New Space and Tech

NASA Spaceline Current Awareness List #1,045 14 April 2023 (Space Life Science Research Results)

By Keith Cowing
Press Release
April 15, 2023
Filed under , , , , , ,
NASA Spaceline Current Awareness List #1,045 14 April 2023 (Space Life Science Research Results)
space biology

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor,

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:


Batatinha H, Diak DM, Niemiro GM, Baker FL, Smith KA, Zúñiga TM, Mylabathula PL, Seckeler MD, Lau B, LaVoy EC, Gustafson MP, Katsanis E, Simpson RJ.

Human lymphocytes mobilized with exercise have an anti-tumor transcriptomic profile and exert enhanced graft-versus-leukemia effects in xenogeneic mice.

Front Immunol. 2023 Apr 03;14:1067369.

PI: R.J. Simpson

Note: This article is part of Research Topic “Current Advances in Exercise Immunology” ( This article may be obtained online without charge.

Journal Impact Factor: 8.786

Funding: “This project was supported by NASA grant 80NSSC21K0452 and grants from The University of Arizona Cancer Center and PANDA (People Acting Now Discover Answers) to RS and EK.”


Liddell LC, Gentry DM, Gilbert R, Marina D, Massaro Tieze S, Padgen MR, Akiyama K, Keenan K, Bhattacharya S, Santa Maria SR.

BioSentinel: Validating sensitivity of yeast biosensors to deep space relevant radiation.

Astrobiology. 2023 Apr 12. Online ahead of print.

Note: From the abstract: “With the imminent human exploration of deep space, it is more important than ever to understand the biological risks of deep space radiation exposure. The BioSentinel mission will be the first biological payload to study the effects of radiation beyond low Earth orbit in 50 years.” This article may be obtained online without charge.

Journal Impact Factor: 4.045

Funding: “This work was supported by NASA’s Advanced Exploration Systems Program Office.”


Grant LK, Crosthwaite PC, Mayer MD, Wang W, Stickgold R, St Hilaire MA, Lockley SW, Rahman SA.

Supplementation of ambient lighting with a task lamp improves daytime alertness and cognitive performance in sleep-restricted individuals.

Sleep. 2023 Apr 7;zsad096. Online ahead of print.

PIs: M.A. St Hilaire, S.W. Lockley, S.A. Rahman

Journal Impact Factor: 6.313

Funding: “…SAR has received grant/research support from Seoul Semiconductor Co. Ltd., Biological Innovation and Optimization Systems, LLC, Merck & Co. Ltd., Pfizer Inc., Vanda Pharmaceuticals Inc., Lighting Science Group, NIH, and NASA. …”


John SP, Svihla ZT, Hasenstein KH.

Changes in endogenous abscisic acid and stomata of the resurrection fern, Pleopeltis polypodioides, in response to de- and rehydration.

Am J Bot. 2023 Mar 9;e16152. Online ahead of print.

PI: K.H. Hasenstein

Journal Impact Factor: 3.325

Funding: “This research was supported by NASA grant 80NSSC17K0344.”


Wiencek JR, Das S, Beheshti A, Crucian BE, Karouia F, Trudel G, McMonigal KA.

Lab medicine in space.

Clin Chem. 2023 Apr 11;hvad035. Online ahead of print.

Note: From the abstract: “For this Q&A, we invited a diverse group of experts to explore the current and desired future state of laboratory medicine in space as well as innovations that will expand our current horizon within this area of interest.”

Journal Impact Factor: 12.167

Funding: “S. Das is recipient of 1.6 million INR as research grant from the Department of Science and Technology, Government of India. B.E. Crucian, NASA Johnson Space Center and International Partner Space Agencies. G. Trudel’s work is supported by the Canadian Space Agency.”


Adams JD, Sander KB, Criddle CS, Arkin AP, Clark DS.

Engineering osmolysis susceptibility in Cupriavidus necator and Escherichia coli for recovery of intracellular products.

Microb Cell Fact. 2023 Apr 12;22:69.

Note: From the abstract: “Intracellular biomacromolecules, such as industrial enzymes and biopolymers, represent an important class of bio-derived products obtained from bacterial hosts. A common key step in the downstream separation of these biomolecules is lysis of the bacterial cell wall to effect release of cytoplasmic contents. Cell lysis is typically achieved either through mechanical disruption or reagent-based methods, which introduce issues of energy demand, material needs, high costs, and scaling problems. Osmolysis, a cell lysis method that relies on hypoosmotic downshock upon resuspension of cells in distilled water, has been applied for bioseparation of intracellular products from extreme halophiles and mammalian cells. However, most industrial bacterial strains are non-halotolerant and relatively resistant to hypoosmotic cell lysis.” This article may be obtained online without charge.

