: “This research was funded by the NASA Biological and Physical Sciences Division (BPS) through the Space Life Sciences Training Program (SLSTP), the NASA Ames Office of STEM Engagement, the NASA BPS Space Biology Program through grant opportunity NNH20ZDA001N-SB, and a MathWorks Teaching Fellowship.”
7
Schwartz AM, Marcotte HA, Johnson CN.
Evaluation of alternative colony hybridization methods for pathogenic vibrios.
Foods. 2023 Mar 30;12(7):1472.
https://pubmed.ncbi.nlm.nih.gov/37048292
Note: This article is part of Special Issue “Seafood Safety, Quality and Processing Series II” (https://www.mdpi.com/journal/foods/special_issues/TE849555TL). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: 5.561
Funding: “This research was funded by NASA (National Aeronautics and Space Administration, USA: award number 80NSSC20M0216) and the Louisiana Board of Regents (award number: LEQSF (2020-23)-Phase3-14).”
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Other papers of interest:
1
Shishkin N, Kitov V, Sayenko D, Tomilovskaya E.
Sensory organization of postural control after long-term spaceflight.
Front Neural Circuits. 2023 Apr 17;17:1135434.
https://doi.org/10.3389/fncir.2023.1135434
Note: ISS results. This article is part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior-Volume II” (https://www.frontiersin.org/research-topics/47491/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior—volume-ii#overview). The Research Topic also includes an article from previous Current Awareness List #1,041 https://doi.org/10.3389/fphys.2023.1141078. This article may be obtained online without charge.
2
Rengel A, Tran V, Toh LS.
Denosumab as a pharmacological countermeasure against osteopenia in long-duration spaceflight.
Aerosp Med Hum Perform. 2023 May;94(5):389-95.
https://doi.org/10.3357/AMHP.6053.2023
Note: From the abstract: “Prolonged exposure to microgravity is associated with a significant reduction in bone density, exposing astronauts to renal calculi in flight and osteoporotic fractures on return to Earth. While physical countermeasures and bisphosphonates may reduce demineralization, additional therapies are needed for future interplanetary missions. This literature review aims to understand the current background pertaining to denosumab (a monoclonal antibody therapy used in osteoporosis) and its potential use for long duration spaceflight.”
3
Scott JPR, Green DA, Weerts G, Cheuvront SN.
Effects of body size and countermeasure exercise on estimates of life support resources during all-female crewed exploration missions.
Sci Rep. 2023 Apr 12;13(1):5950.
https://pubmed.ncbi.nlm.nih.gov/37045858
Note: From the article: “Using published anthropometric (stature, body mass and BMI) and physiological (relative VO2max
) characteristics of female ISS astronauts, this theoretical study based on stature as the key operational criterion has, for the first time, provided estimates of energy expenditure, O2
use, CO2
and metabolic heat production, and water requirements for hydration, for an all-female crew spanning a stature range of 1.50-1.90-m during exploration missions without, and with, the use of ISS-like aerobic CM exercise.” This article may be obtained online without charge.
4
Papadopoulos A, Kyriakou I, Incerti S, Santin G, Nieminen P, Daglis IA, Li W, Emfietzoglou D.
Space radiation quality factor for Galactic Cosmic Rays and typical space mission scenarios using a microdosimetric approach.
Radiat Environ Biophys. 2023 Apr 16.
https://pubmed.ncbi.nlm.nih.gov/37062024
Note: This article may be obtained online without charge.
5
Schmidt S, Nguyen AT, Vu HQ, Tran NN, Sareela M, Fisk I, Hessel V.
Microfluidic spontaneous emulsification for generation of O/W nanoemulsions – opportunity for in-space manufacturing.