Journal Impact Factor: 6.352

Funding: “This work was supported by the Center for the Utilization of Biological Engineering in Space (CUBES,, a NASA Space Technology Research Institute (Grant Number NNX17AJ31G).”


Bowman CDD, Elkins-Tanton LT, Talamante A, Bell JF 3rd

, Cisneros E, Cook A, Frieman JD, Gainor D, Hunziker J, Khan S, Lawler CR, Maschino J, McCoy TJ, Nessi K, Oran R, Seal D, Simon A, Singh R, Tolbert CM, Valentine K, Weiss B, Wenkert DD, Williams DA.

Mission to psyche: Including undergraduates and the public on the journey to a metal world.

Space Sci Rev. 2023;219(3):25. Review.

Note: From the abstract: “The NASA Psyche mission’s program to engage university undergraduates and the public in the mission is inspired by and built upon the extensive foundation of public engagement, educational outreach activities, and expertise of NASA and mission partner institutions. The program leverages the enthusiasm and contributions of undergraduates nationwide to the benefit of the mission, the students and their institutions and communities, and the broader public.” This article may be obtained online without charge.

Journal Impact Factor: 8.943

Funding: “This work, and Open Access funding, is supported by NASA contract NNM16AA09, ‘Psyche: Journey to a Metal World.'”


Other papers of interest:


Hélissen O, Kermorgant M, Déjean S, Mercadie A, Le Gonidec S, Zahreddine R, Calise D, Nasr N, Galès C, Arvanitis DN, Pavy-Le Traon A.

Autonomic nervous system adaptation and circadian rhythm disturbances of the cardiovascular system in a ground-based murine model of spaceflight.

Life (Basel). 2023 Mar 21;13(3):844.

Note: Hindlimb unloading study. This article is part of Section “Astrobiology” ( and may be obtained online without charge.


Jain V, Chuva de Sousa Lopes SM, Benotmane MA, Verratti V, Mitchell RT, Stukenborg JB.

Human development and reproduction in space-A European perspective.

npj Microgravity. 2023 Mar 27;9(1):24. Review.

Note: From the abstract: “This review summarizes key aspects of the first reproductive and developmental systems Science Community White Paper, supported by the European Space Agency (ESA). Current knowledge regarding human development and reproduction in space is mapped to the roadmap. It acknowledges that sex and gender have implications on all physiological systems; however, gender identity falls outside the scope of the document included in the white paper collection supported by ESA. The ESA SciSpacE white papers on human developmental and reproductive functions in space aim to reflect on the implications of space travel on the male and female reproductive systems, including the hypothalamic-pituitary-gonadal (HPG) reproductive hormone axis, and considerations for conception, gestation and birth. Finally, parallels are drawn as to how this may impact society as a whole on Earth.” This article may be obtained online without charge.


Piscon B, Pia Esposito E, Fichtman B, Samburski G, Efremushkin L, Amselem S, Harel A, Rahav G, Zarrilli R, Gal-Mor O.

The effect of outer space and other environmental cues on bacterial conjugation.

Microbiol Spectr. 2023 Mar 30;e0368822. Online ahead of print.

Note: From the abstract: “Here, we studied the effect of outer space, microgravity, and additional key environmental cues on transfer (tra) gene expression and conjugation efficiency, using the under studied broad-host range plasmid pN3, as a model. High resolution scanning electron microscopy revealed the morphology of the pN3 conjugative pili and mating pair formation during conjugation. Using a nanosatellite carrying a miniaturized lab, we studied pN3 conjugation in outer space, and used qRT-PCR, Western blotting and mating assays to determine the effect of ground physicochemical parameters on tra gene expression and conjugation. We showed for the first time that bacterial conjugation can occur in outer space and on the ground, under microgravity-simulated conditions.” This article may be obtained online without charge.


Pramanik J, Kumar A, Panchal L, Prajapati B.

Countermeasures for maintaining cardiovascular health in space missions.

Curr Cardiol Rev. Mini review. Online ahead of print.

Note: From the abstract: “During space exploration, the human body is subjected to altered atmospheric environments and gravity, exposure to radiation, sleep disturbance, and mental pressures; all these factors are responsible for cardiovascular diseases. Under microgravity, the physiological changes related to cardiovascular diseases are the cephalic fluid shift, dramatic reduction in central venous pressure, changes in blood rheology and endothelial function, cerebrovascular abnormalities, headaches, optic disc edema, intracranial hypertension, congestion of the jugular vein, facial swelling, and loss of taste. Generally, five countermeasures are used to maintain cardiovascular health (during and after space missions), including shielding, nutritional, medicinal, exercise, and artificial gravity. This article concludes with how to reduce space missions’ impact on cardiovascular health with the help of various countermeasures.”


Niemtzow RC.

Aerospace acupuncture and spaceflight: A realm not too distant!

Medical Acupuncture. 2023 Mar 23. Editorial. Online ahead of print.

Note: This article may be obtained online without charge.


Pagnini F, Manzey D, Rosnet E, Ferravante D, White O, Smith N.

Human behavior and performance in deep space exploration: Next challenges and research gaps.

npj Microgravity. 2023 Mar 30;9(1):27. Review.

Note: This article may be obtained online without charge.


Kostoglou M, Karapantsios T.

Cooking in space: Current situation, needs, and perspectives.

Curr Opin Food Sci. 2023 Jun;51:101021.


Cheng G, Yu B, Song C, Zablotskii V, Zhang X.

Bioeffects of microgravity and hypergravity on animals.

Chin J Electr Eng. 2023 Mar;9(1):29-46.

Note: This article may be obtained online without charge.


Yuan L, Zhang R, Li X, Gao C, Hu X, Hussain S, Zhang L, Wang M, Ma X, Pan Q, Lou X, Si S.

Long-term simulated microgravity alters gut microbiota and metabolome in mice.

Front Microbiol. 2023 Mar 24;14:1100747.

Note: This article may be obtained online without charge.


Hönemann JN, Gerlach D, Hoffmann F, Kramer T, Weis H, Hellweg CE, Konda B, Zaha VG, Sadek H, Herwarden AE, Olthaar A, Reuter H, Baldus S, Levine BD, Jordan J, Tank J, Limper U.

Hypoxia and cardiac function in patients with prior myocardial infarction.

Circ Res. 2023 Apr 3. Online ahead of print.


Liang P, Li Z, Li J, Wei J, Li J, Zhang S, Xu S, Liu Z, Wang J.

Impacts of complex electromagnetic radiation and low-frequency noise exposure conditions on the cognitive function of operators.

Front Public Health. 2023 Mar 23;11:1138118.

Note: This article may be obtained online without charge.


Liu X, Wang L, Choera T, Fang X, Wang G, Chen W, Lee YW, Mohamed SR, Dawood DH, Shi J, Xu J, Keller NP.

Paralogous FgIDO genes with differential roles in tryptophan catabolism, fungal development and virulence in Fusarium graminearum.

Microbiol Res. 2023 Jul;272:127382.


Mao L, Wang L, Xu J, Zou J.

The role of integrin family in bone metabolism and tumor bone metastasis.

Cell Death Discov. 2023 Apr 10;9:119. Review.

Note: This article may be obtained online without charge.


Wang R, Wang M, Jin R, Wang Y, Yi M, Li Q, Li J, Zhang K, Sun C, Nie Y, Huang C, Mikos AG, Zhang X.

High strength titanium with fibrous grain for advanced bone regeneration.

Adv Sci (Weinh). 2023 Apr 7;e2207698.

Note: This article may be obtained online without charge.


Sathialingam E, Cowdrick KR, Liew AY, Fang Z, Lee SY, McCracken CE, Akbik F, Samuels OB, Kandiah P, Sadan O, Buckley EM.

Microvascular cerebral blood flow response to intrathecal nicardipine is associated with delayed cerebral ischemia.

Front Neurol. 2023 Mar 17;14:1052232.

Note: This article may be obtained online without charge.


Melnik D, Cortés-Sánchez JL, Sandt V, Kahlert S, Kopp S, Grimm D, Krüger M.

Dexamethasone selectively inhibits detachment of metastatic thyroid cancer cells during random positioning.

Cancers (Basel). 2023 Mar 7;15(6):1641.

Note: This article is part of Special Issue “Tumor Models and Drug Targeting In Vitro” ( and may be obtained online without charge.

SpaceRef co-founder, Explorers Club Fellow, ex-NASA, Away Teams, Journalist, Space & Astrobiology, Lapsed climber.