Adv Healthc Mater. 2023 Apr 11:e2203363.
https://pubmed.ncbi.nlm.nih.gov/37039561
Note: From the introduction: “Nanoemulsions are used for drug delivery, food, cosmetics, pharmaceuticals, and material synthesis, but can also serve as a model system to understand nanoscale colloidal dispersions. Applications are not restricted to Earth alone. In-spacemanufacturing, i.e., currently on a spacecraft as the International Space Station (ISS) and possibly in future on space habitats on the Moon, offers promises for processing colloidal systems due to the lack of gravity. Instrumental advantages are the perfect spherical shape of droplets and allowing to study mass transfer in an ideal environment, i.e., the lack of gravitational forces. Nano-emulsified fortified food items and pharmaceuticals offer diverse advantages for space explorers and astronauts, ranging from high product stability to high bioavailability.” This article may be obtained online without charge.
6
Lvova ID, Sharlo KA, Vilchinskaya NA, Sidorenko DA, Sharlo DT, Shenkman BS.
Accumulation of high-energy phosphates blocks the expression of mitochondrial biogenesis markers and slow-type myosin in soleus muscle under 24 hours of rat hindlimb suspension.
Life Sci Space Res. 2023 Apr 14. Online ahead of print.
https://doi.org/10.1016/j.lssr.2023.04.003
Note: Hindlimb unloading study.
7
Yang H, Wang H, Pan F, Guo Y, Cao L, Yan W, Gao Y.
New findings: Hindlimb unloading causes nucleocytoplasmic Ca2+
overload and DNA damage in skeletal muscle.
Cells. 2023 Apr 3;12(7):1077.
https://pubmed.ncbi.nlm.nih.gov/37048150
Note: Hindlimb unloading study. This article is part of Topic “Skeletal Muscle Structure and Function in Health and Disease” (https://www.mdpi.com/topics/skeletal_muscle) and may be obtained online without charge.
8
Copeland K, Whinnery JE.
Cerebral blood flow based computer modeling of Gz
-induced effects.
Aerosp Med Hum Perform. 2023 May;94(5):409-14.
https://doi.org/10.3357/AMHP.6179.2023
Note: From the abstract: “There is continued interest in acceleration (G) effects in civil aviation, as G-induced loss of consciousness (G-LOC), impaired consciousness, and visual effects play a role in aerobatic, agricultural, and military aviation accidents.”
9
Ma C, Duan X, Lei X.
3D cell culture model: From ground experiment to microgravity study.
Front Bioeng Biotechnol. 2023 Mar 24;11:1136583. Review.
https://pubmed.ncbi.nlm.nih.gov/37034251
Note: This article is part of Research Topic: “Advances in 3D Cell Culture for Drug Screening and Toxicology Evaluation” (https://www.frontiersin.org/research-topics/41345/advances-in-3d-cell-culture-for-drug-screening-and-toxicology-evaluation#overview). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
10
Bushby AJR, Gaydos SJ.
Spatial disorientation scenarios for the AW159 helicopter within a synthetic training environment.
Aerosp Med Hum Perform. 2023 May;94(5):377-83.
https://doi.org/10.3357/AMHP.6172.2023
Note: From the abstract: “Spatial disorientation (SD) remains a stubborn and formidable challenge among rotary wing (RW) aircrews, particularly during times of high workload and deceptive visual cues. With tri-Service agreement, British RW Forces employ a layered training approach that now includes simulator-based immersive scenarios.”
11
Sagirov AF, Sergeev TV, Shabrov AV, Yurov AY, Guseva NL, Agapova EA.
Postural influence on intracranial fluid dynamics: An overview.
J Physiol Anthropol. 2023 Apr 13;42:5. Review.
https://pubmed.ncbi.nlm.nih.gov/37055862
Note: This article may be obtained online without charge.
12
Masi G, Amprimo G, Ferraris C, Priano L.
Stress and workload assessment in aviation-A narrative review.
Sensors (Basel). 2023 Mar 28;23(7):3556. Review.
https://pubmed.ncbi.nlm.nih.gov/37050616
Note: This article is part of Special Issue “Physiological Signal Sensing for Mental Health Monitoring and Management” (https://www.mdpi.com/journal/sensors/special_issues/Physiological_Signal_Processing_MHMM). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
